Category: alcohols-buliding-blocks

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1202577-61-4, name is trans-(4-(Trifluoromethyl)cyclohexyl)methanol. This compound has unique chemical properties. The synthetic route is as follows. Quality Control of trans-(4-(Trifluoromethyl)cyclohexyl)methanol

[00173] To a mixture of oxalyl chloride (24.96 g, 13.84 mL, 197.7 mmol) in CH2C12 (250 mL) was added dropwise DMSO (20.72 g, 28 mL, 395.4 mmol) at -65 C. The mixture was stirred at -65 C for 30 min. (iraw5,-4-(trifluoromethyl)cyclohexyl)methanol (12 g, 65.9 mmol) dissolved in CH2C12 (50 mL) was added dropwise at -65 C and the mixture was stirred at -65 C for another 30 min. Triethylamine (66.4 g, 91.2 mL, 659 mmol) was added dropwise below -65 C. The mixture was stirred at -65 C for 30 min, then stirred at rt for 1.5 h. The mixture was quenched with water (200 mL) and separated. The aqueous layer was extracted with CH2C12 (2 x 300 mL). The combined organic layers were washed with water (200 mL) and brine (200 mL), dried over anhydrous sodium sulfate, filtered and concentrated under vacuum. The residue was purified by silica gel chromatography (eluting with petroleum ether: ethyl acetate = 10: 1) to give trans-4- (trifluoromethyl)cyclohexanecarbaldehyde (8.9 g, 75%) as a slight yellow oil. 1H NMR (CDCI3, 400 MHz): delta 9.70 (s, 1H), 2.16-2.65 (m, 3H), 2.04-2.12 (m, 3H), 1.00-1.39 (m, 4H).

With the rapid development of chemical substances, we look forward to future research findings about 1202577-61-4.

Reference:
Patent; VITAE PHARMACEUTICALS, INC.; CLAREMON, David, A.; DILLARD, Lawrence, Wayne; DONG, Chengguo; FAN, Yi; JIA, Lanqi; LOTESTA, Stephen, D.; MARCUS, Andrew; SINGH, Suresh, B.; TICE, Colin, M.; YUAN, Jing; ZHAO, Wei; ZHENG, Yajun; ZHUANG, Linghang; (102 pag.)WO2016/61160; (2016); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 5333-42-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 5333-42-6, name is 2-octyldodecan-1-ol. This compound has unique chemical properties. The synthetic route is as follows.

2-Octyl-l-dodecanol (5 g, 16.7 mmol) was taken in a 100 mL round bottomed flask, pyridiniumchlorochromate (10.8 g, 50.24 mmol) was added to it and the mixture was dissolved in anhydrous CH2C12 (120 mL). The reaction mixture was stirred at room temperature (27C) for 3 h and filtered through a short pad of silica gel to provide the required aldehyde as a colourless liquid. 4.68 g, Yield: 94%.1H NMR (400 MHz, CDC13) delta: 9.54 (d, / = 3.2 Hz, 1 H), 2.26 – 2.14 (m, 1 H), 1.68 – 1.53 (m, 2 H), 1.42 (dd, / = 14.2, 5.6 Hz, 2 H), 1.25 (broad s, 28 H), 0.87 (t, / = 6.8 Hz, 6 H); 13C NMR (100 MHz, CDC13) delta: 211.9, 182.8, 161.1, 77.3, 77.2, 76.7, 74.6, 72.1, 45.5, 42.8, 37.4, 34.0, 32.2, 31.9, 31.8, 29.7, (0101) 29.6, 29.6, 29.5, 29.5, 29.3, 29.3, 29.3, 29.1, 27.4, 25.6, 25.2, 23.9, 22.7, 14.1; MALDI-TOF (m/z): [M]+ calcd for C20H40O: 296.3079; found: 296.2517.

According to the analysis of related databases, 5333-42-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH; NITHYANANDAN, Jayaraj; ALAGUMALAI, Ananthan; FAIROOS, Munavvar; VELLIMALAI, Punitharasu; (47 pag.)WO2018/20518; (2018); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 440-60-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 440-60-8, name is (Perfluorophenyl)methanol. A new synthetic method of this compound is introduced below.

Example 10 In a 30 ml two-necked flask were added 0.004 g of LiOH.H2O, 0.31 g of methyl 2,2-dimethyl-3-(2-methyl-1-propenyl)cyclopropanecarboxylate, 1.00 g of (2,3,4,5,6-pentafluorophenyl)methyl alcohol and 0.6 g of toluene, and the mixture was stirred for 8 hours at a toluene refluxing temperature. Analysis of the reaction mixture by a gas chromatography showed that the yield of (2,3,4,5,6-pentafluorophenyl)methyl 2,2-dimethyl-3-(2-methyl-1-propenyl)cyclopropanecarboxylate was 92% based on the starting ester.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,440-60-8, (Perfluorophenyl)methanol, and friends who are interested can also refer to it.

Reference:
Patent; Sumitomo Chemical Company, Limited; US6441220; (2002); B1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 27489-62-9, name is trans-4-Aminocyclohexanol, the common compound, a new synthetic route is introduced below. Product Details of 27489-62-9

A mixture of Methyl 2-bromo-1 -methyl-1 H-benzimidazoIe-5-carboxylate (37.0 g, 0.137 mol), frans-4-aminocyclohexanol (38.0 g, 0.33 mol), cesium fluoride CsF (29.24 g, 0.29 mol), and DMSO (350 mL) was stirred at 110 C for 6 h and kept overnight at room temperature (TLC control, silica gel, chloroform/ethanol 20:1 ). The reaction mixture was poured into cold water (1.5 L). The precipitate was separated by filtration and recrystallized from acetonitrile (900 mL) to give the title compound in 84% (35.0 g) yield.

The synthetic route of 27489-62-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PFIZER PRODUCTS INC.; WO2007/69053; (2007); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 4442-79-9, name is 2-Cyclohexylethanol. A new synthetic method of this compound is introduced below., category: alcohols-buliding-blocks

150 mg (1.17 mmol, 1 eq) of 2-cyclohexylethanol were diluted in 4 mL of DCM, 214 muL (1.52 mmol, 1.3 eq) of triethylamine were added. The mixture was cooled to 0C and 100 muL (1.29 mmol, 1.1 eq) of mesyl chloride were added. The mixture was stirred for 15 min at 00C then water was added. The aqueous phase was extracted with dichloromethane. The organic phase was washed with water, brine, dried over MgSO4, filtered and concentrated in vacuo. The crude product (241 mg) was used directly for synthesis of 2. TLC : Rf : 0.48 (eluant : Heptane/EtOAc : 1/1).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 4442-79-9, 2-Cyclohexylethanol.

Reference:
Patent; AMGEN INC.; WO2009/9122; (2009); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 873-76-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 873-76-7, name is (4-Chlorophenyl)methanol, molecular formula is C7H7ClO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: To a suspension of polymer-bound triphenylphosphine (1.2 mmol) in anhydrous acetonitrile (10 mL) were added iodine (1 mmol) and 1,6-hexanediol diol (1mmol). The reaction mixture was irradiated in microwave reactor at 120 C for 3 min. The reaction mixture was filtered over a filter paper and washed with chloroform.The filtrate was extracted with aqueous sodium thiosulfate solution and dried with anhydrous sodium sulfate.The reafter, solvent was removed under reduced pressure to obtain 6-iodohexan-1-ol (30) in 93%

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 873-76-7, (4-Chlorophenyl)methanol.

Reference:
Article; Das, Diparjun; Chanda, Tridib; Rokhum, Lalthazuala; Acta Chimica Slovenica; vol. 62; 4; (2015); p. 775 – 783;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 2240-88-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 2240-88-2, name is 3,3,3-Trifluoropropan-1-ol. A new synthetic method of this compound is introduced below.

To the solution of 2.00 g Preparation 9a3 (8.61 mmol) in acetonitrile 2.38 g K2C03 (17.2 mmol), then 3,3,3-trifluoropropan-1-ol were added and the so obtained mixture was stirred for I Oh at 60°C. The reaction mixture was cooled, filtered and the filtrate concentratedunder reduced pressure. The residue was purified via flash chromatography using heptane and ethyl-acetate as eluents to give 4-(dimethoxymethyl)-2-(3,3,3-trifluoropropoxy) pyrimidine.?11 NMR (400 MHz, DMSO-d6): 8.68 (d, 111), 7.22 (d, 111), 5.22 (s, 111), 4.53 (t, 211), 3.33 (s, 611), 2.83 (m, 211).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,2240-88-2, 3,3,3-Trifluoropropan-1-ol, and friends who are interested can also refer to it.

Reference:
Patent; LES LABORATOIRES SERVIER; VERNALIS (R&D) LIMITED; KOTSCHY, Andras; SZLAVIK, Zoltan; CSEKEI, Marton; PACZAL, Attila; SZABO, Zoltan; SIPOS, Szabolcs; RADICS, Gabor; PROSZENYAK, Agnes; BALINT, Balazs; BRUNO, Alain; GENESTE, Olivier; DAVIDSON, James Edward Paul; MURRAY, James Brooke; CHEN, I-Jen; PERRON-SIERRA, Francoise; WO2015/97123; (2015); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 67853-03-6, Methyl 3-(hydroxymethyl)benzoate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 67853-03-6, blongs to alcohols-buliding-blocks compound. Product Details of 67853-03-6

To the solution of compound B4 (28 g, 0.168 mol) in 700 mL of Et2O was added PBr3 (17.4 mL, 0.185 mol) dropwise. The solution was stirred for 2 h, and then the reaction was poured into 500 mL of ice-water. The aqueous layer was extracted with Et2O. The combined organic layers were washed with sat. NaHCO3, water, and brine consecutively. The organic phase was dried over Na2SO4, filtered and concentrated under reduced pressure to give 34 g of compound B5 as an oil (yield: 70%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,67853-03-6, its application will become more common.

Reference:
Patent; PHENEX PHARMACEUTICALS AG; KREMOSER, Claus; ABEL, Ulrich; STEENECK, Christoph; KINZEL, Olaf; WO2011/20615; (2011); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 124-68-5 ,Some common heterocyclic compound, 124-68-5, molecular formula is C4H11NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A (2-Hydroxy-1,1-dimethyl-ethyl)-carbamic acid tert-butyl ester 2-Amino-2-methyl-propan-1-ol (53 g, 0.59 mol) and di-tert-butyl dicarbonate (65.0 g, 0.297 mol) were combined in H2O (500 mL) and stirred at 25 C. for 1 h. The reaction mixture was extracted with CHCl3 (2*250 mL) The organics were dried and concentrated to a white amorphous solid which was recrystallized from hot hexanes to afford desired material (30 g, 53%) as a white solid: 13C NMR (CD3OD, 100 MHz) delta 157.76, 80.135, 70.095, 54.992, 29.247, 24.695.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 124-68-5, 2-Amino-2-methyl-1-propanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Lombardo, Louis J.; Bhide, Rajeev S.; Kim, Kyoung S.; Lu, Songfeng; US2003/232832; (2003); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 403-41-8, name is 1-(4-Fluorophenyl)ethyl Alcohol. This compound has unique chemical properties. The synthetic route is as follows. Quality Control of 1-(4-Fluorophenyl)ethyl Alcohol

To a stirred solution l-(4-fluorophenyl)ethan-l-ol (2, 0.5 g, 3.57 mmol) in DCM (5 mL), was added SOCl2(0.7 mL, 7.10 mmol) drop wise at 0 C and the reaction mixture was stirred at rt for 1 h (Reaction condition b). The reaction mixture was evaporated under vacuum and dried to afford the product as brown oil (3) (0.5 g, 89%, Yield).XHNMR (400 MHz, DMSO-d6) delta (ppm): 7.53-7.51 (m, 2H), 7.21-7.16 (m, 2H), 5.36-5.33 (m, 1H), 1.76 (d, = 6.8 Hz, 3H).

With the rapid development of chemical substances, we look forward to future research findings about 403-41-8.

Reference:
Patent; JUBILANT BIOSYS LIMITED; HALLUR, Gurulingappa; DURAISWAMY, Athisayamani Jeyaraj; PURRA, Buchi Reddy; RAO, N.V.S.K.; RAJAGOPAL, Sridharan; KRISTAM, Rajendra; (200 pag.)WO2019/77631; (2019); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts