Author: tianli

Pieckowski, Michal published the artcileCombination of large volume sample stacking with polarity switching and cyclodextrin electrokinetic chromatography (LVSS-PS-CDEKC) for the determination of selected preservatives in pharmaceuticals, Recommanded Product: trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, the publication is Talanta (2020), 120673, database is CAplus and MEDLINE.

In this study, a large volume sample stacking (LVSS) with polarity switching (PS) and cyclodextrin electrokinetic chromatog. (CDEKC) method has been developed for the simultaneous separation and determination of 8 preservatives: methylparaben (MP), ethylparaben (EP), propylparaben (PP), butylparaben (BP), isobutylparaben (IBP), sorbic acid (SA), benzoic acid (BA), p-hydroxybenzoic acid (PHBA) in pharmaceuticals. The effects of some typical parameters such as sample volume, applied voltage, composition and pH of the running buffer and organic modifier concentration were examined and optimized. Moreover, the impact of type and concentration of cyclodextrin as electrolyte modifiers was also investigated. The detection limits of analytes for the elaborated LVSS-PS-CDEKC method were found to be in 0.8-5 ng mL^-1 range, which were around 500 times lower than normal CDEKC without preconcentration technique. All analytes were completely resolved in less than 11 min in an uncoated fused-silica capillary of 75μm internal diameter (I.D) x 50 cm length. The electrophoretic separation was performed in a 2 mM α-cyclodextrin and 25 mM tetraborate system (pH = 9.3) with an applied voltage of 25 kV. The established method was validated and confirmed to be applicable for the determination of the preservatives in a quality control of pharmaceuticals.

Talanta published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Recommanded Product: trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ulaszewska, Maria M. published the artcileTwo apples a day modulate human:microbiome co-metabolic processing of polyphenols, tyrosine and tryptophan., Synthetic Route of 621-37-4, the publication is European Journal of Nutrition (2020), 59(8), 3691-3714, database is CAplus and MEDLINE.

Methods: Using an untargeted metabolomics approach, we aimed to identify biomarkers of long-term apple intake and explore how apples impact on the human plasma and urine metabolite profiles. Forty mildly hypercholesterolemic volunteers consumed two whole apples or a sugar and energy-matched control beverage, daily for 8 wk in a randomized, controlled, crossover intervention study. The metabolome in plasma and urine samples was analyzed via untargeted metabolomics. Results: We found 61 urine and 9 plasma metabolites being statistically significant after the whole apple intake compared to the control beverage, including several polyphenol metabolites that could be used as BFIs. Furthermore, we identified several endogenous indole and phenylacetyl-glutamine microbial metabolites significantly increasing in urine after apple consumption. The multiomic dataset allowed exploration of the correlations between metabolites modulated significantly by the dietary intervention and fecal microbiota species at genus level, showing interesting interactions between Granulicatella genus and phenyl-acetic acid metabolites. Phloretin glucuronide and phloretin glucuronide sulfate appeared promising biomarkers of apple intake; however, robustness, reliability and stability data are needed for full BFI validation. Conclusion: The identified apple BFIs can be used in future studies to assess compliance and to explore their health effects after apple intake.

European Journal of Nutrition published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C8H8BFO2, Synthetic Route of 621-37-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Arla, Rambabu published the artcileDevelopment and validation of stability-indicating gas chromatography method for the quantitative determination of ethylhexylglycerin and its impurities in bulk and pharmaceutical dosage forms, Synthetic Route of 70445-33-9, the publication is Asian Journal of Pharmaceutics (2018), 12(1Suppl.), S243-S250, database is CAplus.

A stability-indicating gas chromatog. flame ionization detection (FID) method for the quant. determination of ethylhexylglycerin (EHG) and its impurities in drug substance and drug product has been developed and validated. The developed method was also applied to related substances identification in the bulk sample. The chromatog. separation was performed on a fused silica capillary (DB-1, 30 m, 0.32 mm, and 0.25μm film thickness) column, and with a gradient technique. The column oven was programmed as follows: Initial column oven temperature, 60°C; ramped linearly to 280°C at the rate of 8°C/min; hold for 10 min. The runtime of anal. was 30 min. The injector and detector temperature was kept at 240°C and 260°C, resp. Nitrogen was used as a carrier gas with a constant flow rate of 2 mL/min. The split ratio was set at 20: Results and Discussion: The developed method was validated as per the ICH guidelines. The stability-indicating nature of the method has been proved by establishing peak purity and confirming the mass balance of all samples by subjecting them to stress conditions such as hydrolysis, oxidation, photolysis, and thermal degradation studies. The method was successfully applied to anal. of different bulk sample of EHG and its impurities. The proposed gas chromatog. coupled with FID method was also found to be specific and selective for the anal. of com. formulation samples.

Asian Journal of Pharmaceutics published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C11H24O3, Synthetic Route of 70445-33-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chatzopoulou, Maria published the artcileClauson-Kaas-type synthesis of pyrrolyl-phenols, from the hydrochlorides of aminophenols, in the presence of nicotinamide, Recommanded Product: 4-(1H-Pyrrol-1-yl)phenol, the publication is Synthetic Communications (2013), 43(21), 2949-2954, database is CAplus.

A facile Clauson-Kaas-type pyrrolyl-phenol synthesis was achieved in the presence of nicotinamide, which is inexpensive and nontoxic. The starting material is aminophenol hydrochloride. This is advantageous in certain cases because it is the only isolable form of the corresponding aminophenol.

Synthetic Communications published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, Recommanded Product: 4-(1H-Pyrrol-1-yl)phenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Stavber, Stojan published the artcileNew, mild method for direct introduction of a fluorine atom into aromatic molecules, Synthetic Route of 596-38-3, the publication is Journal of the Chemical Society, Chemical Communications (1992), 274-5, database is CAplus.

Hydroxyalkyl groups in various aromatic mols. are replaced with a fluorine atom by CsSO₄F at room temperature, regioselectively forming aryl fluorides in high to excellent yields. Thus, reaction of CsSO₄F with 4-methoxybenzyl alc. in MeCN gives 4-methoxyfluorobenzene in 70% yield.

Journal of the Chemical Society, Chemical Communications published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C14H12O2, Synthetic Route of 596-38-3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Jafarirad, Saeed published the artcileEffect of the green synthesized rGO and Mg/rGO nanocomposites on the phytochemical assay, toxicity, and metabolism of Mentha longifolia in vitro cultures, SDS of cas: 106-25-2, the publication is Environmental Science and Pollution Research (2022), 29(30), 46243-46258, database is CAplus and MEDLINE.

Reduced graphene oxide (rGO) and Mg/rGO nanocomposites (NCs) were prepared by an eco-friendly technique using Rosa canina fruit extract Physicochem. properties and cytotoxicity to Mentha longifolia in vitro cultures of these nanomaterials were examined by using XRD, FESEM, EDX, FT-IR, DLS/zeta potential, UV-Visible, and GC-MS techniques. The characterization techniques confirmed the synthesis of rGO and Mg/rGO NCs with particle sizes less than 20 nm (based on FESEM). In accordance to the biol. measurements, rGO showed in vitro cytotoxicity to M. longifolia shoot cultures. Mg/rGO NCs showed no significant difference in the growth parameters except for a decrease in the shoot number at the concentrations of 50 and 150 mg/L and a decrease in the length of the tallest root at the concentrations of 100 and 150 mg/L, however efficiently improved the photosynthetic pigment contents. The phytochem. assay depicted that the total content of volatile compounds was increased in the treated cultures with 25, 50, and 100 mg/L of rGO and Mg/rGO NCs in comparison to the control. Generally, the more oxygenated and hydrocarbon sesquiterpenes were observed in the cultures treated with 25 and 100 mg/L of rGO and 25 and 50 mg/L of Mg/rGO NCs.

Environmental Science and Pollution Research published new progress about 106-25-2. 106-25-2 belongs to alcohols-buliding-blocks, auxiliary class Natural product, name is cis-3,7-Dimethyl-2,6-Octadien-1-Ol, and the molecular formula is C10H18O, SDS of cas: 106-25-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Perina, Dragutin published the artcileCharacterization of Nme5-like gene/protein from the red alga Chondrus crispus, Safety of Triisopropanolamine, the publication is Marine Drugs (2020), 18(1), 13, database is CAplus and MEDLINE.

The Nme gene/protein family of nucleoside diphosphate kinases (NDPK) was originally named after its member Nm23-H1/Nme1, the first identified metastasis suppressor. Human Nme proteins are divided in two groups. They all possess nucleoside diphosphate kinase domain (NDK). Group I (Nme1-Nme4) display a single type NDK domain, whereas Group II (Nme5-Nme9) display a single or several different NDK domains, associated or not associated with extra-domains. Data strongly suggest that, unlike Group I, none of the members of Group II display measurable NDPK activity, although some of them autophosphorylate. The multimeric form is required for the NDPK activity. Group I proteins are known to multimerize, while there are no data on the multimerization of Group II proteins. The Group II ancestral type protein was shown to be conserved in several species from three eukaryotic supergroups. Here, we analyzed the Nme protein from an early branching eukaryotic lineage, the red alga Chondrus crispus. We show that the ancestral type protein, unlike its human homolog, was fully functional multimeric NDPK with high affinity to various types of DNA and dispersed localization throughout the eukaryotic cell. Its overexpression inhibits both cell proliferation and the anchorage-independent growth of cells in soft agar but fails to deregulate cell apoptosis. We conclude that the ancestral gene has changed during eukaryotic evolution, possibly in correlation with the protein function.

Marine Drugs published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C9H21NO3, Safety of Triisopropanolamine.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bilgic, Gulbahar published the artcileSynthesis, structural, and electrochemical properties of boron-based ionic liquid, SDS of cas: 96-20-8, the publication is Ionics (2022), 28(7), 3289-3300, database is CAplus.

In the present work, a new boron-based room-temperature ionic liquid (BBRTIL) is reported. An ionic liquid based on the boron cation was synthesized by an easy metathesis procedure yielding clean products. The composition, thermal behavior, phys., and electrochem. properties of the BBRTIL were identified by NMR spectra (NMR), Fourier transform IR (FTIR) thermogravimetric anal. (TGA), linear sweep voltammetry (LSV), and cyclic voltammetry (CV), resp. NMR and FTIR have confirmed the structure formation of 0.3-0.4-mm-sized B₂O₃-based BBRTIL. Furthermore, the correlation between the electrochem. stability and the identified electrolyte equilibrium species was investigated via voltammetry. This procedure, in the future, could be an original alternative to the deposition of elemental boron through easy, one-step synthesis from high-temperature molten salt electrolysis.

Ionics published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H11NO, SDS of cas: 96-20-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ryzhkov, O. G. published the artcileInterrelation of the structure and properties of mono- and dialkylpyrocatechols, Related Products of alcohols-buliding-blocks, the publication is Khimiya Tverdogo Topliva (Leningrad) (1975), 154-9, database is CAplus.

Alkylation of pyrocatechol, by olefins (e.g., propene trimer and diisobutylene) and alcs. (e.g., Me2CHCH2OH, Me2CHCH2CH2OH), catalyzed by cationite KU 2, gave 3- and 4-monoalkyl and 3,5-dialkyl derivatives; product compositions were determined by uv, ir, and thin-layer chromatog. Ionization constants of the monoalkyl derivatives were determined

Khimiya Tverdogo Topliva (Leningrad) published new progress about 1139-46-4. 1139-46-4 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Phenol, name is 4-(2,4,4-Trimethylpentan-2-yl)benzene-1,2-diol, and the molecular formula is C14H22O2, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Koroleva, Sofia V. published the artcileMolecular Thermodynamic Modeling of the Specific Effect of Salt on the Aggregation of Nonionic Surfactants, Recommanded Product: (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, the publication is Journal of Chemical & Engineering Data (2020), 65(3), 987-992, database is CAplus.

The specific chem. of added salt has a strong effect on the aggregation of surfactants. Although the mol. mechanism of this effect is still debated in the literature and there is no generally accepted quant. theory, substantial progress has recently been achieved in the mol. thermodn. modeling of ion-specific effects for solutions of ionic surfactants. In this work, we extend our previous aggregation model of ionic surfactants to solutions of nonionic surfactants in the presence of salts. Within this model, the specificity of ions is reflected by the difference in ionic diameters, the dispersion interaction with the micelle, and an effective parameter δ_± that takes into account the hydration/dehydration of an ion in the micellar corona and is specific to every ion-surfactant head pair. The effect of specific salt on the hydrophobic contribution to the aggregation free energy is described via the Setchenov salting-out constants We apply the model for sugar-based surfactants: n-alkyl glucosides and N-acyl-N-methylglucosides. This choice is motivated by the importance of this family of surfactants in biotechnol. We report the set of model parameters, including the Setchenov constants, for the surfactants in this family in combination with a number of 1:1 salts and illustrate good performance of the model in the description of the specific effect of added salt on the critical micelle concentration (CMC) and the growth of micellar aggregates.

Journal of Chemical & Engineering Data published new progress about 85618-21-9. 85618-21-9 belongs to alcohols-buliding-blocks, auxiliary class Tetrahydropyran,Chiral,sulfides,Alcohol, name is (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C14H28O5S, Recommanded Product: (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts