Category: alcohols-buliding-blocks

Adding a certain compound to certain chemical reactions, such as: 456-47-3, 3-Fluorobenzyl alcohol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C7H7FO, blongs to alcohols-buliding-blocks compound. Formula: C7H7FO

General procedure: A round-bottom flask was charged with alcohol (2 mmol), CuOTf (0.1 mmol, 0.05 equiv) (S)-5-(pyrrolidin-2-yl)-1H-tetrazole (0.1 mmol, 0.05 equiv), TEMPO (0.1 mmol, 0.05 equiv), DMAP (0.15 mmol, 0.075 equiv) and CH3CN (5 ml). The reaction mixture was stirred at 25 C open to air until the completion of the reaction, as monitored by TLC. After completion, CH3CN was evaporated under vacuum. The residue was then diluted with CH2Cl2 (5 ml) and filtered through a plug of silica gel to afford the desired product.

The synthetic route of 456-47-3 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Liu, Yangyang; Xie, Aming; Li, Junjian; Xu, Xiao; Dong, Wei; Wang, Boliang; Tetrahedron; vol. 70; 52; (2014); p. 9791 – 9796;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 3840-31-1, name is (3,4,5-Trimethoxyphenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows. HPLC of Formula: C10H14O4

20 mg of Au-Co composite particle load (0.1 mol%), 13.8 mg K2CO3 (10 mol%), 198.0 mg 3,4,5-trimethoxybenzyl alcohol (1 mmol), 4 mL of methanol was sequentially added to a pressure vessel with a 25 mL glass lining. After replacing the oxygen three times, the pressure was increased to 0.1 MPa, and the reaction was carried out at 80 C for 12 h, and cooled to room temperature. The gas is depressurized, the catalyst is filtered, the filtrate is concentrated by rotary evaporation, and the residue is subjected to column chromatography.White solid productMethyl 3,4,5-trimethoxybenzoate 169.5 mg,The yield was 78%.

With the rapid development of chemical substances, we look forward to future research findings about 3840-31-1.

Reference:
Patent; Dalian Institute of Chemical Physics; Gao Shuang; Li Guosong; Lv Ying; (9 pag.)CN109824513; (2019); A;,
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Related Products of 2854-16-2, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 2854-16-2 as follows.

Example 19N-(2-{[(2-hydroxy-2-methylpropyl)amino]methyl}-1-methyl-1H-indol-5-yl}-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamideN-(2-Formyl-1-methyl-1H-indol-5-yl)-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide (300 mg) obtained in Reference Example 10 and 1-amino-2-methylpropan-2-ol (143 mg) were suspended in NMP (3.0 mL), acetic acid (1.0 mL) was added at room temperature, and the mixture was stirred at the same temperature for 3 hr.Sodium triacetoxyborohydride (336 mg) was added, the mixture was stirred at room temperature for 90 hr, and diluted with ethyl acetate, and 2N aqueous sodium hydroxide solution (20 mL) was added at room temperature.The mixture was poured into THF-water, and the organic layer was washed twice with saturated brine, dried over sodium sulfate, and concentrated under reduced pressure.The obtained solid was suspended in ethyl acetate, and the precipitate was collected by filtration, washed with ethyl acetate, and dried under reduced pressure to give the title compound (323 mg, yield 90percent) as a pale-brown solid.1H NMR (300 MHz, CDCl3) delta: 1.19 (6 H, s), 1.71 – 1.88 (1 H, m), 1.90 – 2.20 (3 H, m), 2.65 (2 H, s), 2.77 (1 H, br. s.), 3.78 (3 H, s), 3.80 – 3.90 (1 H, m), 3.90 – 4.01 (3 H, m), 4.04 (2 H, d, J=4.9 Hz), 4.31 (1 H, tt, J=7.0, 5.3 Hz), 6.38 (1 H, s), 7.01 (2 H, d, J=8.7 Hz), 7.24 – 7.29 (1 H, m), 7.30 – 7.36 (1 H, m), 7.75 (1 H, s), 7.86 (2 H, d, J=9.1 Hz), 7.88 (1 H, s).melting point: 188-190°Celemental analysis (C26H33N3O4)Calculated: C, 69.16; H, 7.37; N, 9.31.Found: C, 69.02; H, 7.47; N, 9.30.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2854-16-2, its application will become more common.

Reference:
Patent; Takeda Pharmaceutical Company Limited; EP2522657; (2012); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 37729-18-3, name is 2-([1,1′-Biphenyl]-4-yl)ethanol. A new synthetic method of this compound is introduced below., SDS of cas: 37729-18-3

Under nitrogen atmosphere, to a stirred solution of 2-(4-phenylphenyl)-ethanol (0.30 g,1.41 mmol) in dry CH2C12 (15 mL), DMAP (0.014 g, 0.11 mmol) and 2-DPC (0.37 g, 1.70mmol) were added. The reaction mixture was stirred at r.t. for 16h, then diluted with CH2C12 (15mL) and sequentially washed with sat. NH4C1 solution (15 mL) and sat. NaHCO3 solution (315 mL). The organic layer was dried over Na2SO4, filtered and concentrated to dryness giving an oily residue (0.46 g), as a mixture (1:1.7 ratio) of 2-(4-phenylphenyl)-ethyl-2-pyridyl carbonate and 2-(4-phenylphenyl)-ethyl-2-oxopyridine- 1 -carboxylate. The mixture of isomers was not separated and used in the next step without any further purification. R = 2.63 mm. MS (ESI)m/z: 244 [M-H], 266 [M-Na]. MS (ESI) m/z: 242 EM-Hr.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 37729-18-3, 2-([1,1′-Biphenyl]-4-yl)ethanol.

Reference:
Patent; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA; PIOMELLI, Daniele; BANDIERA, Tiziano; BERTOZZI, Fabio; NUZZI, Andrea; FIASELLA, Annalisa; PONZANO, Stefano; PAGLIUCA, Chiara; REGGIANI, Angelo Mario; WO2014/144836; (2014); A2;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.5456-63-3, name is trans-2-Aminocyclohexanol hydrochloride, molecular formula is C6H14ClNO, molecular weight is 151.6345, as common compound, the synthetic route is as follows.Recommanded Product: 5456-63-3

a) 5-Bromo-N-((ilS,R,2RlS,)-2-hydroxy-cyclohexyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinamide5-Bromo-6-(2,2,2-trifluoro-ethoxy)-nicotinic acid (75.0 g, 0.25 mol) was dissolved in DMF (850 mL). To the solution was added TBTU (91.0 g, 0.275 mol), N,N-diisopropylethyl amine (214 mL, 1.25 mol) and (7SR,2RS)-2-amino-cyclohexanol hydrochloride (41.7 g, 0.275 mol). The reaction mixture was stirred for 1.5 h at room temperature. The solvent wasevaporated in vacuo, the residue was partitioned between ethyl acetate (2500 mL) and 1 N sodium hydroxide solution (2000 mL), the water phase was separated, extracted once more with ethyl acetate (1000 mL) and the organic phases were washed 2 times with water (2×1500 mL). Organic phases were pooled, dried with MgS04 and concentrated to about 900 mL. The product precipitated upon stirring and cooling to 0C. Filtration, washing with ethyl acetate/n-heptane (1: 1) and drying in vacuo gave the title compound (81.1 g) as a white solid; MS (ISP) 397, 399 (M)+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,5456-63-3, trans-2-Aminocyclohexanol hydrochloride, and friends who are interested can also refer to it.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; ROEVER, Stephan; WRIGHT, Matthew; WO2011/29827; (2011); A1;,
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Synthetic Route of 30379-58-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 30379-58-9, name is Benzyl 2-hydroxyacetate, molecular formula is C9H10O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a mixture of starting compound 68 (16 g, 41,1 mmol) and benzyl 2 -hydroxy-acetate 77a (13,6 g, 82,2 mmol) in 160 ml DCE was added Sc(OTf)3 (1,41 g, 2,88 mmol). The solution was stirred at 90C for 16 h to achieve complete conversion. The reaction mixture was poured into 200 ml sat. NaHC03 and extracted with 3 x 100 ml DCM. The combined organic phases were dried over anhydrous Na2S04, filtered and the filtrate was concentrated in vacuo. The residue was purified by column chromatography (PE:EtOAc 1:1) and then reverse flash chromatography (neutral), yielding 12,0 g (60 %) of the title compound 78a as yellow oil. MS [M+H]+ (m/z) = 496,0

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 30379-58-9, Benzyl 2-hydroxyacetate.

Reference:
Patent; SANOFI; HOFMEISTER, Armin; JAHN-HORMANN, Kerstin; (0 pag.)WO2019/170731; (2019); A1;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.30379-58-9, name is Benzyl 2-hydroxyacetate, molecular formula is C9H10O3, molecular weight is 166.17, as common compound, the synthetic route is as follows.SDS of cas: 30379-58-9

(S)-l -benzyl 2-methyl aziridine-l,2-dicarboxylate (5.105 g, 21.70 mmol), and benzyl 2-hydroxyacetate (6.16 ml, 43.4 mmol) were dissolved in DCM (43.4 ml) and cooled to 0C followed by the addition of BF3.0Et2 (0.275 ml, 2.170 mmol). The reaction was stirred for 2 h. TLC showed the aziridine starting material to be consumed. The reaction was stirred for and additional 14 h. Saturated sodium bicarbonate solution was added to the reaction and the biphasic mixture was vigorously stirred for 20 min. The reaction was diluted with DCM and separated from the aquious phase. The organic layer was washed with brine, dried over sodium sulate and concentrated under vacuum. The crude material was purified by flash chromatography using 10-40% EtOAc/Hexanes. The product fractions were collected and the solvent removed under vacuum to give methyl 0-(2-(benzyloxy)-2-oxoethyl)-N-((benzyloxy)carbonyl)-L-serinate, 3.0 (34%). ESI-MS(+) m/z 402.1 (M+l). NMR (400MHz, CHLOROFORM-d) d 7.43 – 7.30 (m, 10H), 5.95 (d, J=8.0 Hz, IH), 5.18 (s, 2H), 5.15 (s, 2H), 4.50 (dt, J=8.4, 3.1 Hz, IH), 4.12 (d, J=2.8 Hz, 2H), 4.10 – 4.04 (m, IH), 3.81 (dd, J=9.4, 3.1 Hz, IH), 3.77 (s, 3H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,30379-58-9, Benzyl 2-hydroxyacetate, and friends who are interested can also refer to it.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; SUN, Li-Qiang; ZHAO, Qian; MULL, Eric; GILLIS, Eric P.; SCOLA, Paul Michael; (290 pag.)WO2016/57624; (2016); A1;,
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Reference of 90369-75-8, Adding some certain compound to certain chemical reactions, such as: 90369-75-8, name is (3-Chloro-2-methylphenyl)methanol,molecular formula is C8H9ClO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 90369-75-8.

To a solution of phosphorus tribromide (0.422 mL, 4.47 mmol) in Toluene (30 mL) was added (3-chloro-2-methylphenyl)methanol (2 g, 12.77 mmol). The reaction was stirred at RT overnight. The solvent was removed and the residue was partitioned between EtOAc and brine. The organic layer was concentrated and the residue was purified by biotage (5% EA/hexane) to give the product (2.Og, 71%). 1H NMR (400 MHz, CDC13) deltappm 7.36 (m, IH), 7.24 (m, IH), 7.12 (m, IH), 4.56 (s, 2H). 2.48 (s, 3H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 90369-75-8, (3-Chloro-2-methylphenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; GLAXOSMITHKLINE LLC; LIN, Hong; LUENGO, Juan, I.; RIVERO, Ralph, A.; SCHULZ, Mark, James; XIE, Ren; ZENG, Jin; WO2010/135504; (2010); A1;,
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Synthetic Route of 5333-42-6, Adding some certain compound to certain chemical reactions, such as: 5333-42-6, name is 2-octyldodecan-1-ol,molecular formula is C20H42O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5333-42-6.

Into a 250 ml glass reactor fitted with an Argon purge was placed the hexanoic acid (23.2 grams, 0.2 moles), 2-octyl-1-dodecanol (29.9 grams, 0.1 moles) (Aldrich 97%) (the “C20-alcohol”, which is a Guerbet alcohol) and p-toluene sulfonic acid monohydrate (19 grams, 0.1 mole). The mixture above was purged with Argon at room temperature for one hour. The mixture was then heated to 100 C. under Argon purge for 18 hours. The mixture was then cooled to room temperature. The residue was then dissolved into 100 ml with ethyl acetate and placed into a separatory funnel. The ethyl acetate solution was extracted once with 100 ml of distilled water. The ethyl acetate layer was washed with 250 ml 10 wt % NaHCO3 aqueous solution followed by 250 ml saturated NaCl aqueous solution. The ethyl acetate solution was dried over MgSO4 and then filtered. The ethyl acetate was removed on the rotary evaporator from the solution. The residue from the rotary evaporator was placed on a Kugelrohr vacuum distillation apparatus where the ester was distilled. 1H NMR (CDCl13): delta3.96 (d, 2H, O-CH2-), 2.31 (d, 2H, O=C-CH2-), 1.61-1.26 (m, 39H, -CH2-), 0.80 (t, 9H, CH3). IR (cm-1): 2955, 2925, 2854, 1733, 1466, 1378, 1234, 1168, 1102, 722.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 5333-42-6, 2-octyldodecan-1-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ExxonMobil Chemical Patents Inc.; Patil, Abhimanyu O.; Lewis, Kyle G.; Bodige, Satish; Zushma, Stephen; US2019/62663; (2019); A1;,
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Adding a certain compound to certain chemical reactions, such as: 109-83-1, 2-(Methylamino)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 109-83-1, blongs to alcohols-buliding-blocks compound. Safety of 2-(Methylamino)ethanol

Example 1 N-(2-hydroxy-ethyl)-4-methoxy-2.6,N-trimethyl-benzenesulphonamide (C) [0152] 3,5-dimethylanisol (A) were dissolved in 50.0 L dichloromethane. After cooling to -35 C. a solution of 17.46 kg (149.85 mol) chlorosulphonic acid in 15.0 L dichloromethane was metered in and the mixture was stirred for about another 30 minutes at -35 C.±5 C. After the reaction was complete 40.0 L of water were metered in at -35 C. to 5 C. and then the organic phase was separated off. The organic phase was diluted with 10.0 L dichloromethane, before a solution of 1.23 kg (14.69 mol) of sodium hydrogen carbonate in 29.0 L water was added. After separation of the organic phase and dilution with 10 L of dichloromethane, a solution consisting of 11.58 kg (154.20 mol) of N-methylaminoethanol (B) in 20.0 L dichloromethane was slowly metered in at 10±5 C. After the reaction was complete, a mixture of 42.0 L water and 4.10 kg (42.59 mol) conc. hydrochloric acid was added, starting at 10 C. The organic phase was separated off, diluted with 10.0 L of dichloromethane and the product ( C) was totally freed from the solvent in vacuo. [0154] Yield: 14.34 kg (71% of theory)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,109-83-1, its application will become more common.

Reference:
Patent; Boehringer Ingelheim International GmbH; Pachur, Thorsten; Pfrengle, Waldemar; Birk, Manfred; Schnaubelt, Juergen; Werthmann, Ulrike; US2013/289049; (2013); A1;,
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