Category: alcohols-buliding-blocks

Electric Literature of 29171-20-8, Adding some certain compound to certain chemical reactions, such as: 29171-20-8, name is 3,7-Dimethyloct-6-en-1-yn-3-ol,molecular formula is C10H16O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 29171-20-8.

EXAMPLE 3 Manufacture of 4-methyl-4-(4-methyl-3-pentenyl)-5-methylene-1,3-dioxolan-2-one According to the methodology described in Example 1, but with a heating period of 8 hours at 20 bar (2000 kPa) and 80¡ã C., and starting from 68.51 g (0.45 mol) of 3,7-dimethyl-oct-1-yn-6-en-3-ol (dehydrolinalool) there are obtained 69.41 g (97.79percent content) of 4-methyl-4-(4-methyl-3-pentenyl)-5-methylene-1,3-dioxolan-2-one; the yield is 76.9percent based on the dehydrolinalool used.

According to the analysis of related databases, 29171-20-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Roche Vitamins Inc.; US5817838; (1998); A;,
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Adding a certain compound to certain chemical reactions, such as: 2568-33-4, 3-Methylbutane-1,3-diol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C5H12O2, blongs to alcohols-buliding-blocks compound. HPLC of Formula: C5H12O2

Example 2OC; N-r(2Z)-3-butviri.31thiazolor4.5-clpyridin-2(3H)-ylidenel-2-(3-hvdroxy-3-methylbutoxy)-5-(trifluoromethyl)benzamide; 3-Methylbutane-l,3-diol (42 mg, 0.4 mmol) in THF (1 mL) was treated with NaH (60%) (16 mg, 0.4 mmol) at room temperature for 20 min. To the above mixture, which was cooled to 0-5 0C, was added the product from Example 2OB (80 mg, 0.2 mmol) in THF (1 mL). After 20 min. the reaction mixture was quenched with saturated aqueous NaHCO3 (20 mL) and extracted with ethyl acetate (2 x 30 mL). The combined organic extracts were dried over anhydrous Na2SO4, filtered, and concentrated under reduced pressure. The residue was purified by column chromatography using an Analogix Intelliflash280 (SiO2, 0-100 % ethyl acetate in hexanes) to afford 87 mg (90 %) of the title compound. 1H NMR (500 MHz, CDCl3) delta ppm 1.04 (t, J=7.32 Hz, 3 H) 1.36 (s, 6 H) 1.47 – 1.55 (m, 2 H) 1.88 – 1.96 (m, 2 H) 2.13 (t, J=5.80 Hz, 2 H) 4.35 (t, J=5.80 Hz, 2 H) 4.54 (t, J=7.63 Hz, 2 H) 5.12 (brs, 1 H) 7.11 (d, J=8.54 Hz, 1 H) 7.61 (d, J=5.19 Hz, 1 H) 7.74 (dd, J=8.54, 2.14 Hz, 1 H) 8.49 (d, J=5.19 Hz, 1 H) 8.68 (s, 1 H) 8.72 (s, 1 H); MS (ESI+) m/z 482 (M+H)+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,2568-33-4, 3-Methylbutane-1,3-diol, and friends who are interested can also refer to it.

Reference:
Patent; ABBOTT LABORATORIES; FROST, Jennifer, M.; LATSHAW, Steven, P.; DART, Michael, J.; CARROLL, William, A.; PEREZ-MEDRANO, Arturo; KOLASA, Teodozyj; PATEL, Meena; NELSON, Derek, W.; LI, Tongmei; PEDDI, Sridhar; WANG, Xueqing; LUI, Bo; WO2010/71783; (2010); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 55489-58-2, name is 2-(2-(2-(Benzyloxy)ethoxy)ethoxy)ethanol, the common compound, a new synthetic route is introduced below. Formula: C13H20O4

2-(2-(2-(benzyloxy)ethoxy)ethoxy)ethanol (1.0 g, 4.16 mmol) and carbon tetrabromide (1.40 g, 4.2 mmol) were dissolved in dichloromethane under an argon atmosphere. The flask was placed in a water bath and triphenylphosphine (1.10 g, 4.2 mmol) in dichloromethane (10 ml_) was added drop-wise over 15 minutes. After stirring for an additional 2 hours at room temperature, the solution was concentrated and the product was purified by flash column chromatography on silica gel (30 g), eluting with a mixture of heptanes/ethyl acetate (3:1 ). The experiment generated ((2-(2-(2- bromoethoxy)ethoxy)ethoxy)methyl)benzene 5 (1 .0 g, 80% yield) as a colorless liquid. 1H NMR (300 MHz, CDCI3): 7.60-7.40 (m, 5H), 4.56 (s, 2H), 3.79 (t, 2H, J = 6.3 Hz), 3.72-3.55 (m, 8H), 3.44 (t, 2H, J = 6.3 Hz). 13C (75 MHz, CDCI3): 138.24, 128.37, 127.74, 127.61 , 73.34, 71.32, 70.83, 70.76, 70.66, 69.55, 30.55.

The synthetic route of 55489-58-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; RODOS BIOTARGET GMBH; AUGUSTUS BIOTARGET, INC.; SCOLARO, Michael, J.; SULLIVAN, Sean, M.; GIESELER, Robert, K.; HOZSA, Constantin; FURCH, Marcus; (68 pag.)WO2017/17148; (2017); A1;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 7073-69-0, name is 2-(2-Bromophenyl)propan-2-ol. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C9H11BrO

2-(2-Bromophenyl)propene (6b) was synthesized in a similar way by dehydration of 65.00 g (0.33 mol) of compound 5b with 49.50 g (0.36 mol) of phthalic anhydride. The oily crude product, 49.50 g, was distilled under reduced pressure. Yield 46.50 g (77%), purity 98% (GLC), bp 64-65C (1 mm), d420 = 1.5365,nD20 = 1.5595; MRD 47.50, calcd. 47.46; published data [21]: bp 55-65C (0.9 mm), nD27 = 1.553. IR spectrum,nu, cm-1: 3090, 1648, 910 (C=CH2), 740 (C-Br).1H NMR spectrum, delta, ppm: 2.07 m (3H, CH3), 4.95 mand 5.23 m (2H, =CH2), 7.03-7.37 m (3H, Harom),7.58 d (1H, 3-H, J = 7 Hz). 13C NMR spectrum, deltaC,ppm: 145.5 (C1), 128.1 (C2), 129.5 (C3, C4), 126.9(C5), 132.8 (C6), 121.7 (C7), 116.0 (C8), 23.5 (CH3).Found, %: C 54.51; H 4.40; Br 40.35. C9H9Br. Calculated,%: C 54.85; H 4.60; Br 40.55.

With the rapid development of chemical substances, we look forward to future research findings about 7073-69-0.

Reference:
Article; Fedorov; Fedorova; Sheverdov; Pavlov; Eremkin; Russian Journal of Organic Chemistry; vol. 52; 6; (2016); p. 806 – 812; Zh. Org. Khim.; vol. 52; 6; (2016); p. 806 – 812,7;,
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Electric Literature of 17100-58-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 17100-58-2, name is (4-Bromo-2-methylphenyl)methanol, molecular formula is C8H9BrO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Step 2: 4-bromo-l-(bromomethyl)-2-methylbenzene; Hydrobromic acid (cone, 2 eq.) was added to a stirred solution of the alcohol from step 1 (1 eq.) in acetic acid (0.22M). The mixture was stirred at 50 C for 12 h, cooled down to room temperature, poured in water and extracted with Et2O. The organic extract was washed with water, aqueous sodium hydrogen carbonate (3x), brine, dried over MgSO4, filtered and concentrated to afford the desired benzyl bromide as a light yellow solid.

According to the analysis of related databases, 17100-58-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; MERCK FROSST CANADA LTD.; WO2009/23964; (2009); A1;,
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Adding a certain compound to certain chemical reactions, such as: 10160-24-4, 7-Bromo-1-heptanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C7H15BrO, blongs to alcohols-buliding-blocks compound. Computed Properties of C7H15BrO

2-(7-Bromoheptyloxy)tetrahydro-2H-pyran2 (3): Dihydropyran (5.20 g, 6.11 mmol) was added to a stirring 0C solution of 7-bromoheptane-l-ol (2) (1 1.0 g, 56.7 mmol) and a catalytic amount of PTSA in CH2C12. After stirring at rt for 12 h, the reaction mixture was diluted with CH2C12 (200 mL), washed with water (100 mL x 2), brine (100 mL chi 3), dried over anhydrous sodium sulphate, and evaporated. The residue was purified by silica gel column chromatography using a gradient of 10-20% ethyl acetate/hexane as eluent to give 2-(7- bromoheptyloxy)tetrahydro-2H-pyran (3) (14.50 g, 92%) as a colorless oil. TLC: 10% EtOAc/hexanes, Rf ~ 0.55; NMR (400 MHz, CDC13) delta 4.58-4.56 (m, 1H), 3.84-3.88 (m, 1H), 3.68-3.77 (m, 1H), 3.46-3.51 (m, 1H), 3.33-3.43 (m, 3H), 1.80-1.81 (m, 2H), 1.30-1.62 (m, 14 H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,10160-24-4, 7-Bromo-1-heptanol, and friends who are interested can also refer to it.

Reference:
Patent; MCW RESEARCH FOUNDATION, INC.; IMIG, John, David; CAMPBELL, William, B.; FALCK, John, Russell; WO2012/138706; (2012); A1;,
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Adding a certain compound to certain chemical reactions, such as: 86770-74-3, 2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 86770-74-3, blongs to alcohols-buliding-blocks compound. Product Details of 86770-74-3

Example 4 This example describes two methods for the preparation of bis-N,N’-(2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)ethyl)perylenetetracarboxylic diimide. Method A: 2-[2-[2-(2-Aminoethoxy)ethoxy]ethoxy]ethanol (2.6 g, 13.5 mmol), perylenetetracarboxylic dianhydride (2.2 g, 5.6 mmol), and triethylamine (25 mL, 180 mmol) were mixed with 50 mL of dry DMSO (4A activated MS, 3 days) in a 250-mL flask under argon. After the reaction mixture was stirred for 4 h at 150 C., the reaction solution was cooled to 80 C. and transferred to a 1000-mL flask. A mixture of 600 mL 10% aqueous HCl and 300 mL methanol was added to the reaction solution, then the solution was stirred for additional 2 hours at 60 C. After the mixture was cooled to RT overnight, the precipitate was collected using paper filter. The resulting collection was washed with 400 mL water, and the water layer was re-extracted with 50 mL chloroform. The filtrate could be extracted with chloroform to gain more products, but these products were contaminated and needed column purification. The combined organic layer was concentrated to give the crude title product; further purification was carried out on a silica-gel column eluted with CH2Cl2/CH3OH (5:1). Detection of the products on TLC plates was accomplished using UV light or sulfuiric acid solution (5% conc. sulfuric acid in EtOH). The title compound was obtained as dark-red solid (3.6 g, 86% yield): Rf0.4 (CH2Cl2/CH3OH, 10:1). 1H-NMR (60-70 mg/0.5 ml; CDCl3/CD3OD/100/5) delta7.96 (d, 4H, J=8.1 Hz, aromatic ring), 7.61 (d, 4H, J=8.1 Hz, aromatic ring), 4.32 (t, 4H, J=5.7 Hz, CH2N), 3.65-3.29 (m, 28H, CH2OCH2, HOCH2); 13C-NMR (60-70 mg/0.5 ml; CDCl3/CD3OD/100/5) delta162.7, 133.1, 130.4, 128.1, 124.7, 122.5, 122.4, 72.9, 70.79, 70.76, 70.4, 70.2, 68.0, 61.6, 39.5. 1H-NMR (DMSO-d6) delta7.13 (bd, 4H, aromatic ring), 6.92 (bd, 4H, aromatic ring), 4.59 (t, 4H, J=5.7 Hz, CH2N), 3.65-3.29 (m, 28H, CH2OCH2, HOCH2); 13C-NMR (DMSO-d6) delta161.2, 131.4, 128.8, 125.9, 122.6, 120.2, 72.3, 69.8, 69.7, 69.6, 66.5, 60.2, 45.67. MS (MALDI): m/z 765.82 [M+Na]+. Anal. Calcd. for C40H42N2O12 (742.77): C, 64.68; H, 5.70; N, 3.77. Found: C, 64.24; H, 5.52; N, 3.83.

The synthetic route of 86770-74-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Washington State University Research Foundation; US7238792; (2007); B2;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 3973-18-0, name is Propynol ethoxylate. A new synthetic method of this compound is introduced below., Quality Control of Propynol ethoxylate

Production of 2-((4-methylcyclohexa-l,4-dienyl)methoxy)ethyl 4-methylbenzenesulfonate and 2-((5 -methylcyclohexa- 1 ,4-dienyl)methoxy)ethyl 4-methylbenzenesulfonate[Chem. 24] 100.00 g (0.59 mol) of the diene alcohol obtained in Example 36, 90.29 g (0.89 mol) of Iriethylamine, and 73.20 g (0.89 mol) of 1-methylimidazole were dissolved in 400 ml of toluene. In an ice bath, a toluene solution (400 ml) of 130.33 g (0.68 mol) of p-toluenesulfonyl chloride was slowly added dropwise to the solution, and then the resulting mixture was stirred for one hour at room temperature. Water was added thereto, and the organic layer was separated. The obtained organic layer was washed sequentially with 15% sulfuric acid, water, and a saturated aqueous sodium hydrogen carbonate. The solvent was distilled off under reduced pressure, and thus 188.01 g of the desired tosylate was obtained as a colorless oil. Yield 98.1% (l,4-type/l,5-type = 91/9).1.67 (s, 3H), 2.44 (s, 3H), 2.58 (brs, 4H), 3.58 – 3.55 (m, 2H), 3.84 (s, 2H), 4.18 – 4.14 (m, 2H), 5.41 – 5.40 (m, 1H), 5.64 – 5.63 (m, 1H), 7.33 (d, J = 8.3 Hz, lH), 7.80 (d, J = 8.3 Hz, 1H);HRMS (ESI):Calculated value: [M+H]+ 323.1312Found value: 323.1325

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 3973-18-0, Propynol ethoxylate.

Reference:
Patent; TAKASAGO INTERNATIONAL CORPORATION; TOUGE, Taichiro; NARA, Hideki; HAKAMADA, Tomohiko; WO2012/26201; (2012); A1;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1450754-41-2, name is 2-(3-But-3-ynyl-3H-diazirin-3-yl)-ethanol, molecular formula is C7H10N2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Safety of 2-(3-But-3-ynyl-3H-diazirin-3-yl)-ethanol

(f) imidazole (740 mg, 10.87 mmol, 3.0 eq),Triphenylphosphine (1.05 g, 3.99 mmol, 1.1 eq)Add dichloromethane (5ml) to the reaction flask and cool to 0 C.Add iodine (1.1 g, 4.35 mmol, 1.2 eq),Add the insulation reaction for 30 minutes.Add compound 5 (500 mg, 3.62 mmol, 1 eq) at low temperatureA solution of methylene chloride (1 ml) was added and the reaction was kept for 4 hours.Quenched with saturated sodium sulfite solution, extracted with ethyl acetate.Dry, spin dry, and purified by column to obtain 400 mg of compound 6,Yield: 46%

With the rapid development of chemical substances, we look forward to future research findings about 1450754-41-2.

Reference:
Patent; Suzhouguangdian Biological Technology Co., Ltd.; Ni Runyan; Wang Wei; (7 pag.)CN109438211; (2019); A;,
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Adding a certain compound to certain chemical reactions, such as: 112-47-0, 1,10-Decanediol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Application In Synthesis of 1,10-Decanediol, blongs to alcohols-buliding-blocks compound. Application In Synthesis of 1,10-Decanediol

Hydrobromic acid (1.2 mL 48% aqueous solution, 9.5 mmol) was added to a suspension of 1,10-decanediol 1 (1.5 g, 8.6 mmol) in 30 mL of toluene in a round-bottomed flask equipped with a Dean-Stark trap and a cooler. The mixture was refluxed for 16 h. After cooling, the solvent was removed under reduced pressure. The residue obtained was chromatographed on silica gel using hexane/ethyl acetate (8:2) to yield the pure compound 2 (Scheme 1). Yield 74%; yellow oily product: IR (KBr): v = 3325, 2925, 2850,1450, 1250, 1050, 700, 625, 550 cm-1. 1H NMR (200 MHz, CDCl3): delta1.20-1.40 (m, 12H), 1.45-1.60 (m, 2H), 1.84 (qn, J=6.8 Hz, 2H), 3.39 (t, J=6.8 Hz, 2H), 3.62 (t, J=6.4 Hz, 2H) ppm. 13C NMR (50 MHz, CDCl3) delta: 25.67, 28.11, 28.69, 29, 32, 29.42, 32.73, 32.77, 33.98, 62.99 ppm.

The synthetic route of 112-47-0 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Guimaraes, Daniel Silqueira Martins; de Sousa Luz, Leticia Silveira; do Nascimento, Sara Batista; Silva, Lorena Rabelo; de Miranda Martins, Natalia Rezende; de Almeida, Heloisa Goncalves; de Souza Reis, Vitoria; Maluf, Sarah El Chamy; Budu, Alexandre; Marinho, Juliane Aparecida; Abramo, Clarice; Carmona, Adriana Karaoglanovic; da Silva, Marina Goulart; da Silva, Gisele Rodrigues; Kemmer, Victor Matheus; Butera, Anna Paola; Ribeiro-Viana, Renato Marcio; Gazarini, Marcos Leoni; Junior, Clebio Soares Nascimento; Guimaraes, Luciana; dos Santos, Fabio Vieira; de Castro, Whocely Victor; Viana, Gustavo Henrique Ribeiro; de Brito, Cristiana Ferreira Alves; de Pilla Varotti, Fernando; European Journal of Pharmaceutical Sciences; vol. 138; (2019);,
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