Author: tianli

Thangavelu, Prabha published the artcileAnalytical method development and validation for the simultaneous estimation of salbutamol sulphate, guaifenesin, and ambroxol hydrochloride by RP-HPLC method in commercial oral liquid dosage form, Formula: C13H19Br2ClN2O, the publication is International Journal of Pharmaceutical Sciences and Research (2019), 10(1), 260-265, database is CAplus.

Salbutamol is a bronchodilator, Guaifenesin is an expectorant and Ambroxol is a mucolytic. Combination of these drugs is used in the formulation of cough syrups. In the literature, there is no method reported for the simultaneous estimation of the drugs in oral liquid dosage form. Hence, the present work is aimed to develop reverse phase HPLC method for the simultaneous determination of Salbutamol sulfate (SAL), Guaifenesin (GUA) and Ambroxol hydrochloride (AMB) in oral liquid dosage form and validation of the developed method. The chromatog. separation of the drugs was achieved with the mobile phase system sodium dihydrogen phosphate buffer pH 3.0: acetonitrile: methanol in the ratio of 65:10:25 with the flow rate of 1 mL/min and injection volume 10μL. An Inertsil C8-3 (250 × 4.6 mm, 5μm) column was used, and the detection wavelength was 276 nm. This system produced sharp peaks with good resolution, min. tailing and satisfactory retention times of SAL, GUA and AMB were found to be 3.157, 9.949 and 11.883 min resp. indicating the suitability of the system. The developed method was validated for various parameters accuracy, precision, linearity, robustness, and specificity as per ICH guidelines.

International Journal of Pharmaceutical Sciences and Research published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C18H26ClN3O, Formula: C13H19Br2ClN2O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kirschenlohr, Heide L. published the artcileEstimation of systolic and diastolic free intracellular Ca²⁺ by titration of Ca²⁺ buffering in the ferret heart, COA of Formula: C6H3F2NO3, the publication is Biochemical Journal (2000), 346(2), 385-391, database is CAplus.

Spectroscopic Ca²⁺-indicators are thought to report values of free intracellular Ca²⁺ concentration ([Ca²⁺]_i) that may differ from unperturbed values because they add to the buffering capacity of the tissue. To check this for the heart we have synthesized a new ¹⁹F-labeled NMR Ca²⁺ indicator, 1,2-bis-[2-bis-(carboxymethyl)amino-4,5-difluorophenoxy]ethane (“4,5FBAPTA”), with a low affinity (K_d 2950 nM). The new indicator and four previously described ¹⁹F-NMR Ca²⁺ indicators 1,2-bis-[2-(1-carboxyethyl)(carboxymethyl)amino-5-fluorophenoxy]ethane (“DiMe-5FBAPTA”), 1,2-bis-[2-(1-carboxyethyl)(carboxymethyl)-amino-4-fluorophenoxy]ethane (“DiMe-4FBAPTA”), 1,2-bis-[2-bis(carboxymethyl)amino-5-fluorophenoxy]ethane (“5FBAPTA”) and 1,2-bis-[2-bis(carboxymethyl)amino-5-fluoro-4-methylphenoxy]ethane (“MFBAPTA”), with dissociation constants for Ca²⁺ ranging from 46 to 537 nM, have been used to measure [Ca²⁺]_i, over the range from less than 100 nM to more than 3 μM, in Langendorff-perfused ferret hearts (30°C, pH 7.4, paced at 1.0 Hz) by ¹⁹F-NMR spectroscopy. Loading hearts with indicators resulted in buffering of the Ca²⁺ transient. The measured end-diastolic and peak-systolic [Ca²⁺]_i were both pos. correlated with indicator K_d. The pos. correlations between indicator K_d and the measured end-diastolic and peak-systolic [Ca²⁺]_i were used to estimate the unperturbed end-diastolic and peak-systolic [Ca²⁺]_i by extrapolation to K_d = 0 (diastolic) and to K_d = ∞ (systolic) resp. The extrapolated values in the intact beating heart were 161 nM for end-diastolic [Ca²⁺]_i and 2650 nM for peak-systolic [Ca²⁺]_i, which agree well with values determined from single cells and muscle strips.

Biochemical Journal published new progress about 55346-97-9. 55346-97-9 belongs to alcohols-buliding-blocks, auxiliary class Fluoride,Nitro Compound,Benzene,Phenol, name is 4,5-Difluoro-2-nitrophenol, and the molecular formula is C6H3F2NO3, COA of Formula: C6H3F2NO3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ihndris, Ray W. published the artcileEffect of promising insect repellents on plastics and paints, Related Products of alcohols-buliding-blocks, the publication is United States, Agricultural Research Service, [Report] ARS (1955), 27 pp., database is CAplus.

Action of 380 repellents on Lucite, cellulose acetate, and Vinylite after 48 h. of contact are tabulated (studies in 1946). Sixty-eight of the compounds did not change any of the plastics. Lucite was attacked by 261, cellulose acetate by 126, and Vinylite by 251. Only 99 compounds attacked all 3. Results of studies in 1953 are shown in a tabulation of effects on paint, Plexiglas, Vinylite, rayon, and Plastocel of 136 repellents which had not proved unsatisfactory since 1946 for some other reason. All but 2 compounds affected paint; one of them, octyl crotonate, affected only varnish and vinylite, and the other, 3,6,8-trimethyl-4-nonyne-3-6-diol affected only varnish. Vinylite was damaged by 107, Plexiglas by 58, rayon by 55, and Plasticel by 46. In other tests only 2 chems., 2-benzyloxynaphthalene and 2-iso-pentyloxynaphthalene, affected polyethylene, and they only slightly. Fourteen materials slightly stained nylon. In still other tests, Lucite and Plexiglas were found to differ slightly in their resistance to various agents.

United States, Agricultural Research Service, [Report] ARS published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C11H24O3, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Weber, Christine published the artcileCarbohydrate-Based Initiators for the Cationic Ring-Opening Polymerization of 2-Ethyl-2-Oxazoline, Category: alcohols-buliding-blocks, the publication is Methods in Molecular Biology (New York, NY, United States) (2016), 49-59, database is CAplus and MEDLINE.

The advancement in the field of living and controlled polymerization techniques provides the opportunity for careful bottom-up design of polymers for biomedical applications according to their specific needs. This contribution describes the detailed methodol. to functionalize poly(2-ethyl-2-oxazoline), a polymer with properties very similar to polyethylene glycol, in a stereo-selective manner with a range of carbohydrates that can serve as biol. targeting units. The obtained building blocks can subsequently be applied for the synthesis of more complex polymeric architectures.

Methods in Molecular Biology (New York, NY, United States) published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C5H12BrO3P, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chakraborty, Shampa published the artcileRapid and efficient synthesis of 2,2-dimethylaminobenzazoles and 2,2-dimethylaminoazoles in a sustainable way, Synthetic Route of 96-20-8, the publication is Materials Research Innovations (2021), 25(2), 90-94, database is CAplus.

Reactions of 2-aminophenol, 2-aminobenzenethiol and other 2-substituted anilines, ethylene amines and amino acid containing 1,2 amino hydroxy groups with TBTU [2-(1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluroniumtetrafluoroborate], easily formed corresponding benzazoles (single crystal X-ray structure) and azoles attached with a di-Me amino group at 2-position via a guanidine intermediate which cyclizes and aromatizes by eliminating one dimethylamino group to afford benzazoles and azoles. The nobality of the synthesis is, single step and can occur at ambient temperature

Materials Research Innovations published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H11NO, Synthetic Route of 96-20-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Skarzynska, Magdalena Beata published the artcileEffectiveness of surgical approach of insertion ventilation tubes (Tympanostomy) and adenoidectomy in comparison with non-surgical approach (Watchful Waiting Approach) in children at the age between 1 and 6 and who suffer from otitis media with effusion (OME) in 12-month period of observation-the retrospective analysis, Application In Synthesis of 23828-92-4, the publication is International Journal of Environmental Research and Public Health (2021), 18(23), 12502, database is CAplus and MEDLINE.

Otitis media with effusion (OME) is one of the most common diseases in childhood. The objective was to assess clin. the effectiveness of the surgical approach (tube insertion with adenoidectomy) in comparison with the non-surgical approach (watchful waiting) during a 12-mo observation period. This study was retrospective and obtained approval from the bioethics committee. The criteria of inclusion in the first group (surgical approach) were: (1) a diagnosis of chronic otitis media with effusion in children aged between 1 and 6 years; (2) their medical history showed that they had undergone adenoidectomy and tympanostomy with the insertion of ventilation tubes (VTs). The criteria for inclusion in the second group (non-surgery) were similar to the first group except that their medical history showed they had not undergone adenoidectomy or tympanostomy with the insertion of VTs. There were 422 children included in the surgical group and 50 children in the non-surgical group, and the period of observation was 12 mo. For the entire surgical group, the number of healthy days ranged from 20 to 365, with a mean of 328.0 days (SD = 91.4).In the non-surgical group, the number of healthy days ranged from 13 to 365, with a mean of 169.2 days (SD = 127.3). The difference in the number of healthy days was statistically significant (p < 0.001). The certainty of treatment in the first group was higher than in the second group, and the number of days without recurrence was significantly higher than in the second group. In the first group, there were 71 recurrences from 422 children (16.8%), and, in the second subgroup, there were 40 recurrences of acute otitis media (AOM) from 50 children (80%). The RR was 0.21. The surgical approach in children aged 1-6 years who have been diagnosed with otitis media with effusion is reasonable and beneficial for the child.

International Journal of Environmental Research and Public Health published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C10H11NO4, Application In Synthesis of 23828-92-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Vinogradov, M. G. published the artcileSelective method of 5-chloro-2-pentanone preparation, Synthetic Route of 20117-47-9, the publication is Izvestiya Akademii Nauk, Seriya Khimicheskaya (1995), 774-6, database is CAplus.

5-Chloro-2-pentanone (1) was prepared by reaction of 1-methylcyclobutanol (3) with Ca(OCl)₂, followed by decomposition of the 1-methylcyclobutyl hypochlorite in the presence of a Fe^II salt. The selectivity of 1 formation from 3 was 98%, and the conversion of 3 was 35-40%.

Izvestiya Akademii Nauk, Seriya Khimicheskaya published new progress about 20117-47-9. 20117-47-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic cyclic hydrocarbon,Alcohol, name is 1-Methylcyclobutan-1-ol, and the molecular formula is C14H10N2O, Synthetic Route of 20117-47-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kirpichenok, M. A. published the artcileSynthesis of 4-chloro-7-(dialkylamino)coumarins, Related Products of alcohols-buliding-blocks, the publication is Khimiya Geterotsiklicheskikh Soedinenii (1990), 830-5, database is CAplus.

The title coumarins I (R = Et, R₂N = piperidino, morpholino, R¹ = H, Et, cyclohexyl, benzyl) and II were prepared in 15-42% yields by heating aminophenols III or benzoquinolizinol IV with R¹CH(CO₂H)₂ in excess POCl₃. Treating I (R = Et, R¹ = H) with NaOEt, Bu₂NH, and N₂H₄.H₂O gave 45, 63, and 17% coumarins V (R² = OEt, Bu₂N, NHNH₂).

Khimiya Geterotsiklicheskikh Soedinenii published new progress about 27292-49-5. 27292-49-5 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Benzene,Phenol, name is 3-Morpholinophenol, and the molecular formula is C10H13NO2, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kumar, Naresh published the artcileExtrapolation of hydroxytyrosol and its analogues as potential anti-inflammatory agents, COA of Formula: C8H8O3, the publication is Journal of Biomolecular Structure and Dynamics (2021), 39(15), 5588-5599, database is CAplus and MEDLINE.

Discovery of potential lead mol. is a challenging, and complex process which require lots of money, patience, and manpower. Human beings are using natural products, predominantly secondary metabolites, for this purpose since ancient time and they are still working on them as a potent source for drug discovery due to their wide structural diversity. Phenolic phytochems. such as hydroxytyrosol and tyrosol are natural antioxidant and involved in many biol. disease cure. Herein, we have carried out the quantum chem. calculations for conformational anal., geometry optimization and computation of electronic as well as optical properties of hydroxytyrosol and its analogs (1a-1k) in terms of d. functional theory by using Gaussian 09 program suite. The eventual charge transfer within the mols. has been confirmed by the anal. of frontier MOs. The mol. docking studies of 1a-1k with cyclooxygenase-2 showed the noticeable binding affinity as compared to other nonsteroidal anti-inflammatory drugs viz. aspirin, naproxen and celecoxib. Computation of pharmacokinetics and pharmacol. properties confirmed the lead/drug like potential of these screened mols. Furthermore, the mol. dynamics simulation of best three docked ligands (1f, 1h and 1k)-receptor complex and their binding free energy calculations reveals that these mols. bind in the catalytic cavity of cyclooxygenase-2 and found stable during the 100 ns of simulation.

Journal of Biomolecular Structure and Dynamics published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C8H8O3, COA of Formula: C8H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Taljaard, Benjamin published the artcileSynthesis of hydrogen peroxide: acid-catalysed decomposition of 9-hydroperoxy-9-phenylxanthene and its derivatives, Related Products of alcohols-buliding-blocks, the publication is South African Journal of Chemistry (1987), 40(2), 139-45, database is CAplus.

9-Aryl-9-hydroperoxyxanthenes and the corresponding dixanthenyl peroxides were decomposed with various acids under different conditions. Excess strong acid is required for optimum xanthenyl cation and hydrogen peroxide production Inductive effects of the aryl p-substituents in the 9-aryl-9-hydroperoxyxanthenes influence the course of the reaction. Treatment of the hydroperoxides with acetic acid gives the corresponding dialkyl peroxides. Increased conjugation was investigated, with 14-aryl-14-hydroperoxydibenzo[a,j]xanthenes, and has been shown to inhibit carbocation and hydrogen peroxide formation.

South African Journal of Chemistry published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C4H10OS, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts