Author: tianli

Chen, Jing-jing published the artcileSimultaneous determination of dissolved 1-methylphenanthrene and its metabolites by derivative synchronous fluorescence spectrometry with double scans method, Computed Properties of 86-48-6, the publication is Fenxi Huaxue (2021), 49(4), 636-641, database is CAplus.

Derivative synchronous fluorescence spectrometry with double scans method was established to simultaneously determine the dissolved 1-methylphenanthrene (1-MP) and its metabolites such as 1-hydroxy-2-naphthoic acid (1H2NA) and salicylic acid (SA). With this method, the linear ranges for determination of 1-MP, 1H2NA and SA were 0.02-1.30 μmol/L, 0.02-7.60 μmol/L and 0.01-5.20 μmol/L, the detection limits (LODs) of 1-MP, 1H2NA and SA were 0.11, 0.33 and 2.90 nmol/L, the relative standard deviations (RSD) were less than 2%, and the recoveries were 97.4%-108.6%. This method was suitable for the simultaneous determination of 1-MP, 1H2NA and SA in the dissolved 1-MP microbial degradation process under the laboratory simulation condition, showing practical application potential in investigation of 1-MP degradation process and mechanism in situ.

Fenxi Huaxue published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, Computed Properties of 86-48-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Haolan published the artcileTargeting MCL-1 in cancer: current status and perspectives, Recommanded Product: 2-((4-(4-Bromophenylsulfonamido)-1-hydroxynaphthalen-2-yl)thio)acetic acid, the publication is Journal of Hematology & Oncology (2021), 14(1), 67, database is CAplus and MEDLINE.

A review. Myeloid leukemia 1 (MCL-1) is an antiapoptotic protein of the BCL-2 family that prevents apoptosis by binding to the pro-apoptotic BCL-2 proteins. Overexpression of MCL-1 is frequently observed in many tumor types and is closely associated with tumorigenesis, poor prognosis and drug resistance. The central role of MCL-1 in regulating the mitochondrial apoptotic pathway makes it an attractive target for cancer therapy. Significant progress has been made with regard to MCL-1 inhibitors, some of which have entered clin. trials. Here, we discuss the mechanism by which MCL-1 regulates cancer cell apoptosis and review the progress related to MCL-1 small mol. inhibitors and their role in cancer therapy.

Journal of Hematology & Oncology published new progress about 518303-20-3. 518303-20-3 belongs to alcohols-buliding-blocks, auxiliary class Apoptosis,Bcl-2, name is 2-((4-(4-Bromophenylsulfonamido)-1-hydroxynaphthalen-2-yl)thio)acetic acid, and the molecular formula is C7H7ClN2, Recommanded Product: 2-((4-(4-Bromophenylsulfonamido)-1-hydroxynaphthalen-2-yl)thio)acetic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gomola, Kinga published the artcileAn optically uniaxial antiferroelectric smectic phase in asymmetrical bent-core compounds containing a 3-aminophenol central unit, Formula: C7H9NO, the publication is Journal of Materials Chemistry (2010), 20(37), 7944-7952, database is CAplus.

Two series of asym. bent-core compounds possessing 3-aminophenol and its N-Me derivative have been synthesized. The asymmetry arose from the different linkages between the central unit and the chem. chains of the substituents, and in two cases also from different lateral substituents. The mesomorphic properties were investigated by differential scanning calorimetry, polarizing optical microscopy, switching current and electro-optical measurements, X-ray anal., and second-harmonic generation. All materials possessing 3-aminophenol as a central unit showed liquid crystalline properties, and two of them exhibited the orthogonal smectic phase (SmA family phase) and very stable columnar phases, while the N-Me analogs exhibited no mesophase. Because of the optically uniaxial nature, double switching current peaks, and SHG activity associated with a distinct threshold elec. field, this orthogonal smectic phase was assigned to a novel type, which has a short-range antiferroelec. order with a long-range randomized polar plane (SmAP_AR).

Journal of Materials Chemistry published new progress about 14703-69-6. 14703-69-6 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Phenol, name is 3-(Methylamino)phenol, and the molecular formula is C7H9NO, Formula: C7H9NO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Li, Xiuru published the artcileMultifunctional Surface Modification of Gold-Stabilized Nanoparticles by Bioorthogonal Reactions, Recommanded Product: (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol, the publication is Journal of the American Chemical Society (2011), 133(29), 11147-11153, database is CAplus and MEDLINE.

Nanocarriers that combine multiple properties in an all-in-one system hold great promise for drug delivery. The absence of technol. to assemble highly functionalized devices has, however, hindered progress in nanomedicine. To address this deficiency, the authors have chem. synthesized poly(ethylene oxide)-β-poly(ε-caprolactone) (PEO-b-PCL) block polymers modified at the apolar PCL terminus with thioctic acid and at the polar PEO terminus with an acyl hydrazide, amine, or azide moiety. The resulting block polymers were employed to prepare nanoparticles that have a gold core, an apolar polyester layer for drug loading, a polar PEO corona to provide biocompatibility, and three different types of surface reactive groups for surface functionalization. The acyl hydrazide, amine, or azide moieties of the resulting nanoparticles could be reacted with high efficiencies with modules having a ketone, isocyanate, or active ester and alkyne function, resp. To demonstrate proof of principle of the potential of multisurface functionalization, nanoparticles that have various combinations of an oligo-arginine peptide were prepared to facilitate cellular uptake, a histidine-rich peptide to escape from lysosomes, and an Alexa Fluor 488 tag for imaging purposes. It has been shown that uptake and subcellular localization of the nanoparticles can be controlled by multisurface modification. It is to be expected that the modular synthetic methodol. provides unique opportunities to establish optimal configurations of nanocarriers for disease-specific drug delivery.

Journal of the American Chemical Society published new progress about 96345-79-8. 96345-79-8 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Gal and Man, name is (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C13H15NO6S, Recommanded Product: (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Mou, Lin-Yun published the artcilePhytochemical and chemotaxonomic investigation from the roots of Anemone vitifolia Buch.-Ham. (Ranunculaceae), HPLC of Formula: 20880-92-6, the publication is Biochemical Systematics and Ecology (2021), 104306, database is CAplus.

Phytochem. investigation from the roots of Anemone vitifolia Buch.-Ham. led to the isolation of eight compounds, including one triterpenoid saponin, two sugars, one coumarin, one amide, one saturated alkane, one olefin and one fatty acid. The structures of these metabolites were elucidated by spectroscopic data and comparisons with the data available in the literature. Among them, compound 7 ((6Z,9Z,12Z)-6,9,12-Eicosatriene) was isolated for the first time as a natural product. Furthermore, compounds 2 (D-(+)-raffinose), 3 (mixture of β-D-fructopyranose and β-D-fructofuranose) and 5 (bonaroside) were obtained from the Ranunculaceae family for the first time. Compounds 4 (siderin) and 6 (n-hexadecane) were isolated from A. vitifolia for the first time. The chemotaxonomic significance of the isolated compounds was discussed.

Biochemical Systematics and Ecology published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C12H20O6, HPLC of Formula: 20880-92-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Deng, Xiufeng published the artcileEffect of organic alkali on hydration of GGBS-FA blended cementitious material activated by sodium carbonate, Category: alcohols-buliding-blocks, the publication is Ceramics International (2022), 48(2), 1611-1621, database is CAplus.

Sodium carbonate (SC) activated ground granulated blast-furnace slag (GGBS) and fly ash (FA) is a potential substitute of traditional cement with ultra-low carbon footprint. However, its hydration rate and strength growth are limited, owing to the slow leaching of ions during the activation of weak base. In this work, 60% wet-grinded GGBS and 40% FA were blended as the binder, and two organic alkalis, i.e. triethanolamine (TEA) and triisopropanolamine (TIPA), were adopted to facilitate the ions dissolution and pozzolanic reaction of SC activated GGBS-FA blended cementitious material (SCSF). The compressive strength was tested and the hydration kinetics was studied by hydration heat and chem. shrinkage. Besides, ions leaching behavior was characterized by ICP; hydrates and microstructure were also detected by XRD, TG-DTG and SEM. Results indicated that the addition of TEA or TIPA significantly promoted the ions dissolution 0.05% TEA increased the concentration of leached Ca2+, Al3+ and Fe3+ by 36%, 33% and 1545%, resp. This solubilizing effect was also found in TIPA. Moreover, these two chems. could promote the formation of hydrates, such as C-S(A)-H gel, hydrotalcite, calcite and aragonite, especially at the early period; these also activated the hydration process of SCSF effectively, and the compressive strength of the mortar reached above 40.0 MPa at 7 d and 48.0 MPa at 28 d. The carbon emission of the designed system is 85.9% and 55.9% lower than that of PC and strong base activated GGBS system, resp.

Ceramics International published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C9H21NO3, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Xu, Shiyang published the artcileRh(I)-Catalyzed Coupling of Azides with Boronic Acids Under Neutral Conditions, Category: alcohols-buliding-blocks, the publication is Organic Letters (2022), 24(30), 5546-5551, database is CAplus and MEDLINE.

A neutral amination reaction using azides RN₃ (R = Ph, 4-nitrophenyl, 4-bromophenyl, etc.) as the nitrogen source and arylboronic acids ArB(OH)₂ (Ar = 4-cyanobutyl, cyclooctyl, Ph, etc.) with a rhodium(I) catalyst to afford alkyl-aryl and aryl-aryl secondary amines RNHAr was presented. Natural products and pharmaceutical derivatives were applied, and gram-scale reactions were performed, which demonstrated the utility. Mechanistic experiments and DFT calculations suggested that the reaction involves a metal-nitrene intermediate.

Organic Letters published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C4H8Cl2S2, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lin, Yi-Wen published the artcileGrowth of Pseudomonas sp. TX1 on a wide range of octylphenol polyethoxylate concentrations and the formation of dicarboxylated metabolites, Related Products of alcohols-buliding-blocks, the publication is Bioresource Technology (2010), 101(8), 2853-2859, database is CAplus and MEDLINE.

Pseudomonas sp. TX1, is able to use octylphenol polyethoxylates (OPEO_n, or Triton X-100; average n = 9.5) as a sole carbon source. It can grow on 0.05-20% of OPEO_n with a specific growth rate of 0.34-0.44 h^-1. High-performance liquid chromatog.-mass spectrometer anal. of OPEO_n degraded metabolites revealed that strain TX1 was able to shorten the ethoxylate chain and produce octylphenol (OP). Furthermore, formation of the short carboxylate metabolites, such as carboxyoctylphenol polyethoxylates (COPEO_n, n = 2, 3) and carboxyoctylphenol polyethoxycarboxylates (COPEC_n, n = 2, 3) began at the log stage, while octylphenol polyethoxycarboxylates (OPEC_n, n = 1-3) was formed at the stationary phase. All the short-ethoxylated metabolites, OPEO_n, OPEC_n, COPEO_n, and COPEC_n, accumulated when the cells were in the stationary phase. This study is the first to demonstrate the formation of COPEO_n and COPEC_n from OPEO_n by an aerobic bacterium.

Bioresource Technology published new progress about 1139-46-4. 1139-46-4 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Phenol, name is 4-(2,4,4-Trimethylpentan-2-yl)benzene-1,2-diol, and the molecular formula is C14H22O2, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

He, Meilian published the artcileDetermination of ambroxol hydrochloride in human plasma by ultra high performance liquid chromatography-tandem mass spectrometry and bioequivalence evaluation of its preparation, Related Products of alcohols-buliding-blocks, the publication is Sepu (2018), 36(11), 1099-1104, database is CAplus and MEDLINE.

A rapid, simple and sensitive ultra high performance liquid chromatog.-tandem mass spectrometry (UHPLC-MS/MS) method was developed for the determination of ambroxol hydrochloride in human plasma, and bioequivalence of its preparation was evaluated. The 50 μL-plasma sample was treated with methanol for protein precipitation, while ambroxol-d5 was used as an internal standard (IS). The separation was carried out on a Waters XBridge BEH C18 column (50 mm × 2.1 mm, 2.5 μm) by gradient elution at a flow rate of 0.4 mL/min, with 0.1% (volume/volume) formic acid aqueous solution and methanol containing 0.1% (volume/volume) formic acid as the mobile phases. The analyte was detected using an electrospray ionization source in pos. ion multiple reaction monitoring (MRM) mode. The calibration curves were linear in the range of 2-400 ng/mL (r = 0.998). The intra- and inter-run accuracies were 97.1-108.7%, and the intra- and inter-run precisions were 1.0-5.6%. The method was applied to the determination of the plasma concentration of the six healthy subjects after the oral administration of 30 mg of test and reference preparations The bioavailability was (102.3 ± 14.8)%. The 90% confidence intervals of the test preparation’s pharmacokinetic parameters were 80.0-125.0% of the reference preparation’s corresponding parameters. Thus, it is proved that the test preparation and reference preparation are bioequivalent.

Sepu published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Capon, Brian published the artcileSome studies on the tautomerism of heterocyclic and homocyclic compounds, Quality Control of 17236-59-8, the publication is Pure and Applied Chemistry (1987), 59(12), 1577-84, database is CAplus.

The following hydroxy derivatives of heterocyclic compounds have been generated in solution and characterized by ¹H-NMR spectroscopy: 3-hydroxyfuran, 3-hydroxythiophene, 3-hydroxypyrrole, 3-hydroxy-1-methylpyrrole, 3-hydroxybenzofuran, 3-hydroxybenzothiophene, 3-hydroxyindole, 3-hydroxy-1-methylindole, 2-hydroxythiophene, 2-hydroxybenzothiophene, 2,5-dihydroxythiophene. The rate and equilibrium constants for their ketonization have been measured and are discussed. The following hydroxy derivatives of homocyclic compounds were also generated, characterized and investigated: 1-hydroxyindene, 2-hydroxyindene, 1-hydroxycyclohepta-1,3,5-triene, 3-hydroxycyclohepta-1,3,5-triene, hydroxycyclooctatetraene, and 3-hydroxycycloocta-1,3,5-triene. The mechanism of hydrolysis of heterocyclic Me ethers derived from furan, thiophene, 1-methylpyrrole and their benzo-derivatives has been investigated and a change in rate limiting step from C-protonation to nucleophilic attack by water on the intermediate cation detected.

Pure and Applied Chemistry published new progress about 17236-59-8. 17236-59-8 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Alcohol, name is Thiophen-3-ol, and the molecular formula is C4H4OS, Quality Control of 17236-59-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts