Author: tianli

Tamargo Santos, Beatriz published the artcileRemote induction of cellular immune response in mice by anti-meningococcal nanocochleates – nanoproteoliposomes, Product Details of C14H28O5S, the publication is Science of the Total Environment (2019), 1055-1063, database is CAplus and MEDLINE.

New adjuvant formulations, based on proteoliposomes <40 nm and cochleates <100 nm, without Al(OH)₃ adjuvant, were evaluated regarding their ability to generate Th1 immune response through a Delayed-Type Hypersensitivity Test, at the mouse model, by using a Neisseria meningitidis B protein complex as antigen. The formulations were administered by i.m. (IM) (2 inoculations – at baseline and after 14 days) and intranasal (IN) (3 inoculations at 7 days) immunization pathways. All IM immunized groups were able to induce similar response to these formulations as well as to VA-MENGOC-BC vaccine – containing Al(OH)₃ adjuvant (used as pos. control of the trial). In all groups, the induced inflammation (IP) rate was statistically higher than in the neg. control group (CN) (p < 0.05). Immunogenicity, measured by HSR and CD4⁺ lymphocyte increase was equivalent to the control vaccine and most important, granuloma reactogenicity at the site of injection was eliminated, fact demonstrated by histol. study. All groups of animals immunized by IN route showed HSR reactions and statistically significant differences with respect to the CN group. However, IP values were lower, with statistical differences (p < 0.05) for the same adjuvant formulation IM administered, except the AIF2-nCh formulation that generated statistically similar induction (p > 0.05) by both immunization pathways, suggesting it to be the best candidate for the next IN trial. Proteoliposome and cochleate formulations tested were able to mount potent Th1 immune response, equivalent to the original vaccine formulation, with the advantage of less reactogenicity in the site of the injection, caused by the toxicity of Al(OH)₃ adjuvant gel.

Science of the Total Environment published new progress about 85618-21-9. 85618-21-9 belongs to alcohols-buliding-blocks, auxiliary class Tetrahydropyran,Chiral,sulfides,Alcohol, name is (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C4H11NO, Product Details of C14H28O5S.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Derz, Wiebke published the artcileGuiding Molecularly Imprinted Polymer Design by Pharmacophore Modeling, Quality Control of 86-48-6, the publication is Molecules (2021), 26(16), 5101, database is CAplus and MEDLINE.

Molecularly imprinted polymers (MIP) combine the selectivity of immunoaffinity chromatog. with the robustness of common solid-phase extraction in what is referred to as molecularly imprinted solid-phase extraction (MISPE). This contribution shows how MIP design may be guided by pharmacophore modeling for the example of citrinin, which is an emerging mycotoxin from cereals. The obtained pharmacophore model allowed searching public databases for a set of citrinin-mimicking mol. surrogates. Imprinted and non-imprinted polymers were subsequently obtained through bulk and core-shell polymerization in the presence of these surrogates. Evaluation of their binding ability for citrinin and structurally related ochratoxin A revealed a promising MIP derived from rhodizonic acid. A protocol for MISPE of citrinin from cereals was subsequently developed and compared to immunoaffinity chromatog. with respect to clean-up efficiency and recovery.

Molecules published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, Quality Control of 86-48-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Jamnik, Thomas published the artcileNext-generation biomonitoring of the early-life chemical exposome in neonatal and infant development, Computed Properties of 80-09-1, the publication is Nature Communications (2022), 13(1), 2653, database is CAplus and MEDLINE.

Exposure to synthetic and natural chems. is a major environmental risk factor in the etiol. of many chronic diseases. Investigating complex co-exposures is necessary for a holistic assessment in exposome-wide association studies. In this work, a sensitive liquid chromatog.-tandem mass spectrometry approach was developed and validated. The assay enables the anal. of more than 80 highly-diverse xenobiotics in urine, serum/plasma, and breast milk; with detection limits generally in the pg-ng mL-1 range. In plasma of extremely-premature infants, 27 xenobiotics are identified; including contamination with plasticizers, perfluorinated alkylated substances and parabens. In breast milk samples collected longitudinally over the first 211 days post-partum, 29 analytes are detected, including pyrrolizidine- and tropane alkaloids which have not been identified in this matrix before. A preliminary estimation of daily toxicant intake via breast milk is conducted. In conclusion, we observe significant early-life co-exposure to multiple toxicants, and demonstrate the method′s applicability for large-scale exposomics-type cohort studies.

Nature Communications published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, Computed Properties of 80-09-1.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Blagov, N A published the artcile[Microparasitocenosis of the intestines and the activity of intestinal enzymes in patients with trichocephaliasis during treatment]., Safety of N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, the publication is Meditsinskaia parazitologiia i parazitarnye bolezni (1989), 49-53, database is MEDLINE.

Results of the studies of large intestine microflora, enterokinase and alkaline phosphatase activity in the feces of 298 children and adults suffering from trichocephaliasis are presented. Intestinal dysbacteriosis was observed in 51.7% cases, increased enterokinase activity, in 57.6% cases and increased alkaline phosphatase activity, in 55% cases. Enteric enzyme activity relation to the state of enteric microflora is demonstrated. Specific bephenium hydroxynaphthoate and mebendazole treatment was followed by increased dysbacteriosis and higher intestinal enzyme activity, especially in case of bephenium hydroxynaphthoate treatment. Normalization of the above-mentioned parameters was observed 90-120 days after the end of the treatment.

Meditsinskaia parazitologiia i parazitarnye bolezni published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, Safety of N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Jiang, Ji published the artcileDiscovery of hydroxyl 1,2-diphenylethanamine analogs as potent cholesterol ester transfer protein inhibitors, Recommanded Product: (R)-Oxiran-2-ylmethanol, the publication is Bioorganic & Medicinal Chemistry Letters (2016), 26(14), 3278-3281, database is CAplus and MEDLINE.

Hydroxyl 1,2-diphenylethanamine analogs were identified as potent inhibitors of cholesterol ester transfer protein (CETP), a therapeutic target to raise HDL cholesterol. In an effort to improve the pharmaceutical properties in the previously disclosed DiPhenylPyridineEthanamine (DPPE) series, polar groups were introduced to the N-linked quaternary center. Optimization of analogs for potency, in vitro liability profile and efficacy led to identification of lead compound 16 which demonstrated robust pharmacodynamic effects in human CETP/apo-B100 dual transgenic mice.

Bioorganic & Medicinal Chemistry Letters published new progress about 57044-25-4. 57044-25-4 belongs to alcohols-buliding-blocks, auxiliary class Epoxides,Chiral,Aliphatic hydrocarbon chain,Alcohol, name is (R)-Oxiran-2-ylmethanol, and the molecular formula is C3H6O2, Recommanded Product: (R)-Oxiran-2-ylmethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bettinger, Holger F. published the artcileMetal-free conversion of methane and cycloalkanes to amines and amides by employing a borylnitrene, Synthetic Route of 25240-59-9, the publication is Angewandte Chemie, International Edition (2008), 47(25), 4744-4747, database is CAplus and MEDLINE.

C-H insertion: Borylnitrenes, which were generated in situ by photolysis of azides, convert unactivated alkanes by intermol. C-H insertion into aminoboranes, which in turn can be reacted further to give amines or amides. The boryl group serves two purposes: it converts the nitrene into a highly reactive BN vinylidene analog, and it is easily cleaved from the product. Caution: B azides may be explosive, and appropriate precautions must be taken when handling these compounds To study the reaction of catechol borylnitrene (C₆H₄O₂BN:, 1a) with methane, the authors isolated 2-azido-1,3,2-benzodioxaborole (C₆H₄O₂BN₃, 3a) in Ar doped with methane (1-2% CH₄ or CD₄) at 10 K. Photolysis of 3a using UV irradiation resulted in the complete disappearance of 3a, the concomitant formation of nitrene C₆H₄O₂BN: (1a) and of aminoborane C₆H₄O₂BN(H)Me (2a) according to IR spectra and DFT calculations of vibrational modes. Reaction of trimethylsilyl azide and 2-chloro-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (pinacolboron chloride (pinBCl)) gave 2-azido-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (3b, pinacolboron azide (pinBN₃)) in 96% yield. Photolysis of 3b in cycloalkane solutions at room temperature afforded the expected aminoboranes pinBN(H)R (R = cyclopentyl, cyclohexyl, cycloheptyl) in 79% to 85% yield. The aminoboranes can conveniently be transformed into the corresponding primary amines or amides by alcoholysis or acylation, resp. The mol. structures of pinBN(H)R (R = cyclopentyl, cyclohexyl) were determined by x-ray crystallog.

Angewandte Chemie, International Edition published new progress about 25240-59-9. 25240-59-9 belongs to alcohols-buliding-blocks, auxiliary class Boronic acid and ester,Boronic Acids,Boronate Esters, name is 4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-ol, and the molecular formula is C6H13BO3, Synthetic Route of 25240-59-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Higgins, Clare L. published the artcileSynthesis, characterisation, and performance evaluation of tri-armed phenolic antioxidants, Product Details of C9H21NO3, the publication is Tetrahedron Letters (2020), 61(28), 152127, database is CAplus.

In this study, a series of core units (glycerol, triethanolamine and triisopropanolamine derivatives) were investigated for their use in tri-armed phenolic antioxidants. The antioxidant ability of these tri-armed phenolic compounds featuring different core units were then evaluated in a hydrocarbon lubricant using differential scanning calorimetry (DSC) and compared to the com. available antioxidants Irganox L135 and Irganox L57. An impressive oxidation induction time of ∼9-12 min was observed for the glycerol based antioxidants when compared to the com. antioxidants (∼4-6 min), whereas in contrast in the case of triethanolamine and triisopropanolamine derived antioxidants, a solubilizing unit was incorporated to provide appropriate solubility within the hydrocarbon medium and revealed an excellent oxidation induction time of ∼11-12 min.

Tetrahedron Letters published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C9H21NO3, Product Details of C9H21NO3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Paul, Aparup published the artcileDouble μ₂-(phenoxido)-bridged dinuclear and polynuclear nickel(II) complexes: Magnetic properties and DNA/protein interaction, Category: alcohols-buliding-blocks, the publication is Polyhedron (2019), 39-48, database is CAplus.

One dinuclear and one 1-dimensional polymeric Ni(II) complex, {[Ni₂(HL)₂(pa)₂(H₂O)₂]·DMF} (1) and {[Ni₂(HL)₂(ppda)(H₂O)₂]·DMF·H₂O}_n (2) (H₂L = (E)-2-((1-hydroxybutan-2-ylimino)methyl)phenol, pa = 3-phenylacrylate, ppda = p-phenylenediacrylate) were synthesized and characterized by x-ray single crystal structure determination Complex 1 is double phenoxo-bridged dinuclear Ni(II) complex, whereas complex 2 is a 1-dimensional polynuclear chain where double phenoxo-bridged dinuclear units are connected through bridging ppda ligands. The variable temperature magnetic behavior of the complexes was studied using the Hamiltonian H = -JS₁S₂, S₁ = S₂ = S_Ni and confirms the presence of an overall antiferromagnetic interaction in both complexes. Good agreement between the exptl. and simulated curves were found using the parameters: g_Ni = 2.15, D_Ni = 4.0 cm^-1 and J_Ni-Ni = -0.60 cm^-1 for 1, and g_Ni = 2.15, D_Ni = 4.8 cm^-1 and J_Ni-Ni = -3 cm^-1 for 2. The interactions of the complexes with CT-DNA were studied using UV-visible absorption and fluorescence spectroscopic methods and both the complexes interact with CT-DNA. The intrinsic binding constants values for interaction with CT-DNA are 3.9(±0.10) × 10⁵ and 3.43(±0.09) × 10⁵ M^-1 for 1 and 2, resp. The interactions of the complexes with bovine serum albumins (BSA) and human serum albumins (HSA) were also studied using electronic absorption and fluorescence spectroscopic techniques and both complexes interact with the serum albumins via a ground state association process.

Polyhedron published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H11NO, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Macchi, Marianela published the artcileDesign and evaluation of synthetic bacterial consortia for optimized phenanthrene degradation through the integration of genomics and shotgun proteomics, Formula: C11H8O3, the publication is Biotechnology Reports (2021), e00588, database is CAplus and MEDLINE.

Two synthetic bacterial consortia (SC) composed of bacterial strains Sphingobium sp. (AM), Klebsiella aerogenes (B), Pseudomonas sp. (Bc-h and T), Burkholderia sp. (Bk) and Inquilinus limosus (Inq) isolated from a natural phenanthrene (PHN)-degrading consortium (CON) were developed and evaluated as an alternative approach to PHN biodegradation in bioremediation processes. A metabolic network showing the potential role of strains was reconstructed by in silico study of the six genomes and classification of dioxygenase enzymes using RHObase and AromaDeg databases. Network anal. suggested that AM and Bk were responsible for PHN initial attack, while Inq, B, T and Bc-h would degrade PHN metabolites. The predicted roles were further confirmed by physiol., RT-qPCR and metaproteomic assays. SC-1 with AM as the sole PHN degrader was the most efficient. The ecol. roles inferred in this study can be applied to optimize the design of bacterial consortia and tackle the biodegradation of complex environmental pollutants.

Biotechnology Reports published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, Formula: C11H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Macchi, Marianela published the artcileAssessing interactions, predicting function, and increasing degradation potential of a PAH-degrading bacterial consortium by effect of an inoculant strain, Related Products of alcohols-buliding-blocks, the publication is Environmental Science and Pollution Research (2019), 26(25), 25932-25944, database is CAplus and MEDLINE.

A natural phenanthrene-degrading consortium CON was inoculated with an exogenous strain Sphingobium sp. (ex Sp. paucimobilis) 20006FA yielding the consortium called I-CON, in order to study ecol. interactions into the bacterial community. DGGE and proteomic profiles and analyses by HTS (High-Throughput Sequencing) technologies demonstrated inoculant establishment and changes on CON composition Inoculation increased degradation efficiency in I-CON and prevented intermediate HNA accumulation. This could be explained not only by the inoculation, but also by enrichment in Achromobacter genus at expense of a decrease in Klebsiella genus. After inoculation, cooperation between Sphingobium and Achromobacter genera were improved, thereby, some competition could have been generated, and as a consequence, species in minor proportion (cheaters), as Inquilinus sp. and Luteibacter sp., were not detected. Sequences of Sphingobium (corresponding to the inoculated strain) did not vary. PICRUSt predicted a network with bacterial phylotypes connected with enzymes, showing functional redundancy in the phenanthrene pathway, with exception of the first enzymes biphenyl-2,3-diol 1,2-dioxygenase and protocatechuate 4,5-dioxygenase that were only encoded in Sphingobium sp. This is the first report where a natural consortium that has been characterized by HTS technologies is inoculated with an exogenous strain in order to study competitiveness and interactions.

Environmental Science and Pollution Research published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts