Author: tianli

Gazizov, A. S. published the artcileSynthesis of new polyphenols containing sym-triazine fragment, SDS of cas: 6346-09-4, the publication is Russian Journal of General Chemistry (2016), 86(3), 761-763, database is CAplus.

Synthesis of 2-[4,4-bis(3-methyl-2,4-dihydroxyphenyl)alkylamino]-4,6-dimorpholino-1,3,5-trazines by the condensation of a sym-triazine acetals and 2-methylresocinol and the effect of the length of the methylene spacer between the acetal group and sym-triazine moiety on the reaction were presented.

Russian Journal of General Chemistry published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, SDS of cas: 6346-09-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Khan, Atta Ullah published the artcileIron-doped zinc oxide nanoparticles-triggered elicitation of important phenolic compounds in cell cultures of Fagonia indica, Product Details of C8H8O3, the publication is Plant Cell, Tissue and Organ Culture (2021), 147(2), 287-296, database is CAplus and MEDLINE.

The callus cultures of Fagonia indica could prove as factories for the production of important phytochems. when triggered through different types of stress. In this study, we initiated callus cultures from healthy stem explants in the presence of iron-doped zinc oxide nanoparticles (Fe-ZnO-NPs). We performed experiments with the callus cultures of F. indica to determine the impact of Fe-ZnO-NPs in concentrations (15.62-250μg/mL) on biomass accumulation, production of important phenolic and flavonoids, and antioxidative potential. Our results showed that maximum callus biomass [Fresh weight (FW) = 13.6 g and Dry weight (DW) = 0.58 ± 0.01] was produced on day 40 when the media was supplemented with 250μg/mL Fe-ZnO-NPs. Similarly, maximum total phenolic content (268.36μg GAE/g of DW) was observed in 40 days old callus added with 125μg/mL Fe-ZnO-NPs. Maximum total flavonoid content (78.56μg QE/g of DW) was recorded in 20 days old callus grown in 62.5μg/mL Fe-ZnO-NPs containing media. Maximum total antioxidant capacity (390.74μg AAE/g of DW) was recorded in 40 days old callus with 125μg/mL Fe-ZnO-NPs treated cultures, resp. Similarly, the highest free radical scavenging activity (93.02%) was observed in callus derived from media having 15.62μg/mL Fe-ZnO-NPs. The antioxidant potential was observed to have pos. correlation with TPC (r = 0.44). HPLC anal. showed that Fe-ZnO-NPs produced compounds (e.g., Epigallocatechin gallate) that were either absent or in lesser quantities in the control group. These results showed that Fe-ZnO-NPs elicitors could increase the biomass and activate secondary metabolism in F. indica cells.

Plant Cell, Tissue and Organ Culture published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, Product Details of C8H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ali, Barkat published the artcileImpact of Soy-Cow’s mixed milk enzyme modified cheese on bread aroma, Synthetic Route of 111-29-5, the publication is LWT–Food Science and Technology (2022), 112793, database is CAplus.

The effect of spray-dried Soy-Cow’s mixed milk enzyme modified (SC-EM) cheese on wheat dough properties and bread aroma was evaluated at either 0.1, 0.5, 1.0, 1.5 or 2.0% (weight/weight). Significant accumulation of amino acids and peptides of dough were noted as SC-EM cheese levels increased. After baking a total of 118 volatile compounds (VCs) were identified in breads having aldehydes, alcs., esters and acids in major proportions. Higher contents of Maillard product 3-hydroxy-2-butanone, 2-methyl-1-propanol, phenylethyl alc., undecane, L-limonene, 2-pentyl furan and lipid oxidation compounds hexanoic acid Et ester, octanoic acid Et ester, decanoic acid Et ester, butanoic acid, hexanoic acid and octanoic acid were observed Isoamyl alc., lactic acid Et ester, Et sorbate and sorbic acid were the newly identified VCs. These results revealed that SC-EM cheese could be used as improver in dough and contribution to bread aroma. Thus, SC-EM cheese has been proposed to be included in fortified bakery products.

LWT–Food Science and Technology published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C5H12O2, Synthetic Route of 111-29-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Habibi, Azadeh Ebrahim published the artcileThermostabilization of Bacillus amyloliquefaciens α-amylase by chemical crosslinking, Recommanded Product: Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, the publication is Journal of Biotechnology (2006), 123(4), 434-442, database is CAplus and MEDLINE.

Chem. crosslinking of a mesophilic α-amylase from Bacillus amyloliquefaciens (BAA) was carried out. Intramol. crosslinks between Lys residues upon treatment of the enzyme with ethylene glycol bis(succinic acid N-hydroxy succinimide ester) resulted in enhancement of thermostability as indicated by irreversible thermoinactivation experiments Enhancement of thermostability coincided with a dramatic protection against aggregation, combined with a decrease in surface hydrophobicity. Deamidation, another important mechanism of irreversible thermoinactivation, was also diminished upon modification. While no significant changes in the kinetic parameters were evident, rigidification of the protein structure was suggested by CD and fluorescence studies.

Journal of Biotechnology published new progress about 70539-42-3. 70539-42-3 belongs to alcohols-buliding-blocks, auxiliary class pyrrolidine,Ester,Amide,Inhibitor,Inhibitor, name is Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, and the molecular formula is C18H20N2O12, Recommanded Product: Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gazizov, Mukattis B. published the artcileO, o-Dialkyl-S-(1,1-dimethyl-2-oxoethyl)dithiophosphates: Synthesis and Reactions with N-Nucleophiles, Category: alcohols-buliding-blocks, the publication is Heteroatom Chemistry (2015), 26(6), 436-440, database is CAplus.

Hydrolysis of the new types of iminium salts was used to synthesize O,O-dialkyl-S-(1,1-dimethyl-2-oxoethyl)dithiophosphates or 2-dialkoxythiophosphorylthio-substituted aldehydes with C isochain. Reactions of aldehydes with N-, N,N-, and O,N-nucleophiles gave new phosphorylated imines containing an acetal group at different positions, perhydro-1,3-diazol and oxazol with the diisopropoxythiophosphorylthio group in a side chain, and hydrazone of this aldehyde and diphenylphosphinylacetic acid hydrazide.

Heteroatom Chemistry published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ahmad, Sufiyan published the artcileQuality by design approach to develop stability indicating reversed-phase high-performance liquid chromatography method development for ambroxol, Quality Control of 23828-92-4, the publication is Asian Journal of Pharmaceutical and Clinical Research (2021), 14(12), 44-49, database is CAplus.

As per requisition of current regulatory requirements, simple, rapid and sensitive method by 33 factorial quality by design approach was established and validated for Ambroxol (AMB) by reversed-phase high-performance liquid chromatog. (RP-HPLC). A simple RP-HPLC method has been developed and validated with different parameters such as linearity, precision, repeatability, limit of detection (LOD), limit of quantitation (LOQ), accuracy as per International Conference for Harmonisation guidelines (Q2R1). Statistical data anal. was done for data obtained from different aliquots Runs on Agilent Tech. Gradient System with Auto injector, UV diode-array detection and Gradient Detector. Equipped with Reverse Phase (Agilent) C18 column (4.6 mm x 100 mm; 2.5μm), a 20μl injection loop and UV730D Absorbance detector at 244 nm wave length and running chemstation 10.1 software and drugs along with degradants were separated via Methanol: (0.1% orthophosphoric acid) Water (75:25) of pH 3 as mobile phase setting flow rate 0.7 mL/min at ambient temperature the retention time of AMB were found to be 4.85 min. The industrialized method was found linear over the concentration range of 10-50μg/mL for AMB while the LOD and LOQ of AMB was found to be 0.5174-0.2739μg/mL, anal. method that concluded. There are no interfering peaks underperformed degradation conditions. Therefore, a sensitive, robust, accurate, and stability indicating method was developed with high degree of practical utility.

Asian Journal of Pharmaceutical and Clinical Research published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Quality Control of 23828-92-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kennedy, Sean published the artcileSuperacid-promoted synthesis of indolizidine derivatives, Recommanded Product: 4,4-Diethoxybutan-1-amine, the publication is Tetrahedron Letters (2018), 59(20), 1932-1935, database is CAplus.

A series of amido-acetals were reacted with the Bronsted superacid, CF₃SO₃H, to provides indolizidine derives by a cyclization cascade. A mechanism is proposed involving formation of a vinylogous enol which undergoes a 6π-electrocyclization reaction with an adjacent N-acyl iminium ion group. With aryl substituents, there is a strong tendency for the N-acyl iminium ion group to undergo Friedel-Crafts type cyclizations with the aryl group. The synthetic methodol. was used to prepare the alkaloid natural product, ipalbidine.

Tetrahedron Letters published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, Recommanded Product: 4,4-Diethoxybutan-1-amine.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Guo, Chuangxing published the artcileDiscovery of 3-aryloxy-lactam analogs as potent androgen receptor full antagonists for treating castration resistant prostate cancer, COA of Formula: C4H9BrO, the publication is Bioorganic & Medicinal Chemistry Letters (2012), 22(2), 1230-1236, database is CAplus and MEDLINE.

High throughput cell-based screening led to the identification of 3-aryloxy lactams as potent androgen receptor (AR) antagonists. Refinement of these leads to improve the ADME profile and remove residual agonism led to the discovery of 12, a potent full antagonist with greater oral bioavailability. Improvements in the ADME profile were realized by designing more ligand-efficient mols. with reduced mol. weights and lower lipophilicities.

Bioorganic & Medicinal Chemistry Letters published new progress about 55376-31-3. 55376-31-3 belongs to alcohols-buliding-blocks, auxiliary class Polymerization Reagents,ATRP Initiators, name is 2-Bromo-2-methylpropan-1-ol, and the molecular formula is C4H9BrO, COA of Formula: C4H9BrO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bernhardt, Annika published the artcileThe Strong β-CF₃ Shielding Effect in Hexafluoroisopropanol and 100 Other Organic Solvents Revisited with ¹⁷O NMR Spectroscopy, Related Products of alcohols-buliding-blocks, the publication is ChemCatChem (2018), 10(7), 1547-1551, database is CAplus and MEDLINE.

An ¹⁷O NMR spectroscopy survey of more than 100 ubiquitous organic solvents and compounds, including some typical oxofluorinated solvents such as hexafluoroisopropanol, trifluoroethanol, trifluoroacetic acid, and others, is presented with D₂O as a reference A strong alternating α,β-CF₃-substituent chem. shift effect was thus observed This alternating deshielding-shielding effect is suspected to have a role in the exceptional properties of these oxofluorinated solvents, notably in oxidative cross-coupling reactions.

ChemCatChem published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Boehme, Thomas M. published the artcileStructure-Activity Relationships of Dimethindene Derivatives as New M₂-Selective Muscarinic Receptor Antagonists, Quality Control of 101-98-4, the publication is Journal of Medicinal Chemistry (2003), 46(5), 856-867, database is CAplus and MEDLINE.

2,3-Disubstituted indenes, such as I [R = (Me₂CH)₂N, (FCH₂CH₂)MeN; n = 2], analogs of the widely used histamine H₁ receptor antagonist dimethindene, are prepared as potential M₂-selective muscarinic receptor antagonists. (-)-I [R = (Me₂CH)₂N; n = 2] has comparable affinity for M₂ receptors to (S)-dimethindene with 5-275-fold selectivities for the M₂ muscarinic receptor over other muscarinic receptor subtypes and over histamine H₁ receptors. I [R = (FCH₂CH₂)MeN; n = 2] also has high affinity for the muscarinic M₂ receptor and is selective for the M₂ receptor over other muscarinic receptors but possesses high affinity for histamine H₁ receptors. I (R = Me₂N; n = 1) has the highest affinity of the tested indenes for M₂ muscarinic receptors but low selectivity for M₂ muscarinic receptors over other muscarinic receptor subtypes.

Journal of Medicinal Chemistry published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Quality Control of 101-98-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts