Author: tianli

Neumeyer, Markus published the artcileControlling the Substitution Pattern of Hexasubstituted Naphthalenes by Aryne/Siloxyfuran Diels-Alder Additions: Regio- and Stereocontrolled Synthesis of Arizonin C1 Analogs, HPLC of Formula: 17877-23-5, the publication is European Journal of Organic Chemistry (2017), 2017(20), 2883-2915, database is CAplus.

3,4-Dimethoxybenz-1-yne and 2-siloxylated furans without or with a bromine atom at C-3 undergo Diels-Alder reactions with orientational selectivity. Hydrolysis furnished a bromine-free or a bromine-containing naphthalene, resp. Bromination of the former provided a regioisomer of the latter. Either of the two compounds was processed to give a variety of unnatural naphthoquinonopyrano-γ-lactones. This occurred by a succession of (1) Heck coupling, (2) asym. dihydroxylation, (3) oxa-Pictet-Spengler cyclization, and (4) oxidation The fifteen monomeric naphthoquinonopyrano-γ-lactone structures that we prepared resemble the natural product (-)-arizonin C1 (I) or its C-5 epimer. Accordingly, they represent hexasubstituted naphthalenes likewise. The sixteenth naphthoquinonopyrano-γ-lactone that we synthesized is a kind of dimer. Its moieties are bridged differently than those in naturally occurring naphthoquinonopyrano-γ-lactone dimers.

European Journal of Organic Chemistry published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, HPLC of Formula: 17877-23-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Verevkin, Sergey P. published the artcileSustainable hydrogen storage: Thermochemistry of amino-alcohols as seminal liquid organic hydrogen carriers, COA of Formula: C4H11NO, the publication is Journal of Chemical Thermodynamics (2021), 106591, database is CAplus.

Amino-alcs. are considered for sustainable hydrogen storage systems based on catalytic peptide formation. Exptl. and theor. thermochem. studies of amino-alcs. have been performed, including vapor pressure measurements, combustion calorimetry, and quantum-chem. calculations The standard molar enthalpies of vaporization of amino-alcs. were calculated from the temperature dependence of the vapor pressures measured by the transpiration method. Energies of combustion for six amino-alcs. were measured using the high-precision combustion calorimetry. The available in the literature primary data on vapor pressures, enthalpies of vaporization, and enthalpies of formation of amino-alcs. were collected and evaluated. The exptl. standard molar gas-phase enthalpies of formation of amino-alcs. were derived from the evaluated results. The high-level G3B3, G3MP2, and G4 quantum-chem. methods were used to establish consistency of the exptl. and theor. results. The surprisingly low enthalpy of reaction of the reversible dehydrogenation of 2-amino-ethanol, calculated from the exptl. data, makes this liquid organic hydrogen carrier system (LOHC) promising for further optimization and development.

Journal of Chemical Thermodynamics published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C15H16O3, COA of Formula: C4H11NO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

van Dyck, Jeroen F. published the artcileNative mass spectrometry for the characterization of structure and interactions of membrane proteins, SDS of cas: 85618-21-9, the publication is Methods in Molecular Biology (New York, NY, United States) (2017), 205-232, database is CAplus and MEDLINE.

Over the past years, native mass spectrometry and ion mobility have grown into techniques that are widely applicable to the study of aspects of protein structure. More recently, it has become apparent that this approach provides a very promising avenue for the investigation of integral membrane proteins in lipid or detergent environments. In this chapter, we discuss applications of native mass spectrometry and ion mobility in membrane protein research-what is important to take into consideration when working with membrane proteins, and what the requirements are for sample preparation for native mass spectrometry. Furthermore, we will discuss the types of information provided by the measurements, including the oligomeric state, subunit composition and stoichiometry, interactions with detergents or lipids, conformational transitions, and the binding and structural effect of ligands and drugs.

Methods in Molecular Biology (New York, NY, United States) published new progress about 85618-21-9. 85618-21-9 belongs to alcohols-buliding-blocks, auxiliary class Tetrahydropyran,Chiral,sulfides,Alcohol, name is (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C5H10O2S, SDS of cas: 85618-21-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Rakhmatullina, L. Kh. published the artcileSynthesis of 2-pentanol, Category: alcohols-buliding-blocks, the publication is Khimiko-Farmatsevticheskii Zhurnal (1989), 23(3), 321-6, database is CAplus.

A review with 8 references including the following methods of 2-pentanol synthesis: (1) hydration of methylenecyclobutane, followed by hydrogenolysis of the 1-methylcyclobutanol obtained, (2) hydrogenolysis of 2-methylfuran along with hydrogenation of the 2-pentanone (I) formed, and (3) condensation of PrCO₂H with acetone, followed by hydrogenation of the I obtained.

Khimiko-Farmatsevticheskii Zhurnal published new progress about 20117-47-9. 20117-47-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic cyclic hydrocarbon,Alcohol, name is 1-Methylcyclobutan-1-ol, and the molecular formula is C5H10O, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kadnikova, O. Yu. published the artcileSynthesis and structures of tris(2-hydroxypropyl)amine complexes with Ni^II, Zn^II, Cu^II, and Co^II salts of biologically active carboxylic acids, Recommanded Product: Triisopropanolamine, the publication is Russian Chemical Bulletin (2020), 69(5), 958-964, database is CAplus.

New trimethylhydrometallatranes, tris(2-hydroxypropyl)amine complexes with Ni^II, Zn^II, Cu^II, and Co^II salts of biol. active carboxylic acids (benzoic, cinnamic, salicylic, succinic), were synthesized. The structure of the tris(2-hydroxypropyl)amine complex with nickel(II) cinnamate was determined by single-crystal x-ray diffraction. Thermal stability of the synthesized tris(2-hydroxypropyl)amine complexes was compared with that of tris(2-hydroxyethyl)- amine complexes. Zinc(II) benzoate, zinc(II) cinnamate, copper(II) cinnamate, copper(II) salicylate, copper(II) succinate, nickel(II) cinnamate, nickel(II) benzoate, cobalt(II) cinnamate, cobalt(II) succinate, and cobalt(II) chloride.

Russian Chemical Bulletin published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C9H21NO3, Recommanded Product: Triisopropanolamine.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Malviya, Yogendra published the artcileFormulation development and evaluation of gastroretentive floating tablets of ambroxol hydrochloride, Formula: C13H19Br2ClN2O, the publication is Journal of Drug Delivery and Therapeutics (2019), 9(4Suppl.), 1016-1021, database is CAplus.

The present study is focused on the development of gastroretentive floating drug delivery system of ambroxol hydrochloride, which acts as a mucolytic agent that is reported to be useful in gastric neoplasms which are designed to increase the gastric residence time, thus prolonging the drug release in the stomach. Gastro retentive floating tablets of ambroxol hydrochloride were prepared by direct compression method using altered concentrations of HPMC K4, HPMC K15 and PVP K30 as polymers. Sodium bicarbonate and citric acid was used as gas releasing agent. The prepared tablets of ambroxol hydrochloride were evaluated for hardness, thickness, friability, weight variation, drug content uniformity, buoyancy lag time, total floating time, in-vitro dissolution study, etc. All the compositions were resulted in adequate Pharmacopoeial limits. Compatibility studies was execution during FTIR shown that there was absence of probable chem. interaction between pure drug and excipients. The varying concentration of gas generating agent and polymers was found to affect on in-vitro drug release and floating lag time. In vitro drug release of floating gastro retentive tablet of ambroxol hydrochloride shown that the formulation F6 was found to be the best formulation as it releases 99.87% in a controlled manner for an extended period of time (up to 12 h). The release data was fitted to various math. models such as Higuchi, Korsmeyer-Peppas, First order and Zero order to evaluate the kinetics and mechanism of the drug release. The optimized formulation (F6) showed no significant change in phys. parameters such as, hardness, friability, weight variation and %drug content for accelerated stability condition at 40±2°C temperature and 75±5% relative humidity for a period 3 mo. Prepared floating tablets of ambroxol hydrochloride may prove to be a potential candidate for safe and effective controlled drug delivery over an extended period of time for gastro retentive drug delivery system.

Journal of Drug Delivery and Therapeutics published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Formula: C13H19Br2ClN2O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Janak, J. published the artcileSeparation and analysis of dihydric phenols by gas chromatography, Recommanded Product: 4-(2,4,4-Trimethylpentan-2-yl)benzene-1,2-diol, the publication is Collection of Czechoslovak Chemical Communications (1959), 1960-6, database is CAplus.

Specific elution volumes (chromatographic spectra) of some dihydric phenols (pyrocatechol, 3-methyl-, 4-methyl-, 4-ethyl-, 4-tert-butyl-, 4-tert-octyl-, 3,4-dimethyl-, 3,5-dimethyl-, 4,5-dimethyl-, 3,5-di-tert-butylpyrocatechol, resorcinol, 4-ethylresorcinol, quinol, and ethylquinol) were determined on nonpolar (dimethyl polysiloxane) or (better) on polar stationary phases (mannitol at temperature 170-90°, dulcitol at 200°, inositol at 230-45°, and galactonic acid lactone at 190°). As the carrier, Celite C 545 was used. The relation between chem. structure of the (substituted) dihydric phenol and chromatographic behavior is discussed on the basis of the interaction with the stationary phase (H bonding). The method was applied for the analysis of raw pyrocatechol from Northern Bohemia brown coal tar used in the manufacture of tanning materials.

Collection of Czechoslovak Chemical Communications published new progress about 1139-46-4. 1139-46-4 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Phenol, name is 4-(2,4,4-Trimethylpentan-2-yl)benzene-1,2-diol, and the molecular formula is C14H22O2, Recommanded Product: 4-(2,4,4-Trimethylpentan-2-yl)benzene-1,2-diol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Jing published the artcileEnantioselective synthesis of an octahydroindolizine (indolizidine) alcohol using an enzymatic resolution, Synthetic Route of 6346-09-4, the publication is Organic & Biomolecular Chemistry (2017), 15(14), 2953-2961, database is CAplus and MEDLINE.

A homo-chiral synthesis of (7R,8aS)-octahydro-5,5-dimethylindolizin-7-amine 8 and (7S, 8aS)-octahydro-5,5-dimethylindolizin-7-ol 9, amine building blocks which have found applications within the pharmaceutical industry, is presented. The approach uses a Novozym 435-mediated kinetic resolution of racemic octahydroindolizine (indolizidine) alc. 13 as a key step (up to 100 g scale).

Organic & Biomolecular Chemistry published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H5F3O2S, Synthetic Route of 6346-09-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Grabosch, Carsten published the artcileGlycoarrays by a New Tandem Noncovalent-Covalent Modification of Polystyrene Microtiter Plates and their Interrogation with Live Cells, Recommanded Product: (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol, the publication is ChemBioChem (2012), 13(13), 1874-1879, S1874/1-S1874/18, database is CAplus and MEDLINE.

Thiourea bridging was used for fabrication of glycoarrays on polystyrene microtiter plates, to allow assaying of carbohydrate recognition in a optimally easy and flexible way. For the noncovalent modification of polystyrene microtiter plates, dodecylamine and dodecyl isothiocyanate were selected. This first immobilization step was followed by thiourea bridging with a suitable carbohydrate derivative and subsequent carbohydrate-specific read out. For the testing system, mannose-specific bacterial adhesion was employed with green fluorescent protein (GFP)-tagged Escherichia coli bacteria (pPKLl 162). A selection of inhibitors of type 1 fimbriae-mediated bacterial adhesion was used. Tandem noncovalent-covalent modification of polystyrene microtiter plates led to stable glycoarrays that yield valuable and valid data in adhesion inhibition tests with live bacterial cells. Nonspecific adhesion to polystyrene is excluded in this protocol. In addition to polystyrene plates, polypropylene (PP) microtiter plates were tested by the same approach and showed results that were in good accordance with the assays on analogously modified polystyrene plates.

ChemBioChem published new progress about 96345-79-8. 96345-79-8 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Gal and Man, name is (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C13H15NO6S, Recommanded Product: (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gangireddy, Ramana published the artcileDesign and evaluation of gastroretentive floating matrix tablets of ambroxol hydrochloride, COA of Formula: C13H19Br2ClN2O, the publication is International Journal of Pharmacy and Biological Sciences (2019), 9(2), 1386-1396, database is CAplus.

Gastro retentive drug delivery is a special approach which remains in the gastric region for a prolonged period to increase gastric residence time and also have the advantage of site-specific drug delivery especially in the upper gastrointestinal tract (GIT) for local or systemic effects. Ambroxol hydrochloride is a systemically active mucolytic agent with a half-life of 3-4 h. It acts by breakdown of acid muco polysaccharide fibers which make the sputum thinner and less viscous as long as treatment is maintained and therefore more easily sputum was removed by coughing. The main aim of the present work is to develop the oral controlled release floating matrix tablets of Ambroxol hydrochloride by direct compression method, using various hydrophilic polymers such as HPMCK100M, Carbopol971P, Polyethylene oxide. FT-IR studies revealed that there was no incompatibility between the drug and polymers used. All the formulations remained buoyant without any disintegration. The formulations F4, F9, F15 have shown the extended drug release close to that of marketed formulation for a period of 12 h. To ascertain the mechanism of drug release in-vitro data was fitted into various release kinetic models like zero order, first order, Higuchi and Peppas. The values indicated the non-fickian diffusion with slow erosion of polymer matrix followed by drug diffusion and resulted in linear drug release profile over a prolonged period of time.

International Journal of Pharmacy and Biological Sciences published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, COA of Formula: C13H19Br2ClN2O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts