Author: tianli

Adhikari, Suraj published the artcileLiquid Chromatographic Enantiomeric Separation of Chiral Aliphatic Amines Using 2-Hydroxynaphthaldehyde as a Derivatizing Agent on Polysaccharide-Derived Chiral Stationary Phases, Quality Control of 96-20-8, the publication is Chromatographia (2018), 81(9), 1337-1344, database is CAplus.

A new liquid chromatog. enantiomer separation of chiral amines as 2-hydroxynaphthaldimine derivatives on several coated and immobilized chiral stationary phases (CSPs) derived from polysaccharides is described. 2-Hydroxynaphthaldehyde was introduced as a derivatizing agent for the enantiomeric separation of chiral aliphatic amines under the normal phase conditions, and was found to both enhance detection sensitivity and provide suitable interaction sites for enantiodiscrimination. Cellulose-derived CSPs, in general, exhibited better enantiomeric separation than amylose-derived CSPs. Amongst the examined six covalently bonded and four coated-type CSPs, covalently bonded Chiralpak IC, which contains a cellulose-based chiral selector, showed the best enantioseparation The method was applied to the determination of the enantiomeric purity of com. available (R)- and (S)-leucinol. The enantiomeric impurities of the studied analytes procured from two suppliers are 0.06-1.20%. The developed anal. method was also validated in accordance with ICH guidelines and is enantioselective, sensitive and effective for the enantiomeric separation of chiral aliphatic amines as 2-hydroxynaphthaldimine derivatives under UV detection.

Chromatographia published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H11NO, Quality Control of 96-20-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Subramanian, R. published the artcileTissue distribution of indium-111-labeled human monoclonal antibody (16.88) in nude mice bearing tumor xenografts: effect of diester linkage, COA of Formula: C18H20N2O12, the publication is Antibody, Immunoconjugates, and Radiopharmaceuticals (1990), 3(2), 127-36, database is CAplus.

A human IgM anticolorectal monoclonal antibody 16.88 was coupled to DTPA using a diester linkage in an attempt to reduce retention of radioactivity in normal organs of animals receiving the ¹¹¹In-labeled conjugate. For comparison, a 16.88-DTPA conjugate with a peptide linkage was also prepared The diester and peptide conjugates contained 3.4 and 4.3 mols. of DTPA per 16.88, resp., and their immunoreactivity was >90% as assessed by a direct-cell binding assay. Biodistribution studies in nude mice bearing THO human colon tumor xenografts indicated that diester linked conjugate was retained to a lesser extent in tumor and normal organs such as liver and kidney as compared to the peptide conjugate. The clearance of the diester conjugate from blood, however, was much faster than that of the peptide conjugate. This resulted in 2-fold higher tumor-to-serum ratio for the diester conjugate than for the peptide conjugate.

Antibody, Immunoconjugates, and Radiopharmaceuticals published new progress about 70539-42-3. 70539-42-3 belongs to alcohols-buliding-blocks, auxiliary class pyrrolidine,Ester,Amide,Inhibitor,Inhibitor, name is Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, and the molecular formula is C19H21N3O3S, COA of Formula: C18H20N2O12.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Liu, Yao published the artcileFinely Tuned Polymer Interlayers Enhance Solar Cell Efficiency, Name: 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, the publication is Angewandte Chemie, International Edition (2015), 54(39), 11485-11489, database is CAplus and MEDLINE.

Three conjugated polymer zwitterions (CPZs), containing thiophene-, diketopyrrolopyrrole- (DPP), and naphthalene diimide (NDI) backbones, were synthesized with pendant zwitterions, specifically sulfobetaine groups. Diboronate-ester-functionalized bithiophene and benzothiadiazole monomers were copolymerized with zwitterion-substituted dibromothiophene, DPP, and NDI monomers by A₂+B₂ Suzuki polymerization The CPZs were incorporated into polymer solar cells (PSCs) as interlayers between the photoactive layer and Ag cathode. The thiophene-based CPZs gave power conversion efficiencies (PCEs) of about 5 %, while the narrow-energy-gap DPP- and NDI-based CPZs performed exceptionally well, giving PCEs of 9.49 % and 10.19 %, resp. The interlayer thickness had only a minor impact on the device performance for the DPP- and NDI-CPZs, a finding attributed to their electron-transport properties. UV photoelectron and reflectance spectroscopies, combined with external quantum efficiency measurements, provided structure-property relationships that lend insight into the function of CPZ interlayers in PSCs. NDI-based CPZ interlayers provide some of the best performing organic solar cells reported to date, and prove useful in conjunction with high-performing polymer-active layers and stable, high-work-function, metal cathodes.

Angewandte Chemie, International Edition published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, Name: 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Tuncer, Sevgican published the artcileSpectroscopic and thermodynamic approach to the interaction of nonperipherally substituted cationic phthalocyanines with calf thymus (CT)-DNA, Recommanded Product: 2-Morpholinoethanol, the publication is Turkish Journal of Chemistry (2018), 42(2), 274-295, database is CAplus.

Novel, nonperipherally tetrasubstituted cationic metal-free and metallophthalocyanines (Zn, In) were synthesized in the present study. The binding constants, the disappearance of quenching effect of all cationic phthalocyanines on the fluorescence intensity of SYBR Green-disodium salt of DNA from calf thymus complex, and the changes in Tm of double helix DNA with thermal denaturation profile were investigated by UV-Vis and fluorescence spectrophotometric methods. To investigate the spontaneity of the reactions between DNA and novel quaternized phthalocyanines in buffer, thermodn. parameters were employed.

Turkish Journal of Chemistry published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C18H24N6O6S4, Recommanded Product: 2-Morpholinoethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Watson, Christine published the artcileOptimization of a novel series of selective CNS penetrant CB₂ agonists, Formula: C4H10OS, the publication is Bioorganic & Medicinal Chemistry Letters (2011), 21(14), 4284-4287, database is CAplus and MEDLINE.

A series of benzimidazole CB₂ receptor agonists were prepared and their properties investigated. Optimization of the three benzimidazole substituents led to the identification of I [R = cyclopropylmethyl, II], a potent CB₂ full agonist (EC₅₀ 2.7 nM) with excellent selectivity over the CB₁ receptor (>3000-fold). II demonstrated good CNS penetration in rats. Further optimization led to the identification of I [R = (2R)-2-tetrahydrofuranylmethyl] with improved selectivity over hERG and excellent CNS penetration in rat.

Bioorganic & Medicinal Chemistry Letters published new progress about 73303-88-5. 73303-88-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Alcohol, name is 2-Methyl-2-sulfanylpropan-1-ol, and the molecular formula is C9H20Cl2Si, Formula: C4H10OS.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Penders-van Elk, Nathalie J. M. C. published the artcileCombined Effect of Temperature and pK_a on the Kinetics of Absorption of Carbon Dioxide in Aqueous Alkanolamine and Carbonate Solutions with Carbonic Anhydrase, Related Products of alcohols-buliding-blocks, the publication is Industrial & Engineering Chemistry Research (2016), 55(38), 10044-10054, database is CAplus.

In present work the absorption of carbon dioxide in aqueous N-methyldiethanolamine, N,N-dimethylethanolamine, and triisopropanolamine solutions with and without the enzyme carbonic anhydrase has been studied in a stirred cell reactor at temperatures varying between 278 and 313 K, at an alkanolamine concentration of 1 kmol m^-3 and carbonic anhydrase concentrations ranging from 0 to 2.4 kg m^-3, resp. The exptl. data from these experiments have been used to fit the obtained rate constant for the enzymic CO₂ hydration to the Bronsted relation: ln(k) = A(pK_a) + B + C/T. In addition to the carbon dioxide absorption in the three tertiary alkanolamines, the absorption of carbon dioxide in next three solvents had been studied: 0.3 kmol m^-3 potassium carbonate, 0.3 kmol m^-3 sodium carbonate, and 0.2 kmol m^-3 2-amino-2-methyl-1-propanol. The kinetics from these solvents are well predicted by the relation fitted to the data of the tertiary amines only.

Industrial & Engineering Chemistry Research published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C9H21NO3, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Du, Bingnan published the artcileThioether-Directed NiH-Catalyzed Remote γ-C(sp³)-H Hydroamidation of Alkenes by 1,4,2-Dioxazol-5-ones, SDS of cas: 4410-99-5, the publication is Journal of the American Chemical Society (2021), 143(37), 14962-14968, database is CAplus and MEDLINE.

A NiH-catalyzed thioether-directed cyclometalation strategy was developed to enable remote methylene C-H bond amidation of unactivated alkenes. Due to the preference for five-membered nickelacycle formation, the chain-walking isomerization initiated by the NiH insertion to an alkene could be terminated at the γ-methylene site remote from the alkene moiety. By employing 2,9-dibutyl-1,10-phenanthroline as the ligand and dioxazolones as the reagent, the amidation occurs at the γ-C(sp³)-H bonds to afford the amide products in up to 90% yield (<40 examples) with remarkable regioselectivity (up to 24:1 rr).

Journal of the American Chemical Society published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, SDS of cas: 4410-99-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Chunfang published the artcileTo explore the best time of hemabate in prevention and treatment of postpartum hemorrhage, Safety of 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, the publication is Hebei Yixue (2017), 23(1), 52-54, database is CAplus.

Objective: To study the best time of hemabate in prevention and treatment of postpartum hemorrhage, to provide basis for clin. diagnosis and treatment. Methods: 114 cases of cesarean section with bleeding tendency from Feb. 2014 to Feb. 2016 in our hospital were selected, the patients were randomly divided into group I, group II and group III, 38 cases in each group, group I injection of oxytocin and hemabate immediately after fetal delivery, group II injection of the oxytocin immediately after fetal delivery, application of hemabate when uterine atony, group III injection of oxytocin immediately after fetal delivery, not using hemabate, the bleeding intraoperative, back to the ward to postoperative 2H and 2H to postpartum 24 h were compared between the three groups. Results: The bleeding during operation of group I significantly lower than II group and III group (P<0.05), there were no significant amount of intraoperative blood loss in group II and group III (P>0.05); back to the ward to postoperative 2H bleeding of group I and group II were significantly lower than those in the group III (P<0.05), group I and group II were not statistically significant (P>0.05), 2H to postpartum 24h bleeding of group I and group II were significantly lower than those in the group III (P<0.05), group I and group II were not statistically significant (P>0.05). Conclusion: Fetal delivery immediately injection of oxytocin and hemabate could effectively reduce the amount of postpartum hemorrhage, it is the best time to prevent postpartum hemorrhage.

Hebei Yixue published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C8H11BO2, Safety of 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Pan, Bendu published the artcileIridium-catalyzed intramolecular asymmetric allylic etherification of salicylic acid derivatives with chiral-bridged biphenyl phosphoramidite ligands, Related Products of alcohols-buliding-blocks, the publication is Organic Chemistry Frontiers (2021), 8(16), 4514-4519, database is CAplus.

Iridium-catalyzed intramol. asym. allylic etherification of salicylic acid derivatives was successfully realized for the first time. By using chiral-bridged biphenyl phosphoramidite ligand, a class of novel chiral 1,4-benzoxazepinones I [R¹ = H, 6-Me, 9-MeO, 8-F; R² = Bn, 4-MeOC₆H₄CH₂] was prepared conveniently with good to excellent yields (up to 99%) and high enantioselectivities (up to 99% ee). The effect of different substituents on the enantioselectivity was also discussed. Compared with BINOL or biphenol-derived counterparts, catalysis with ligand had obvious advantages in terms of catalytic activity and enantioselectivity. Mild conditions and a wide substrate scope demonstrated the practicability of this method. It was also found that the configuration of the product was directly related to the configuration of the alkene substrate and the E-substrate is more suitable for this reaction to obtain better enantioselectivity.

Organic Chemistry Frontiers published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Heger, Matthias published the artcileBracketing subtle conformational energy differences between self-solvated and stretched trifluoropropanol, Application of 3,3,3-Trifluoropropan-1-ol, the publication is Physical Chemistry Chemical Physics (2015), 17(15), 9899-9909, database is CAplus and MEDLINE.

The intramol. OH···F hydrogen bond in 3,3,3-trifluoropropanol (TFP) exerts a subtle stabilizing effect that, when compared to the non-fluorinated analog, reorders the five distinguishable conformers and widens the gap between the two most stable structures. Here, we combine findings from Raman spectroscopy in supersonic expansions and high-level quantum-chem. calculations to bracket the energy difference between the two most stable TFP structures at 1.7(5) kJ mol^-1. The torsional potential energy surface suggests consecutive backbone and OH torsional motions for the conformer interconversion, which are discussed in the framework of supersonic jet cooling as a function of nozzle temperature The picture of a bistable cold mol. with trans or gauche backbone emerges, in which the OH group controls the energy difference and modulates the high barrier separating the heavy atom frames.

Physical Chemistry Chemical Physics published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, Application of 3,3,3-Trifluoropropan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts