Author: tianli

Refaee, Ayaat A. published the artcileNano-bio finishing of cotton fabric with quaternized chitosan Schiff base-TiO₂-ZnO nanocomposites for antimicrobial and UV protection applications, Safety of Triisopropanolamine, the publication is European Polymer Journal (2022), 111040, database is CAplus.

The purpose of this work is to offer a novel approach to designing multifunctional tech. cotton textiles by coating them with smart bio-materials. Two different ternary nanocomposites (NC1, NC2) comprising (ammonium-salicylidene) chitosan Schiff base (ASCSB), TiO₂, and ZnO nanoparticles were in-situ prepared and applied for treating cotton fibers using the facile pad-dry-cure process to impart antimicrobial and UV protection characteristics. Notably, NC1 is TiO₂-rich, while NC2 is rich in ZnO. The physicochem. and visual characteristics of the new nanocomposites and the treated fabrics were investigated by spectral, microscopic, and thermal methods. The as-prepared NC1 exhibited a more homogeneous distribution, higher depositing d. and smaller mean nanoparticle size (48 nm) when compared to NC2 (56 nm). In contrast, NC2-treated fabrics showed a higher depositing d. of nanoparticles than NC1-treated ones. The treated cotton fibers demonstrated strong and sustainable antimicrobial impacts on S. aureus, E. coli, and C. albicans pathogens, with more effective performance for NC2-treated textiles in comparison to NC1-treated fabrics. The NC2-remediated cotton fabrics demonstrated a higher UV protection factor (UPF) value (53) as compared to NC1-coated fabrics (35), indicating that the ZnO-rich nanocomposite endowed cotton fabrics with more UV protection than TiO₂-rich nanocomposite.

European Polymer Journal published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C9H21NO3, Safety of Triisopropanolamine.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

El-Sayed, A. published the artcileFacile approaches for determination of Bromhexine Hydrochloride and its active metabolite Ambroxol Hydrochloride using Eosin Y, Name: trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, the publication is Annales Pharmaceutiques Francaises, database is CAplus and MEDLINE.

New validated Spectroscopic methods were developed to assay Bromhexine Hydrochloride and its active metabolite Ambroxol Hydrochloride sep. in pure form and pharmaceutical formulations. The spectrophotometric assay (method I) shows complex formation between each of the drugs and Eosin Y at 540 nm at pH 3.6 and 3.4 mL of 4 x 10^-4M Eosin for Bromhexine and Ambroxol. The Spectrofluorimetric assay (method II) depends on quenching eosin native fluorescence by the studied drugs, which measured at 540 nm after excitation at 302 nm. The spectrophotometric absorbance-concentration plot is rectilinear over the ranges (1.0-5.0) and (1.0-10.0) μg/mL for bromhexine and ambroxol with LOD of 0.31 and 0.14 μg/mL and LOQ of 0.94 and 0.42 μg/mL for the two drugs resp. The fluorometric-concentration plot is linear along the range (1.0-5.0) μg/mL and (1-10) μg/mL for the two drugs resp. with LOD of 0.13 μg/mL and 0.22 μg/mL and LOQ of 0.4 μg/mL and 0.65 μg/mL for the two drugs, resp. Developed assays have been validated in agreement with ICH recommendations and they were used in the anal. of com. drug formulations containing the two mucolytic drugs and the results were matching with those obtained by the comparison method.De nouvelles methodes spectroscopiques validees ont etedeveloppes pour doser le chlorhydrate de bromhexine et son metabolite actif, le chlorhydrate d′Ambroxol, sous forme pure et dans des formulations pharmaceutiques. Le dosage spectrophotometrique (methode I) montre la formation d′un complexe entre chacun des medicaments et l′eosine Y a540 nm a pH 3,6 et 3,4 mL d′eosine 4 x 10^-4M pour la bromhexine et l′ambroxol. Le dosage spectrofluorimetrique (methode II) depend de l′extinction de la fluorescence native de l′eosine par les medicaments etudies, qui a ete mesuree a 540 nm apres excitation a 302 nm. Le trace spectrophotometrique. Le trace spectrophotometrique absorbance-concentration est lineaire sur les plages (1,0-5,0) et (1,0-10,0) μg/mL pour la bromhexine et l′ambroxol avec LOD de 0,31 et 0,14 μg/mL et LOQ de 0,94 et 0,42 μg/mL pour les deux medicaments respectivement. Le trace de la concentration fluorometrique est lineaire le long de la plage (1,0-5,0) μg/mL et (1-10) μg/mL pour les deux medicaments respectivement avec LOD de 0,13 μg/mL et 0,22 μg/mL et LOQ de 0,4 μg/ mL et 0,65 μg/mL pour les deux medicaments, respectivement. Les tests developpes ont ete valides en accord avec les recommandations de l′ICH et ils ont ete utilizes dans l′analyze des formulations de medicaments commerciaux contenant les deux medicaments mucolytiques et les resultats correspondaient a ceux obtenus par la methode de comparaison.

Annales Pharmaceutiques Francaises published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Name: trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bodor, Nicholas published the artcileImproved delivery through biological membranes. 26. Design, synthesis, and pharmacological activity of a novel chemical delivery system for β-adrenergic blocking agents, Application In Synthesis of 30165-97-0, the publication is Journal of Medicinal Chemistry (1988), 31(1), 100-6, database is CAplus and MEDLINE.

Novel ketoxime analogs, e.g., I and II, of known β-blockers (propranolol, timolol, carteolol) were synthesized and tested as potential site-specific chem. delivery systems. It was assumed that a hydrolysis-reduction sequence could produce the active β-blockers in the iris-ciliary body. Some of these bioprecursors are remarkably active in reducing intraocular pressure in rabbits. I is more effective and a much less irritant than its parent β-blocker. While the ketoximes also displayed activity on isoprenaline-induced tachycardia after i.v. administration, they were void of activity when given orally. Propranolol was found for a prolonged time and in significant concentrations in the rabbit’s eye following topical administration of I; however, the inactive ketoximes apparently were not converted to the corresponding β-blockers in the eye. A correlation was found between the physicochem. properties of the ketoximes and their conversion to the amino alc. and thus their subsequent activity. The results suggest that at least some of the ketoxime precursors could have a use as antiglaucoma agents without systemic side effects.

Journal of Medicinal Chemistry published new progress about 30165-97-0. 30165-97-0 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Thiadiazole,Alcohol, name is 4-Morpholino-1,2,5-thiadiazol-3-ol, and the molecular formula is C6H9N3O2S, Application In Synthesis of 30165-97-0.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lape, Michael published the artcileMolecular determinants of sarco/endoplasmic reticulum calcium ATPase inhibition by hydroquinone-based compounds, Computed Properties of 903-19-5, the publication is Proteins: Structure, Function, and Bioinformatics (2008), 70(3), 639-649, database is CAplus and MEDLINE.

The ion transport activity of the sarco/endoplasmic reticulum calcium ATPase (SERCA) is specifically and potently inhibited by the small mol. 2,5-di-tert-butylhydroquinone (BHQ). In this study, we investigated the relative importance of the nature and position of BHQ’s four substituents for enzyme inhibition by employing a combination of exptl. and computational techniques. The inhibitory potencies of 21 com. available or synthesized BHQ derivatives were determined in ATPase activity assays, and 11 compounds were found to be active. Maximum inhibitory potency was observed in compounds with two para hydroxyl groups, whereas BHQ analogs with only one hydroxyl group were still active, albeit with a reduced potency. The results also demonstrated that two alkyl groups were an absolute requirement for activity, with the most potent compounds having 2,5-substituents with four or five carbon atoms at each position. Using the program GOLD in conjunction with the ChemScore scoring function, the structures of the BHQ analogs were docked into the crystal structure of SERCA mimicking the enzyme’s E₂ conformation. Anal. of the docking results indicated that inhibitor binding to SERCA was primarily mediated by a hydrogen bond between a hydroxyl group and Asp59 and by hydrophobic interactions involving the bulky inhibitor alkyl groups. Attempts to dock BHQ into crystal structures corresponding to the E₁ conformation of the enzyme failed, because the conformational changes accompanying the E₂/E₁ transition severely restricted the size of the binding site, suggesting that BHQ stabilizes the enzyme in its E₂ form. The potential role of Glu309 in enzyme inhibition is discussed in the context of the computational results. The docking scores correlated reasonably well with the measured inhibitory potencies and allowed the distinction between active and inactive compounds, which is a key requirement for future virtual screening of large compound databases for novel SERCA inhibitors.

Proteins: Structure, Function, and Bioinformatics published new progress about 903-19-5. 903-19-5 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Phenol, name is 2,5-Bis(2,4,4-trimethylpentan-2-yl)benzene-1,4-diol, and the molecular formula is C22H38O2, Computed Properties of 903-19-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Khodja, Maroua published the artcileTuning nanotubular structures by templateless electropolymerization with thieno[3,4-b]thiophene-based monomers with different substituents and water content, Synthetic Route of 2240-88-2, the publication is Journal of Colloid and Interface Science (2020), 19-27, database is CAplus and MEDLINE.

Here, templateless electropolymerization is employed to produce nanotubular structures from various thieno[3,4-b]thiophene-based monomers that differ in substituent structure and size, as well as the linker connecting the thieno[3,4-b]thiophene core and substituent. The formation of densely packed vertically aligned are obtained from monomers with a pyrene substituent and when a significant amount of water (CH₂Cl₂ + H₂O) is included in the solvent. The geometrical parameters of the nanotubes are highly dependent on the electopolymn. method. A significant amount of air is trapped within the structure of the densely packed open nanotubes obtained with Qs = 100 mC cm^-2 causing an increase in water contact angle (θ_w) up to 82.6° (intermediate state between the Wenzel and the Cassie-Baxter state), and θ_w can become even more hydrophobic by further modifying the deposition method or the electrolyte.

Journal of Colloid and Interface Science published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, Synthetic Route of 2240-88-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Mengozzi, Luca published the artcilePhenoxyaluminum(salophen) Scaffolds: Synthesis, Electrochemical Properties, and Self-Assembly at Surfaces of Multifunctional Systems, Recommanded Product: 4-(1H-Pyrrol-1-yl)phenol, the publication is Chemistry – A European Journal (2018), 24(46), 11954-11960, database is CAplus and MEDLINE.

Salophens and Salens are Schiff bases generated through the condensation of two equivalent of salicylaldehyde with either 1,2-phenylenediamines or aliphatic diamines, resp. Both ligands have been extensively exploited as key building blocks in coordination chem. and catalysis. In particular, their metal complexes have been widely used for various catalytic transformations with high yield and selectivity. Through the modification of the phenol unit it is possible to tune the steric hindrance and electronic properties of Salophen and Salen. The introduction of long aliphatic chains in salicylaldehydes can be used to promote their self-assembly into ordered supramol. structures on solid surfaces. Herein, the authors report a novel method towards the facile synthesis of robust and air-stable [Al(Salophen)] derivatives capable of undergoing spontaneous self-assembly at the graphite/solution interface forming highly-ordered nanopatterns. The new synthetic approach relies on the use of [MeAl^III(Salophen)] as a building unit to introduce, via a simple acid/base reaction with functionalized acidic phenol derivatives, selected frameworks integrating multiple functions for efficient surface decoration. STM imaging at the solid/liquid interface made it possible to monitor the formation of ordered supramol. structures. In addition, the redox properties of the Salophen derivatives functionalized with ferrocene units in solution and on surface were unraveled by cyclic voltammetry. The use of a five-coordinate aluminum alkyl Salophen precursor enables the tailoring of new Salophen mols. capable of undergoing controlled self-assembly on HOPG, and thereby it can be exploited to introduce multiple functionalities with subnanometer precision at surfaces, ultimately forming ordered functional patterns.

Chemistry – A European Journal published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, Recommanded Product: 4-(1H-Pyrrol-1-yl)phenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Hammad, M. published the artcileSynthesis of some new pyrazolones and benzimidazole acetonitriles derived from xanthene, Product Details of C19H14O2, the publication is Egyptian Journal of Chemistry (1987), 29(6), 617-22, database is CAplus.

Cyclizations of α-cyano xanthenyl hydrazides I [R = H, Me, PhCH₂, Ph, 4-MeC₆H₄; R¹ = CH(CN)CONHNH₂] gave xanthenylpyrazolones II. Condensation of xanthenol I (R same as above, R¹ = OH) with benzimidazol-2-ylacetonitrile gave benzimidazolylxanthenylacetonitriles III.

Egyptian Journal of Chemistry published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C19H14O2, Product Details of C19H14O2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Freichel, Tanja published the artcileToward orthogonal preparation of sequence-defined monodisperse hetero-multivalent glyco-macromolecules on solid support using Staudinger ligation and copper-catalyzed click reactions, Category: alcohols-buliding-blocks, the publication is Journal of Organic Chemistry (2017), 82(18), 9400-9409, database is CAplus and MEDLINE.

The investigation of hetero-multivalent interactions of complex glyco-ligands and proteins is critical for understanding important biol. processes and developing carbohydrate-based pharmaceutics. Synthetic glycomimetics, derived by mimicking complex glyco-ligands on a variety of scaffolds, have become important tools for studying the role of carbohydrates in chem. and biol. In this paper, we report on a new synthetic strategy for the preparation of mono-disperse, sequence-defined glyco-oligomers or so-called precision glyco-macromols. based on solid phase oligomer synthesis and the Staudinger ligation. This strategy employs a solid-supported synthetic approach using a novel carboxy-functionalized building block which bears a functional handle required for Staudinger ligation on solid support. Furthermore, we combined Staudinger ligation and copper catalyzed azide alkyne cycloaddition (CuAAC) reactions to synthesize hetero-multivalent glyco-oligomers on solid support for the first time, demonstrating the utility of this approach for the synthesis of hetero-functional glyco-macromols.

Journal of Organic Chemistry published new progress about 70539-42-3. 70539-42-3 belongs to alcohols-buliding-blocks, auxiliary class pyrrolidine,Ester,Amide,Inhibitor,Inhibitor, name is Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, and the molecular formula is C18H20N2O12, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kreevoy, Maurice M. published the artcileEffect of structure on mercaptan dissociation constants, HPLC of Formula: 73303-88-5, the publication is Journal of Organic Chemistry (1964), 29(6), 1641-2, database is CAplus.

A redetn. of the K_A for PhSH, and also a number of other K_A values, some new and some redtd., were reported. It was concluded that there was no Baker-Nathan effect, but that there was a resonance exaltation of mercaptan dissociation constants of ∼1.3 log units for conjugated mercaptans. These results were given in a table for RSH when R was as follows: Ac, Ph, (2-pyridyl)methyl, EtO₂CCH₂CH₂, HOCH₂CMe₂ Me, tert-Bu, and tert-Am. These results were discussed.

Journal of Organic Chemistry published new progress about 73303-88-5. 73303-88-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Alcohol, name is 2-Methyl-2-sulfanylpropan-1-ol, and the molecular formula is C4H10OS, HPLC of Formula: 73303-88-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Font, Bernard published the artcileInteraction of creatine kinase and hexokinase with the mitochondrial membranes, and self-association of creatine kinase: crosslinking studies, Related Products of alcohols-buliding-blocks, the publication is Molecular and Cellular Biochemistry (1987), 78(2), 131-40, database is CAplus and MEDLINE.

Covalent coupling of protein by crosslinking reagents has been used to study the interaction of mitochondrial creatine kinase (CKm) and hexokinase (HK) with the mitochondrial membranes. The effects of crosslinkers were studied either by following the inhibition of solubilization of enzymic activities or by modification of the electrophoretic patterns of proteins solubilized from mitochondria after treatment with different crosslinkers. Dimethylsuberimidate (DMS) efficiently reduced the amount of HK activity solubilized by various agents but it did not modify solubilization of CKm from mitochondria. The effect of DMS on HK solubilization did not result from nonspecific crosslinking since it did not impede the solubilization of adenylate kinase. The bissuccinimidyl class of crosslinkers was also tested. Ethyleneglycolbis(succinimidylsuccinate) (EGS) efficiently reduced HK solubilization, but it addnl. induced osmotic stabilization of mitochondria and thus impeded release of soluble or solubilized proteins from the intermembrane space. Furthermore, this agent drastically inhibited CKm activity and thus, in a second set of experiments the effect of crosslinkers were studied by the disappearance of protein bands in the electrophoretic pattern of soluble fractions obtained from mitochondria, the outer membranes of which have been ruptured to allow free release of soluble proteins. Results of these experiments showed that succinimidyl reagents and Cu²⁺-phenanthroline substantially reduced the amount of CKm released from mitochondria and confirmed that bisimidates were ineffective in inhibiting CKm solubilization. In addition, crosslinking reagents were used to study subunit interactions in purified CKm. The results showed, in contrast with control experiments with a monomeric protein (ovalbumin) which did not give rise to polymers, that under the same conditions, electrophoresis of crosslinked CKm resolved a set of species with mol. weights roughly equal to integral multiples of the protomer. These results prove that the polymeric form of CKm is an octamer.

Molecular and Cellular Biochemistry published new progress about 70539-42-3. 70539-42-3 belongs to alcohols-buliding-blocks, auxiliary class pyrrolidine,Ester,Amide,Inhibitor,Inhibitor, name is Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, and the molecular formula is C18H20N2O12, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts