Category: alcohols-buliding-blocks

Electric Literature of 16545-68-9 ,Some common heterocyclic compound, 16545-68-9, molecular formula is C3H6O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

At 0C and under nitrogen flux, NaH (60% dispersion in mineral oil) (0.510 g; 12.8 mmol) was added portionwise to a solution of cyclopropanol (0.64 mL, 12.74 mmol) in Me-THF (24mL). The reaction was stirred at room temperature for 10 minutes. (1844) At -78C, the above described suspension was added dropwise to a solution of 1,4- dinitro-lH-pyrazole (3.00 g; 18.98 mmol) in Me-THF (6.50 mL, 64.9 mmol). The reaction mixture was stirred at -78C for 1 h then allowed to stir at rt for 5 hours. The reaction mixture was poured out onto water, made acidic with 3N HCl(aq), extracted with DCM, dried over MgS04, filtered and evaporated. The crude was purified via preparative LC (Stationary phase irregular SiOH 15-40muiotaeta 24g GraceResolv, Mobile phase: gradient from 80% Heptane, 20% EtOAc to 40% heptane, 60% EtOAc). The pure fractions were collected and the solvent was evaporated to give 466 mg of intermediate 746 (22%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,16545-68-9, its application will become more common.

Reference:
Patent; JANSSEN PHARMACEUTICA NV; STANSFIELD, Ian; QUEROLLE, Olivier, Alexis, Georges; LIGNY, Yannick, Aime, Eddy; GROSS, Gerhard, Max; JACOBY, Edgar; MEERPOEL, Lieven; GREEN, Simon, Richard; HYND, George; KULAGOWSKI, Janusz, Jozef; MACLEOD, Calum; MANN, Samuel, Edward; (472 pag.)WO2018/2217; (2018); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 60211-57-6, name is 3,5-Dichlorobenzyl alcohol. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of 3,5-Dichlorobenzyl alcohol

Example C Preparation of 3,5-dichlorophenylacetic acid To a solution of 3.5 g of 3,5-dichlorobenzyl alcohol (Aldrich) in 75 mL of dichloromethane at 0C was added 1.8 mL of methane sulfonylchloride followed by 3.5 mL of triethylamine added dropwise. After 2 hours the solution was diluted to 150 mL with dichloromethane, washed with 3N HCl, saturated aqueous NaHCO3 dried with Na2SO4 and the solvents removed to yield the desired 3,5-dichlorobenzyl methanesulfonate as a yellow oil that was used without purification.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 60211-57-6, 3,5-Dichlorobenzyl alcohol.

Reference:
Patent; Elan Pharmaceuticals, Inc.; ELI LILLY AND COMPANY; EP951464; (2005); B1;,
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Adding a certain compound to certain chemical reactions, such as: 106-28-5, (2E,6E)-3,7,11-Trimethyldodeca-2,6,10-trien-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 106-28-5, blongs to alcohols-buliding-blocks compound. Recommanded Product: 106-28-5

Synthesis was carried out with farnesol as a starting material. The hydroxy group of farnesol was chlorinated using N-chlorosuccinimide (NCS) and dimethyl sulfide (DMS) in anhydrous dichloromethane in a nitrogen atmosphere to obtain a chloride (compound represented by (i) below) (yield: 91%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,106-28-5, (2E,6E)-3,7,11-Trimethyldodeca-2,6,10-trien-1-ol, and friends who are interested can also refer to it.

Reference:
Patent; YAMAGATA UNIVERSITY; SUMITOMO RUBBER INDUSTRIES, LTD.; Miyagi, Yukino; Ichikawa, Naoya; Ohya, Norimasa; US2014/171675; (2014); A1;,
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Synthetic Route of 558-42-9, Adding some certain compound to certain chemical reactions, such as: 558-42-9, name is 1-Chloro-2-methyl-2-propanol,molecular formula is C4H9ClO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 558-42-9.

EXAMPLE 102 1-(4-{5-[4-(3,4-Dichloro-phenyl)-1H-imidazol-2-yl]-pyridin-2-yl}-piperazin-1-yl)-2-methyl-propan-2-ol: (Reference: Ind. Acad. Sci. 1939, 49,101-4.) A solution of 1-{5-[4-(3,4-dichloro-phenyl)-1H-imidazol-2-yl]-pyridin-2-yl}-piperazine (155 mg, 0.41 mmol), sodium carbonate (66 mg, 0.62 mmol, 1.5 equiv) and 1-chloro-2-methyl-propan-2-ol (51 mul, 53 mg, 0.50 mmol, 1.2 equiv) in 50percent aqueous ethanol (20 ml) under nitrogen atmosphere was heated at reflux overnight. The reaction mixture was then diluted with brine and extracted with ethyl acetate (3*25 ml). The combined organic phases were dried over anhydrous magnesium sulfate, filtered, and concentrated in vacuo. Purification of the residue by flash column chromatography (50percent THF/0.5percent ammonium hydroxide/hexanes) provided the desired product (100 mg, 54percent). MS m/z 446 (M++1).

According to the analysis of related databases, 558-42-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Elliott, Richard L.; Hank, Richard F.; Hammond, Marlys; US2001/39277; (2001); A1;,
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Reference of 355-80-6, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 355-80-6 as follows.

In a typical experiment, 5,10,15-tris(3-acetoxyphenyl)-20-(pentafluorophenyl)-porphyrin (60.0 mg, 68.2 mupiiotaomicronGamma) was dissolved in a dry DMSO/THF (4: 1) mixture under argon atmosphere, KOH (103.4 mg, 1.84 mmol) and lH, lH,5H-octafluoropentanol (342 ml, 2.46 mmol) were added and the reaction mixture stirred under room temperature for 30 minutes. After aqueous workup, extraction with ethyl acetate and drying with Na2SO/t, the crude product was purified by column cromatography (DCM/MeOH = 95:5) and recrystallized (DCM/hexane) to obtain a purple solid (58.4 mg, 60.5 mupiiotaomicron, 88%). 5,10,15-Tris(3-hydroxy-phenyl)-20-[2,3,5,6-tetra-fluoro-4-(lH,lH,5H-octafluoro- pentyloxy)-phenyl]-porphyrin ^-NMR (500 MHz, acetone-d6): delta = -2.78 (s, 2H, NH), 5.32 (t, J = 13.8 Hz, 2H, OCH2), 6.93 (tt, J = 50.9, 5.5 Hz, 3H, CF2H), 7.30-7.34 (m, 3H, Ar-H-6), 7.62 (mc, 1H, Ar H-5), 7.62 (mc, 2H, Ar2-H-5), 7.68-7.78 (m, 6H, Ar-H-2 + Ar-H-4), 8.80-9.28 (m, 8H, ^-HPylTol) ppm. 13C-NMR (126 MHz, acetone-d6): delta = 70.3 (OCH2), 100.9 (ArF-Cmeso), 108.4 (CF2H), 115.2 (Ar-C-6), 116.4 (ArF-C,pso), 120.8 (Ar-Cmeso), 121.9 (Ar-Cmeso), 122.0 (Ar C-2), 122.0 (Ar2-C-2), 126.3 (Ar C- 4), 126.3 (Ar2-C-4), 127.8 (Ar C-5), 127.8 (Ar2-C-5), 137.4 141.4 (d, lJc.F = 246.2 Hz, ArF-CM), 142.8 (Ar2-C,pso), 143.0 (Ar C,pso), 146.9 (d, lJc.F = 241.0 Hz, ArF-Cort0), 156.0 (Ar C-3), 156.0 (Ar2-C-3) ppm. F-NMR (376 MHz, acetone-d6): delta = -121.25 – -121.42 (m, 2F, CF2), -125.24 – -125.36 (m, 2F, CF2), -130.48 – -130.62 (m, 2F, CF2), -138.95 (d, 2JH.F = 50.8 Hz, 2F, CF2H), -140.83 – -141.01 (m, 2F, Ar-Fort0), -158.30 – -158.48 (m, 2F, Ai-Fmeta) ppm. HRMS (ESI-TOF): m/z calc. for C49H29Fi2N404 [M + H]+: 965.1992; found: 965.2041 UV-VIS (acetone), Amax [log epsilon (L · mol 1 · cm”1)]: 414 (5.37), 511 (4.41), 545 (4.04), 587 (4.08), 643 (3.84) nm.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,355-80-6, its application will become more common.

Reference:
Patent; BIOLITEC UNTERNEHMENSBETEILIGUNGS II AG; FREIE UNIVERSITAeT BERLIN; GOLF, Hartwig Richard Arthur; WIEHE, Arno; GRAeFE, Susanna; ALBRECHT, Volker; REISSIG, Hans-ulrich; (110 pag.)WO2016/51361; (2016); A1;,
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Related Products of 2240-88-2, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 2240-88-2 as follows.

b) Methyl 4-(benzyloxy)-3-(3,3,3-trifluoropropoxy)benzoateDiisopropyl azodicarboxylate (0.372 mL, 1.89 mmol) and triphenylphosphine (0.489 g, 1.86 mmol) were added to a solution of methyl 4-(benzyloxy)-3-hydroxybenzoate (0.355 g, 1.37 mmol) in tetrahydrofuran (20 mL) and the resulting reaction mixture was stirred for 55 min at room temperature. 3,3,3-Trifluoro-l-propanol (0.121 mL, 1.37 mmol) was added and the reaction mixture was stirred over night. The solvent was evaporated. Purification by column chromatography, using heptane/ethyl acetate (6:1) as the eluent, gave 0.162 g (33percent yield) of the title compound. GC MS (EI) m/z 354 [M]+*.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2240-88-2, its application will become more common.

Reference:
Patent; ASTRAZENECA AB; BYLUND, Johan; EK, Maria, E; HOLENZ, Joerg; KERS, Annika; OeHBERG, Liselotte; WO2010/132016; (2010); A1;,
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Related Products of 29683-23-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 29683-23-6, name is Tetrahydro-2H-thiopyran-4-ol, molecular formula is C5H10OS, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Phosphorus tribromide (3.9 g, 14 mmol) was added dropwise in 30 min to a solution of alcohol 5 (3.73 g, 32 mmol) in CH2Cl2 (50 mL) at ambient temperature. Upon completion of the addition, the reaction mixture was slowly heated to the boiling point and stirred overnight. After cooling to room temperature the mixture was quenched with water and extracted with diethyl ether (2 × 100 mL). The organic phase was washed with a saturated solution of NaHCO3, dried over anhydrous MgSO4 and evaporated to yield 3.37 g (19 mmol, 59%) of a yellow oil. deltaH (CDCl3) 4.32 (m, 1H, CHBr), 2.90 (m, 2H, SCH2), 2.55 (m, 2H, SCH2), 2.38 (m, 2H, SCH2CH2), 2.23 (m, 2H, SCH2CH2). deltaC (CDCl3) 45.3 (CBr), 36.9 (SCC), 26.9 (SC).

According to the analysis of related databases, 29683-23-6, the application of this compound in the production field has become more and more popular.

Reference:
Article; Van Walree, Cornelis A.; Lutz, Martin; Spek, Anthony L.; Jenneskens, Leonardus W.; Havenith, Remco W.A.; Journal of Molecular Structure; vol. 1036; (2013); p. 115 – 120;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 403-41-8, name is 1-(4-Fluorophenyl)ethyl Alcohol. This compound has unique chemical properties. The synthetic route is as follows. category: alcohols-buliding-blocks

To a solution of 1-(4-fluorophenyl)ethanol (200 mg, 0.0014 mol, commercial source: Aochem) in dichloromethane (4 mL), triethylamine (0.4 mL, 0.0029 mol, commercial source: Finar) and mesyl chloride (0.16 mL, 0.0021 mol, commercial source: Avra) were added at 0 C. The reaction mixture was stirred at 26 C for 16 h. Upon completion, dichloromethane (60 mL) and water (10 mL) were added. The organic layer was dried over anhydrous Na2S04, filtered and the filtrate was concentrated under reduced pressure to afford crude 1-(4-fluorophenyl)ethyl methanesulfonate (300 mg) as a pale tellow liquid that was used in the next step without further purification.

With the rapid development of chemical substances, we look forward to future research findings about 403-41-8.

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; ALEMPARTE-GALLARDO, Carlos; ENCINAS, Lourdes; ESQUIVIAS PROVENCIO, Jorge; (206 pag.)WO2019/34729; (2019); A1;,
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Electric Literature of 5339-85-5, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 5339-85-5 as follows.

The conversion of 2-(o-aminophenyl)ethanol and the yield of indole were 100% and 91.6%, respectively.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,5339-85-5, its application will become more common.

Reference:
Patent; Research Association for Utilization of Light Oil; US4757152; (1988); A;,
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Synthetic Route of 110-73-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 110-73-6, name is 2-(Ethylamino)ethanol. This compound has unique chemical properties. The synthetic route is as follows.

in a four-necked flask of 300ml, formula dye intermediate 34.3 parts obtained in step 5-1, put the NMP146 parts of 2- (ethylamino) ethanol 16.3 parts, 90 in it stirred 1.5 hours.The reaction mixture was poured into 2N aqueous hydrochloric acid, the precipitated crystals were collected by filtration, washed, and dried to give Intermediate 34.9 parts of the dye represented by the following formula (104).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 110-73-6, 2-(Ethylamino)ethanol.

Reference:
Patent; NIPPON KAYAKU COMPANY LIMITED; MIFUJI, AKIHIRO; (16 pag.)JP2016/65220; (2016); A;,
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