Category: alcohols-buliding-blocks

Application of 7541-49-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 7541-49-3, name is 3,7,11,15-Tetramethylhexadec-2-en-1-ol, molecular formula is C20H40O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

0.90 g (6.7 mmol) of N-chlorosuccinimide was suspended in methylene chloride (8 mL). After addition of 0.52 mL (7.1 mmol) of dimethylsulfide at 0 C., the solution was stirred for 20 min. After addition of 1.0 g (3.4 mmol) of phytol, the mixture was stuffed for 1 hour at 0 C., and further stirred for 6 hours at room temperature. After addition of sodium bicarbonate aqueous solution, the reaction mixture was extracted with methylene chloride. The extract was washed with saturated brine, and dried over anhydrous sodium sulfate. After filtration, the filtrate was concentrated to obtain 3,7,11,15-tetramethylhexadec-2-ene-1-chloride as a crude product.

According to the analysis of related databases, 7541-49-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; FARNEX INCORPORATED; TABATA, YASUHIKO; HIRAI, KENJIRO; HIJIKURO, ICHIRO; TANOMURA, MASAHISA; MORI, SAYAKA; (61 pag.)JP2016/40339; (2016); A;,
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Electric Literature of 179811-63-3 ,Some common heterocyclic compound, 179811-63-3, molecular formula is C8H10ClNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Compound VI (9.63 g, 25.0 mmol), 2-amino-2-(3-chlorophenyl)ethyl-1-ol (VII-2) (4.29 g, 25.0 mmol) and triethylamine (10.4 mL, 74.9mmol) dissolved in methanol (100mL), reflux reaction for about 6h, until TLC (dichloromethane: methanol = 20:1) detection of the reaction of the raw materials was completed, cooled to below 10 C in an ice bath, stirred for 30min, solid precipitation, suction filtration ,A white solid 7.2 g was obtained, yield: 64.9%

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 179811-63-3, 2-Amino-2-(3-chlorophenyl)ethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; China Pharmaceutical University; Xu Yungen; Ji Dezhong; Zhang Lingzhi; Zhu Qihua; Bai Ying; Wu Yaoyao; (41 pag.)CN109608444; (2019); A;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 30379-58-9, name is Benzyl 2-hydroxyacetate. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C9H10O3

Example 166; 2-[5-{2-[(4R,6S)-8-Chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-2-oxo-1,3,4-oxadiazol-3(2H)-yl]acetic acid [Show Image] 5-{2-[(4R,6S)-8-Chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1,3,4-oxadiazol-2(3H)-one (73 mg) was dissolved in tetrahydrofuran (2 mL). To the resulting solution were added triphenylphosphine (103 mg) and benzyl glycolate (33 mul). A toluene solution (40% solution, 178 mul) of diethyl diazodicarboxylate was added. The resulting mixture was stirred at room temperature for 4 hours. After concentration of the reaction mixture under reduced pressure, the residue was purified by silica gel column chromatography (hexane:ethyl acetate=7:1) and dissolved in ethyl acetate (2 mL). To the resulting solution was added 10% palladium-carbon (water content: 50%) (85 mg). Under a hydrogen gas stream, the resulting mixture was vigorously stirred at room temperature under a constant pressure for 7 hours. The reaction mixture was filtered through a Kiriyama funnel. The filtrate was concentrated under reduced pressure. The residue was purified by thin layer silica gel chromatography (chloroform:methanol=10:1) to give the title compound (35 mg). MS(FAB)m/z:526(M++H). 1H-NMR(CDCl3)delta:2.20-2.42(2H,m),2.57-2.77(1H,m),2.79-2.94(1H,m),3.36(3H,s),3.79(3H,s),4.10-4.42(3H,m),5.65(1H,s),6.26(2H,br s),6.67(1H,s),6.81-6.91(1H,m),7.10(1H,m),7.15(1H,s),7.20-7.39(3H,m).

With the rapid development of chemical substances, we look forward to future research findings about 30379-58-9.

Reference:
Patent; Daiichi Sankyo Company, Limited; EP1939205; (2008); A1;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.56456-47-4, name is 2,4-Difluorobenzyl Alcohol, molecular formula is C7H6F2O, molecular weight is 144.12, as common compound, the synthetic route is as follows.HPLC of Formula: C7H6F2O

EXAMPLE 4 4-Cyano-6-(2,4-difluorobenzyloxy)-2-(1 -methyl-3-trifluoromethylpyrazol-5-yloxy)pyridine Sodium hydride (0.1 g, 60%, 2.5 mmol) is added to a solution of 2,4-difluorobenzyl alcohol (0.28 ml, 2.5 mmol) in sulfolane (5 ml) at 50 C. After 1 hour at 50 C., 4-cyano-2,6-bis(1-methyl-3-trifluoromethylpyrazol-5-yloxy)pyridine (1 g, 2.3 mmol) (from Example 2) is added to the reaction mixture. The mixture is heated to 90 C. overnight. After cooling, the reaction mixture is diluted with pentane/ethyl acetate (by volume ration 1/1) and filtered through a bed of silica gel. The filtrate is washed 6 times with water. The organic layer is dried with anhydrous magnesium sulfate, filtered and evaporated in vacuo. Purification by flash chromatography (silica gel: pentane/ethyl acetate 8/2 v/v) and washing of the product with diisopropyl ether yields the title compound (0.2 g, 21% yield) of melting point 109 C.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,56456-47-4, 2,4-Difluorobenzyl Alcohol, and friends who are interested can also refer to it.

Reference:
Patent; American Cyanamid Company; US5922738; (1999); A;,
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Reference of 2516-33-8 ,Some common heterocyclic compound, 2516-33-8, molecular formula is C4H8O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Sodium hydride (4.83 g, 0.12 mol) was added into cyclopropanemethanol (CAN 2516-33-8, 30 g) at 0 C. and the mixture was stirred at 0 C. for 1 h. Then to the mixture was added methyl 5-bromo-6-chloro-pyridine-2-carboxylic acid methyl ester (3 g, 12.75 mmol). The obtained solution was heated to 90 C. for 2 h. Then the mixture was evaporated to dryness, the residue was dissolved in 40 mL of water, and adjusted to pH=4 with hydrochloric acid (3 N), and extracted with ethyl acetate (3¡Á30 mL). The combined organic layer was washed with water (2¡Á30 mL) and brine (2¡Á50 mL) then evaporated to dryness to obtain the product as a white solid (2.5 g, 76.7%); MS (EI): m/e=272.0 [M+H]+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2516-33-8, its application will become more common.

Reference:
Patent; Bissantz, Caterina; Grether, Uwe; Hebeisen, Paul; Kimbara, Atsushi; Liu, Qingping; Nettekoven, Matthias; Prunotto, Marco; Roever, Stephan; Rogers-Evans, Mark; Schulz-Gasch, Tanja; Ullmer, Christoph; Wang, Zhiwei; Yang, Wulun; US2012/316147; (2012); A1;,
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Related Products of 100058-61-5, Adding some certain compound to certain chemical reactions, such as: 100058-61-5, name is 3-(Benzyloxy)cyclobutanol,molecular formula is C11H14O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 100058-61-5.

[00278] To a solution of 3-(benzyloxy)cyclobutan-1 -ol (500 mg, 2.8 mmol, cis/trans 85% : 15%), 4-nitrobenzoic acid (935 mg, 5.6 mmol) and PPh3 (2.2 g, 8.4 mmol) in dry THF (25 mL) was added DIAD (1 .7 g, 8.4 mmol) dropwise at 0 C under N2 atmosphere. After addition was completed, the mixture was stirred at 0 C for 15 min and then allowed to room temperature overnight. The mixture was concentrated and then purified by column chromatography on silica gel (PE:EA=10:1) to give the title compound (900 mg, 98%) as a yellow solid. 1H NMR (300 MHz, CDCI3) delta ppm 8.31 – 8.26 (m, 2H), 8.23 – 8.18 (m, 2H), 7.39 – 7.27 (m, 5H), 5.44 (dq, 1 H), 4.47 (d, 2H), 4.37 (tt, 1 H), 2.67 – 2.56 (m, 2H), 2.55 – 2.44 (m, 2H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 100058-61-5, 3-(Benzyloxy)cyclobutanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; NOVARTIS AG; HE, Feng; DU-CUNY, Lei; XIAO, Qitao; XUN, Guoliang; ZHENG, Qiangang; (152 pag.)WO2017/149463; (2017); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 623-50-7, name is Ethyl 2-hydroxyacetate. A new synthetic method of this compound is introduced below., Formula: C4H8O3

In the reactor the magnetic stirring, 0 C lower, will 7.9g acetyl chloride (0.1mol) dissolved in 30 ml of tetrahydrofuran, add 10.6g (1.05 eq) triethylamine, then in the 0 C slowly dripping 10.4g hydroxy acetate (0.1mol), completion of the dropping, to 10 C, stirring 1h, decompression boil off some solvent, by adding a proper amount of water, tetrahydrofuran extraction three times, the organic phase dried, vacuum evaporating the organic solvent to obtain 2-acetoxy-ethyl ester (14.6g g, yield 100%).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 623-50-7, Ethyl 2-hydroxyacetate.

Reference:
Patent; Shanghai pill whole Chemical Technology Co., Ltd.; no proclaimed; (7 pag.)CN106008419; (2016); A;,
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Adding a certain compound to certain chemical reactions, such as: 16545-68-9, Cyclopropanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C3H6O, blongs to alcohols-buliding-blocks compound. HPLC of Formula: C3H6O

A mixture of intermediate 525 (858 mg; 2.83 mmol), cyclopropanol (717 jiL; 11.3mmol) and cesium carbonate (1.84 g; 5.66 mmol) in 1,4-dioxane (9.5 mL) was heatedat 100C for 2h. The reaction mixture was heated at 100C overnight, cooled to roomtemperature and diluted with DCM. Water was added and the reaction mixture was extracted with DCM (three times). The combined organic layers were washed withwater, dried over MgSO4, filtered and evaporated to dryness. The residue was purified by chromatography over silica gel (irregular SiOH, 40 g; mobile phase: gradient from10% EtOAc, 90% heptane to 20% EtOAc, 80% heptane). The pure fractions were collected and evaporated to dryness yielding 581 mg (60%) of intermediate 526.

The synthetic route of 16545-68-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; JANSSEN PHARMACEUTICA NV; STANSFIELD, Ian; QUEROLLE, Olivier Alexis Georges; PONCELET, Virginie Sophie; GROSS, Gerhard Max; JACOBY, Edgar; MEERPOEL, Lieven; KULAGOWSKI, Janusz Jozef; MACLEOD, Calum; MANN, Samuel Edward; GREEN, Simon Richard; HYND, George; (477 pag.)WO2017/125530; (2017); A1;,
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Related Products of 22348-44-3, Adding some certain compound to certain chemical reactions, such as: 22348-44-3, name is trans-4-(Methylamino)cyclohexanol,molecular formula is C7H15NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 22348-44-3.

630 mg of sodium hydride (95%) were suspended in 40 mL of dimethyl acetamide. 1.45 g of 4-methylamino-cyclohexanol (150), dissolved in 40 mL of dimethyl acetamide, were added dropwise and 15 min. later 2.48 g of 6-fluoro-2-(4-methoxy- benzyl)-2H-isoquinolin-1-one (177), dissolved in another 40 mL of dimethyl acetamide, were added. The reaction mixture was stirred at 80 0C until the reaction was complete. The mixture was poured into an ice-water mixture, extracted three times with methyl- tert.-butyl ether and the combined organic layer was dried over sodium sulfate and evaporated. Water was added and the crude product was subjected to lyophilization to remove remainders of dimethyl acetamide.The obtained product is sufficiently pure for further conversion. Rt = 1.24 min (Method B), detected mass: 393.2 (M+H+).

According to the analysis of related databases, 22348-44-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SANOFI-AVENTIS DEUTSCHLAND GMBH; WO2007/12422; (2007); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 55362-80-6, name is 9-Bromononan-1-ol. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 55362-80-6

Preparation of the raw material compounds (8-carboxyoctyl)triphenylphosphonium bromide (h) 9-Bromononyl alcohol (f) (3.347 g) was reacted with sodium metaperiodate and ruthenium chloride in the mixture of carbon tetrachloride, acetonitrile and water to give 9-bromo nonanoic acid (g). Yield:2.632 g (74.0%)

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 55362-80-6, 9-Bromononan-1-ol.

Reference:
Patent; R-Tech Ueno; US6242485; (2001); B1;,
Alcohol – Wikipedia,
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