Category: alcohols-buliding-blocks

Application of 106-28-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.106-28-5, name is (2E,6E)-3,7,11-Trimethyldodeca-2,6,10-trien-1-ol, molecular formula is C15H26O, molecular weight is 222.37, as common compound, the synthetic route is as follows.

To a stirred mixture of (E,E)-farnesol 1 (0.50 g, 2.25 mmol) in non-dried DCM (50 mL) under nitrogen was added Dess-Martin periodinane (1.43 g, 3.40 mmol), and the resulting mixture stirred for 2 h 50 min. Saturated aqueous sodium bicarbonate solution (20 mL) was added dropwise, the mixture stirred 10 min, then extracted with DCM (3 x 25 mL). The organic layer was dried (MgSO4), and the solvent was removed in vacuo. The crude product was purified using flash chromatography (19:1 hexanes: ethyl acetate) to give the title product (0.495 g, 99%) as a clear colourless oil.

Statistics shows that 106-28-5 is playing an increasingly important role. we look forward to future research findings about (2E,6E)-3,7,11-Trimethyldodeca-2,6,10-trien-1-ol.

Reference:
Article; Duhamel, Nina; Martin, Damian; Larcher, Roberto; Fedrizzi, Bruno; Barker, David; Tetrahedron Letters; vol. 57; 40; (2016); p. 4496 – 4499;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3597-91-9, name is [1,1′-Biphenyl]-4-ylmethanol, the common compound, a new synthetic route is introduced below. Quality Control of [1,1′-Biphenyl]-4-ylmethanol

In a 10 mL round bottom flask, 0.85 g of 4-hydroxymethylbiphenyl (4-phenylbenzyl alcohol) and 2 g of diethylene glycol dimethyl ether were sequentially added, and the resulting mixture was subjected to an ultrasonic reaction apparatus at 40 KHz/30 W/70. C Ultrasonic radiation was allowed to open for 35 minutes. The diethylene glycol dimethyl ether was removed under reduced pressure, and recrystallized to give 0.95 g of 4-phenylbenzoic acid, yield 96%.

The synthetic route of 3597-91-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Central South University; Xiao Fang; Xiao Yuanyuan; Zeng Ming; Li Na; Yin Lirong; (15 pag.)CN108467342; (2018); A;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6240-11-5, name is 1-Adamantaneethanol, molecular formula is C12H20O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. SDS of cas: 6240-11-5

General procedure: To a three-necked, cylindrical Pyrex glass reaction vessel equipped with a rubber balloon, rubberseptum, and glass stopper, a N2 atmosphere was introduced by flowing via cannula for 5 min. Au(0.6 wt %)/TiO2 (117.3 mg, 0.17 mol % Au), 1a (271.5 mg, 1.99 mmol), and dehydrated ethylacetate (25 mL) were added successively to the vessel. After N2 gas was reintroduced more than 5min, the rubber balloon was connected to the vessel and the mixture was sonicated. The vessel wasimmersed in a oil bath (kept at 45 oC) and stirred for 10 h under irradiation (lambda = 300-470 nm). 1HNMR analysis of this crude mixture using mesitylene as an internal standard indicated 97%conversion of 1a and the formation of 2a in 86% yield, as determined based on the signals at delta 3.61ppm and 2.94 ppm (shifted from 2.89 ppm due to the presence of ethyl acetate), respectively. Theproduct was purified by silica gel column chromatography (n-hexane/ethyl acetate 3:1) to afford 2a(180 mg, 66% yield, with inclusion of small amounts of unidentified impurities).

With the rapid development of chemical substances, we look forward to future research findings about 6240-11-5.

Reference:
Article; Shibata, Masaki; Nagata, Ryoko; Saito, Susumu; Naka, Hiroshi; Chemistry Letters; vol. 46; 4; (2017); p. 580 – 582;,
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Adding a certain compound to certain chemical reactions, such as: 2919-23-5, Cyclobutanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C4H8O, blongs to alcohols-buliding-blocks compound. Formula: C4H8O

A quartz glass tube charged with 50 g of catalyst (H1044, composition approx. 27 g of copper oxide, approx. 4 g of chromium oxide, approx. 5 g of barium oxide, on SiO2) and bounded at both ends with Raschig rings was installed in a commercial, electrically heated laboratory tubular furnace and the temperature in the catalyst zone was set to 200 C. 30 g of crude cyclobutanol product (purity approx. 73%, 0.3 mol) were evaporated using a preevaporator and then passed over the catalyst (LHSV=0.18/h). After leaving the catalyst zone, the reaction mixture was cooled using a condenser and collected in a cold trap. 27 g of reaction effluent were obtained, having a composition of 59% of cyclobutanone and 19% of cyclobutanol (conversion: 77%, selectivity: 96%). Example 7 Gas Phase Dehydrogenation [0043] In the experimental apparatus described in Example 6 (same catalyst), 256 g of crude cyclobutanol (purity approx. 74%) were converted at 250 C. (LHSV=0.33/h). 243 g of reaction effluent were obtained having an average composition of 63% of cyclobutanone and 12% of cyclobutanol (conversion: 84%, selectivity >98%). Distillation of the product mixture through a 1 m Multifil column provided 102 g of cyclobutanone in a purity of >99% (b.p.: 97-99 C., distillation yield: 67%). Example 8 Gas Phase Dehydrogenation [0044] The quartz glass tube was filled with 50 g of catalyst (H1044, calcined at 700 C.) and was stored in the laboratory tubular furnace as in Example 7. Likewise as described, 135 g (1.3 mol) of crude cyclobutanol (purity 71%) were passed over the catalyst at 250 C. (LHSV=0.33/h). 127 g of reaction effluent were obtained having an average composition of 58% of cyclobutanone and 2.5% of cyclobutanol (conversion: 97%, selectivity: 82%). Example 9 Gas Phase Dehydrogenation [0045] The quartz glass tube was filled with 50 g of catalyst (H1044, calcined at 650 C.) and stored in the laboratory tubular furnace as described in Example 7. 776 g of crude cyclobutanol (purity: 71%) were then passed in gaseous form over the catalyst at 250 C. (LHSV=0.33/h). 719 g of reaction effluent were obtained having an average composition of 67% of cyclobutanone and 5% of cyclobutanol (conversion: 94%, selectivity: 97%). Distillation of the product mixture through a 1 m Multifil column resulted in 380 g of cyclobutanone (purity >95%, distillation yield 81%). Example 10 Gas Phase Dehydrogenation [0046] The quartz glass tube was filled with 50 g of catalyst (H1044, calcined at 650 C.) and stored in the laboratory tubular furnace as described in Example 7. 876 g of crude cyclobutanol (purity: 75%) were then passed in gaseous form over the catalyst at 250 C. (LHSV=1.5 h-1). 832 g of reaction effluent were obtained having an average composition of 67% of cyclobutanone and 8% of cyclobutanol (conversion: 90%, selectivity: 97%). Distillation of the product mixture through a 1 m Multifil column resulted in 516 g of cyclobutanone (purity >95%, distillation yield 80%)

The synthetic route of 2919-23-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Degussa AG; US2004/254401; (2004); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 90369-75-8, name is (3-Chloro-2-methylphenyl)methanol, the common compound, a new synthetic route is introduced below. Application In Synthesis of (3-Chloro-2-methylphenyl)methanol

Diphenylphosphoryl azide (6.00 mL, 27.80 mmol) was added to a cooled (0 C.) solution of (3-chloro-2-methyl-phenyl)-methanol (3.66 g, 23.40 mmol) in ether. The resulting mixture was stirred for a few minutes and DBU (4.20 mL, 28.00 mmol) was added slowly. The reaction mixture was stirred for 14 hours, decanted into a clean flask and the residue was washed with more ether. The combined organic phases were concentrated to give the crude title azido compound. Spectroscopic data: 1H NMR (300 MHz, CDCl3.) delta 2.41 (s, 3H), 4.36 (s, 2H), 7.11-7.26 (m, 2H), 7.35 (dd, J=7.33 Hz, 1H).

The synthetic route of 90369-75-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Allerghan, Inc.; US2008/194650; (2008); A1;,
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Reference of 10602-04-7 ,Some common heterocyclic compound, 10602-04-7, molecular formula is C9H8O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

4-Ethynylbenzyl alcohol a_(l g, 7.57 mmol) was diluted in 20 ml DCM, and cooled to 0¡ã in ice bath. Phosphorus tribromide (4.1 g, 15 mmol) was added dropwise. The reaction was allowed to warm to room temperature gradually, and stirred under nitrogen overnight. The reaction was quenched by addition of H2O in ice bath, extracted by DCM. Combined organic layers were washed with brine, dried over Na2SO4 and concentrated to dryness. The crude material was purified by chromatography (ISCO) using 100percent hexane to give pure 4-ethynylbenzyl bromide b (220 mg). M+H+ 195.1

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 10602-04-7, (4-Ethynylphenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; GENENTECH, INC.; WO2008/134679; (2008); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 89-95-2, name is 2-Methylbenzyl alcohol. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of 2-Methylbenzyl alcohol

General procedure: In a round-bottom flask, benzylic alcohol 1a (10 mmol, 2.0 equiv.), benzenesulfonyl chloride 2a (13 mmol, 1.3 equiv.) and NMP (2.5 equiv.). Then, DCE (3 mL) were added. The mixture was stirred at 80 C for 1.5 h. After completion of the reaction (monitoredby TLC), water (10 mL) was added and the mixture was extracted with ethyl acetate (3*10 mL). The combined organic phase was dried over anhydrous Na2SO4, filtered, and evaporated under reduced pressure. The crude product was purified by flash chromatography on silica gel to give the desired alkyl chlorides 3.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 89-95-2, 2-Methylbenzyl alcohol.

Reference:
Article; Zheng, Dagui; Mao, Liu-Liang; Zhu, Xian-Hong; Zhou, An-Xi; Synthetic Communications; vol. 48; 21; (2018); p. 2793 – 2800;,
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Related Products of 148043-73-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 148043-73-6, name is 4,4,5,5,5-Pentafluoropentan-1-ol. This compound has unique chemical properties. The synthetic route is as follows.

Into a reactor (internal capacity: 200 mL, made of glass) equipped with a stirrer and a dropping funnel, linear C2F5CH2CH2CH2OH (23.6g), triethylamine (16.1 g) and acetone (80 mL) were put and stirred. Then, by an ice bath, the inner temperature of the reactor was adjusted to be at most 10C, and in a nitrogen atmosphere, a solution of 4-(chloromethyl)benzoic acid chloride (25.0 g) in acetone (15 mL) was dropwise added. Further, the temperature was returned to room temperature, and stirring was continued for 2 hours. The obtained reaction crude liquid was transferred to a separating funnel, dichloropentafluoropropane (tradename: AK-225, manufactured by Asahi Glass Company, Limited) (100 mL) was added, followed by washing three times with distilled water (100 mL), and the solvent in the AK-225 phase was distilled off to obtain 40.2 g of a compound (C-2) (pale yellow liquid) represented by the following structural formula (C-2) and classified into the above compound (C). The yield was 93%.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 148043-73-6, 4,4,5,5,5-Pentafluoropentan-1-ol.

Reference:
Patent; Asahi Glass Company, Limited; EP2497763; (2012); A1;,
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Adding a certain compound to certain chemical reactions, such as: 124-68-5, 2-Amino-2-methyl-1-propanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 124-68-5, blongs to alcohols-buliding-blocks compound. name: 2-Amino-2-methyl-1-propanol

(1) Acetic acid (5.4 ml) was added to a solution of 2-amino-2-methyl-1-propanol (8.4 g) and benzaldehyde (10 g) in 1,2-dichloroethane (140 ml) under ice-cooling. After 30 minutes of stirring at the same temperature, sodium triacetoxyborohydride (26 g) was added by small portions to the solution over 10 minutes. After 2 hours of stirring at room temperature, the mixture was poured into a solution of sodium hydrogen carbonate (48 g) in water (300 ml). The aqueous layer was separated and adjuster to pH 12 with 24% sodium hydroxide aqueous solution. The alkaline solution was extracted with ethyl acetate 12 times. The extract was dried over sodium sulfate and evaporated under reduced pressure to give colorless crystals of 2-benzylamino-2-methyl-1-propanol (13.2 g). mp: 46.0-47.0 C. IR (Nujol): 3330, 3100, 2900, 1450, 1380, 1355 cm-1 NMR (DMSO-d6, delta): 0.99 (6H, s), 3.23 (2H, d, J=3.9Hz), 3.62 (2H, s), 4.50-4.60 (1H, m), 7.16-7.36 (5H, m)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,124-68-5, its application will become more common.

Reference:
Patent; MIYAKE, HIROSHI; TAKE, KAZUHIKO; SHIGENAGA, SHINJI; AZAMI, HIDENORI; SASAKI, HIROSHI; EIKYU, YOSHITERU; NAKAI, KAZUO; ISHIDA, JUNYA; MANABE, TAKASHI; KONISHI, NOBUKIYO; TERASAKA, TADASHI; US2003/114668; (2003); A1;,
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Electric Literature of 42822-86-6 ,Some common heterocyclic compound, 42822-86-6, molecular formula is C10H20O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: para-Methane-3,8-diol (3, 5.0 g, 0.029 mol) and an appropriatemolar equivalent of acid anhydride were transferred into thereactor concurrently. Both reagents were stirred and heated at60 Cfor 10 minutes. The homogeneous mixture was achievedand 0.3 g of polymer-bound scandium triflate (PS-Sc(OTf)3)catalyst was added into the reaction mixture. The reaction washeated at the appropriate temperature for 24 hours, while followed by sampling at an hourly interval. Upon the completionof the reaction, the catalyst was separated from the product mixture by filtration and the acid byproduct was removed byvacuum distillation. The obtained crude sample was subsequently purified by column chromatography hexane/EtOAc(98:2).Diacetate 9:The reaction was carried out in accordance withthe general procedure using para-menthane-3,8-diol (3, 5.0 g,0.029 mol) and acetic anhydride (5, 7.4 g, 0.073 mol) to givethe title compound 9as viscous colourless oily liquid,bp 288 C, (6.8 g, 91%); 1H NMR (400 MHz, CDCl3, ppm)delta0.78-0.79 (m, 3H), 0.89-1.04 (m, 2H), 1.35 (br d, J= 12 Hz,6H), 1.53-1.60 (m, 3H), 1.72 (d, J= 16 Hz, 1H), 1.82 (d, J= 12Hz, 1H), 1.88 (s, 3H), 1.96 (s, 3H), 2.02-2.08 (m, 1H) and 5.17(br s, 1H); 13C NMR(100 MHz, CDCl3, ppm) delta21.4, 21.9,22.2, 22.3, 24.0, 25.1, 26.6, 34.6, 39.4, 47.3, 69.8, 84.2, 169.9and 170.3; FTIR (cm-1): 2949, 1728, 1180 and 1144; m/z(CI)256 (M+, 1), 197 (78), 137 (71), 95 (62) and 81 (100); GC tR=17.8 min.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 42822-86-6, 2-(2-Hydroxypropan-2-yl)-5-methylcyclohexanol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Mafu, Lubabalo; Zeelie, Ben; Watts, Paul; Beilstein Journal of Organic Chemistry; vol. 12; (2016); p. 2046 – 2054;,
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