Category: 42514-50-1

Electric Literature of 42514-50-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 42514-50-1, name is 3-Amino-3-methylbutan-1-ol. This compound has unique chemical properties. The synthetic route is as follows.

48.7 mL (668 mmol) thionyl chloride were slowly added dropwise at 0 C. with vigorous stirring to a solution of 53.0 g (514 mmol) 3-amino-3-methyl-butanol in 255 mL methylene chloride/dimethylformamide (50:1). After the addition had ended the reaction mixture was refluxed for 1 h at reflux temperature and then stirred for 16 h at ambient temperature. The solvent was removed and the residue was combined with 50 mL acetonitrile with stirring. The solid was filtered off and dried for 18 h at 45 C. 67.9 g (430 mmol, 84%) 3-chloro-1,1-dimethylpropylamine-hydrochloride were obtained as a colourless solid.

According to the analysis of related databases, 42514-50-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Boehringer Ingelheim International GmbH; US2005/245526; (2005); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 42514-50-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 42514-50-1, name is 3-Amino-3-methylbutan-1-ol, molecular formula is C5H13NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

b 3-(N-BOC-amino)-3-methyl-butan-1-ol A solution of 24.88 g (0.114 mol) of di-tert-butyl dicarbonate in 70 ml of methylene chloride is added dropwise to a solution of 11.2 g (0.1086 mol) of 3-amino-3-methyl-butan-1-ol [Z. Naturforsch., Teil B, 38, 1146 (1983)] in 70 ml of methylene chloride and the mixture is stirred at room temperature for 90 hours. After evaporation of the reaction mixture in vacuo, the oily title compound is obtained as a crude product, Rf value=0.52 (silica gel/methylene chloride:methanol (9:1)).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 42514-50-1, 3-Amino-3-methylbutan-1-ol.

Reference:
Patent; Ciba-Geigy Corporation; US5610195; (1997); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 42514-50-1, 3-Amino-3-methylbutan-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: 3-Amino-3-methylbutan-1-ol, blongs to alcohols-buliding-blocks compound. name: 3-Amino-3-methylbutan-1-ol

Step 1: Synthesis of 3-chloro-1,1-dimethylpropylamine-hydrochloride 48.7 mL (668 mmol) thionyl chloride were slowly added dropwise at 0 C. to a solution of 53.0 g (514 mmol) 3-amino-3-methyl-butanol in 255 mL dichloromethane/dimethylformamide (50/1). After the addition had ended the reaction mixture was refluxed for 1 h and then stirred for 16 h at ambient temperature. The reaction mixture was evaporated down using the rotary evaporator and the residue was combined with 50 mL acetonitrile with stirring. It was filtered and the solid obtained was dried for 18 h at 45 C. 67.9 g (430 mmol, 84%) 3-chloro-1,1-dimethylpropylamine-hydrochloride were obtained as a colourless solid (60%). Further reacted in the next step. ESI MS [M+H]+=122/124/Cl); Rf=0.52 (silica gel, dichloromethane/methanol/ammonia 90:10:1)

At the same time, in my other blogs, there are other synthetic methods of this type of compound,42514-50-1, 3-Amino-3-methylbutan-1-ol, and friends who are interested can also refer to it.

Reference:
Patent; Trieselmann, Thomas; Walter, Rainer; Netherton, Matthew R.; Hamilton, Bradford S.; US2008/269281; (2008); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

42514-50-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 42514-50-1, name is 3-Amino-3-methylbutan-1-ol. This compound has unique chemical properties. The synthetic route is as follows.

a. Tert-butyl (3-hvdroxy-1 ,1-dimethylpropyl)-carbamidate200 g (1.94 mol) 3-amino-3-methylbutan-1 -ol in 0.75 I ethyl acetate are combined with a solution of 435.0 g (1.99 mol) di-tert-butyl-dicarbonate in 0.75 I ethyl acetate within one hour. The reaction mixture is stirred for 30 min and the solvent is eliminated in vacuo. The residue obtained is used in the next step without further purification. Yield: 412.5 g1H-NMR (DMSO, 400 MHz): 1.19 (s, 9H); 1.36 (s, 6H); 1.68-1.74 (m, 2H); 3.42-3.50 (m, 2H); 4.39 (t, J = 4.8, 1 H); 6.36 (br s, 1 H).Alternatively, tert-butyl (3-hydroxy-1 ,1-dimethylpropyl)-carbamidate may also be prepared by the methods described for example in J. of Labell. Compounds & Radioph. 2001 , 44(4), 265-275 or WO 03/037327, p. 82/83.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 42514-50-1, 3-Amino-3-methylbutan-1-ol.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; WO2008/132162; (2008); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts