Category: alcohols-buliding-blocks

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 756520-66-8, name is 1-(2,6-Dichloro-3-fluorophenyl)ethanol. This compound has unique chemical properties. The synthetic route is as follows. Safety of 1-(2,6-Dichloro-3-fluorophenyl)ethanol

182 g of Compound 2 and 135 g of phthalic anhydride were dissolved in 124 mL of triethylamine, and 2 g of 4-dimethylaminopyridine (DMAP) was added.After refluxing for 2 hours, the heating was stopped.Cool to about 50 C and add 40 mL of ethyl acetate.Then adjust the pH to about 1.5 with 2N hydrochloric acid.Stir for another half an hour,a lot of white solids appear,Filter and wash twice with water,Compound 3 was obtained in a yield of 93%.The content is 98.5%.

With the rapid development of chemical substances, we look forward to future research findings about 756520-66-8.

Reference:
Patent; Kairuiside Biochemical (Suzhou) Co., Ltd.; Wu Shengwen; Wu Lei; Song Qianqian; (6 pag.)CN109438180; (2019); A;,
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Electric Literature of 1562-00-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1562-00-1, name is Sodium isethionate, molecular formula is C2H5NaO4S, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Preparation of Dowex 1×8 HES. Dowex 1×8 Cl (5 g) was suspended in a minimum amount of water (10 mL), stirred for 10 min and filtered. The residue was suspended in a freshly prepared sodium isethionate (3.7 g, 25 mmol) solution in water (10 mL). The mixture was stirred for 10 min, filtered and the residue was washed with water (50 mL x 3) and methanol (50 mL x 3) successively. The resin was dried by vacuum suction for 15 min to give Dowex 1×8 isethionate (4.0 g, 0.96 milliequivalent/g).Synthesis of COHPyrv-24-HES. To a solution of CoHPyrv-24 (30 mg, 0.04 mmol) in 50:50, MeOH: H20 (1 .5 ml.) was added Dowex 1×8 isoethionate (0.21 g, 0.2 meq) and the mixture was stirred at room temperature for 30 min. The resulting mixture was then filtered and washed with water, 50:50 Me()H 20 and MeOH successively (50 mL total vol .) until the resin turned colorless. The filtrate was concentrated and dried under high vacuum to give 29 mg of the title compound.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1562-00-1, Sodium isethionate.

Reference:
Patent; CITY OF HOPE; JONES, Jeremy; PAL, Sumanta, Kumar; (187 pag.)WO2017/41040; (2017); A1;,
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Electric Literature of 3068-00-6, Adding some certain compound to certain chemical reactions, such as: 3068-00-6, name is 1,2,4-Butanetriol,molecular formula is C4H10O3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3068-00-6.

To a 500 ml_ flask, 1 ,2,4-trihydroxybutane (III, 159 g, 1.5 mol, 1 equ.) and p-toluenesulfonic acid monohydrate (1.5 g, 8.72 mmol, 0.006 equ.) were added. The solution was heated to 160-180 C. Reaction was monitored by GC. The resulting mixture was purified by fractional distillation to give 3-OH-tetrahydrofuran as colorless oil (120.5 g 91.3% yield): bp 86-88 C (23 mmHg) 1H NMR (400 MHz, CDCI3) delta 4.43-4.42 (1 H, t), 3.95-3.67 (4H, m), 3.08- 3.07 (1 H, d), 2.07-1.82 (2H, m). GCMS m/z 88 (M+).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 3068-00-6, 1,2,4-Butanetriol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL TRADING (SHANGHAI) CO., LTD; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; XING, Lidong; DONG, Weitong; LU, Jun; SCHOLZ, Ulrich; YAN, Jun; YANG, Jinsong; WO2014/140017; (2014); A1;,
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Adding a certain compound to certain chemical reactions, such as: 78573-45-2, 3-(3-(Trifluoromethyl)phenyl)propan-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C10H11F3O, blongs to alcohols-buliding-blocks compound. Computed Properties of C10H11F3O

Example 20; [00088] 3.0 g of crude material of compound V were dissolved in DCM (60 ml). TEA (5.6 ml) was added followed by drop-wise addition of Methanesulfonyl chloride (1.2 ml) at room temperature. The reaction mixture was stirred at room temperature for 2 hours. Then the reaction mixture was poured into crushed ice (98 g) and INHCl (30 ml). DCM (30 ml) was added to the mixture. Phase separation was done and the aqueous phase was extracted with DCM (30 ml) once again. The organic phase was EPO dried over Sodium sulfate and the solvent was evaporated under vacuum to give 3.39 g of the compound VI.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,78573-45-2, 3-(3-(Trifluoromethyl)phenyl)propan-1-ol, and friends who are interested can also refer to it.

Reference:
Patent; TEVA PHARMACEUTICAL INDUSTRIES, LTD.; TEVA PHARMACEUTICALS USA, INC.; WO2006/125026; (2006); A2;,
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Synthetic Route of 722-92-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 722-92-9, name is 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol, molecular formula is C9H7F6NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To the stirred solution of 2-(4-aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol (1.0 g, 3.86 mmol) in dry tetrahydrofuran (THF) under inert atmosphere, triphenylphosphine (3.04 g, 11.58 mmol) was added and stirred for 20 minutes. (E)-Diisopropyl diazene-1,2- dicarboxylate (0.936 g, 4.63 mmol) and methanol (0.23 mL, 5.79 mmol) were added to the reaction mixture at 0-5 °C. The reaction mixture was refluxed for 4-5 hours. Aftercompletion of the reaction, the reaction mixture was diluted with methylene chloride and purified using column chromatography (silica gel, hexane and ethyl acetate).

According to the analysis of related databases, 722-92-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; PIRAMAL ENTERPRISES LIMITED; SHARMA, Rajiv; SAHU, Bichismita; MALI, Sunil, Vasantrao; SINGH, Deepak; KUMAR, Pramod, Bhaskar; DAWANGE, Mahesh; MISTRY, Hitesh; (108 pag.)WO2015/145371; (2015); A1;,
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Related Products of 148043-73-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 148043-73-6, name is 4,4,5,5,5-Pentafluoropentan-1-ol. A new synthetic method of this compound is introduced below.

Synthesis of compound 17 A 250 ml flask containing a solution of compound 18 (20 g, 1 12.3 mmol) in 50 ml of dry acetonitrile under inert nitrogen atmosphere. Triethylamine (19.9 ml, 142.6 mmol) and a solution of Methanesulfonyl chloride (9.9 ml, 128 mmol) in 35 ml ACN were slowly added at a temperature below 20 C. The mixture was stirred at room temperature 4 h. The mixture was concentrated by evaporating most of the ACN and extracted with CH2CI2. The organic phase was washed with saturated NaCI solution, dried over anhydrous MgS04, filtered and evaporated to dryness. 24.45 g of a yellow liquid was obtained (122% by mass).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,148043-73-6, 4,4,5,5,5-Pentafluoropentan-1-ol, and friends who are interested can also refer to it.

Reference:
Patent; CRYSTAL PHARMA, S.A.U.; PEREZ ENCABO, Alfonso; TURIEL HERNANDEZ, Jose Angel; GALLO NIETO, Francisco Javier; LORENTE BONDE-LARSEN, Antonio; GARCIA ESCUDERO, Luis Angel; WO2015/181116; (2015); A1;,
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Synthetic Route of 7589-27-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 7589-27-7, name is 2-(4-Fluorophenyl)ethanol. A new synthetic method of this compound is introduced below.

Example 316 Synthesis of 2-(4-fluorophenyl)acetaldehyde To a stirred suspension of pyridinium chlorochromate (6.9 g, 21.4 mmol) in CH2Cl2 (100 ml) was added a solution of 2-(4-fluorophenyl)ethanol (3.0 g, 21.4 mmol) in CH2Cl2 (10 ml). The resulting suspension was stirred for 2 hours at room temperature and was then diluted with ether. The resulting suspension was filtered through a pad of Celite and washed with ether. The solvents were removed under reduced pressure to yield the crude title compound as a green oil (2.6 g, 86%), which was used as such for further reaction. 1H NMR (300 MHz, CDCl3, 25 C.): b=9.75 (s, 1H, CH), 7.19-7.22 (m, 2H, PhH), 7.06 (t, J=8.5 Hz, PhH), 3.68 (s, 2H, CH2) ppm.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,7589-27-7, 2-(4-Fluorophenyl)ethanol, and friends who are interested can also refer to it.

Reference:
Patent; KATHOLIEKE UNIVERSITEIT LEUVEN, K.U.LEUVEN R&D; De Jonghe, Steven; Gao, Ling-Jie; Herdewijn, Piet; Herman, Jean; Jang, Miyeon; Leyssen, Pieter; Louat, Thierry; Neyts, Johan; Pannecouque, Christophe; Vanderhoydonck, Bart; US2013/190297; (2013); A1;,
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Application of 5456-63-3, Adding some certain compound to certain chemical reactions, such as: 5456-63-3, name is trans-2-Aminocyclohexanol hydrochloride,molecular formula is C6H14ClNO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5456-63-3.

To a solution of 5,8-difluoro-1-[4-(1H-pyrazol-1-yl)benzyl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (100 mg) known from a document (Bioorganic and Medicinal Chemistry Letters, 2010, 20, 1334.) in DMF (4 mL) were added (1,2-trans)-2-hydroxycyclohexylamine hydrochloride (60 mg), N1-[(ethylimino)methylene]-N3,N3-dimethylpropane-1,3-diamine hydrochloride (75 mg), 1H-benzo[d][1,2,3]triazol-1-ol monohydrate (60 mg) and triethylamine (0.11 mL), and the mixture was stirred at room temperature for 15 hr. Water (10 mL) was added to the reaction solution, the mixture was stirred, and the precipitated solid was collected by filtration and dried to give the title compound (110 mg). MS (ESI+): [M+H]+ 479.3 1H NMR (400 MHz, DMSO-d6) delta 1.16-1.38 (4H, m), 1.54-1.70 (2H, m), 1.80-1.91 (1H, m), 1.97-2.07 (1H, m), 3.36-3.44 (1H, m), 3.61-3.71 (1H, m), 4.83 (1H, d, J = 4.9 Hz), 5.82 (2H, d, J = 2.4 Hz), 6.53 (1H, s), 7.20-7.33 (3H, m), 7.59-7.69 (1H, m), 7.72 (1H, s), 7.80 (2H, d, J = 8.3 Hz), 8.45 (1H, d, J = 2.4 Hz), 8.93 (1H, s), 9.81 (1H, d, J = 7.3 Hz).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 5456-63-3, trans-2-Aminocyclohexanol hydrochloride, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Takeda Pharmaceutical Company Limited; SAKAMOTO, Hiroki; SUGIMOTO, Takahiro; EP2821401; (2015); A1;,
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Electric Literature of 34598-50-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.34598-50-0, name is 5-Bromo-2,3-dihydro-1H-inden-1-ol, molecular formula is C9H9BrO, molecular weight is 213.07, as common compound, the synthetic route is as follows.

5-bromo-l-phenoxy-2,3-dihydro-lH-indene. A solution of 5-bromo-2,3-dihydro-lH- inden-l-ol (1 g, 4.7 mmol), phenol (835 mg, 8.9 mmol) and triphenylphosphine (1.8 g, 6.9 mmol) in anhydrous tetrahydrofuran (70 mL) was stirred at 0C under nitrogen atmosphere. To this mixture was added dropwise diisopropyl azodicarboxylate (1.4 g, 6.9 mmol) over 5 minutes. Until TLC indicated that starting material was consumed, the solvent was evaporated in vacuo and the resulting oil was purified by column chromatography (silica gel, hexane/ethyl acetate = 1/1) to give the product 5-bromo-l-phenoxy-2,3-dihydro-lH-indene (1.1 g, 85%) as a white solid. LRMS (M + H+) mlz: calcd 288.01; found 288. 1H NMR (300MHz, CDC13): delta 7.46-7.27 (m, 6H), 7.02 (s, 1H), 6.99-6.98 (m, 1H), 5.73-5.70 (m, 1H), 3.14-3.09 (m, 1H), 2.96-2.95 (m, 1H), 2.59-2.54 (m, 1H), 2.27-2.23 (m, 1H).

Statistics shows that 34598-50-0 is playing an increasingly important role. we look forward to future research findings about 5-Bromo-2,3-dihydro-1H-inden-1-ol.

Reference:
Patent; CONSTELLATION PHARMACEUTICALS; ALBRECHT, Brian, K.; AUDIA, James, Edmund; COOK, Andrew; GAGNON, Alexandre; HARMANGE, Jean-christophe; NAVESCHUK, Christopher, G.; WO2013/75083; (2013); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 27489-62-9, name is trans-4-Aminocyclohexanol. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 27489-62-9

Preparation of trans-4-(3-bromoimidazo[1,2-b]pyridazin-6-ylamino)cyclohexanol To 6-chloro-3-bromoimidazo[1,2-b]pyridazine (1.00 g, 4.30 mmol, 1.0 equiv) and p-TSA (818 mg, 4.30 mmol, 1.0 equiv) in DMSO (7.00 mL) was added trans-4-aminocyclohexanol (1.49 g, 12.9 mmol, 3.0 equiv). The mixture was heated at 100 C. for 24 h. Purification by column chromatography using 5% methanol in dichloromethane elution gave 1.1 g of the yellow solid, 83%.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 27489-62-9, trans-4-Aminocyclohexanol.

Reference:
Patent; Califia Bio, Inc.; GOODFELLOW, VAL S.; NGUYEN, THONG X.; RAVULA, SATHEESH B.; GELBARD, HARRIS A.; US2014/256733; (2014); A1;,
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