Category: alcohols-buliding-blocks

Electric Literature of 3279-95-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 3279-95-6, name is 2-(Aminooxy)ethanol, molecular formula is C2H7NO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: 4a-c (1 equiv) were dissolved in ethanol (10mL). O-(2-hydroxyethyl)hydroxylamine (14, 2 equiv), acetic acid (2 equiv), pyridine (2 equiv) were added to the solution. After being refluxed for 5h, ethanol was removed under reduced pressure. The products were extracted with CH2Cl2. The combined extracts were washed with 2M HCl aqueous solution and brine. The organic layer was dried with anhydrous Na2SO4. The solvent was removed under reduced pressure and the residue was purified by column chromatography (PE: EtOAc=6: 1) to yield 15a-c. 3alpha-O-(2,3,4,6-tetra-O-benzoyl-beta-d-glucopyranosyl)-17-(O-(2-hydroxyethyl)oxime)-5beta-androstane (15a). The title compound was obtained starting from 4a (600mg, 0.69mmol) (white solid, 530mg, 82.8% yield, mp 91-94C). Analytical data for 15a: ESI-MS m/z (%) 950.4 [M+Na]+; 1H NMR (400MHz, CDCl3) delta 7.87-7.67(m, 8H, Bz-H), 7.48-7.18(m, 12H, Bz-H), 5.76 (t, J=9.7Hz, 1H, H-3?), 5.49 (t, J=9.7Hz, 1H, H-2?), 5.39-5.28 (m, 1H, H-4?), 4.80 (d, J=7.9Hz, 1H, H-1?), 4.41 (m, 2H, H-6?), 3.95 (m, 3H, H-5?, =NOCH2CH2OH), 3.72 (m, 2H, =NOCH2CH2OH), 3.49 (m, 1H, H-3), 2.28 (m, 2H, H-16), 1.73-0.85 (m, 20H), 0.73 (s, 3H, 18-CH3), 0.70 (s, 3H, 19-CH3).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 3279-95-6, 2-(Aminooxy)ethanol.

Reference:
Article; Li, Haihong; Wang, Ke; Wan, Qi; Chen, Ying; Steroids; vol. 141; (2019); p. 81 – 95;,
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Synthetic Route of 621-63-6, Adding some certain compound to certain chemical reactions, such as: 621-63-6, name is 2,2-Diethoxyethanol,molecular formula is C6H14O3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 621-63-6.

(b) 2,2-Diethoxyethyl (S)-(+)-Camphorsulfonate 2,2-Diethoxyethanol (3.82 g), Et3N (3.17 g), dichloromethane (40 mL) and DMAP (4 mg) are combined and the solution is cooled to 4° C. (S)-Camphorsulfonyl chloride (7.5 g) is added at a rate of 1 g /min. The ice-water bath is removed and the reaction is allowed to progress for about 1 hour at room temperature. About 40 mL of water is added slowly to quench the reaction, the phases are separated and the dichloromethane phase is washed with saturated sodium bicarbonate (20 mL) and water (20 mL). The solution is vacuum concentrated to produce 7.9 g of 2,2-diethoxyethyl (S)-(+)-camphorsulfonate.

According to the analysis of related databases, 621-63-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Brantford Chemicals Inc.; US6380388; (2002); B1;,
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Related Products of 534-03-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.534-03-2, name is 2-Aminopropane-1,3-diol, molecular formula is C3H9NO2, molecular weight is 91.1091, as common compound, the synthetic route is as follows.

735 ml of methylenechloride is put in a flask after a stir bar is put in the flask and cooled down to 0 C. under a nitrogen stream, 85 g (147 mmol) of sulforhodamine B acid chloride is added thereto, and the mixture is agitated. Subsequently, 16.1 g (177 mmol) of serinol, 0.899 g (7.37 mmol) of N,N-dimethylamino pyridine, and 38.3 g (53 ml, 295 mmol) of triethyl amine are further added thereto, and the mixture is agitated at room temperature for 15 hours. Then, the mixture is concentrated under a reduced pressure by using a rotary evaporator to obtain a red solid, and the red solid is rinsed with ethylacetate, obtaining 70.1.5 g of a solid compound represented by the following Chemical Formula 6-4 (a yield of 69%).

The chemical industry reduces the impact on the environment during synthesis 534-03-2, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Cheil Industries Co., Ltd.; Kim, Won Jung; Kang, Kyung Hee; Park, Chae Won; Sin, Myung Yeop; Jeon, Hwan Sung; Jung, Uii Soo; Hwang, Ki Wook; (43 pag.)KR2016/91878; (2016); A;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 33036-62-3, name is 4-Bromo-1-butanol, molecular formula is C4H9BrO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. name: 4-Bromo-1-butanol

2-(4-Bromobutoxy)-tetrahydro-2H-pyran (2): 3,4-Dihydro-2H-pyran (8.5 mL, 90.96 mmol) was added dropwise to the dichloromethane (20 mL) solution of 1 (10.7 g, 69.93 mmol) and p-toluenesulfonic acid monohydrate (26.5 mg, 0.1372 mmol). The mixture was stirred at room temperature over night. After removing the solvent, the residue was purified by flash chromatography on silica gel with 5:1 hexanes/ethyl acetate as the eluent to yield product 2 as a colorless oil (15.3 g, 92 %). 1H NMR (400 MHz, CDCI3): delta 1.48-1.62 (m, 4H), 1.68-1.85 (m, 4H), 1.94-2.02 (m, 2H), 3.40-3.53 (m, 4H), 3.74-3.88 (m, 2H), 4.57-4.59 (m, 1 H).

With the rapid development of chemical substances, we look forward to future research findings about 33036-62-3.

Reference:
Patent; DIETRICH, Evelyne; REDDY, Ranga; TANAKA, Kelly; KANG, Ting; LAFONTAINE, Yanick; RAFAI FAR, Adel; TARGANTA THERAPEUTICS CORP.; WO2010/19511; (2010); A2;,
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Adding a certain compound to certain chemical reactions, such as: 7073-69-0, 2-(2-Bromophenyl)propan-2-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of 2-(2-Bromophenyl)propan-2-ol, blongs to alcohols-buliding-blocks compound. Quality Control of 2-(2-Bromophenyl)propan-2-ol

General procedure: A glass vial equipped with a magnetic stir bar and fitted with a Teflon screw cap was charged with BBA (90 mg, 1.0 mmol), KOAc (98 mg, 1.0 mmol) and the aryl halide (0.50 mmol). To this vessel was added EtOH (2.5 mL) and the reaction media was degassed with Argon for 5 minutes. XPhos Pd G2 (79 mg, 10 mol%) was then added, and the solution was stirred (750 rpm) and heated at 80C until full conversion was observed. The reaction media was filtered over celite and the crude filtrate was purified using Teledyne Isco Combiflash device (silica gel column chromatography 15 mum) and Hept:DCM (90:10 to 0:100) as solvent.

The synthetic route of 7073-69-0 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Lafitte, Guillaume; Kunihiro, Kana; Bonneaud, Celine; Drean, Benedicte; Gaigne, Frederic; Parnet, Veronique; Pierre, Romain; Raffin, Catherine; Vatinel, Rodolphe; Fournier, Jean-Francois; Musicki, Branislav; Ouvry, Gilles; Bouix-Peter, Claire; Tomas, Loic; Harris, Craig S.; Tetrahedron Letters; vol. 58; 39; (2017); p. 3757 – 3759;,
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Electric Literature of 534-03-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.534-03-2, name is 2-Aminopropane-1,3-diol, molecular formula is C3H9NO2, molecular weight is 91.1091, as common compound, the synthetic route is as follows.

Intermediate 131: 2-(l,3-Dihvdroxypropan-2-yl)isoindoline-l,3-dione (0848) To a stirring solution of 2-aminopropane-l,3-diol (327.2 mg, 3.59 mmol, commercially available from, for example, Sigma-Aldrich) in DMF (15 ml.) was added phthalic anhydride (533.6 mg, 3.60 mmol) portionwise. The resulting colourless solution was stirred at 90 C under nitrogen for 5 h, after which the reaction mixture was cooled to rt and the volatiles evaporated in vacuo. This was partitioned between ethyl acetate (25 ml.) and water (25 ml.) and the layers separated. The aqueous phase was extracted with further ethyl acetate (4 x 25 ml.) and the organic layers combined and filtered through a cartridge fitted with a hydrophobic frit. The filtrate was evaporated in vacuo. This was redissolved in ethyl acetate (approx. 4 ml.) and 3: 1 ethyl acetate :ethanol (approx. 4 ml.) and directly applied to the top of a 25 g SNAP cartridge and purified by flash column chromatography. The column was eluted with a gradient of 0% – 40% (3: 1 ethyl acetate:ethanol) in cyclohexane. The appropriate fractions were combined and evaporated in vacuo to give 2-(l,3-dihydroxypropan-2- yl)isoindoline-l,3-dione (380.0 mg, 1.72 mmol, 48 % yield) as a white solid. (0849) LCMS (2 min High pH): Rt = 0.55 min, [MH]+ = 222.3.

The chemical industry reduces the impact on the environment during synthesis 534-03-2, I believe this compound will play a more active role in future production and life.

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED; ATKINSON, Stephen John; DEMONT, Emmanuel Hubert; HARRISON, Lee Andrew; LEVERNIER, Etienne; PRESTON, Alexander G; SEAL, Jonathan Thomas; WALL, Ian David; WATSON, Robert J; WOOLVEN, James Michael; (225 pag.)WO2017/174621; (2017); A1;,
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Adding a certain compound to certain chemical reactions, such as: 929-06-6, 2-(2-Aminoethoxy)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 929-06-6, blongs to alcohols-buliding-blocks compound. Quality Control of 2-(2-Aminoethoxy)ethanol

Step 1 2-(2-N-Boc-aminoethoxy)ethanol To a solution of 2-(2-aminoethoxy)ethanol (5.3 g, 50 mmol) and diisopropylethylamine (13 ml, 75 mmol) in DCM (10 ml) at 0 C. was added dropwise a is solution of di-tert-butyl dicarbonate (12 g, 55 mmol) in DCM (20 ml). The reaction was agitated for 4 hours, extracted with DCM and purified by flash chromatography (EtOAc/PE) (75/25) to give the title compound (5.9 g, 60%). 1H NMR (CDCl3) delta 3.65 (dd, J=8.6, 3.8 Hz 2H), 3.47 (m, 5H), 2.23 (dd, J=8.6, 3.8 Hz 2H), 1.35 (s, 9H); 13C NMR (CDCl3) delta 56.1, 79.1, 72.1, 70.1, 61.3, 40.3, 28.2.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,929-06-6, its application will become more common.

Reference:
Patent; Gustavsson, Anna-Lena; Jendeberg, Lena; Roussel, Patrick; Slater, Martin; Thor, Markus; US2003/73862; (2003); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 56456-51-0, name is 2-Chloro-4-(trifluoromethyl)benzyl alcohol, the common compound, a new synthetic route is introduced below. SDS of cas: 56456-51-0

To a solution of 2-chloro-4-trifluoromethylbenzyl alcohol (38.8 g) and pyridine (3.0 ml) in diethyl ether (320 ml)- tetrahydrofuran (80 ml) was added thionyl chloride (32.8 g) , and the mixture was stirred at room temperature for 15 hr. The reaction solution was concentrated, water was poured’ into the residue and the mixture was extracted with ethyl acetate. The o ethyl acetate layer was washed with IN hydrochloric acid, a saturated aqueous sodium hydrogencarbonate solution and saturated brine, dried (MgSO4), and concentrated. The residue was subjected to silica gel column chromatography, and eluted with ethyl acetate-hexane (1:25 – 1:12, v/v) to give 2-chloro- 4-trifluoromethylbenzyl chloride (38.9 g, yield: 92%) as a colorless oil.1H-NMR (300 MHz, CDCl3) delta:4.72 (2 H,, s) , 7.51 – 7.57 (1 H, m) , 7.60 – 7.70 (2 H, m) .

The synthetic route of 56456-51-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; WO2007/18314; (2007); A2;,
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Application of 629-41-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 629-41-4, name is 1,8-Octanediol, molecular formula is C8H18O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

The compound 2-1-1 (octanediol) (1.01 g, 6.91 mmol) was dissolved in 20 ml of toluene, and 40% HBr (aq) (1.12 ml, 7.81 mmol) was added to the reaction system at room temperature, bath reflux.72h after TLC monitoring, there is still the remaining raw materials, add 40% HBr (aq) (0.5ml, 3.49mmol), continue to return 24h.The system was cooled to room temperature, diluted with ether, saturated sodium bicarbonate solution, saturated sodium chloride solution, washed once, sodium sulfate dried about half an hour after the filter, steamed ether.The residue was purified by column chromatography on silica gel, eluting with petroleum ether: ethyl acetate = 6: 1 to give an oily product, 1.21 g, in 84.3% yield.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 629-41-4, 1,8-Octanediol.

Reference:
Patent; PEKING UNIVERSITY; YE, XINSHAN; HOU, JINGFEI; (25 pag.)CN103373955; (2016); B;,
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Related Products of 94022-96-5, Adding some certain compound to certain chemical reactions, such as: 94022-96-5, name is 2-(Trifluoromethyl)phenethyl alcohol,molecular formula is C9H9F3O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 94022-96-5.

General procedure: A mixture of the substituted phenylethyl alcohol (10 mmol), Chloromethyl methyl ether (15mmol) and N,N-diisopropylethylamine (20 mmol) in dry dichloromethane (25 mL)was stirred under nitrogen atmosphere for 2.5 h at rt. The reaction mixture wasthen washed with water (2×50 mL), dried (NaSO4) and the solvent wasremoved in vacuo. The crude MOM acetal was dissolved in dried CH3CN (25mL) and added to cooled (0 oC) solution of Trimethylsilyltrifluoromethanesulfonate (TMSOTf) (10 mmol). The reaction was carried outunder nitrogen atmosphere for 3 h. Then the mixture was quenched by theaddition of l M NaHCO3 (20 mL ). The orgnic phase was washed withbrine (2×50 mL), dried (NaSO4) and evaporated under reducedpressure. Purification by FC afforded relevant substituted isochromans.

According to the analysis of related databases, 94022-96-5, the application of this compound in the production field has become more and more popular.

Reference:
Article; Zhou, Mei-Yan; Kong, Shan-Shan; Zhang, Ling-Qiong; Zhao, Ming; Duan, Jin-Ao; Ou-Yang, Zhen; Wang, Min; Tetrahedron Letters; vol. 54; 30; (2013); p. 3962 – 3964;,
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