Category: alcohols-buliding-blocks

Related Products of 4415-82-1 , The common heterocyclic compound, 4415-82-1, name is Cyclobutylmethanol, molecular formula is C5H10O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example 62A 3-(Cyclobutyloxy)pyridine hydrochloride With ice cooling, 2.59 g (13.7 mmol) of triphenylphosphine were added to a solution of 1.00 g (10.5 mmol) of 3-hydroxypyridine and 1.3 ml (13.7 mmol) of cyclobutylmethanol in 20 ml of THF, and the mixture was stirred for 5 min. 2.7 ml (13.7 mmol) of diisopropyl azodicarboxylate were then added dropwise and the reaction mixture was warmed to RT overnight. For work-up, water was added and the mixture was extracted twice with in each case 50 ml of ethyl acetate. The combined organic phases were washed with saturated sodium chloride solution, dried over magnesium sulphate and concentrated. The crude product was stirred with 50 ml of cyclohexane and the white solid was filtered off with suction and washed three times with in each case 20 ml of cyclohexane. The filtrate was concentrated and dissolved in 40 ml of diethyl ether, and 3 ml (12 mmol) of a 4N solution of hydrogen chloride in dioxane were added with ice cooling. The resulting beige precipitate was filtered off, washed twice with in each case 20 ml of diethyl ether and dried under HV. This gave 1.67 g (76% of theory) of the target compound. LC-MS [Method 10]: Rt=1.46 min; MS (ESIpos): m/z=164 (M+H)+ 1H-NMR (400 MHz, DMSO-d6): delta [ppm]=1.77-2.01 (m, 4H), 2.03-2.17 (m, 2H), 2.68-2.84 (m, 1H), 4.19 (d, 2H), 7.90 (dd, 1H), 8.10 (dd, 1H), 8.47 (d, 1H), 8.65 (d, 1H).

The synthetic route of 4415-82-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Bayer Pharma Aktiengesellschaft; BECKER-PELSTER, Eva Maria; BUCHGRABER, Philipp; BUCHMUeLLER, Anja; ENGEL, Karen; GNOTH, Mark Jean; HIMMEL, Herbert; KAST, Raimund; KELDENICH, Joerg; KLAR, Juergen; KNORR, Andreas; LANG, Dieter; LINDNER, Niels; SCHMECK, Carsten; SCHOHE-LOOP, Rudolf; TINEL, Hanna; TRUeBEL, Hubert; WUNDER, Frank; (97 pag.)US2016/318866; (2016); A1;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 756520-66-8, name is 1-(2,6-Dichloro-3-fluorophenyl)ethanol. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 756520-66-8

To a solution of 1-(2,6-dichloro-3-fluorophenyl)ethan-1-one 11 (20.00 g, 96.60 mmol) in 100 mL of MeOH was added portionwise NaBH4 (7.31 g, 193.21 mmol). The resulting mixture was stirred at room temperature for 2 h and then quenched with 20 mL of water. After the removal of MeOH under vacuum, the residue was extracted with EA and washed with brine. The organic layer was dried over anhydrous Na2SO4 and concentrated under vacuum to afford 1-(2,6-dichloro-3-fluorophenyl)ethan-1-ol, which was pure enough for use in the next step. 1H NMR (400 MHz, CDCl3) delta 7.26 (dd, J = 4.8, 8.8 Hz, 1H), 7.02 (dd, J = 8.0, 8.8 Hz, 1H), 5.57 (q, J = 6.8 Hz, 1H), 2.86 (br, 1H), 1.64 (d, J = 6.8 Hz, 3H). To a solution of 1-(2,6-dichloro-3-fluorophenyl)ethan-1-ol (19.00 g, 90.89 mmol) in 150 mL of CH2Cl2 was added Et3N (13.27 mL, 95.43 mmol) and catalytic amount of DMAP. The resulting solution was cooled in an ice bath and added dropwise MsCl (7.39 mL, 95.43 mmol). After complete addition of MsCl, the reaction mixture was maintained in the ice bath for 1 h and then 30 mL of water was added to the reaction mixture. The organic phase was washed with brine, dried over anhydrous Na2SO4 and concentrated under vacuum to afford 1-(2,6-dichloro-3-fluorophenyl)ethyl methanesulfonate (12), which was pure enough for use in the next step. Yield: 84%; 1H NMR (300 MHz, CDCl3) delta 7.33 (dd, J = 4.8, 9.0 Hz, 1H), 7.12 (dd, J = 8.1, 9.0 Hz, 1H), 6.45 (q, J = 6.9 Hz, 1H), 2.91 (s, 3H), 1.84 (d, J = 6.9 Hz, 3H).

With the rapid development of chemical substances, we look forward to future research findings about 756520-66-8.

Reference:
Article; Zhang, Dengyou; Zhang, Xiaowei; Ai, Jing; Zhai, Yun; Liang, Zhongjie; Wang, Ying; Chen, Yi; Li, Chunpu; Zhao, Fei; Jiang, Hualiang; Geng, Meiyu; Luo, Cheng; Liu, Hong; Bioorganic and Medicinal Chemistry; vol. 21; 21; (2013); p. 6804 – 6820;,
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Related Products of 7735-42-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.7735-42-4, name is 1,16-Hexadecanediol, molecular formula is C16H34O2, molecular weight is 258.44, as common compound, the synthetic route is as follows.

The acetone is then evaporated off with the rotary evaporator, the residue is taken up in ethyl ether and water and the product is extracted three times with ether. The ethereal phases are combined and are dried over magnesium sulphate. The white solid obtained is then recrystallized from methanol (M.p. 42-43 C.). Yield=95%. 1,16-diiodohexadecane is obtained from hexadecane-1,16-diol, by adding 5 g of this diol and 19 g of potassium iodide to a solution of 2.5 g of phosphoric anhydride and 5.2 mL of 85% phosphoric acid. The mixture is heated at 100 C. for 5 hours. A dense oil forms, and the mixture is poured into 50 mL of water. The organic phase is separated, and the aqueous phase extracted with ether. The organic phases are discoloured by stirring with 50 mL of a 10% solution of sodium thiosulphate. The ether is evaporated off. The oil obtained is crystallized from methanol (M.p.=52 C.). Yield: 82%.

The chemical industry reduces the impact on the environment during synthesis 7735-42-4, I believe this compound will play a more active role in future production and life.

Reference:
Patent; CNRS; US6972343; (2005); B1;,
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Electric Literature of 149965-40-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 149965-40-2, name is (5-Bromo-2-chlorophenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows.

(5-Bromo-2-chloro-benzyloxy)-tert-butyl-dimethyl-silane TBDMS-Cl (10.6 g, 66.7 mmol) was added to a sol. of (5-bromo-2-chloro-phenyl)-methanol (12.8 g, 55.6 mmol) and imidazole (9.42 g, 138 mmol) in DMF (190 mL) at 0 C. The mixture was stirred for 2 h at 0 C., and aq. sat. NH4Cl was added. The mixture was extracted with heptane (2*). The combined org. extracts were dried over MgSO4, filtered, and the solvents were removed under reduced pressure. Purification of the residue by FC (heptane?EtOAc/heptane 1:49) yielded the title compound (18.0 g, 96%). LC-MS: tR=1.22 min.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 149965-40-2, (5-Bromo-2-chlorophenyl)methanol.

Reference:
Patent; Bezencon, Olivier; Bur, Daniel; Corminboeuf, Olivier; Dube, Daniel; Grisostomi, Corinna; MacDonald, Dwight; McKay, Dan; Powell, David; Remen, Lubos; Richard-Bildstein, Sylvia; Scheigetz, John; Therien, Michel; Weller, Thomas; US2009/176823; (2009); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 6920-22-5, name is Hexane-1,2-diol. A new synthetic method of this compound is introduced below., SDS of cas: 6920-22-5

At room temperature, to the right amount of organic solvent (volume ratio 4:1 of the 1,4-dioxane and polyethylene glycol 200 (PEG-200) mixture), add 100mmol said formula (I) compound, 150mmol said formula (II) compound, 140mmol said formula (III) compound, 10mmol catalyst (2mmol 1-(1-ferrocenylethyl)-3-isopropyl-1-imidazolium iodide and 8mmol nickel chloride mixture), 200mmol oxidant copper chromite (Cr2Cu2O5), 120mmol base N,N-dimethylethanolamine (DMEA) and 10mmol promoter tetraphenylporphyrin, then heat up to 70 C, and at this temperature the stirring reaction 12 hours;After the reaction, the filtering net filtering, the filtrate pH value is adjusted to the neutral, and then saturated sodium carbonate aqueous solution for washing, adding acetone extraction of 2 – 3 times, the combined organic phase, concentrated under reduced pressure, the residue over 300 – 400 mesh silica gel column chromatography, for the volume ratio of 1:2 of the mixture of ethyl acetate and petroleum ether elution, so as to obtain the compound of formula (IV), and the yield is 92.9%.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 6920-22-5, Hexane-1,2-diol.

Reference:
Patent; Liu, Zhihua; (11 pag.)CN106083917; (2016); A;,
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Related Products of 63478-76-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.63478-76-2, name is 6-Heptyn-1-ol, molecular formula is C7H12O, molecular weight is 112.1696, as common compound, the synthetic route is as follows.

Using the methodology in stage (vi) of Process C, hept-6-ynal was prepared from hept-6-yn-1-ol (C. Crisan Chem . Abs . 51 :5061b). The preparation of hept-2-en-6-ynal and 1,1,1-trichloropentan-4-one is described in EP 029 4 229.

Statistics shows that 63478-76-2 is playing an increasingly important role. we look forward to future research findings about 6-Heptyn-1-ol.

Reference:
Patent; THE WELLCOME FOUNDATION LIMITED; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; EP372816; (1990); A1;,
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Related Products of 349-75-7, Adding some certain compound to certain chemical reactions, such as: 349-75-7, name is (3-(Trifluoromethyl)phenyl)methanol,molecular formula is C8H7F3O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 349-75-7.

Example 11; [Show Image] Compound 6 was reacted with various benzylalcohols to give Compounds A-21, A-22, A-23 and A-24 via Mitsunobu reaction.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 349-75-7, (3-(Trifluoromethyl)phenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Shionogi & Co., Ltd.; EP1953145; (2008); A1;,
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Adding a certain compound to certain chemical reactions, such as: 534-03-2, 2-Aminopropane-1,3-diol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: alcohols-buliding-blocks, blongs to alcohols-buliding-blocks compound. category: alcohols-buliding-blocks

The preparation of (S)-1-((3,5-bis((1,3-dihydroxypropan-2-yl)carbamoyl)-2,4,6-triiodo-phenyl)amino)-1-oxopropan-2-yl acetate was carried taking as reference the procedures described in the literature. 20 g (28.2 mmol) of (S)-1-((3,5-bis(chlorocarbonyl)-2,4,6-triiodophenyl)amino)-1-oxopropan-2-yl acetate from example 3 was reacted with 2-amino-1,3-propanediol (6.4 g, 70.5 mmol) in DMA (100 ml) in the presence of triethylamine (10.0 ml, 71.4 mmol) at 50 C. for 6 hours. After complete reaction and removal of the salts by filtration, the solvent was distilled under vacuum at below 70 C. until a viscous oil was obtained. While the residue was still hot, alcohol was added (20 ml) to fluidize, followed by the addition of acetone (120 ml) in portions for about 1 hour and reflux for another hour. The resulting suspension was filtered and the product was dried under vacuum at 50 C. for 16 hours to give (S)-1-((3,5-bis((1,3-dihydroxypropan-2-yl)carbamoyl)-2,4,6-triiodophenyl)amino)-1-oxopropan-2-yl acetate as a white solid (19.0 g, 23.1 mmol). [0026] Yield: 82.0% [0027] HPLC purity: 98% (including 2% lopamidol)

The synthetic route of 534-03-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; HOVIONE INTER LIMITED; Galindro, Jose Manuel; Cruz, Ana Cristina; Bandarra, Joao Jose; Heggie, William; US2014/155648; (2014); A1;,
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Related Products of 6282-88-8 ,Some common heterocyclic compound, 6282-88-8, molecular formula is C9H11ClO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

(f) 135 ml of pyridine are added dropwise to 150 g of 3-(4-chlorophenyl)-propan-1-ol and 206.6 g of p-toluenesulphonyl chloride in 300 ml of chloroform at 0. After the addition, the mixture is stirred at room temperature for 3 hours and the solution is poured into a mixture of 400 ml of water and 120 ml of concentrated hydrochloric acid. The organic phase is separated off, washed 3 times with water, dried over sodium sulphate and concentrated to a yellowish viscous oil in vacuo, yield: 285 g of p-toluenesulphonic acid 3-(4-chlorophenyl)-propyl ester.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 6282-88-8, 3-(4-Chlorophenyl)propan-1-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Byk Gulden Lomberg Chemische Fabrik Gesellschaft; US4334089; (1982); A;,
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Electric Literature of 39590-81-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 39590-81-3, name is 1,1-Bis(Hydroxymethyl)cyclopropane, molecular formula is C5H10O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

(1) [1-(tert-Butyldiphenylsilanyloxymethyl)cyclopropyl]methanol 1,1-Bis(hydroxymethyl)cyclopropane (2 g) and imidazole (6.67 g) were dissolved in N,N-dimethylformamide (100 mL) and the solution was ice-cooled. tert-Butyldiphenylchlorosilane (5.39 g) was added dropwise to the solution. Then, the reaction mixture was gradually heated to room temperature and stirred for 18 hours. tert-Butyl methyl ether and a saturated sodium chloride solution were added to the reaction mixture, and the organic layer was separated. The organic layer was dried over anhydrous magnesium sulfate. The drying agent was removed by filtration. The filtrate was concentrated under reduced pressure to obtain a residue. The residue was subjected to silica gel column chromatography (heptane-ethyl acetate) to obtain the title compound (2.62 g). 1H-NMR (400 MHz, CDCl3) delta (ppm): 0.30-0.40 (m, 2H), 0.45-0.53 (m, 2H), 1.07 (s, 9H), 2.56 (t, J=5.6 Hz, 1H), 3.61 (d, J=5.6 Hz, 2H), 3.62 (s, 2H), 7.35-7.46 (m, 6H), 7.64-7.70 (m, 4H).; (1) [1-(tert-Butyldiphenylsilanyloxymethyl)cyclopropyl]methanol 1,1-Bis(hydroxymethyl)cyclopropane (3.6 g) and imidazole (2.4 g) were dissolved in N,N-dimethylformamide (35 mL) in a nitrogen atmosphere. tert-Butylchlorodiphenylsilane (9.2 mL) was added to the solution at -15C, and the mixture was stirred at – 15C for one hour. Methanol and water were sequentially added to the reaction mixture, followed by extraction with ethyl acetate twice. The organic layers were sequentially washed with water and a saturated sodium chloride solution and dried over magnesium sulfate. The drying agent was removed by filtration and then the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (heptane-ethyl acetate) to obtain the title compound (5.58 g). 1H-NMR (400 MHz, CDCl3) delta(ppm): 0.34-0.38 (m, 2H), 0.47-0.51 (m, 2H), 1.06 (s, 9H), 2.57 (t, J=5.6 Hz, 1H), 3.61 (d, J=5.6 Hz, 2H), 3.62 (s, 2H), 7.35-7.45 (m, 6H), 7.64-7.68 (m, 4H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 39590-81-3, 1,1-Bis(Hydroxymethyl)cyclopropane.

Reference:
Patent; Eisai R&D Management Co., Ltd.; EP2017275; (2009); A1;,
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