Author: tianli

Vana, Lubomir published the artcileSynthesis of Aza[n]helicenes (n = 4-7) via Photocyclodehydrochlorination of 1-Chloro-N-aryl-2-naphthamides, Quality Control of 86-48-6, the publication is Journal of Organic Chemistry (2022), 87(11), 7150-7166, database is CAplus and MEDLINE.

A series of 5-aza[4]helicene, e.g., I was synthesized using a photocyclodehydrochlorination of 1-chloro-N-aryl-2-naphthamides, e.g., 1-chloro-N-phenyl-2-naphthamide as a general synthetic procedure introducing the nitrogen atom to the third ring of the helicene framework. The effect of the nitrogen presence in the helicene skeleton on the physicochem. properties of the prepared 5-aza[4]helicene was studied and compared to those of the parent carbo-analogs. The insertion of a nitrogen atom into the outer edge of the helicene mol. has a severe impact on certain physicochem. properties such as optical rotation, electrostatic potentials, and intermol. interactions. On the other hand, some other properties such as UV/vis, fluorescence, and phosphorescence spectra remained almost unaffected when compared to the parent carbohelicenes. A nitrogen atom can be also used for further derivatization, which can lead to further modification of helicene properties, as manifested here in the fluorescence changes induced by protonation.

Journal of Organic Chemistry published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C10H9ClN2O, Quality Control of 86-48-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Patel, Gopi published the artcileSimultaneous Estimation of azithromycin and ambroxol hydrochloride in combined dosage form by RP-HPLC method, Formula: C13H19Br2ClN2O, the publication is Journal of Chemical and Pharmaceutical Research (2018), 10(5), 142-147, database is CAplus.

A simple, accurate and precise RP-HPLC method was developed and subsequently validated for simultaneous determination of Azithromycin and Ambroxol Hydrochloride in combined dosage form. The Proposed HPLC method utilizes C18 (250 mm × 4.6 mm × 5 μm) column with mobile phase comprising of KH2PO4 (pH 5.0 adjusted with 1% Orthophosphoric acid: Methanol (60:40% volume/volume) at a flow rate of 1.0 mL/min. Selection of wavelength for determination of Azithromycin (50 μg/mL) and Ambroxol Hydrochloride (15 μg/mL) show reasonably good response at 215 nm. Quantitation was achieved based on peak area with linear calibration curves at concentration ranges 25 – 75 μg/mL for Azithromycin and 7.5 – 22.5 μg/mL for Ambroxol Hydrochloride with Correlation Coefficient of 0.999.The Retention times of Azithromycin and Ambroxol Hydrochloride were found to be 6.73 min and 4.17 min resp. The limit of detection (LOD) was 0.36 and 0.18 for Azithromycin and Ambroxol Hydrochloride resp. The limit of quantification (LOQ) was 1.09 and 0.56 for Azithromycin and Ambroxol Hydrochloride resp. The accuracy was found within the limit. The precision (inter – day, intra – day and repeatability) was found within the limit. The method was validated as per ICH guideline. The method can be successfully employed for simultaneous estimation of Azithromycin and Ambroxol Hydrochloride in combined dosage form.

Journal of Chemical and Pharmaceutical Research published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Formula: C13H19Br2ClN2O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Mandrah, Kapil published the artcileA study on bisphenol S induced nephrotoxicity and assessment of altered downstream kidney metabolites using gas chromatography-mass spectrometry based metabolomics, Product Details of C12H10O4S, the publication is Environmental Toxicology and Pharmacology (2022), 103883, database is CAplus and MEDLINE.

The global use of bisphenol S (BPS) has now been significantly increased for commensurate utilization as a substitute for BPA for its regulatory concerns. Though, previous reports indicated that BPS been also appeared as a toxic congener comparable to BPA. In the present study, we determined nephrotoxicity condition induced due to BPS exposure. Anal. indicated that BPS significantly promoted histopathol. disturbance in the kidney, and altered the levels of biomarkers of kidney damage in serum and urine samples of Wistar rats. It is also indicated that BPS altered the expression of kidney damage biomarkers associated with glomerular and tubular injury. Addnl., we determined the perturbation of kidney metabolites in the underlying pathophysiol. response of kidney injury due to BPS exposure. Gas chromatog.-mass spectrometry based untargeted metabolomics exhibited 20 significantly perturbed metabolites. Moreover, metabolic pathway anal. revealed significant disturbance in the TCA cycle and pyruvate metabolism pathways.

Environmental Toxicology and Pharmacology published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, Product Details of C12H10O4S.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Joshi, Suraj R. published the artcileConstruction, analysis and validation of co-expression network to understand stress adaptation in Deinococcus radiodurans R1, Related Products of alcohols-buliding-blocks, the publication is PLoS One (2020), 15(6), e0234721, database is CAplus and MEDLINE.

In the current study, we have performed system-level anal. for Deinococcus radiodurans R1 by constructing a gene co-expression network based on several microarray datasets available in the public domain. This condition-independent network was constructed by Weighted Gene Co-expression Network Anal. (WGCNA) with 61 microarray samples from 9 different exptl. conditions. We identified 13 co-expressed modules, of which, 11 showed functional enrichments of one or more pathway/s or biol. process. Comparative anal. of differentially expressed genes and proteins from radiation and desiccation stress studies with our co-expressed modules revealed the association of cyan with radiation response. We obtained 7 TFs for radiation and desiccation responsive modules. The expressions of 3 TFs were validated in response to gamma radiation using qRT-PCR. Along with the TFs, selected close neighbor genes of two important TFs, viz., DR_0997 (CRP) and DR_2287 (AsnC family transcriptional regulator) in the darkgreen module were also validated. In our network, among 13 hub genes associated with 13 modules, the functionality of 5 hub genes which are annotated as hypothetical proteins (hypothetical hub genes) in D. radiodurans genome has been revealed. Overall the study provided a better insight of pathways and regulators associated with relevant DNA damaging stress response in D. radiodurans.

PLoS One published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C9H21NO3, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Blaauwendraad, Sophia M. published the artcileAssociations of maternal urinary bisphenol and phthalate concentrations with offspring reproductive development, Synthetic Route of 80-09-1, the publication is Environmental Pollution (Oxford, United Kingdom) (2022), 119745, database is CAplus and MEDLINE.

Fetal exposure to bisphenols and phthalates may influence development of the reproductive system. In a population-based, prospective cohort study of 1059 mother-child pairs, we examined the associations of maternal gestational urinary bisphenols and phthalates concentrations with offspring reproductive development from infancy until 13 years. We measured urinary bisphenol and phthalate concentrations in each trimester. We obtained information on cryptorchidism or hypospadias after birth from medical records. At 9.7 years, we measured testicular and ovarian volume by MRI. At 13.5 years, we measured child Tanner stages and menstruation through questionnaire. We performed linear or logistic regression models for boys and girls to assess the associations of maternal urinary average and trimester-specific bisphenols and phthalates with child reproductive outcomes. Next, to further explore potential synergistic or additive effects of exposures together, we performed mixed exposure models using a quantile g computation approach. Models were adjusted for maternal age, ethnicity, body-mass index, education, parity, energy intake, smoking and alc. use, and childs gestational age at birth, birthweight and body-mass index. In boys, no associations of maternal gestational phthalate or bisphenol with offspring cryptorchidism and hypospadias were found. Higher maternal high-mol.-weight phthalate and total bisphenol, but not phthalic acid or low-mol.-weight phthalate, were associated with larger child testicular volume at 10 years. Higher maternal phthalic acid and total bisphenol were associated with earlier genital and pubic hair development at 13 years, resp. (p-values<0.05). In girls, we found no associations of maternal urinary bisphenol and phthalate with ovarian volume or menstrual age. Only higher maternal urinary high-mol.-weight phthalate was associated with earlier pubic hair development at 13 years (p-values <0.05). Higher mixture exposure was associated with earlier pubic hair development in both sexes. In conclusion, higher maternal gestational urinary bisphenol and phthalate concentrations were associated with alterations in offspring reproductive development, mainly in boys.

Environmental Pollution (Oxford, United Kingdom) published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, Synthetic Route of 80-09-1.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ge, Jun published the artcileSustained release of nucleic acids from polymeric nanoparticles using microemulsion precipitation in supercritical carbon dioxide, Related Products of alcohols-buliding-blocks, the publication is Chemical Communications (Cambridge, United Kingdom) (2010), 46(47), 9034-9036, database is CAplus and MEDLINE.

A general approach for producing biodegradable nanoparticles for sustained nucleic acid release is presented. The nanoparticles are produced by precipitating a water-in-oil microemulsion in supercritical CO₂. The microemulsion consists of a tRNA aqueous solution (water phase), dichloromethane containing poly(L-lactic acid)-poly(ethylene glycol) (oil phase), the surfactant n-octyl β-D-glucopyranoside, and the cosurfactant n-butanol.

Chemical Communications (Cambridge, United Kingdom) published new progress about 85618-21-9. 85618-21-9 belongs to alcohols-buliding-blocks, auxiliary class Tetrahydropyran,Chiral,sulfides,Alcohol, name is (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C14H28O5S, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Pestova, S. V. published the artcileSynthesis and membranoprotective properties of new disulfides with monoterpene and carbohydrate fragments, Computed Properties of 20880-92-6, the publication is Russian Chemical Bulletin (2015), 64(3), 723-731, database is CAplus.

A cooxidn. of carbohydrate and terpene thiols gives mixtures of disulfides containing 51-90% of the unsym. product. Membranoprotective and antioxidant properties of obtained unsym. and sym. disulfides were evaluated based on their ability to inhibit the H₂O₂-induced hemolysis of erythrocytes, as well as the accumulation of secondary products of the peroxy oxidation of lipids and the oxidation of Hb.

Russian Chemical Bulletin published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C12H20O6, Computed Properties of 20880-92-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Pestova, S. V. published the artcileSynthesis and membrane protective activity of bis-sulfides derived from monoterpenoids and monosaccharides, Product Details of C12H20O6, the publication is Russian Journal of Bioorganic Chemistry (2017), 43(3), 302-310, database is CAplus.

Hydroxyl- and chloroethyl derivatives of neomenthane- and isobornanethiol in yields of to 80% were synthesized. They served as the basis for the preparation of new bis-sulfides with diacetone-protected galacto- and fructopyranose fragments in yields up to 98%. The bis-sulfides synthesized were screened for membrane protective and antioxidant properties in a model cell system (in vitro) based on their ability to inhibit the H₂O₂-induced hemolysis of erythrocytes and retard the oxy-Hb oxidation

Russian Journal of Bioorganic Chemistry published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C12H20O6, Product Details of C12H20O6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Shibanuma, Tadao published the artcileSynthesis of optically active 2-(N-benzyl-N-methylamino)ethyl methyl 2,6-dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate (nicardipine), HPLC of Formula: 101-98-4, the publication is Chemical & Pharmaceutical Bulletin (1980), 28(9), 2809-12, database is CAplus and MEDLINE.

(+)- And (-)-nicardipine (I) were prepared from (-)- and (+)-1-ethoxymethyl-5-methoxycarbonyl-2,6-dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid (II). Resolution of II was carried out using cinchonidine and cinchonine. The vertebral vasodilating activity of (+)-I.HCl was about 3 times that of (-)-I.HCl.

Chemical & Pharmaceutical Bulletin published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C4H6BrFO2, HPLC of Formula: 101-98-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gazizov, Mukattis B. published the artcileSynthesis and properties of 4-(dibromomethyl)benzenecarbaldehyde, SDS of cas: 6346-09-4, the publication is Tetrahedron Letters (2016), 57(2), 210-212, database is CAplus.

The 4-(dibromomethyl)benzenecarbaldehyde was synthesized for the first time using a new method, which also allowed the co-preparation of terephthalic aldehyde. The reaction of this aldehyde with primary amines RNH₂ [R = CH(CH₃)₂, 4-OCH₃C₆H₄, CH₂CH(O(C₂H₅)₂), etc.] resulted in the formation of imines RN=CHC₆H₄CHBr₂, including those containing an addnl. acetal group, while the reaction with trialkyl orthoformates HC(OR¹)₃ (R¹ = Me, Et) led to the formation of acetals R¹O(OR¹)CHC₆H₄CHBr₂. The latter compounds were transformed into 4-(dibromomethyl)-substituted benzenes containing a phosphorus functional group in the side chain via consecutive reactions with phosphorus trichloride and the esters of P(III) acids.

Tetrahedron Letters published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, SDS of cas: 6346-09-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts