Author: tianli

Yang, Bo Yeun published the artcileDevelopment of a multimodal imaging probe by encapsulating iron oxide nanoparticles with functionalized amphiphiles for lymph node imaging, Application of (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol, the publication is Nanomedicine (London, United Kingdom) (2015), 10(12), 1899-1910, database is CAplus and MEDLINE.

Aim: We tried to develop a multimodal iron oxide nanoparticles (IO NP) imaging probe by an encapsulation method using specific amphiphiles for ⁶⁸Ga-labeling and lymph node-targeting. Materials & methods: Nanoparticles (NPs) were encapsulated with a solution containing polysorbate 60 and the amphiphiles. The prepared NPs were labeled with ⁶⁸Ga and tested in vitro and in vivo. Results: Prepared 1,4,7-triazacyclononane-1,4,7-triacetic acid-IO-Mannose (NOTA-IO-Man) showed a narrow size distribution, and no significant aggregation or degradation under harsh conditions. The relaxivity coefficient of ⁶⁸Ga-NOTA-IO-Man was higher than that of ferumoxide. The accumulation of ⁶⁸Ga-NOTA-IO-Man in the lymph node after injection into rat’s footpad was confirmed by both positron emission tomog. and MRI. Conclusion: We successfully developed PET/MRI dual-modality imaging probe targeting lymph nodes by using the facile encapsulation method.

Nanomedicine (London, United Kingdom) published new progress about 96345-79-8. 96345-79-8 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Gal and Man, name is (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C17H28ClNO3, Application of (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kim, Sung Phil published the artcileComposition of Herba Pogostemonis Water Extract and Protection of Infected Mice against Salmonella Typhimurium-Induced Liver Damage and Mortality by Stimulation of Innate Immune Cells, HPLC of Formula: 526-98-7, the publication is Journal of Agricultural and Food Chemistry (2012), 60(49), 12122-12130, database is CAplus and MEDLINE.

GC-MS anal. of a hot water extract of Herba Pogostemonis (HP) revealed the presence of 131 compounds HP slightly inhibited Salmonella Typhimurium bacteria in culture and stimulated uptake of the bacteria into RAW 264.7 murine macrophage cells as indicated by both increased fluorescence from internalized FITC-dextran and increased colony-forming unit (CFU) counts of the lysed macrophages. Postinfection, the HP-treated cells showed lower bacterial counts than the control. HP elicited altered morphol., elevated inducible NO synthase (iNOS) mRNA, and reduced pro-inflammatory cytokine expression in macrophage cells. Salmonella induced increased expression of iNOS mRNA, cognate polypeptides, and NO. Histol. of mice infected with a sublethal dose (1 × 10⁴ CFU) of Salmonella showed that i.p. administered HP protected against necrosis of the liver, a biomarker of in vivo salmonellosis. The lifespan of mice infected with a LD (1 × 10⁵ CFU) was significantly extended. These results suggest that the activity of HP against bacterial infection in mice occurs through the activation of innate immune macrophage cells. The relationship of composition of HP to bioactivity is discussed.

Journal of Agricultural and Food Chemistry published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C6H10O7, HPLC of Formula: 526-98-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wiensch, Eric M. published the artcileNickel-Catalyzed Amination of Silyloxyarenes through C-O Bond Activation, Category: alcohols-buliding-blocks, the publication is Angewandte Chemie, International Edition (2018), 57(34), 11045-11049, database is CAplus and MEDLINE.

Silyloxyarenes were utilized as electrophilic coupling partners with amines in the synthesis of aniline derivatives A diverse range of amine substrates were used, including cyclic or acyclic secondary amines, secondary anilines, and sterically hindered primary anilines. Addnl., a range of sterically hindered and unhindered primary aliphatic amines were employed, which have previously been challenging with other classes of aryl ether electrophiles. Orthogonal couplings of silyloxyarenes with aryl Me ethers are illustrated, where selectivity between the two C-O electrophiles is determined by ligand control, thereby allowing complementary and selective late-stage diversification of either electrophile. Finally, a sequential coupling displays the utility of this amination method along with the reversal in intrinsic reactivity between aryl Me ethers and silyloxyarenes.

Angewandte Chemie, International Edition published new progress about 27292-49-5. 27292-49-5 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Benzene,Phenol, name is 3-Morpholinophenol, and the molecular formula is C9H8BNO2, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Hermoso, R. published the artcileSurvival study of parasitic helminths. III. Effects of antihelminthic and other drugs on survival of Ascaris lumbricoides, Recommanded Product: N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, the publication is Revista Iberica de Parasitologia (1970), 30(4), 567-85, database is CAplus.

The metabolism of A. lumbricoides from pigs was studied in media with the addition of anthelmintics and other drugs; intake of glucose, NH3 production, dry residue, and final glycogen were also determined The action of these substances was observed on the worm’s mobility, the elapsed time until inhibition, and recuperation (if any). Santonin, dimethoate, Sevin, piperazine, NaF, bephenium, hydroxynaphthoate, pyrvinium pamoate, arecoline bromide, hexylresorcinol, dithiazanine iodide, and dithiocarbo(bisethylenediamine) totally inhibited Ascaris activity. Naphthalophos, thiabendazole, phenothiazine, diethylcarbamazine, and Na N1-(2-quinoxalinyl)sulfanilamide partially inhibited muscular activity.

Revista Iberica de Parasitologia published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, Recommanded Product: N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Marzi, Elena published the artcileFluorophenols and (trifluoromethyl)phenols as substrates of site-selective metalation reactions: to protect or not to protect, Formula: C8H5F3O3, the publication is European Journal of Organic Chemistry (2001), 2911-2915, database is CAplus.

O-Methoxymethyl (MOM) protected fluorophenols can be cleanly metalated and subsequently be submitted to site-selective electrophilic substitution. The 2- and 4-isomers exhibit ambivalent reactivity: deprotonation occurs at the position adjacent to the O when butyllithium is employed whereas the position adjacent to the F is attacked by the superbasic mixture of butyllithium and K tert-butoxide (LIC-KOR). The MOM-protected (trifluoromethyl)phenols react exclusively at O-neighboring positions. The meta isomer provides another example of optional site selectivity, undergoing H/metal exchange at the 2-position with the LIC-KOR reagent and at the 6-position with sec-butyllithium. Unprotected (trifluoromethyl)phenols can also be ortho-metalated after O-deprotonation, although the products are formed in only moderate yields.

European Journal of Organic Chemistry published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, Formula: C8H5F3O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Guin, Amit Kumar published the artcileRuthenium-Catalyzed Dehydrogenative Functionalization of Alcohols to Pyrroles: A Comparison between Metal-Ligand Cooperative and Non-cooperative Approaches, Safety of 2-Aminobutan-1-ol, the publication is Journal of Organic Chemistry (2022), 87(11), 7106-7123, database is CAplus and MEDLINE.

Herein, authors report the synthesis and characterization of two ruthenium-based pincer-type catalysts, I (X = Cl, PF₆) and II (R = H, Cl), containing two different tridentate pincer ligands, 2-pyrazolyl-(1,10-phenanthroline) and 2-(phenyldiazenyl)-1,10-phenanthroline; 2-((4-chlorophenyl)diazenyl)-1,10-phenanthroline), and their application in the synthesis of substituted pyrroles via dehydrogenative alc. functionalization reactions. In catalyst I (X = Cl, PF₆), the tridentate scaffold 2-pyrazolyl-(1,10-phenanthroline) is apparently redox innocent, and all the redox events occur at the metal center, and the coordinated ligands remain as spectators. In contrast, in catalysts II (R = H, Cl), the coordinated azo-aromatic scaffolds are highly redox-active and known to participate actively during the dehydrogenation of alcs. A comparison between the catalytic activities of these two catalysts was made, starting from the simple dehydrogenation of alcs. to further dehydrogenative functionalization of alcs. to various substituted pyrroles to understand the advantages/disadvantages of the metal-ligand cooperative approach. Various substituted pyrroles were prepared via dehydrogenative coupling of secondary alcs. and amino alcs., and the N-substituted pyrroles were synthesized via dehydrogenative coupling of aromatic amines with cis-2-butene-1,4-diol and 2-butyne-1,4-diol, resp.

Journal of Organic Chemistry published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H11NO, Safety of 2-Aminobutan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Varma, Anil Kumar published the artcilePyrolysis of pine needles: effects of process parameters on products yield and analysis of products, Quality Control of 23351-09-9, the publication is Journal of Thermal Analysis and Calorimetry (2018), 131(3), 2057-2072, database is CAplus.

Pyrolysis of pine needles was carried out in a semi-batch reactor. The effects of pyrolysis parameters such as temperature (350-650°C), heating rate (10 and 50°C min^-1), nitrogen flow rate (50-200 cm³ min^-1) and biomass particle size (0.25-1.7 mm) were examined on products yield. Maximum bio-oil yield of 43.76% was obtained at pyrolysis temperature of 550°C with a heating rate of 50°C min^-1, nitrogen flow rate of 100 cm³ min^-1 for biomass particle size of 0.6 < d_p < 1 mm. The characterization of pyrolysis products (bio-oil, bio-char) has been made through different instrumental methods like Fourier transform IR spectroscopy, gas chromatog.-mass spectrometry, NMR spectroscopy (¹H NMR), X-ray powder diffraction, field emission scanning electron microscope and Brunauer-Emmett-Teller surface area anal. The empirical formula of the bio-oil and bio-char was found as CH_1.47O_0.36N_0.005 and CH_0.56O_0.28N_0.013 with heating value of 26.25 and 25.50 MJ kg^-1, resp. Results show that bio-oil can be potentially valuable as a renewable fuel after upgrading and can be used as a feedstock for valuable chems. production The properties of bio-char reveal that it can be used as solid fuels, as a cheap adsorbent and as a feedstock for activated carbon production

Journal of Thermal Analysis and Calorimetry published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C13H10O2, Quality Control of 23351-09-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Flotenmeyer, M. published the artcileHydrophobic and hydrophilic radio-iodination, crosslinking, and differential extraction of cell surface proteins in Paramecium tetraurelia cells, HPLC of Formula: 70539-42-3, the publication is Journal of Membrane Biology (1999), 172(1), 77-88, database is CAplus and MEDLINE.

We combined widely different biochem. methods to analyze proteins of the cell surface of P. tetraurelia since so far one can isolate only a subfraction of cell membrane vesicles enriched in the GPI-anchored surface antigens (immobilization or i-AGs). We also found that i-AGs may undergo partial degradation by endogenous proteases. Genuine intrinsic membrane proteins were recognized particularly with lipophilic 5-[¹²⁵I]-iodonaphthalene-1-azide (INA) labeling which reportedly “sees” integral proteins and cytoplasmic cell membrane-associated proteins. With INA (+DTT), bands of ≤55 kDa were similar as with hydrophilic iodogen (+DTT), but instead of large size bands including i-AGs, a group of 122, 104 and 94 kDa appeared. Several bands of the non i-AG type are compatible with integral (possibly oligomeric) or associated proteins of the cell membrane of established mol. identity, as we discuss. In summary, we can discriminate between i-AGs and some functionally important minor cell membrane components. Our methodical approach might be relevant also for an anal. of some related protozoan parasites.

Journal of Membrane Biology published new progress about 70539-42-3. 70539-42-3 belongs to alcohols-buliding-blocks, auxiliary class pyrrolidine,Ester,Amide,Inhibitor,Inhibitor, name is Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, and the molecular formula is C18H20N2O12, HPLC of Formula: 70539-42-3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ruiz, Cristobal Carnero published the artcileSelf-assembly, surface activity and structure of n-octyl-β-D-thioglucopyranoside in ethylene glycol-water mixtures, SDS of cas: 85618-21-9, the publication is International Journal of Molecular Sciences (2013), 3228-3253, database is CAplus and MEDLINE.

The effect of the addition of ethylene glycol (EG) on the interfacial adsorption and micellar properties of the alkylglucoside surfactant n-octyl-β-D-thioglucopyranoside (OTG) has been investigated. Critical micelle concentrations (cmc) upon EG addition were obtained by both surface tension measurements and the pyrene 1:3 ratio method. A systematic increase in the CMC induced by the presence of the co-solvent was observed This behavior was attributed to a reduction in the cohesive energy of the mixed solvent with respect to pure water, which favors an increase in the solubility of the surfactant with EG content. Static light scattering measurements revealed a decrease in the mean aggregation number of the OTG micelles with EG addition Moreover, dynamic light scattering data showed that the effect of the surfactant concentration on micellar size is also controlled by the content of the co-solvent in the system. Finally, the effect of EG addition on the microstructure of OTG micelles was investigated using the hydrophobic probe Coumarin 153 (C153). Time-resolved fluorescence anisotropy decay curves of the probe solubilized in micelles were analyzed using the two-step model. The results indicate a slight reduction of the average reorientation time of the probe mol. with increasing EG in the mixed solvent system, thereby suggesting a lesser compactness induced by the presence of the co-solvent.

International Journal of Molecular Sciences published new progress about 85618-21-9. 85618-21-9 belongs to alcohols-buliding-blocks, auxiliary class Tetrahydropyran,Chiral,sulfides,Alcohol, name is (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C14H28O5S, SDS of cas: 85618-21-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Hierrezuelo, J. M. published the artcileOn the Urea Action Mechanism: A Comparative Study on the Self-Assembly of Two Sugar-Based Surfactants, Synthetic Route of 85618-21-9, the publication is Journal of Physical Chemistry B (2009), 113(20), 7178-7187, database is CAplus and MEDLINE.

Studies on the effect of urea on micelle formation and structure of n-octyl-β-D-thioglucoside (OTG) and N-decanoyl-N-methylglucamide (MEGA-10) were carried out by using the steady-state and time-resolved fluorescence techniques, together with combined static and dynamic light scattering measurements. A similar increase in the critical micelle concentration with the urea addition was observed for both surfactants. This behavior was attributed to a rise in the solubility of hydrocarbon tails and the increase of solvation of the headgroup of the surfactants in the presence of urea. Structural studies mainly based on the anal. of the hydrodynamic radius and aggregation number of micelles revealed that urea induces changes much more significant on micelles of OTG. Particularly, it was found that, whereas the surface area per headgroup of OTG increases with the urea concentration, it does decrease in the case of MEGA-10. This fact suggests that different action mechanisms operate for both surfactants. Accordingly, investigations on the micellar microstructure based on the study of microenvironmental properties such as micropolarity and microviscosity also indicated a more pronounced effect in the case of OTG. Although changes were not observed in the hydrophobic inner region of both micellar systems, a significant increase of polarity and viscosity in the micellar interface of OTG suggests a direct participation of urea in the micellar solvation layer. The differences between the observed behaviors for both micellar systems were interpreted on the basis of two features: the weaker hydration and greater rigidity of the OTG headgroup as compared with MEGA-10.

Journal of Physical Chemistry B published new progress about 85618-21-9. 85618-21-9 belongs to alcohols-buliding-blocks, auxiliary class Tetrahydropyran,Chiral,sulfides,Alcohol, name is (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C14H28O5S, Synthetic Route of 85618-21-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts