Author: tianli

Wang, Cai-Yun published the artcileEstablishing an innovative carbohydrate metabolic pathway for efficient production of 2-keto-l-gulonic acid in Ketogulonicigenium robustum initiated by intronic promoters, Quality Control of 526-98-7, the publication is Microbial Cell Factories (2018), 81/1-81/14, database is CAplus and MEDLINE.

Background: 2-Keto-l-gulonic acid (2-KGA), the precursor of vitamin C, is currently produced by two-step fermentation In the second step, l-sorbose is transformed into 2-KGA by the symbiosis system composed of Ketogulonicigenium vulgare and Bacillus megaterium. Due to the different nutrient requirements and the uncertain ratio of the two strains, the symbiosis system significantly limits strain improvement and fermentation optimization. Results: In this study, Ketogulonicigenium robustum SPU_B003 was reported for its capability to grow well independently and to produce more 2-KGA than that of K. vulgare in a mono-culture system. The complete genome of K. robustum SPU_B003 was sequenced, and the metabolic characteristics were analyzed. Compared to the four reported K. vulgare genomes, K. robustum SPU_B003 contained more tRNAs, rRNAs, NAD and NADP biosynthetic genes, as well as regulation- and cell signaling-related genes. Moreover, the amino acid biosynthesis pathways were more complete. Two species-specific internal promoters, P1 (orf_01408 promoter) and P2 (orf_02221 promoter), were predicted and validated by detecting their initiation activity. To efficiently produce 2-KGA with decreased CO2 release, an innovative acetyl-CoA biosynthetic pathway (XFP-PTA pathway) was introduced into K. robustum SPU_B003 by expressing heterologous phosphoketolase (xfp) and phosphotransacetylase (pta) initiated by internal promoters. After gene optimization, the recombinant strain K. robustum/pBBR-P1_xfp2502-P2_pta2145 enhanced acetyl-CoA approx. 2.4-fold and increased 2-KGA production by 22.27% compared to the control strain K. robustum/pBBR1MCS-2. Accordingly, the transcriptional level of the 6-phosphogluconate dehydrogenase (pgd) and pyruvate dehydrogenase genes (pdh) decreased by 24.33 ± 6.67 and 8.67 ± 5.51%, resp. The key genes responsible for 2-KGA biosynthesis, sorbose dehydrogenase gene (sdh) and sorbosone dehydrogenase gene (sndh), were up-regulated to different degrees in the recombinant strain. Conclusions: The genome-based functional anal. of K. robustum SPU_B003 provided a new understanding of the specific metabolic characteristics. The new XFP-PTA pathway was an efficient route to enhance acetyl-CoA levels and to therefore promote 2-KGA production

Microbial Cell Factories published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C17H18N2O6, Quality Control of 526-98-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Jiao, Shulin published the artcileThe synthesis of an antifungal 1,2,4-triazole drug and the establishment of a drug delivery system based on zeolitic imidazolate frameworks, Related Products of alcohols-buliding-blocks, the publication is New Journal of Chemistry (2019), 43(47), 18823-18831, database is CAplus.

Invasive fungal infections (IFIs) are deadly fungal infections with a high mortality rate, particularly in patients who have undergone prolonged use of chemotherapy drugs, transplant surgery and so on. Among them, Candida albicans has attracted great attention as an important pathogen. Triazoles such as voriconazole and fluconazole are considered to be some of the most effective and widely used antifungal drugs. However, the resistance of fungi to these drugs and the toxicity of triazoles to normal human cells are the main reasons for the difficulty of treating invasive fungal infections. In this paper, a novel trifluoromethyl-containing triazole compound, TPHMB, was designed and synthesized for the first time. The single crystal was obtained by the solution evaporation method, and its mol. structure was determined by a single crystal diffractometer. The activity against Candida albicans was detected (MIC₉₀ = 8μg ml^-1). In addition, for the first time, we used the metal organic framework ZIF-8 to establish an effective, low-toxicity and pH-responsive antifungal drug delivery system with less side effects via reducing the non-specific aggregation in normal tissues and improving water solubility Detailed material characterizations confirmed the successful encapsulation of TPHMB in the ZIF-8 matrix, which demonstrated good drug release at pH = 5; plate count was used to find the excellent synergy of ZIF-8 against Candida albicans. This study not only provides a reference for the development of new triazole drugs, but also helps develop an effective delivery system of such drugs in vivo to achieve an effective treatment of fungal infections.

New Journal of Chemistry published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Liu, Liming published the artcileComplete genome sequence of the industrial strain Ketogulonicigenium vulgare WSH-001, Formula: C6H10O7, the publication is Journal of Bacteriology (2011), 193(21), 6108-6109, database is CAplus and MEDLINE.

Ketogulonicigenium vulgare is an industrial organism commonly used in the vitamin C industry. This report presents the finished, annotated, and compared 3.28-Mbp high-quality genome sequence of Ketogulonicigenium vulgare WSH-001, a 2-keto-L-gulonic acid-producing industrial strain. The complete genome sequence is deposited in GenBank/EMBL/DDBJ with accession numbers CP002018 (chromosome), CP002019 (plasmid pKVU_100), and CP002020 (plasmid pKVU_200).

Journal of Bacteriology published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C6H10O7, Formula: C6H10O7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bi, Jicai published the artcileEffect of different cooking methods on flavor compounds of Chinese traditional condiment Wuxiang powder, Name: cis-3,7-Dimethyl-2,6-Octadien-1-Ol, the publication is Journal of Food Processing and Preservation (2022), 46(3), e16358, database is CAplus.

The Wuxiang powder is a Chinese traditional condiment with a strong aroma and flavor. Moreover, it is suitable for dishes prepared using several cooking methods. Gas chromatog.-ion mobility spectrometry was used to analyze the changes in the flavor of the original Wuxiang powder, the air-fried Wuxiang powder and the stewed Wuxiang powder. A total of 49 volatile compounds were studied, including 17 aldehydes, 9 alkenes, 9 esters, 7 alcs., 2 ethers, 2 furans, 1 acid, 1 ketone and 1 phenol. The contents of aldehydes, hydrocarbons, esters and alcs. were higher than others. The principal component anal. elucidated significant differences in the aroma among different cooking methods of the Wuxiang powder. According to the relative odor activity value, the major flavor compounds that contributed to the difference in the aroma among different cooking methods were (Z, Z)-2, 4-decadienal, anethole, decanal, 3-methylbutanal, β-caryophyllene, α-pinene, linalool, eugenol, octanal, heptanal, and hexanal.

Journal of Food Processing and Preservation published new progress about 106-25-2. 106-25-2 belongs to alcohols-buliding-blocks, auxiliary class Natural product, name is cis-3,7-Dimethyl-2,6-Octadien-1-Ol, and the molecular formula is C10H18O, Name: cis-3,7-Dimethyl-2,6-Octadien-1-Ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Liao, Jin-hua published the artcileClinical observation of midazolam for prevention of adverse reactions in cesarean section induced by carboprost tromethamine, Application In Synthesis of 58551-69-2, the publication is Linchuang Mazuixue Zazhi (2014), 30(8), 812-813, database is CAplus.

Role of midazolam and ondansetron for prevention of adverse reactions in cesarean section women induced by carboprost tromethamine was compared. Totally 90 cesarean section women were involved and randomly divided into normal saline (N) group, ondansetron (O) group and midazolam (M) group. SBP, DBP, HR and SpO₂ were observed before, 0 and 5 min after carboprost tromethamine injection (T0, T1 and T2, resp.). SBP and DBP were significantly higher, HR was faster and SpO₂ was lower at T2 compared with those at T1 in 3 groups (P<0.05). SBP and DBP was lower, HR was slower and SpO₂ was higher in M group than those in N group (P<0.05). Midazolam prevents adverse reactions in cesarean section women induced by carboprost tromethamine, and the effect is better than ondansetron.

Linchuang Mazuixue Zazhi published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, Application In Synthesis of 58551-69-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Li, Chunxiu published the artcileVolatile composition changes in lemon during fruit maturation by HS-SPME – GC – MS, Recommanded Product: cis-3,7-Dimethyl-2,6-Octadien-1-Ol, the publication is Journal of the Science of Food and Agriculture (2022), 102(9), 3599-3606, database is CAplus and MEDLINE.

Volatiles are determinants of fruit aroma and flavor characteristics and also provide valuable information for lemon as ingredient for the food and drinks industry. Volatiles in ‘Eureka’ lemon and ‘Xiangshui’ lemon pulps from 130 to 186 days after flowering were enriched by headspace-solid-phase microextraction (HS-SPME), and analyzed by gas chromatog.-mass spectrometry (GC-MS). Seventy-seven volatiles of two lemon cultivars at the different ripening stages were identified and divided into six categories. Varieties and ripening stages had significant effects on individual volatiles in each category. The proportion of monoterpenes was found to be higher in ‘Eureka’ lemon, while ‘Xiangshui’ lemon had a higher proportion of sesquiterpenes, aldehydes and alcs. The proportion of monoterpene fluctuation decreased during fruit ripening, while fluctuation of sesquiterpenes, alcs., aldehydes and esters increased. Among the hydrocarbons, monoterpenes decreased their relative abundance from 91.67% to 81.04% in ‘Eureka’ lemon, and from 83.01% to 60.04% in ‘Xiangshui’ lemon; conversely, sesquiterpenes increased from 0.73% to 2.89% in ‘Eureka’ lemon, and from 3.21% to 8.48% in ‘Xiangshui’ lemon. Among the oxygenated volatiles, the proportions of alcs., aldehydes and esters were higher at 186 days after flowering in both two cultivars. The volatile organic compounds during fruit ripening of lemon varieties with different resistance were elucidated. The proportion of oxygenated volatiles increased during fruit ripening, and disease-resistant varieties had a higher proportion. These results provided important theor. support for the utilization of lemon fruits and the innovation of disease-resistant germplasm resources. 2021 Society of Chem. Industry.

Journal of the Science of Food and Agriculture published new progress about 106-25-2. 106-25-2 belongs to alcohols-buliding-blocks, auxiliary class Natural product, name is cis-3,7-Dimethyl-2,6-Octadien-1-Ol, and the molecular formula is C10H18O, Recommanded Product: cis-3,7-Dimethyl-2,6-Octadien-1-Ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Huang, Hong published the artcileHydration of ternary cement in the presence of triisopropanolamine, Formula: C9H21NO3, the publication is Construction and Building Materials (2016), 513-521, database is CAplus.

The effects of triisopropanolamine (TIPA) on the strength development and hydration kinetics of a ternary cement containing slag and CaCO₃ were investigated by mixture design. The strength development of the blend was considerably enhanced by the accelerated chem. reactions on each component. A very strong interaction effect of slag and CaCO₃ on the strength enhancement prior to 7 d was observed The addition of TIPA promoted the hydration of laboratory cement by promoting the dissolution of ferrite, which resulted in more CH being released to participate in the reaction with slag. The dissolution of the slag itself was markedly accelerated by TIPA in a simulated highly alk. pore solution The use of TIPA promoted the formation of carboaluminate due to the accelerated C4AF/C3A-CaCO₃ reaction, which stabilized the formation of AFt during hydration. In addition, it confirmed that Fe ions were able to enter the AFt structure during hydration with TIPA.

Construction and Building Materials published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C9H21NO3, Formula: C9H21NO3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Li, Ye published the artcile2-KGA metabolism coupling respiratory chain in Ketogulonigenium vulgare-A review, Computed Properties of 526-98-7, the publication is Weishengwu Xuebao (2014), 54(10), 1101-1108, database is CAplus and MEDLINE.

A review. 2-Keto-L-gulonate (2-KGA) is the key intermediate of vitamin C, which can be biosynthesized by Ketogulonigenium vulgare. There are five reactions related to 2-KGA metabolism, including: (1) Oxidation of D-sorbitol to L-sorbose; (2) Oxidation of L-sorbose to L-sorbosone; (3) Oxidation of L-sorbosone (Pyranose form) to 2-KGA; (4) Oxidation of L-sorbosone (Furanose form) to vitamin C, and (5) Reduction of 2-KGA to L-idonate. L-sorbose/L-sorbosone dehydrogenase (SSDH) is responsible for the reaction of 1 through 3, L-sorbose dehydrogenase (SDH) is responsible for the reaction of 2 and 3, L-sorbosone dehydrogenase (SNDH) is responsible for the reaction of 3 and 4, aldehyde dehydrogenase (ALDH) is responsible for the reaction of 3, 2-KGA reductase (2-KGR) is responsible for the reaction of 5. Enzymes of SDH, SSDH and ALDH belong to Quinoprotein Type I that uses PQQ as the only prosthetic group. SNDH belongs to Quinoprotein Type II that is quinohemoprotein assembling heme c and PQQ. They are all soluble in the periplasm and coupled with the respiratory chain. The substrate respiration to generate ATP directly on the outside cellular membrane means this strain can use the substrate quickly in the natural environment for the necessary bioenergy required.

Weishengwu Xuebao published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C6H10O7, Computed Properties of 526-98-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Li, Hui published the artcileExtending the π-conjugated molecules on TiO₂ for the selective photocatalytic aerobic oxidation of sulfides triggered by visible light, Product Details of C11H8O3, the publication is Sustainable Energy & Fuels (2021), 5(7), 2127-2135, database is CAplus.

The assembly of a TiO₂ surface with π-conjugated mols. can give rise to an apparent red-shift of its optical absorption band, and subsequently engender ligand-to-metal charge transfer (LMCT) triggered by visible light. However, the application of LMCT remains elusive due to the vulnerability of these π-conjugated mols. at the vicinity of reactive centers. Therefore, extending the π-conjugation of these mols. was envisioned to overcome this bottleneck with the oxidation of sulfides as a probe reaction. With salicylic acid as the starting mol., extending the benzene ring at 5,6 or 3,4 positions with another one afforded 2-hydroxy-1-naphthoic acid and 1-hydroxy-2-naphthoic acid . Compared to salicylic acid, 2-hydroxy-1-naphthoic acid showed a moderate improvement, while 1-hydroxy-2-naphthoic acid caused a significant enhancement for modifying anatase TiO₂ to conduct the selective aerobic oxidation of sulfides triggered by blue light with (2,2,6,6-tetramethylpiperidin-1-yl)oxyl (TEMPO) as a redox mediator. Ultimately, the aerobic oxidation of organic sulfides to corresponding sulfoxides in CH₃OH was achieved by the 1-hydroxy-2-naphthoic acid-TiO₂ photocatalyst in cooperation with TEMPO. This study introduces the assembly of extended π-conjugated mols. on TiO₂, which may pave the way to construct more efficient visible-light photocatalysts.

Sustainable Energy & Fuels published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, Product Details of C11H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Y. published the artcileIn vitro interactions of ambroxol hydrochloride or amlodipine in combination with antibacterial agents against carbapenem-resistant Acinetobacter baumannii, Related Products of alcohols-buliding-blocks, the publication is Letters in Applied Microbiology (2020), 70(3), 189-195, database is CAplus and MEDLINE.

The aim of this study was to investigate the in vitro interactions of ambroxol hydrochloride (ABH) or amlodipine (AML) with commonly used antibacterial agents, including meropenem, imipenem-cilastatin sodium, biapenem, cefoperazone-sulbactam, polymyxin B, and tigecycline, against six carbapenem-resistant Acinetobacter baumannii (CRAB) clin. isolates. Drug interactions were interpreted using two models, i.e., the fractional inhibitory concentration index (FICI) model and the percentage of growth difference (ΔE) model. The results show that a majority of the combination groups exhibited partial synergy and additive interactions, such as the combinations of carbapenems and cefoperazone-sulbactam (SCF) with ABH or AML. While the combination of PB/AML exhibited synergistic interactions against all tested isolates, and PB/ABH exhibited synergistic interactions against two isolates. The FICI and ΔE model correlated very well for the combinations of PBABH and PB/AML against AB2. The combinations of TGC with ABH or AML mainly exhibited additive and indifferent interactions. There were no antagonistic interactions observed in any of the combinations. In conclusion, this study revealed that the non-antibacterial agents ABH or AML can work synergistically or partial synergistically with antibacterial agents against CRAB. This finding is crucial for overcoming the carbapenem resistance of A. baumannii.

Letters in Applied Microbiology published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C12H25Br, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts