Author: tianli

Tang, Weihua published the artcileIncorporating Perylene Moiety into Poly(phenothiazine-co-bithiophene) Backbone for Higher Charge Transport, SDS of cas: 239075-02-6, the publication is Journal of Physical Chemistry B (2008), 112(12), 3590-3596, database is CAplus and MEDLINE.

Low band gap π-conjugated polymers composed of phenothiazine, bithiophene, and perylene moieties were prepared in high yields by palladium-catalyzed Suzuki coupling reaction. The polymers were characterized by NMR, gel permeation chromatog., and elemental anal. The characterizations revealed that high-mol. weight (weight-average mol. weight up to 42 400 g/mol) polymers were thermally stable with a decomposition temperature at 338-354° and glass transition temperature (T_g) 124-136°. All polymers demonstrated broad optical absorption in the region of 300-550 nm with efficient blue-green light emission. The absorption was broadened further (for ca. 50 nm) when the perylene moiety was incorporated. Cyclic voltammograms displayed that the p- and n-doping processes of all the polymers were partially reversible and that electrochem. band gaps were as low as -2.30 eV with the incorporation of a perylene moiety. The hole mobility of polymers was evaluated by using the space-charge-limited current model with a PLED device structure of ITO/PEDOT:PSS/polymer/Ca. The incorporation of perylene is beneficial for improving the hole mobility of the conjugated polymers.

Journal of Physical Chemistry B published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C8H7NaO4S, SDS of cas: 239075-02-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ren, Guilin published the artcileStudy of the volatilization rules of volatile oil and the sustained-release effect of volatile oil solidified by porous starch, Category: alcohols-buliding-blocks, the publication is Scientific Reports (2022), 12(1), 8153, database is CAplus and MEDLINE.

Volatile oil from traditional Chinese medicine has various biol. activities and has pharmacol. activities in the central nervous system, digestive system, cardiovascular system, respiratory system, etc. These oils are widely used in clin. practice. However, the development of their clin. applications is restricted due to the disadvantages of volatile oils, such as high stimulation, high volatility and poor stability. To improve the stability of a volatile oil in the preparation process, its volatilization and stable release must be controlled. In this paper, porous starch was used as a solid carrier material, and liquid volatile oil was solidified by phys. adsorption. GC-MS was used to determine the chem. constituents of the volatile oil, solidified powder and tablets, and the volatilization rules of 34 chem. constituents were analyzed statistically. The solidified volatile oil/porous starch powder was characterized by XRD, TGA and DSC, and the VOCs of the volatile oil before and after solidification were analyzed by portable GC-MS. Finally, the stable release of the volatile oil could be optimized by changing the porous starch ratio in the formulation. Volatilization was shown to be closely related to the peak retention time and chem. composition, which was consistent with the theory of flavor. The phys. properties and chem. composition of the volatile oil did not change after curing, indicating that the adsorption of the volatile oil by porous starch was phys. adsorption. In this paper, the porous starch-solidified volatile oil had a slow-release effect, and the production process is simple, easy to operate, and has high application value.

Scientific Reports published new progress about 106-25-2. 106-25-2 belongs to alcohols-buliding-blocks, auxiliary class Natural product, name is cis-3,7-Dimethyl-2,6-Octadien-1-Ol, and the molecular formula is C10H18O, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Erkan, Sultan published the artcileStructural, spectral characterization and molecular docking analyses of mer-ruthenium (II) complexes containing the bidentate chelating ligands, Name: (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, the publication is Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy (2020), 117399, database is CAplus and MEDLINE.

The authors analyzed some monofunctional Ru (II) complexes containing chlorine, bromine and fluorine atoms around the central atom. The best calculation level among HF, B3LYP and M062X methods for [Ru (Cl-Ph-tpy)(N-N)X]⁺ (X = F, Cl, Br) was determined in the light of Benchmark anal. and according to this anal. results, the best level is shown as B3LYP-LANL2DZ/6-31G(d). In addition to this, the spectroscopic data (IR, NMR and UV-visible) were also obtained in agreement with exptl. results. The tendency of anticancer activity and structural activity relation (SAR) parameters are predicted with some quantum chem. methods. Surface and contour diagrams, as well as electron densities on mentioned complexes were interpreted through theor. obtained results. Finally, the anticancer activity tendency of the relevant complexes on the human cervical carcinoma cell line (ID: 1 M17) is supported by mol. docking calculations

Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy published new progress about 85618-21-9. 85618-21-9 belongs to alcohols-buliding-blocks, auxiliary class Tetrahydropyran,Chiral,sulfides,Alcohol, name is (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C14H28O5S, Name: (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Hirayama, Ryoichi published the artcileThe autorecycling oxidation of benzylamine by synthetic 8-hydroxy-5-deazaflavin derivatives, SDS of cas: 14703-69-6, the publication is Journal of Heterocyclic Chemistry (1989), 26(5), 1255-9, database is CAplus.

8-Hydroxy-5-deazaflavin derivatives I [R = Me, Ph, R¹ = Me, Et, Bu, hexyl, octyl, dodecyl; R = Me, R¹ = (CH₂)_nCO₂H, n = 3, 5] were synthesized as model compounds of coenzyme F₄₂₀. I (R¹ = alkyl) oxidized PhCH₂NH₂ to PhCHO more efficiently than the 8-unsubstituted 5-deazaflavins. I [R¹ = (CH₂)_nCO₂H] showed little oxidizing ability.

Journal of Heterocyclic Chemistry published new progress about 14703-69-6. 14703-69-6 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Phenol, name is 3-(Methylamino)phenol, and the molecular formula is C7H9NO, SDS of cas: 14703-69-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Sakai, Toshinori published the artcileHemodynamic effects of the new dihydropyridine derivative, (±)-2-[benzyl(phenyl)amino]ethyl 1,4-dihydro-2,6-dimethyl-5-(5,5-dimethyl-2-oxo-1,3,2-dioxaphosphorinan-2-yl)-4-(3-nitrophenyl)-3-pyridinecarboxylate hydrochloride ethanol (NZ-105) in anesthetized dogs, SDS of cas: 111011-76-8, the publication is Oyo Yakuri (1991), 42(1), 43-54, database is CAplus.

The hemodynamic effects of NZ-105 (I) were compared with those of nicardipine in pentobarbital-anesthetized dogs. NZ-105 had a slow onset and prolonged duration of action in decreasing blood pressure. Doses of 10-100 μg/kg i.v. produced a dose-dependent fall in blood pressure but no significant increase in heart rate. The potency of NZ-105 on blood pressure was about half that of nicardipine. However, the duration of action of NZ-105 was longer while the extent of the fall was similar. A small dose of 10 μg/kg of NZ-105 i.v. produced a hypotensive effect, but a large dose of 300 μg/kg i.v. was required to cause prolongation of the P-Q interval in the ECG. In open-chest dogs, NZ-105 (10 and 30 μg/kg i.v.) tended to increase the central venous pressure and transiently increased the left ventricular end-diastolic pressure but produced no significant change in the maximal rate of rise of the left ventricular pressure. NZ-105 (10 and 30 μg/kg i.v.) increased the coronary sinus outflow but caused no significant change in myocardial oxygen consumption. These results suggest that NZ-105 may be a useful agent with a slow onset and long duration of action, vascular selectivity and minimal cardiac effect in the treatment of hypertension.

Oyo Yakuri published new progress about 111011-76-8. 111011-76-8 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Calcium Channel, name is 2-(Benzyl(phenyl)amino)ethyl 5-(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate ethanol hydrochloride, and the molecular formula is C36H45ClN3O8P, SDS of cas: 111011-76-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Abe, Masahiro published the artcileGold(I)-Catalyzed Heteroannulation of Salicylic Amides with Alkynes: Synthesis of 1,3-Benzoxazin-4-one Derivatives, Recommanded Product: 2-Hydroxy-4-(trifluoromethyl)benzoic acid, the publication is Organic Letters (2022), 24(31), 5684-5687, database is CAplus and MEDLINE.

Gold(I)-catalyzed heteroannulation affords the efficient and straightforward construction of heterocyclic compounds Herein, a gold(I)-catalyzed heteroannulation of salicylic amides with alkynes producing a broad range of 1,3-benzoxazin-4-ones is reported. The utility of this protocol was highlighted by synthesizing variously substituted benzoxazinones containing quaternary carbon centers, showing a high functional group tolerance and excellent atom economy of the thus introduced reaction course.

Organic Letters published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, Recommanded Product: 2-Hydroxy-4-(trifluoromethyl)benzoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Sakurai, Shuhei published the artcileStructure-antioxidant activity (oxygen radical absorbance capacity) relationships of phenolic compounds, Name: 3-Hydroxyphenylacetic acid, the publication is Structural Chemistry (2022), 33(4), 1055-1062, database is CAplus.

Antioxidant capacity is the extent to which a compound can eliminate reactive oxygen species, and in vitro methods for its chem. evaluation have been proposed. Among these methods, the oxygen radical absorbance capacity (ORAC) assay comes close to the oxidation reaction in the living body because it generates radical species that mimic the lipid peroxyl radical involved in the peroxidation reaction of biol. components and react in a phosphate buffer. In this study, PM7, a semi-empirical MO method, was used to calculate the thermodn. properties (bond dissociation enthalpy, ionisation potential and proton affinity) associated with ORAC. We also applied the clusterwise linear regression anal. as a statistical method for grouping the antioxidants by structure. By analyzing the data for antioxidants, the trend in the hydrophilic ORAC values was determined using the calculated structures and bond dissociation enthalpies of the groups classified according to the presence or absence of oxygen functional groups in the ortho position of phenol. Further studies of indicators other than bond dissociation enthalpy are needed to predict the ORAC of other antioxidants such as flavonoids and indoles.

Structural Chemistry published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C8H8O3, Name: 3-Hydroxyphenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Umezawa, Toshiaki published the artcileAromatic ring cleavage of various β-O-4 lignin model dimers by Phanerochaete chrysosporium, Quality Control of 70110-65-5, the publication is Wood Research (1986), 8-17, database is CAplus.

In the degradation of β-O-4 lignin model dimers with different aromatic substituents on β-etherated aromatic ring by intact cells of P. chrysosporium, esters of arylglycerol, cyclic carbonates, formate and Me oxalate, were formed as aromatic ring cleavage products of the models. Substituents of aromatic nuclei considerably influenced the formation of aromatic ring cleavage products and O-C₄ cleavage product, arylglycerol.

Wood Research published new progress about 70110-65-5. 70110-65-5 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Alcohol,Ether,Benzene Compounds, name is 2-Phenoxy-1-phenylpropane-1,3-diol, and the molecular formula is C9H7F3O3, Quality Control of 70110-65-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Afanasenko, Anastasiia published the artcileA One-Pot Approach for Bio-Based Arylamines via a Combined Photooxidative Dearomatization-Rearomatization Strategy, Quality Control of 645-56-7, the publication is Chemistry – A European Journal (2022), 28(34), e202200309, database is CAplus and MEDLINE.

The synthesis of arylamines from renewable resources under mild reaction conditions is highly desired for the sustainability of the chem. industry, where the production of hazardous waste is a prime concern. However, to date, there are very few tools in chemists’ toolboxes that are able to produce arylamines in a sustainable manner. Herein, a robust one-pot approach for constructing bio-based arylamines via a combined photooxidative dearomatization-rearomatization strategy is presented. The developed methodol. enables the synthesis of structurally complex amines in moderate-to-good isolated yields using biomass-derived phenols, natural α-amino acids, and naphthols under remarkably mild reaction conditions. For the photooxygenation of phenols, a novel chrysazine-based catalyst system was introduced, demonstrating its efficiency for the synthesis of natural products – hallerone, rengyolone, and the pharmaceutically relevant prodrug DHED (10β-hydroxy-17β-hydroxyestra-1,4-dien-3-one).

Chemistry – A European Journal published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C9H12O, Quality Control of 645-56-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chandra, S. published the artcileDevelopment of sustained release matrix tablet formulation and evaluation of ambroxol hydrochloride, Related Products of alcohols-buliding-blocks, the publication is World Journal of Pharmaceutical Research (2020), 9(3), 295-308, database is CAplus.

A review. Ambroxyl is a Mucolytic expectorant. Ambroxyl has short half life (3- 4hrs) makes the development of sustained release forms extremely advantageous, Ambroxyl is a weak acidic pka 4.5 – 6, it has pH dependent solubility, characterized in low pH condition present in stomach, Which consequently delayed in onset of action, Formulation of SR tablet is effective approach for mucolytic expectorant it gives maximum action with prolong drug concentration due to sustained release from tablet matrix. Different formulation (F1 – F7) designed with HPMC K100, HPMC 5CPS, Povidone K30, MCCP. pre and post -compression parameters for all formulation were studied. Batch F7 selected as optimized batch on the basis of dissolution profile.

World Journal of Pharmaceutical Research published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts