Author: tianli

Diaw, A. K. D. published the artcileNew poly(p-substituted-N-phenylpyrrole)s. Electrosynthesis, electrochemical properties and characterization, Safety of 4-(1H-Pyrrol-1-yl)phenol, the publication is Synthetic Metals (2013), 74-85, database is CAplus.

Poly(N-p-hydroxyphenylpyrrole) [poly(HOPhPy)], poly(N-p-methoxyphenylpyrrole) [poly(MeOPhPy)], poly(N-p-thiophene-phenylpyrrole) [poly(ThPhPy)], poly(1,1′-phenylene dipyrridyl) [poly(PhDPy)] and poly(1,1′-diphenylene dipyrridyl) [poly(DPhDPy)] were electrosynthesized from the corresponding monomers on Pt electrode in 0.1 M tetrabutylammonium hexafluorophosphate (TBAPF₆) acetonitrile solutions, using cyclic voltammetry (CV), galvanostatic and potentiostatic modes. The electrodeposited films were characterized by CV, FT-IR spectrometry, X-ray photoelectron spectra (XPS), and SEM. Electron-donating substituent effects on the polymer electrochem. properties were investigated by CV. The CV of the films indicated a good redox behavior and a peak position depending on the nature of substituent. FT-IR spectral studies allowed one to predict a linear and regular structure of the polymer chains, the coupling taking place in the 2 and 5 positions of the pyrrole rings. XPS anal. showed a variation of the film doping levels (26-42% for oxidized films and 6-12% for reduced films) with the electron-donor character of the Ph p-substituents. The conjugated π-electronic system was extended by strong electron-donating substituents which led to a higher doping level of the polypyrrolic chains and a polymer structure with high-energy and polar bonds like CN⁺ and CN⁺. SEM anal. revealed changes in the polymer film morphol. and thickness with the nature of substituents.

Synthetic Metals published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, Safety of 4-(1H-Pyrrol-1-yl)phenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Diaw, A. K. D. published the artcileAn experimental study of the electronic absorption and fluorescence spectral properties of new p-substituted-N-phenylpyrroles and their electrosynthesized polymers, Application of 4-(1H-Pyrrol-1-yl)phenol, the publication is Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy (2015), 1107-1114, database is CAplus and MEDLINE.

Electronic absorption and fluorescence spectral properties of new p-substituted-N-phenylpyrroles (N-PhPys), including HOPhPy, MeOPhPy, ThPhPy, PhDPy, DPhDPy, PyPhThThPhPy, and their available, electrosynthesized polymers were investigated. Electronic absorption spectra, fluorescence excitation and emission spectra, fluorescence quantum yields (Φ_F) and lifetimes (τ_F), and other photophys. parameters of these N-PhPy derivatives and their polymers were measured in DMF, DMSO diluted solutions and/or solid state at room temperature The electronic absorption spectra of N-PhPy derivatives and their polymers included one to several bands, located in the 270-395 nm region, according to the p-Ph substituent electron-donating effect and conjugated heteroaromatic system length. The fluorescence excitation spectra were characterized by one broad main peak, with, in most cases, one (or more) poorly resolved shoulder (s), appearing in the 270-405 nm region, and their emission spectra were generally constituted of several bands located in the 330-480 nm region. No significant shift of the absorption, fluorescence excitation and emission spectra wavelengths was found upon going from the monomers to the corresponding polymers. Φ_F Values were high, varying between 0.11 and 0.63, according to the nature of substituents(s) and to the conjugated system extension. Fluorescence decays were mono-exponential for the monomers and poly-exponential for PyPhThThPhPy and for polymers. τ_F Values were relatively short (0.35-5.17 ns), and markedly decreased with the electron-donor character of the Ph group p-substituent and the conjugated system extension.

Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, Application of 4-(1H-Pyrrol-1-yl)phenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Salama, Paul published the artcileThe use of catalytic amounts of selected cationic surfactants in the design of new synergistic preservative solutions, Recommanded Product: 3-((2-Ethylhexyl)oxy)propane-1,2-diol, the publication is Cosmetics (2021), 8(2), 54, database is CAplus.

Preservation using combinations of antibacterial mols. has several advantages, such as reducing the level of usage and broadening their antimicrobial spectrum. More specifically, the use of quaternary ammonium surfactants (QAS)-which are profusely used in hair care products and some are known as efficient antimicrobial agents-is limited due to some potential cytotoxicity concerns. This study shows that the concentration of some widely used cosmetic preservatives can be decreased when combined with very small quantities of QAS, i.e., Polyquaternium-80 (P-80) and/or Didecyldimethylammonium chloride (DDAC). The antimicrobial activity of their mixtures was first evaluated by determining the min. inhibitory concentration (MIC) before and after the addition of QAS. Following up on this finding and targeting an ultimate consumer friendly antimicrobial blend, yet with optimal safety, we chose to utilize the food-grade preservative Maltol as the main natural origin antimicrobial agent mixed with min. concentrations of QAS to improve its moderate antimicrobial properties. The preservatives were tested for MIC values, challenge tests and synergy using the fractional inhibitory concentration index (FICI). The antimicrobial efficacy of Maltol was found to be synergistically improved by introducing catalytic amounts of P-80 and/or DDAC.

Cosmetics published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C11H24O3, Recommanded Product: 3-((2-Ethylhexyl)oxy)propane-1,2-diol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Salama, Paul published the artcileWhy Are Wet Wipes So Difficult to Preserve Understanding the Intrinsic Causes, Category: alcohols-buliding-blocks, the publication is Cosmetics (2021), 8(3), 73, database is CAplus.

Over the last two decades, significant advances have been made in developing disposable baby wet wipes. Wet wipes consist of two main components: nonwoven fabric and liquid Being more than 90% water, wet wipes are more susceptible to microbial growth than typical personal care products; hence, high concentrations of preservative compounds are often used to ensure extended protection against contamination. However, there is an obvious tendency to minimize the concentration of irritating actives. Baby wet wipes should contain particularly mild surfactants, well-tolerated preservatives, and a buffer system maintaining the formulation pH at a suitable level for the infant’s skin. Efforts have been centered on removing ingredients with irritation potential, such as phenoxyethanol. In addition, a move towards more natural fabrics is occurring. However, these modifications provoke new challenges in preserving the final products. The nature and composition of the fiber can influence the interactions between the preservative and the wipe, subsequently affecting the performance of the preservative system. In this study, we analyzed the causes of the challenge in preserving wet wipes. We found that fabrics containing natural fibers are the main source of contamination, promoting the generation of biofilms on their surfaces. Moreover, the hydrophilic-lipophilic balance (HLB) was utilized to rationalize the physicochem. interactions between the fabric and the preservatives.

Cosmetics published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C11H24O3, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kuzniewski, Christian N. published the artcileSynthesis, Profiling, and Bioactive Conformation of trans-Cyclopropyl Epothilones, Application In Synthesis of 57044-25-4, the publication is Helvetica Chimica Acta (2019), 102(5), n/a, database is CAplus.

A series of new 3-deoxy-C(12),C(13)-trans-cyclopropyl-epothilones have been prepared, bearing benzothiazole, quinoline, thiazol-5-ylvinyl, or isoxazol-3-ylvinyl side chains (I – IV, resp.). For analogs with fused aromatic side chains, macrocyclic ring-closure was based on ring-closing olefin metathesis (RCM) of a precursor incorporating the fully elaborated heavy atom framework of the target structure (including the side chain moiety), while side chain attachment for the thiazole and isoxazole-containing 16-desmethyl analogs was performed only after establishment of the macrolactone core. Two approaches were elaborated for a macrocyclic aldehyde as the common precursor for the latter analogs that involved ring-closure either by RCM or by macrolactonization. Benzothiazole- and quinoline-based analogs were found to be highly potent antiproliferative agents; the two analogs with a thiazol-5-ylvinyl or an isoxazol-3-ylvinyl side chain likewise showed good antiproliferative activity but were significantly less potent than the parent epothilone A. Surprisingly, the desaturation of the C(10)-C(11) bond in these analogs was associated with a virtually complete loss in antiproliferative activity, which likely reflects a requirement for a ca. 60 ° C(10)-C(11) torsion angle in the tubulin-bound conformation of 12,13-trans-epothilones.

Helvetica Chimica Acta published new progress about 57044-25-4. 57044-25-4 belongs to alcohols-buliding-blocks, auxiliary class Epoxides,Chiral,Aliphatic hydrocarbon chain,Alcohol, name is (R)-Oxiran-2-ylmethanol, and the molecular formula is C3H6O2, Application In Synthesis of 57044-25-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Delgado, Pete published the artcileUse of Green Solvents in Metallaphotoredox Cross-Electrophile Coupling Reactions Utilizing Lipophilic Modified Dual Ir/Ni Catalyst System, Recommanded Product: (1-Bromocyclopropyl)methanol, the publication is Journal of Organic Chemistry (2021), 86(23), 17428-17436, database is CAplus and MEDLINE.

Facilitating photoredox coupling reactions in process friendly green solvents was achieved by the successful application of the dual Ir/Ni catalyst system with enhanced solubility properties. These photochem. reactions (specifically Br-Br sp²-sp³ cross electrophile coupling) are reported in a head to head comparison to the reactions using standard di-t-Bu bipyridine ligand Ir/Ni catalyst system. This presentation highlights the benefits of altering the solubility properties of the ligands used in the Ir/Ni dual catalyst.

Journal of Organic Chemistry published new progress about 50915-29-2. 50915-29-2 belongs to alcohols-buliding-blocks, auxiliary class Cyclopropanes, name is (1-Bromocyclopropyl)methanol, and the molecular formula is C4H7BrO, Recommanded Product: (1-Bromocyclopropyl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Singh, Gurjaspreet published the artcileSelective mercury ion recognition using a methyl red (MR) based silatrane sensor, Safety of Triisopropanolamine, the publication is New Journal of Chemistry (2018), 42(8), 6315-6321, database is CAplus.

A new Methyl red (MR) based silatrane was synthesized in high yield by the transesterification reaction of Methyl red-amidopropyltrimethoxysilane 1 (MR-APTMS) and trisisopropanolamine. Single crystal x-ray diffraction anal. was used to deduce the structure of silatrane 2 which was also supported by NMR (¹H, ¹³C) spectroscopy, mass spectrometry, FTIR, UV-visible and DFT studies. Silatrane 2 when surveyed for cation recognition ability with a library of metal ions in CH₃CN/H₂O (9 : 1, volume/volume) was found to act as an excellent UV-visible probe for the selective recognition of Hg²⁺in vitro. Also, quantum mech. calculations of the interaction complex [MR-APS-Hg]²⁺3 using DFT at the B3LYP level in conjunction with the LanL2DZ basis set determined the geometric and the stability parameters of the surveyed interaction.

New Journal of Chemistry published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C8H6ClN, Safety of Triisopropanolamine.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Barzagli, Francesco published the artcileScreening study of different amine-based solutions as sorbents for direct CO₂ capture from air, Product Details of C4H11NO, the publication is ACS Sustainable Chemistry & Engineering (2020), 8(37), 14013-14021, database is CAplus.

Direct air capture (DAC) is an emerging technol. that can help limit the global temperature rises, as it has the potential to contrast the dispersed CO₂ emissions coming from transport and heating that cannot be captured with traditional CCS methods. Although recent improvements are bringing DAC closer to com. feasibility, an obstacle to its diffusion is the high regeneration energy required by the most common liquid sorbents, Na or K hydroxides. In order to develop efficient and more sustainable sorbents, in the present screening study several alkanolamines, particularly those already known for their utilization in CCS, were tested for DAC. The percentage of CO₂ absorbed from compressed air of their 1.5 mol dm^-3 aqueous solutions was evaluated in 24 h capture experiments and the species formed were identified and quantified by means of ¹³C-NMR spectroscopy. For selected amines, their performance in organic diluents was also evaluated. The correlations between aerial CO₂ absorption, chem. structures of the different amine and species formed in solution have shown that a high yield production of amine carbamate is the decisive factor for an effective CO₂ capture, and that aqueous primary unhindered amines are as efficient as aqueous alkali hydroxides, with the potential of a lower regeneration energy.

ACS Sustainable Chemistry & Engineering published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H11NO, Product Details of C4H11NO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Potawale, Rani S. published the artcileLiquid chromatography tandem-mass spectrometry method development and validation for simultaneous analysis of paracetamol, guaifenesin, phenylephrine hydrochloride, chlorpheniramine maleate, and ambroxol hydrochloride in bulk and in tablet dosage form, HPLC of Formula: 23828-92-4, the publication is Asian Journal of Pharmaceutical and Clinical Research (2018), 11(7), 1-8, database is CAplus.

Objective: The objective is to study liquid chromatog. tandem-mass spectrometry (LC/MS/MS) method for simultaneous quantification of paracetamol (PCM), guaifenesin (GUA), phenylephrine hydrochloride (PE), chlorpheniramine maleate (CPM), and ambroxol hydrochloride (AMB) in tablet dosage form developed and validated as per the International Conference on Harmonization Q2 (R1) guideline. Methods: The chromatograms were developed using a gradient mobile phase of WATER:methanol. Flow rate used was to 0.3 mL/min. Quantitation was performed using multiple reaction monitoring (MRM) mode to study parent to product ion transition, for paracetamol. (m/z 152.0 ≥ 110.0), guaifenesin (m/z 199.0 ≥ 163.0), phenylephrine hydrochloride (m/z 168.0 ≥ 150.0), chlorpheniramine maleate (m/z 275.0 ≥ 230.0) and ambroxol hydrochloride (m/z 379.0 ≥ 263.8). Results: The retention times were found to be 1.76, 1.81, 1.90, 2.10, and 2.33 min for PCM, GUA, PE, CPM, and AMB, resp. The linearity of the method was found to be in the concentration range of 10-200 ng/mL for PCM, GUA, PE, CPM, and AMB. Percentage relative standard deviation values for repeatability and intermediate precision studies were below 2%. Conclusion: Developed method was found to be robust, precise, accurate, rapid and can be used to analyze fixed-dose tablet formulation used in the study.

Asian Journal of Pharmaceutical and Clinical Research published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, HPLC of Formula: 23828-92-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Herzog, B. published the artcileSolubility of UV absorbers for sunscreens is essential for the creation of light feel formulations, Computed Properties of 70445-33-9, the publication is SOFW Journal (2013), 139(7), 7-8,10-14, database is CAplus.

The goals of this paper are the comparison of different methods for the determination of solubility, the presentation of some examples of solubility data for solid UV absorbers, and the introduction of a concept using this knowledge to create light feel formulations. UV filters are the key ingredients necessary for the efficacy of sunscreens. Most of the organic UV absorbers are oil-soluble or even oil-miscible compounds and consequently are incorporated into the oil-phase of sunscreen emulsions.

SOFW Journal published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C11H24O3, Computed Properties of 70445-33-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts