Author: tianli

Hreczycho, Grzegorz published the artcileA new catalytic approach to germasiloxanes, Product Details of C9H22OSi, the publication is Tetrahedron Letters (2011), 52(1), 74-76, database is CAplus.

A new ruthenium(0) complex catalyzed coupling reaction of silanols with vinylgermanes leading to SiO-Ge bond formation with the evolution of ethylene is described. Under optimum conditions the catalytic O-germylation of silanols gives exclusively germasiloxanes.

Tetrahedron Letters published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Product Details of C9H22OSi.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Shiley, R. H. published the artcileFungicidal activity of some fluoroaromatic compounds, Quality Control of 55346-97-9, the publication is Journal of Fluorine Chemistry (1975), 5(4), 371-6, database is CAplus.

Of 52 fluoroaromatic compounds tested (18 prepared) for their fungicidal activity against Stromatinia gladioli, Fusarium oxysporum gladioli, Curvularia trifolii gladioli, Thielaviopsis basicola, and Ceratocystis ulmi, I [327-91-3], II [38636-12-3], and III [327-92-4] were the most effective.

Journal of Fluorine Chemistry published new progress about 55346-97-9. 55346-97-9 belongs to alcohols-buliding-blocks, auxiliary class Fluoride,Nitro Compound,Benzene,Phenol, name is 4,5-Difluoro-2-nitrophenol, and the molecular formula is C3H5BN2O2, Quality Control of 55346-97-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Rozsar, Daniel published the artcileBifunctional Iminophosphorane Catalyzed Enantioselective Sulfa-Michael Addition to Unactivated α,β-Unsaturated Amides, Application of 2-Phenylethanethiol, the publication is Journal of the American Chemical Society (2022), 144(2), 1006-1015, database is CAplus and MEDLINE.

The first metal-free catalytic intermol. enantioselective Michael addition to unactivated α,β-unsaturated amides was described. Consistently high enantiomeric excesses and yields were obtained over a wide range of alkyl thiol pronucleophiles and electrophiles under mild reaction conditions, enabled by a novel squaramide-based bifunctional iminophosphorane (BIMP) catalyst. Low catalyst loadings (2.0 mol %) were achieved on a decagram scale, demonstrating the scalability of the reaction. Computational anal. revealed the origin of the high enantiofacial selectivity via anal. of relevant transition structures and provided substantial support for specific noncovalent activation of the carbonyl group of the α,β-unsaturated amide by the catalyst.

Journal of the American Chemical Society published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, Application of 2-Phenylethanethiol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bijleveld, Johan C. published the artcileControlling morphology and photovoltaic properties by chemical structure in copolymers of cyclopentadithiophene and thiophene segments, Category: alcohols-buliding-blocks, the publication is Solar Energy Materials & Solar Cells (2010), 94(12), 2218-2222, database is CAplus.

A series of polythiophenes (PTn) based on dialkyl-cyclopentadithiophene (CPDT) units alternating with short un-substituted thiophene segments of length n (n being the number of thiophenes) along the chain has been synthesized to control the morphol. of PTn:PCBM blends for solar cell applications via the chem. structure of the polymer rather than via (post) processing conditions. The degree of phase separation in PTn:PCBM blends can be controlled via n, because with increase in n the number of solubilizing side chains per thiophene is reduced. For the most soluble derivative, PT0, we find that PCBM crystallizes first, while for the least soluble version, PT3, polymer aggregation prevails. The most intimately mixed morphol. and best solar cells were obtained for PT2, which exhibits a power conversion efficiency (PCE) of about 1.5% under AM1.5G conditions when mixed with PCBM. Although the final PCE is moderate, the study represents an example of a rational approach towards morphol. control via chem. structure, rather than via processing.

Solar Energy Materials & Solar Cells published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bell, Mark published the artcileDiscovery of super soft-drug modulators of sphingosine-1-phosphate receptor 1, Related Products of alcohols-buliding-blocks, the publication is Bioorganic & Medicinal Chemistry Letters (2018), 28(19), 3255-3259, database is CAplus and MEDLINE.

The oral S1PR1 agonist ponesimod demonstrated substantial efficacy in a phase II clin. trial of psoriasis. Unfortunately, systemic side effects were observed, which included lymphopenia and transient bradycardia. We sought to develop a topical soft-drug S1PR1 agonist with an improved therapeutic index. By modifying ponesimod, we discovered an ester series of S1PR agonists. To increase metabolic instability in plasma we synthesized esters described as specific substrates for paraoxonase and butyrylcholinesterases, esterases present in human plasma.

Bioorganic & Medicinal Chemistry Letters published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C6H13NO2, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chen, Xiaoyu published the artcileA high throughput dimer screening assay for monoclonal antibodies using chemical cross-linking and microchip electrophoresis, Computed Properties of 70539-42-3, the publication is Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences (2009), 877(27), 3012-3018, database is CAplus and MEDLINE.

A high throughput screening assay was developed to determine the total dimer level in antibody samples. This method utilizes high speed microchip electrophoresis separation following chem. crosslinking. Upon reacting with homobifunctional N-hydroxysuccinimide-esters (NHS-esters), covalent linkages can be established between the primary amines of two neighboring antibody mols. The reaction conditions are optimized to achieve quant. crosslinking of only phys. associated monomers within an antibody dimer. The resulting crosslinked dimers, originating from either covalent or non-covalent antibody dimers, can then be separated from monomers by SDS electrophoresis. A com. microchip electrophoresis instrument is used for high speed separation, allowing each sample to be analyzed in about 1 min. This approach was applied to crude mammalian cell culture samples. Using a 96-well gel filtration spin column format, interfering species in the cell culture media were efficiently removed from the samples. This method is well suited to the purpose of high throughput antibody dimer quantitation during cell culture expression, including clone selection and cell culture development. The total dimer content, both covalent and non-covalent, can be determined for hundreds of crude samples in a few hours. The effects of different crosslinking conditions on the determined dimer levels, as well as of different antibody pI values, are discussed.

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences published new progress about 70539-42-3. 70539-42-3 belongs to alcohols-buliding-blocks, auxiliary class pyrrolidine,Ester,Amide,Inhibitor,Inhibitor, name is Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, and the molecular formula is C18H20N2O12, Computed Properties of 70539-42-3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Medina-Ramirez, Iliana E. published the artcileSilylated gallium and indium chalcogenide ring systems as potential precursors to ME (E = O, S) materials, Computed Properties of 597-52-4, the publication is Central European Journal of Chemistry (2013), 11(7), 1225-1238, database is CAplus.

The reaction of R₃M (M = Ga, In) with HESiR’₃ (E = O, S; R’₃=Ph₃, ⁱPr₃, Et₃, ^tBuMe₂) leads to the formation of (Me₂GaOSiPh₃)₂ (1); (Me₂GaOSi^tBuMe₂)₂ (2); (Me₂GaOSiEt₃)₂ (3); (Me₂InOSiPh₃)₂ (4); (Me₂InOSi^tBuMe₂)₂ (5); (Me₂InOSiEt₃)₂ (6); (Me₂GaSSiPh₃)₂ (7); (Et₂GaSSiPh₃)₂ (8); (Me₂GaSSiⁱPr₃)₂ (9); (Et₂GaSSiⁱPr₃)₂ (10); (Me₂InSSiPh₃)₃ (11); (Me₂InSSiⁱPr₃)_n (12), in high yields at room temperature The compounds have been characterized by multinuclear NMR and in most cases by x-ray crystallog. The mol. structures of (1), (4), (7) and (8) have been determined Compounds (3), (6) and (10) are liquids at room temperature In the solid state, (1), (4), (7) and (9) are dimers with central core of the dimer being composed of a M₂E₂ four-membered ring. VT-NMR studies of (7) show facile redistribution between four- and six-membered rings in solution The thermal decomposition of (1)-(12) was examined by TGA and range from 200 to 350°. Bulk pyrolysis of (1) and (2) led to the formation of Ga₂O₃; (4) and (5) In metal; (7)-(10) GaS and (11)-(12) InS powders, resp.

Central European Journal of Chemistry published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C6H16OSi, Computed Properties of 597-52-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Arnett, Edward M. published the artcileTriarylmethanes and 9-arylxanthenes as prototypes amphihydric compounds for relating the stabilities of cations, anions and radicals by C-H bond cleavage and electron transfer, Synthetic Route of 596-38-3, the publication is Journal of Physical Organic Chemistry (1997), 10(7), 499-513, database is CAplus.

Thermodn. stability properties of 11 p-substituted trityl and seven 9-phenylxanthyl carbocations are reported in sulfolane and of their conjugate carbanions in DMSO. The cations are compared by calorimetric heats of hydride transfer from cyanoborohydride ion, their first and second reduction potentials, their pK_R⁺s in aqueous sulfuric acid, ¹³C chem. shifts and free energies of methoxy exchange. Carbanions are compared by their heats and free energies (pK_HA) of deprotonation and their first and second oxidation potentials. Radicals are compared by their oxidation and reduction potentials. Their bond dissociation energies are derived by alternative routes: from the carbocation and its reduction potential and from the carbanion and its oxidation potential. The various properties are correlated against each other and against appropriate Hammett-type substituent parameters. Correlations between the different measured properties reported here range from fair to excellent. Despite their importance as historic prototypes for the three trivalent oxidation states of carbon, trityl and xanthyl systems are atypical models for comparing transmission of electron demand in other series of carbocations, radicals or carbanions with significantly different structures. The 9-arylxanthyl series is especially poor because of its insensitivity to substituent effects. The effects of substituents on various properties which represent the stabilities of R⁺s correlate surprisingly well against those for corresponding R^–s. Accordingly, compensating effects on the oxidation and reduction of a series of related R^.s may lead to a nearly constant electron transfer energy and absolute hardness for the series. In contrast, the free energies for interconversion of the carbocations and carbanions which determine the gap between pK_R+ and pK_HA are very sensitive to structural change.

Journal of Physical Organic Chemistry published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C19H14O2, Synthetic Route of 596-38-3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gonzalez-Sebastian, Lucero published the artcileNickel-Catalyzed Hydrosilylation of CO₂ in the Presence of Et₃B for the Synthesis of Formic Acid and Related Formates, Formula: C6H16OSi, the publication is Organometallics (2013), 32(23), 7186-7194, database is CAplus.

The reaction of CO₂ with Et₃SiH catalyzed by the nickel complex [(dippe)Ni(μ-H)]₂ (1) afforded the reduction products Et₃SiOCH₂OSiEt₃ (12%), Et₃SiOCH₃ (3%), and CO, which were characterized by standard spectroscopic methods. Part of the generated CO was found as the complex [(dippe)Ni(CO)]₂ (2), which was characterized by single-crystal x-ray diffraction. When the same reaction was carried out in the presence of a Lewis acid, such as Et₃B, the hydrosilylation of CO₂ efficiently proceeded to give the silyl formate (Et₃SiOC(O)H) in high yields (85-89%), at 80° for 1 h. Further reactivity of the silyl formate to yield formic acid, formamides, and alkyl formates was also investigated.

Organometallics published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C6H16OSi, Formula: C6H16OSi.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Castellanos-Blanco, Nahury published the artcileNickel-catalyzed reduction of ketones with water and triethylsilane, Application of Triethylsilanol, the publication is Inorganica Chimica Acta (2017), 324-332, database is CAplus.

The acetophenone reduction using catalytically active nickel complexes and water as an efficient and sustainable method to access a new methodol. of transfer hydrogenation of ketones were reported. When triethylsilane (Et₃SiH) was used as sacrificial agent that promoted the transfer hydrogenation from water, 1-phenylethanol was obtained in excellent yield along with silanol (Et₃SiOH) as the reaction’s driving force. Deuterium labeling studies were made using Et₃SiD or D₂O and these studies showed that both compounds participated as hydride sources for the ketone reduction A scope of substrates was assessed, including a variety of mono/diketones, and α,β-unsaturated ketones, to yield the corresponding secondary alcs. and saturated ketones. Addnl., asym. transfer hydrogenation of mono-ketones was studied for the mixture of nickel/(bisphosphine or phospholane) as catalyst precursor, using H₂O/Et₃SiO system and ethanol as hydrogen sources.

Inorganica Chimica Acta published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C6H16OSi, Application of Triethylsilanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts