Author: tianli

Aki, Sudhir N. V. K. published the artcileGeneration of Xanthenium and 9-Phenylxanthenium Carbocations in Subcritical Water and Reactivity with Amylamine, Product Details of C19H14O2, the publication is Journal of Physical Chemistry A (2001), 105(34), 8046-8052, database is CAplus.

The ability of subcritical water to support ionic chem. is evident from the successful generation of 9-R-xanthenium (R = H and C₆H₅) carbocations at temperatures up to 330° from their resp. alc. precursors using laser flash photolysis. The intrinsic carbocation decay in the solvent was found to follow simple Arrhenius behavior at all temperatures, from ambient up to 330 °C. In addition, we determined the bimol. rate constants for the reactions of xanthenium cation and 9-phenylxanthenium cations with amylamine, a neutral nucleophile. The activation energies of the two reactions were 21.6 ± 1.2 kJ mol^-1 and 18.2 ± 3.9 kJ mol^-1, resp. More importantly, we found that the rate equations determined at high temperatures extrapolated extremely well to ambient conditions. Thus, we conclude that for ion/neutral isoCoulombic reactions, it would be reasonable to use low-temperature Arrhenius parameters to predict the rate constants in water at higher temperatures Finally, we found that the effect of pressure on the bimol. rate constants at 22-330° was negligible.

Journal of Physical Chemistry A published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C19H14O2, Product Details of C19H14O2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lu, Xinli published the artcileDetermination of 2-keto-L-gulonic acid in fermented broth by flow injection chemiluminescence using potassium permanganate-rhodamine B system, Product Details of C6H10O7, the publication is Asian Journal of Chemistry (2013), 25(18), 10179-10181, database is CAplus.

In this paper, a flow injection-chemiluminescence (FI-CL) was presented for the determination of 2-keto-L-gulonic acid in fermented broth. This method was based on enhance effect of 2-keto-L-gulonic acid on the chemiluminescence reaction between rhodamine B and potassium permanganate in acid medium. The optimized exptl. conditions were evaluated. Under optimum conditions, calibration curve over the range of 0.2-60 mg L^-1 was obtained. The detection limit of this method was 0.04 mg L^-1. The relative standard deviation was 3.7 % for 2.0 mg L^-1 2-keto-L-gulonic acid. The method validation has been compared vs. HPLC method for determination of 2-keto-L-gulonic acid in fermented broth.

Asian Journal of Chemistry published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C6H10O7, Product Details of C6H10O7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zheng, Ran published the artcileMicrowave-assisted efficient synthesis of 3-substituted bis-isoxazole ether bearing 2-chloro-3-pyridyl via 1,3-dipolar cycloaddition, Recommanded Product: 3-(2-Chlorophenyl)-5-isoxazolemethanol, the publication is Molecular Diversity (2020), 24(2), 423-435, database is CAplus and MEDLINE.

An efficient strategy for synthesizing of 3-substituted bis-isoxazole ether bearing 2-chloro-3-pyridyl under microwave radiation was reported. The reactive regioselectivity was improved by changing mainly the solvent and acid-binding agent. 3-(2-Chloropyridin-3-yl)-5-(((3-substituted Ph isoxazol-5-yl)methoxy)methyl)isoxazoles were synthesized in 31-92% yields and were characterized by FT-IR, HRMS, ¹H and ¹³C NMR spectroscopy. The single crystal of 3-(2-chloropyridin-3-yl)-5-(((3-(p-tolyl)isoxazol-5-yl)methoxy)methyl)isoxazole was obtained and the structure of compound was also determined by X-ray diffraction technique. Weak intra- and intermol. C-H···O interactions and a C-H···π interaction link mols. into a three-dimensional network. The results showed that the synthesized compounds belonged to triclinic system, and their regioselectivity depended on the solvent and acid-binding agent. The merits of this method include the environmentally friendly, efficient, simple operation, and higher regional selectivity. An efficient synthesis of 3-substituted bis-isoxazole ethers was developed via 1,3-dipolar cycloaddition reaction starting from 3-substituted phenyl-5-((prop-2-yn-1-yloxy)methyl)isoxazoles and (Z)-2-chloro-N-hydroxynicotinimidoyl chloride using NaHCO₃ as an acid-binding agent in THF solvent-dissolved trace water under catalyst-free microwave-assisted conditions.

Molecular Diversity published new progress about 438565-33-4. 438565-33-4 belongs to alcohols-buliding-blocks, auxiliary class Isoxazole,Chloride,Benzene,Alcohol, name is 3-(2-Chlorophenyl)-5-isoxazolemethanol, and the molecular formula is C9H4F6O, Recommanded Product: 3-(2-Chlorophenyl)-5-isoxazolemethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Burba, Christopher M. published the artcileThe Effect of Fluorinated Solvents on the Physicochemical Properties, Ionic Association, and Free Volume of a Prototypical Solvate Ionic Liquid, Safety of 2,2′-((Perfluoroethane-1,2-diyl)bis(oxy))bis(2,2-difluoroethanol), the publication is ChemPhysChem (2022), 23(4), e202100548, database is CAplus and MEDLINE.

Solvate ionic liquid (SIL) synthesis and properties depend on a delicate balancing of cation-solvent and cation-anion interactions to produce materials containing only cation-solvent complexes and solvent-separated anions. Most SILs meeting these characteristics fall within the paradigm of oligomeric ethylene oxides (e.g. glymes and glycols) and lithium salts. Targeted functionalization of solvent mols. to achieve desired properties is a relatively unexplored avenue of research. Fluorinated solvents have significantly different elec. charge distributions compared to their nonfluorinated analogs. We test the impact of solvent fluorination for a SIL created from equimolar mixtures of lithium bis(trifluoromethylsulfonyl)imide (LiNTf₂) and triethylene glycol (TEG), hereafter [(TEG)₁Li]NTf₂. In the first experiment, TEG is partially substituted with 2,2,4,4,5,5,7,7-octafluoro-3,6-dioxaoctane-1,8-diol (FTEG). This leads to a precipitous decrease in ionic conductivity and larger quantities of ionically-associated Li(NTf₂)₂^– species, as detected with vibrational spectroscopy. These observations suggest FTEG does not readily coordinate Li⁺ ions in a manner analogous to TEG. Computational studies reinforce this conclusion. Relative complex cation stabilities are ranked as [(FTEG)₁Li]⁺ > [(TEG)₁Li]⁺. A second experiment adds FTEG as a diluent to [(TEG)₁Li]NTf₂. This places FTEG and TEG in competition to coordinate a limited number of Li⁺ ions. The resulting mixtures exhibit conductivity enhancement over the parent SIL and minimal changes in ion speciation due to the poor Li⁺ binding by FTEG compared to TEG. Positron annihilation lifetime spectroscopic studies point to increased amounts of free volume upon dilution of FTEG. This likely explains the origin of the conductivity and viscosity enhancements.

ChemPhysChem published new progress about 129301-42-4. 129301-42-4 belongs to alcohols-buliding-blocks, auxiliary class Fluoride,Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2,2′-((Perfluoroethane-1,2-diyl)bis(oxy))bis(2,2-difluoroethanol), and the molecular formula is C6H6F8O4, Safety of 2,2′-((Perfluoroethane-1,2-diyl)bis(oxy))bis(2,2-difluoroethanol).

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Ruihua published the artcileThe bisphenol F and bisphenol S and cardiovascular disease: results from NHANES 2013-2016, Quality Control of 80-09-1, the publication is Environmental Sciences Europe (2022), 34(1), 4, database is CAplus.

Bisphenol F (BPF) and bisphenol S (BPS) have replaced bisphenol A (BPA) in the manufacturing of products containing polycarbonates and epoxy resins; however, the effects of these substitutes on the risk of cardiovascular disease (CVD), including congestive heart failure, coronary heart disease, angina pectoris, heart attack, and stroke, have not been assessed. To examine the association of urinary BPS and BPF with CVD risk in a U.S. representative U.S. population. Cross-sectional data from 1267 participants aged 20-80 years from the 2013-2016 National Health and Nutrition Examination Survey (NHANES) were analyzed. Survey-weighted multiple logistic regression was used to assess the association between BPA, BPF, BPS and CVD. The Bayesian kernel machine regression (BKMR) model was applied to assess the mixture effect. A total of 138 patients with CVD were identified. After adjusting for potential confounding factors, the T3 tertile concentration of BPS increased the risk of total CVD (OR: 1.99, 95% CI 1.16-3.40). When stratified by age, we found that BPS increased the risk of CVD in the 50-80 age group (OR: 1.40, 95% CI 1.05-1.87). BPS was pos. associated with the risk of coronary heart disease, and the T3 tertile concentration of BPS increased the coronary heart disease risk by 2.22 times (95% CI 1.04-4.74). No significant association was observed between BPF and CVD. Although the BKMR model did not identify the mixed exposure effect of BPS, the risk of CVD increased with increasing compound concentration Our results suggest that BPS may increase the risk of total CVD and coronary heart disease in the US population, and prospective studies are needed to confirm the results.

Environmental Sciences Europe published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C19H14O2, Quality Control of 80-09-1.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Monsigny, Louis published the artcileEfficient reductive depolymerization of hardwood and softwood lignins with Brookhart’s iridium catalyst and hydrosilanes, Product Details of C15H16O3, the publication is Green Chemistry (2018), 20(9), 1981-1986, database is CAplus.

Efficient catalytic reduction of lignin model mols. and reductive depolymerization of softwood and hardwood lignins is presented with the iridium based Brookhart’s catalyst and hydrosilanes R₃SiH as reductant. This catalyst displays increased stability and selectivity in comparison to the B(C₆F₅)₃/hydrosilane system and it enables a convergent reductive depolymerization of wood lignins to isolable mono-aromatics

Green Chemistry published new progress about 70110-65-5. 70110-65-5 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Alcohol,Ether,Benzene Compounds, name is 2-Phenoxy-1-phenylpropane-1,3-diol, and the molecular formula is C15H16O3, Product Details of C15H16O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bredikhina, Zemfira A. published the artcileFrom racemic epichlorohydrin to a single enantiomer of the drug timolol maleate, Computed Properties of 30165-97-0, the publication is Tetrahedron: Asymmetry (2015), 26(15-16), 797-801, database is CAplus.

The synthesis for a single enantiomer timolol maleate based on an initial Jacobsen hydrolytic kinetic resolution of racemic epichlorohydrin and on the stereochem. of the subsequent chem. transformations has been proposed. The feature of this synthesis is that both products of the kinetic resolution, (R)-epichlorohydrin and (S)-3-chloropropane-1,2-diol, have been utilized in the synthesis of the target, (S)-timolol (I). The mirror stereochem. results can be obtained with the use of (R,R)-salen Co(III) catalyst instead of (S,S)-salen Co(III).

Tetrahedron: Asymmetry published new progress about 30165-97-0. 30165-97-0 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Thiadiazole,Alcohol, name is 4-Morpholino-1,2,5-thiadiazol-3-ol, and the molecular formula is C6H9N3O2S, Computed Properties of 30165-97-0.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Boltia, Shereen A. published the artcileFour validated spectrophotometric methods for determination of ambroxol, guaifenesin, and theophylline in their ternary mixture in bulk powder and dosage form, Application In Synthesis of 23828-92-4, the publication is Journal of Pharmacy Research (Mohali, India) (2018), 12(4), 446-454, database is CAplus.

The purpose of the present study was to develop and validate spectrophotometric methods for simultaneous determination of a ternary mixture of ambroxol HCl (AMB), guaifenesin (GUA) and theophylline (THEO) in pharmaceutical dosage forms. (a) Direct spectrophotometry (DS), (b) dual wavelength (DW), (c) first derivative of ratio spectra (1DD), and (d) absorption correction (AC). DS method was applied to determine AMB at its λmax (309.0 nm) without any interference of THEO and GUA. Both THEO and GUA were determined as a binary mixture after removal of AMB contribution from the ternary mixture by ratio subtraction technique. DW method was applied to determine GUA by measuring the difference in absorbance at 224.5 nm and 255.0 nm. 1DD was used to determine THEO at 295.4 nm and GUA at 236.5 nm using 14.0μg/mL GUA and 14.5μg/mL THEO as divisors, resp. AC was applied after the second derivative for determination of GUA at 239.5 nm and THEO at 239.5 nm and 266.0 nm. The methods were accurate, specific, and successfully applied for the determination of the three drugs in laboratory prepared mixtures and their combined dosage form.

Journal of Pharmacy Research (Mohali, India) published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Application In Synthesis of 23828-92-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bennett, Steven H. published the artcileDifunctionalization of C-C σ-Bonds Enabled by the Reaction of Bicyclo[1.1.0]butyl Boronate Complexes with Electrophiles: Reaction Development, Scope, and Stereochemical Origins, Category: alcohols-buliding-blocks, the publication is Journal of the American Chemical Society (2020), 142(39), 16766-16775, database is CAplus and MEDLINE.

Difunctionalization reactions of C-C σ-bonds have the potential to streamline access to mols. that would otherwise be difficult to prepare However, the development of such reactions is challenging because C-C σ-bonds are typically unreactive. Exploiting the high ring-strain energy of polycyclic carbocycles is a common strategy to weaken and facilitate the reaction of C-C σ-bonds, but there are limited examples of highly strained C-C σ-bonds being used in difunctionalization reactions. We demonstrate that highly strained bicyclo[1.1.0]butyl boronate complexes (strain energy ca. 65 kcal/mol), which were prepared by reacting boronic esters with bicyclo[1.1.0]butyl lithium, react with electrophiles to achieve the diastereoselective difunctionalization of the strained central C-C σ-bond of the bicyclo[1.1.0]butyl unit. The reaction shows broad substrate scope, with a range of different electrophiles and boronic esters being successfully employed to form a diverse set of 1,1,3-trisubstituted cyclobutanes (>50 examples) with high diastereoselectivity. The high diastereoselectivity observed has been rationalized based on a combination of exptl. data and DFT calculations, which suggests that sep. concerted and stepwise reaction mechanisms are operating, depending upon the migrating substituent and electrophile used.

Journal of the American Chemical Society published new progress about 608534-44-7. 608534-44-7 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic,Boronic acid and ester,Boronate Esters,Boronic Acids,Boronic acid and ester, name is 2-(2,3-Dihydro-1H-inden-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C15H21BO2, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Maharvi, Ghulam M. published the artcileA synthesis of the γ-secretase inhibitor BMS-708163, SDS of cas: 2240-88-2, the publication is Tetrahedron Letters (2010), 51(50), 6542-6544, database is CAplus.

A concise, convergent racemic synthesis of BMS-708163 (I) was reported. Two fragments consisting of N-4-chlorophenylsulfonyl-3,3,3-trifluoropropylglycine and a 1,2,4-oxadiazole derivative of 2-fluorobenzyl alc. were prepared in sep. pots and then coupled together via a Mitsunobu reaction. Since a convenient chiral synthesis of optically pure (D)-3,3,3-trifluoropropyl glycine Me ester was developed using Schoellkopf reagent alkylation, this methodol. can also be adopted for the enantioselective synthesis of BMS-708163.

Tetrahedron Letters published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, SDS of cas: 2240-88-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts