Author: tianli

Hau, King In published the artcileSynthesis of Metallo-conjugated Copolymer with Electron Deficient Main Chain and the Formation of Polymer-Carbon Nanotube Hybrids, Application In Synthesis of 239075-02-6, the publication is Journal of Inorganic and Organometallic Polymers and Materials (2020), 30(1), 243-253, database is CAplus.

The authors report the synthesis of a conjugated polymer incorporated with electron-deficient dipyrridophenanzine units and pendant ruthenium complexes. The electronic transition and photophys. properties of the polymer were thoroughly studied. Due to the presence of an extended conjugated system, polymer main chain was able to interact strongly with carbon nanotube (CNT) surface by π-π interaction, resulting in the formation of a dispersion in organic solvents. The polymer-nanotube hybrid was characterized by different microscopic and spectroscopic experiments Raman spectroscopic results suggested that the electron d. of the CNT decreased after the formation of polymer/nanotube hybrids, which suggests there is an electronic interaction between the polymer main chain and CNT.

Journal of Inorganic and Organometallic Polymers and Materials published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, Application In Synthesis of 239075-02-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Eriksson, Kjell published the artcileMAb contaminant removal with a multimodal anion exchanger: a platform step to follow protein A, Computed Properties of 101-98-4, the publication is BioProcess International (2009), 7(2), 52-57, database is CAplus.

Monoclonal antibodies (MAbs) constitute approx. 30% of the biopharmaceutical products currently under development. Today, nearly all approved MAb processes include a capture step using protein A. GE Healthcare’s Capto adhere multimodal anion-exchange resin, which has high selectivity for contaminants that remain after protein A separation, represents an addnl. step toward developing highly effective MAb downstream processes. The high purity that follows capture on protein A resins, combined with the multimodal functionality of Capto adhere resin, provides for highly productive, two-step processes.

BioProcess International published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Computed Properties of 101-98-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Tian, Yunfei published the artcileH-Bonding-promoted radical addition of simple alcohols to unactivated alkenes, Quality Control of 2240-88-2, the publication is Green Chemistry (2017), 19(21), 5230-5235, database is CAplus.

A H-Bonding-induced radical addition of simple alcs. such as ethanol, cyclohexanol, 2,2,2-trifluoroethan-1-ol, etc. to unactivated olefins e.g., 4-BrC₆H₄C(O)O(CH₂)₃HC=CH₂ was achieved. It effectively solved the long-standing problems of reactivity and selectivity in this type of reaction. The hydroxyalkylation occurred via site-specific cleavage of the α-hydroxyl-C-H bond in alcs. This method allows a highly atom-economical, operationally simple and environmentally benign access to diverse alcs. such as 6-phenylhexan-2-ol, 1-cyclooctylethanol, 3-(1-hydroxycyclopentyl)propyl 4-bromobenzoate, etc. diols, e.g., 4,5-dihydroxypentyl 4-bromobenzoate and even polyfluorinated alcs., e.g., 7,7,7-trifluoro-6-hydroxyheptyl 4-bromobenzoate. These useful chems. are traditionally synthesized by using com. unavailable organometallics via complex operations. In contrast, they can be facilely obtained through this protocol utilizing widely available starting materials.

Green Chemistry published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C14H10O4, Quality Control of 2240-88-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Shen, Haigen published the artcileTrifluoromethylation of alkyl radicals in aqueous solution, HPLC of Formula: 20880-92-6, the publication is Journal of the American Chemical Society (2017), 139(29), 9843-9846, database is CAplus and MEDLINE.

The copper-mediated trifluoromethylation of alkyl radicals is described. The combination of Et₃SiH and K₂S₂O₈ initiates the radical reactions of alkyl bromides or iodides with BPyCu(CF₃)₃ (BPy = 2,2′-bipyridine) in aqueous acetone at room temperature to afford the corresponding trifluoromethylation products in good yield. The protocol is applicable to various primary and secondary alkyl halides and exhibits wide functional group compatibility. A mechanism involving trifluoromethyl group transfer from Cu(II)-CF₃ intermediates to alkyl radicals is proposed.

Journal of the American Chemical Society published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C12H10O4S, HPLC of Formula: 20880-92-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ye, Danfeng published the artcileCesium Carbonate Catalyzed Esterification of N-Benzyl-N-Boc-amides under Ambient Conditions, Related Products of alcohols-buliding-blocks, the publication is Organic Letters (2019), 21(17), 6888-6892, database is CAplus and MEDLINE.

A general activated amide to ester transformation catalyzed by Cs₂CO₃, is reported. Using this approach, esterification proceeds under relatively mild conditions and without the need for a transition metal catalyst. This method exhibits broad substrate scope and represents a practical alternative to existing esterification strategies. The synthetic utility of this protocol is demonstrated via the facile synthesis of crown ether derivatives and the late-stage modification of a representative natural product and several sugars in reasonable yields.

Organic Letters published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C11H21BO2Si, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhao, Fabao published the artcileChiroptical aggregates from block copolymer bearing amino acid moieties in aqueous solution, Related Products of alcohols-buliding-blocks, the publication is Journal of Polymer Science, Part B: Polymer Physics (2009), 47(14), 1345-1355, database is CAplus.

Optically active poly(ethylene glycol) monomethyl ether-b-poly(methacryloyl-L-leucine Me ester) (denoted as MPEG-b-PMALM) copolymers were prepared via atom transfer radical polymerization (ATRP), using bromine (Br) end-capped poly(ethylene glycol) monomethyl ether (denoted as MPEG-Br) as macroinitiator in the presence of CuBr/tris(2-dimethylaminoethyl)amine (Me₆TREN) as catalytic system. Broad range of morphologies, such as spherical, cylindrical, and vesicular micelles, which were prepared by initially dissolving prepared polymer in organic solvent at different concentration followed by addition various amount of water before dialysis against water to remove any added solvent, was observed by transmission electron microscope (TEM). More detailed chiroptical properties of the micelles/aggregates in aqueous solution were evaluated by CD spectroscopy as a function of micelles morphologies, polymer concentration, solvents employed, temperature, etc. The micellar solutions exhibit almost the same CD spectra regardless of its morphologies. The intensity of the CD spectra of the cylindrical micelles decreased in the molar ellipticities as the micellar concentration in water was increased. The Cotton effect was markedly changed when the solvent hydrophobicity was changed by addition of trifluoromethyl ethanol (TFME) to water. The intensity of the CD spectra decreased not too much within the temperature range from 20° to 90°, indicating good stability of the micelles upon temperature variation. © 2009 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 47: 1345-1355, 2009.

Journal of Polymer Science, Part B: Polymer Physics published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C12H14O2, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yang, Fan published the artcileCobalt single atoms anchored on nitrogen-doped porous carbon as an efficient catalyst for oxidation of silanes, HPLC of Formula: 597-52-4, the publication is Green Chemistry (2021), 23(2), 1026-1035, database is CAplus.

The oxidation reactions of organic compounds are important transformations for the fine and bulk chem. industry. However, they usually involve the use of noble metal catalysts and suffer from toxic or environmental issues. Here, an efficient, environmentally friendly, and atomically dispersed Co catalyst (Co-N-C) was prepared via a simple, porous MgO template and etching method using 1,10-phenanthroline as C and N sources, and CoCl₂·6H₂O as the metal source. The obtained Co-N-C catalyst exhibits excellent catalytic performance for the oxidation of silanes with 97% isolated yield of organosilanol under mild conditions (room temperature, H₂O as an oxidant, 1.8 h), and good stability with 95% isolated yield after nine consecutive reactions. The turnover frequency (TOF) is as high as 381 h^-1, exceeding those of most non-noble metal catalysts and some noble metal catalysts. Aberration-corrected high-angle annular dark-field scanning transmission electron microscopy (HAADF-STEM), extended X-ray absorption fine structure (EXAFS), and wavelet transform (WT) spectroscopy corroborate the existence of atomically dispersed Co. The coordination numbers of Co affected by the pyrolysis temperature in Co-N-C-700, Co-N-C-800, and Co-N-C-900 are 4.1, 3.6, and 2.2, resp. Owing to a higher Co-N₃ content, Co-N-C-800 shows more outstanding catalytic performance than Co-N-C-700 and Co-N-C-800. Moreover, d. functional theory (DFT) calculations reveal that the Co-N₃ structure exhibits more activity compared with Co-N₄ and Co-N₂, which is because the Co atom in Co-N₃ was bound with both H atom and Si atom, and it induced the longest Si-H bond.

Green Chemistry published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C7H5Br2F, HPLC of Formula: 597-52-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Varkuti, Boglarka H. published the artcileHigh-Throughput Small Molecule Screen Identifies Modulators of Mitochondrial Function in Neurons, Recommanded Product: trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, the publication is iScience (2020), 23(3), 100931, database is CAplus and MEDLINE.

We developed a high-throughput assay for modulators of mitochondrial function in neurons measuring inner mitochondrial membrane potential (ΔΨ_m) and ATP production The assay was used to screen a library of small mols., which led to the identification of structural/functional classes of mitochondrial modulators such as local anesthetics, isoflavones, COXII inhibitors, adrenergic receptor blockers, and neurotransmitter system effectors. Our results show that some of the isolated compounds promote mitochondrial health, enhance oxygen consumption rate, and protect neurons against toxic insults found in the cellular environment of Alzheimer disease. These studies offer a set of compounds that may provide efficacy in protecting the mitochondrial system in neurodegenerative disorders.

iScience published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C23H28N2O4, Recommanded Product: trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Zhan-Feng published the artcileAn intermediate state of T7 RNA polymerase provides another pathway of nucleotide selection, SDS of cas: 122-20-3, the publication is Chinese Physics B (2017), 26(10), 100203/1-100203/16, database is CAplus.

Phage T7 RNA polymerase is a single-subunit transcription enzyme, transcribing template DNA to RNA. Nucleoside triphosphate (NTP) selection and translocation are two critical steps of the transcription elongation. Here, using all-atom mol. dynamics simulations, we found that between pre- and post-translocation states of T7 RNA polymerase an intermediate state exists, where the O helix C-terminal residue tyrosine 639, which plays important roles in translocation, locates between its pre- and post-translocation positions and the side chain of the next template DNA nucleotide has moved into the active site. NTP selection in this intermediate state was studied, revealing that the selection in the intermediate state can be achieved relying on the effect of Watson-Crick interaction between NTP and template DNA nucleotide, effect of stability of the components near the active site such as the nascent DNA-RNA hybrid and role of tyrosine 639. This indicates that another NTP-selection pathway can also exist besides the main pathway where NTP selection begins at the post-translocation state upon the entry of NTP.

Chinese Physics B published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C15H23BO2, SDS of cas: 122-20-3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Liu, Chen published the artcileHeat-cured concrete: Improving the early strength and pore structure by activating aluminosilicate internal curing agent with triisopropanolamine, Recommanded Product: Triisopropanolamine, the publication is Journal of the American Ceramic Society (2019), 102(10), 6227-6238, database is CAplus.

Although heat-cured concrete (HCC) has received extensive research interests in recent years, it still suffers from problems including coarsened microstructure and low cement hydration degrees, which limited its application. Some of these problems can be solved by internal curing method resulting in low early strength of HCC and low-production efficiency. This study addressed this issue by activating the aluminosilicate internal curing agent (lightweight fine aggregate, LWFA) with triisopropanolamine (TIPA). More Al³⁺ and Fe³⁺ ions were dissolved from LWFA by TIPA, which assisted the formation of hydrates with cement ions in interfacial transition zone (ITZ), and enhanced the d. of ITZ in the early stage. The introduction of TIPA increased the early compressive strength of HCC, by ∼15.3%, 25.9%, and 28.0%, resp. for the cement cured for 1, 3, and 7 days compared with control samples. Moreover, the results of rapid chloride migration and water absorption depth also suggested that coupling the aluminosilicate internal curing agent with TIPA improved the pore structure of HCC.

Journal of the American Ceramic Society published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C9H21NO3, Recommanded Product: Triisopropanolamine.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts