Category: alcohols-buliding-blocks

Related Products of 1562-00-1 ,Some common heterocyclic compound, 1562-00-1, molecular formula is C2H5NaO4S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

The sodium isethionate is combined with the post-treatment mother liquor. Add ammonia gas, liquid ammonia or aqueous ammonia. The ammonia content is controlled 24 ~ 34% (w/v). Pump into the synthesis tower. The residence time of the material in the tower is not less than 0.5 to 1 hour. Sodium isethionate undergoes ammonolysis to become sodium taurinate; At the same time, solution of sodium isethionate ethylene glycol-type by-product undergoes high temperature and pressure reaction and are converted into polyether alcohol-type by-product.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1562-00-1, its application will become more common.

Reference:
Patent; Jiangyin Huachang Food Additive Co., Ltd.; Zhang, Huaxing; Zhang, Yugao; Xia, Jianhua; (9 pag.)CN105732440; (2016); A;,
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Synthetic Route of 112-27-6, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 112-27-6 as follows.

To a mixture of Ag2O (12.4 g, 100 mmol) and KI (4.42 g, 26.64 mmol) in DCM (200 mL) was added 2,2?-(ethane-1,2-diylbis(oxy))diethanol (10 g, 66.6 mmol) dropwise at room temperature. Then BnBr (12.5 g, 73.26 mmol) was added dropwise into the mixture over 10 min. After addition, the mixture was stirred at room temperature for 2 h. The reaction mixture was filtered. The combined filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography to give 2-(2-(2-(benzyloxy)ethoxy)ethoxy)ethanol (7 g, 43.8%) as a colorless oil. LC/MS (ESI, m/z): [M+1]+=241.0.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,112-27-6, its application will become more common.

Reference:
Patent; Kymera Therapeutics, Inc.; Ji, Nan; Kluge, Arthur F.; Weiss, Matthew M.; Zhang, Yi; (180 pag.)US2020/10468; (2020); A1;,
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Related Products of 1562-00-1, Adding some certain compound to certain chemical reactions, such as: 1562-00-1, name is Sodium isethionate,molecular formula is C2H5NaO4S, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1562-00-1.

General procedure: Synthesis of [CmOHMIM][HOCnSO3]) and [CmOHTEA][HOCnSO3]: ILs were prepared by ion exchange method. The ion exchange of the anion chloride by the anion hydroxyalkanesulphonate was carried out using an exchange column packed with 100 g of Amberlite IR120 H-type strongly acidic cation exchange resin. The column was previously flushed thoroughly with a 1 mol L- 1 [CmOHMIM]Cl or [CmOHTEA]Cl solution until the elution was neutral, then with Milli-Q water until no chloride was detected by silver nitrate. A 100 mL of 1 mol L- 1 Na[HOCnSO3] solution was slowly run over and eluted with Milli-Q water. The eluted liquid was collected and concentrated under reduced pressure in a rotary evaporator. The residue was then vacuum dried at 323 K for 18 h to afford the IL in near-quantitative yield as a colorless viscous liquid. ILs with ions containing hydroxyl groups are usually observed to be rather viscous. 1-(2-Hydroxyethyl)-3-methyl-imidazolium hydroxymethane sulfonate ([C2OHMIM][HOC1SO3]) 1H NMR (400 MHz, D2O, 298 K): 3.89 (s, 3H), 3.91 (t, J = 5.0 Hz, 2H), 4.30 (t, J = 4.83 Hz, 2H), 4.35 (s, 2H), 7.44 (s, 1H), 7.50 (s, 1H), 8.72 (s, 1H); 13C NMR (400 MHz, D2O, 298 K): 35.29, 51.08, 59.35, 73.71, 122.01, 123.18, 135.92. ES-MS: ES+ m/z 127.00 [C2OHMIM]+, 288.87 [C2OHMIM]+?H3O2-?[C2OHMIM]+; ES- m/z 110.80 [HOC1SO3]-, 244.73 [HOC1SO3]-?H3O+?[HOC1SO3]-, 352.80 [HOC1SO3]-?[C2OHMIM]+?[HOC1SO3]-. 1-(2-Hydroxyethyl)-3-methyl-imidazolium 2-hydroxyethane sulfonate ([C2OHMIM][HOC2SO3]) 1H NMR (400 MHz, D2O, 298 K): 3.11 (t, J = 6.64 Hz, 2H), 3.89 (s, 3H), 3.89-3.91 (overlapped, 4H), 4.30 (t, J = 4.84 Hz, 2H), 7.44 (s, 1H), 7.50 (s, 1H), 8.73 (s, 1H); 13C NMR (400 MHz, D2O, 298 K): 35.28, 51.08, 52.44, 56.53, 59.34, 122.01, 123.18, 135.92. ES-MS: ES+ m/z 127.00 [C2OHMIM]+, 288.87 [C2OHMIM]+?H3O2-?[C2OHMIM]+, 378.80 [C2OHMIM]+?[HOC2SO3]-?[C2OHMIM]+; ES- m/z 124.93 [HOC2SO3]-, 272.87 [HOC2SO3]-?H3O+?[HOC2SO3]-, 376.67 [HOC2SO3]-?[C2OHMIM]+?[HOC2SO3]-. 3-Hydroxypropyl-tri(2-hydroxyethyl) ammonium 2-hydroxyethane sulfonate ([C3OHTEA][HOC2SO3]) 1H NMR (Brueker AV-600, 600 MHz, D2O, 298 K): 1.92-1.93 (m, -OH), 3.06 (t, J = 6.55 Hz, 2H), 3.36 (not resolved, 2H), 3.50-3.51 (m, 2H), 3.58 (not resolved, 6H), 3.86 (not resolved, 6H), 3.96 (not resolved, 4H); 13C NMR (Brueker AV-600, 600 MHz, D2O, 298 K): 24.61, 52.99, 55.06, 55.38, 55.47, 57.10, 58.36, 58.58, 61.25. ES-MS (AB SCIEX Triple TOF 5600 +): ES+ m/z 208.1578 [C3OHTEA]+, 266.2013 Na+?H3O2-?[C3OHTEA]+; ES- m/z 124.9882 [HOC2SO3]-.

According to the analysis of related databases, 1562-00-1, the application of this compound in the production field has become more and more popular.

Reference:
Article; Ou, Guangnan; He, Biyan; Halling, Peter; Biochimica et Biophysica Acta – General Subjects; vol. 1860; 7; (2016); p. 1404 – 1408;,
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Related Products of 59854-12-5 , The common heterocyclic compound, 59854-12-5, name is tert-Butyl 4-hydroxybutanoate, molecular formula is C8H16O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Targeting tripodal tethers bearing easily removable protective groups in the side chains, we performed the synthesis of tether 10 (FIG. 13), where the malonic ester moieties are further elongated with C3 alkyl chains terminated by tert-butyl ester groups. In this case, selective hydrolysis of the ester moieties or focal deprotection (debenzylation) of the formed tris-adducts of C60 can give a facile access to structurally different derivatives. For this purpose, tert-butyl 4-hydroxybutyrate (8) was prepared (FIG. 13) and then subjected to a DCC monoesterification reaction with malonic acid to yield the mono-protected diacid 9. Three-fold esterification of trio 4 with acid 9 by using DCC and DMAP in CH2Cl2, afforded the tether 10 in 95% isolated yield.

The synthetic route of 59854-12-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Hirsch, Andreas; Beuerle, Florian; Chronakis, Nikos; US2006/47167; (2006); A1;,
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Electric Literature of 261762-59-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 261762-59-8, name is 2-Chloro-5-fluorobenzyl alcohol. This compound has unique chemical properties. The synthetic route is as follows.

The solution of 2-chloro-5-fluoro-benzoic acid (4.00 g, 23.0 mmol) in THE (200 ml) was added triethylamine (4.14 ml, 29.9 mmol). At -30 C, the mixture was added ethyl chloroformate (2.62 ml, 27.8 mmol) and stirred for 10 min. The solution was added sodium borohydrate (2.60 g, 68.9 mmol) and stirred for 5 min. The mixture was added H2O (10 ml) and stirred for 20 min at room temperature. The solution was concentrated in vacuo and the residue was added CHCl3 and 1 N HClaq. The organic layer was washed with 1 N NaOHaq and dried over Na2SO4. The solution was removed in reduced pressure. The residue was washed with n-hexane to give alcohol as a colorless solid. To the CH2Cl2 suspention of dimethylsulfoxide (2.43 ml, 34.2 mmol) was added a solution of oxalyl chloride (1.47 ml, 17.1 mmol) in 50 ml of dry CH2Cl2 at -78 C, and the resulting mixture was stirred for 20 min. CH2Cl2 (15 ml) solution of the alcohol was added at -78 C. The mixture was allowed to warm to -40 C for 1 h. The mixture was added triethylamine (7.89 ml, 57.0 mmol), allowed to warm to room temperature, and was treated with 0.1 N HClaq. The organic layer was washed with saturated Na2CO3aq, dried over Na2SO4, and concentrated in vacuo to give the title compound (1.33 g, 37%) as a colorless solid after trituration with n-hexane. 1H NMR (400 MHz, CDCl3) delta 7.22-7.28 (1H, m), 7.41-7.47 (1H, m), 7.58-7.64 (1H, m), 10.42 (1H, d, J = 3.2 Hz). MS (EI) m/z 158 M+.

According to the analysis of related databases, 261762-59-8, the application of this compound in the production field has become more and more popular.

Reference:
Article; Ichikawa, Masanori; Yokomizo, Aki; Itoh, Masao; Sugita, Kazuyuki; Usui, Hiroyuki; Shimizu, Hironari; Suzuki, Makoto; Terayama, Koji; Kanda, Akira; Bioorganic and Medicinal Chemistry; vol. 19; 6; (2011); p. 1930 – 1949;,
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Adding a certain compound to certain chemical reactions, such as: 171623-29-3, (4-Cyclopentylphenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C12H16O, blongs to alcohols-buliding-blocks compound. COA of Formula: C12H16O

General procedure: Under nitrogen atmosphere, to a stirred mixture of thecorresponding alcohol 11b-am (1.0 eq.) in dry CH2Cl2 (5.0 mL), DMAP (0.1 eq.), and 2-DPC (1.2 eq.)were added. The reaction mixture was stirred at room temperature for 16 h, then diluted with CH2Cl2(20 mL) and sequentially washed with sat. NH4Cl solution (25 mL), sat. NaHCO3 solution (3 x 25 mL)and brine (25 mL). The organic layer was dried over Na2SO4, filtered and concentrated to dryness atlow pressure, as a mixture of alkyl-2-pyridyl carbonate 12b-am and alkyl-2-oxopyridine-1-carboxylate13b-am. The mixture of isomers was not separated and used in the next step without any furtherpurification.

The synthetic route of 171623-29-3 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Nuzzi, Andrea; Fiasella, Annalisa; Ortega, Jose Antonio; Pagliuca, Chiara; Ponzano, Stefano; Pizzirani, Daniela; Bertozzi, Sine Mandrup; Ottonello, Giuliana; Tarozzo, Glauco; Reggiani, Angelo; Bandiera, Tiziano; Bertozzi, Fabio; Piomelli, Daniele; European Journal of Medicinal Chemistry; vol. 111; (2016); p. 138 – 159;,
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Synthetic Route of 52244-70-9, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 52244-70-9 as follows.

4-Methylphenylsulfonic acid 4-(4-methoxyphenyl)butyl ester (I). Pyridine (15 mL) was added dropwise to a cooled (0° C.) solution of 4-(4-methoxyphenyl)butanol (10.0 g, 0.055 mol) and p-toluenesulfonyl chloride (13.6 g, 0.072 mol) in dry chloroform (100 mL) under stirring. The reaction mixture was stirred overnight at room temperature. After this time, the reaction was quenched with 10percent HCl (300 mL) and extracted with chloroform. The organic fraction was washed with saturated NaHCO3, water and dried over magnesium sulfate. The solvent was removed under reduced pressure and the residue purified by flash chromatography (eluent: hexane, ethyl acetate=15:1) to provide 12.9 g (66percent) of I as clear oil. 1H NMR (360 MHZ, CDCl3) delta1.61 (m, 4H), 2.44 (s, 3H), 2.52 (m, 2H), 3.78 (s, 3H), 4.05 (m, 2H), 6.77 (d, J=12.5 Hz, 2H), 7.05 (d, J=12.5 Hz, 2H), 7.34 (d, J=10.5 Hz, 2H), 7.78 (d, J=10.5 Hz, 2H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,52244-70-9, its application will become more common.

Reference:
Patent; CYFI, INC.; US2003/195160; (2003); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 5259-98-3, name is 5-Chloropentan-1-ol. A new synthetic method of this compound is introduced below., HPLC of Formula: C5H11ClO

EXAMPLE 155 Preparation of 5-chloro-1-(2-furyl)-1-pentanol To a stirred suspension of 2-furyllithium [prepared from 0.53 moles of n-butyllithium and 39.5 g of furan by the procedure of J. Org. Chem., 27, 1216 (1962)] in 350 ml. of ether and with 200 ml. of hexane at -78° C is added a solution of 57.9 g of 5-chloropentanol [Chem. Abstr. 59, 7579F (1963)] in 80 ml. of ether during 25 minutes. The mixtures is warmed to 0° C. during 20 minutes, stirred at 0° C for 15 minutes, and treated with 140 ml. of saturated ammonium chloride. The ether phase is washed with water and brine, dried over magnesium sulfate and potassium carbonate mixture, and concentrated to give a liquid, pmr spectrum (CDCl3) delta 3.59 (triplet, CH2 Cl) and 4.70 (triplet, CH2 CHOH).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 5259-98-3, 5-Chloropentan-1-ol.

Reference:
Patent; American Cyanamid Company; US4131737; (1978); A;,
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Related Products of 928-51-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 928-51-8, name is 4-Chlorobutan-1-ol. A new synthetic method of this compound is introduced below.

Step A: Preparation of 4-(Chlorobutoxy)-3,4,5,6-2H-tetrahydropyran A solution of 4-chlorobutanol (23.2 g, 0.2140 mol) and 2 drops of concentrated hydrochloric acid at 0 C. is treated with 3,4-dihydro-2H-pyran (15 g, 0.1783 mol). The reaction is allowed to warm to room temperature over 3 hours. The reaction mixture is purified by distillation (130 C., 20 mm) to give 18.07 g of 2-(4-chlorobutoxy)-3,4,5,6-2H-tetrahydropyran as a colorless oil.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,928-51-8, its application will become more common.

Reference:
Patent; Warner-Lambert Co.; US5045550; (1991); A;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 534-03-2, name is 2-Aminopropane-1,3-diol, molecular formula is C3H9NO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Safety of 2-Aminopropane-1,3-diol

To a solution of TBDMSCI (7.2 g, 48 mmol), A/,A/-diisopropylethylamine (5.0 mL, 29 mmol) and DMAP (50 mg) in dichloromethane (50.0 mL) was added 2-amino-1 ,3-propan-diol (2.0 g, 22 mmol), and the mixture was stirred overnight. Volatiles were removed under high vacuum to give a residue, which was subjected to flash silica gel column purification on ISCO companion (ethyl acetate/hexane, 50 -100% containing 2% triethylamine) to give 1.2 g (17%) of compound S76 as colorless oil. H NMR (500MHz, CDCI3): 53.70 (2H, dd, J 10.0, 5.5 Hz), 3.63 (2H, dd, J 10.0, 5.5 Hz), 3.04 (1 H, m), 0.90 (18H, s), 0.07 (12H, s)

With the rapid development of chemical substances, we look forward to future research findings about 534-03-2.

Reference:
Patent; SOLSTICE BIOLOGICS, LTD.; BRADSHAW, Curt, W.; ELTEPU, Laxman; KABAKIBI, Ayman; LAM, Son; LIU, Bin; LIU, Dingguo; MEADE, Bryan, R.; SAKAMURI, Sukumar; WO2015/69932; (2015); A1;,
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