Author: tianli

Li, Qihong published the artcileObservation on the effect of dexmedetomidine on reduction of adverse reactions induced by carboprost tromethamine during cesarean section, Product Details of C25H47NO8, the publication is Zhongguo Fuyou Baojian (2015), 30(35), 6368-6370, database is CAplus.

Objective To evaluate the preventive effect of dexmedetomidine on adverse reactions induced by carboprost tromethamine during cesarean section. Methods The pregnant women preparing for low-segment cesarean section were randomly divided into group D (dexmedetomidine), group O (ondansetron), and group C (control group), 30 women in each group. Cesarean section was completed in all the cases under continual epidural anesthesia, then they were treated by i.v. transfusion of 20 U oxytocin after delivery and deltoideus triangularis injection of 250 μg carboprost tromethamine. The cases in group D were treated by i.v. transfusion of dexmedetomidine (load capacity 1 μg/kg, the duration time of i.v. transfusion was less than 10 min, the infusion speed was 0.4 μg·kg^-1·h^-1) before 10 min of carboprost tromethamine treatment. The cases in group C were treated by i.v. injection of ondansetron after delivery. The cases in group C were treated by normal saline at equal quantity. Mean arterial blood pressure (MAP), heart rate, and SpO₂ at 5 min after entering operation room (baseline, T0), 5 min after injection of carboprost tromethamine (T1), and the end of surgery (T2) were recorded. The incidence rates of nausea, vomiting, chest distress, and flushed face from usage of carboprost tromethamine to end of surgery were calculated Modified OAA/S scoring was conducted at T2 and after 2 h of surgery (T3). Results Compared with group D, MAP at T2 and T3 in group C and group O increased significantly, heart rates at T2 and T3 in group C and group O fastened significantly, SpO₂ at T2 and T3 in group C and group O decreased significantly, there were statistically significant differences (P<0.05). Compared with group C, the incidence rates of chest distress, flushed face, nausea, and vomiting in group D decreased significantly, the incidence rates of nausea and vomiting in group O decreased significantly, there were statistically significant differences (P<0.05). Compared with group C, OAA/S score in group D increased significantly (P<0.05). Conclusion I.v. transfusion of dexmedetomidine before carboprost tromethamine during cesarean section can prevent gastrointestinal and cardiovascular reactions caused by carboprost, the effect is superior to ondansetron.

Zhongguo Fuyou Baojian published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, Product Details of C25H47NO8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Li, Yanrui published the artcileThermodynamic parameters and infinite dilution activity coefficients for organic solutes in deep eutectic solvent: Choline Chloride + 1,5-Pentanediol, HPLC of Formula: 111-29-5, the publication is Journal of Chemical Thermodynamics (2022), 106784, database is CAplus.

A series of thermodn. parameters related to choline chloride + 1,5-pentanediol deep eutectic solvent were studied through inverse gas chromatog. at 303.15-343.15 K. The infinite dilution activity coefficient (γ∞12) was used to predict the solute separation ability and the intermol. interaction strength of DES. The interaction between mols. was further described by partial molar excess properties (ΔH^E,∞₁,TΔS^E,∞₁, ΔG^E,∞₁). The value of γ∞12 was also used to compute the separation parameters for common separation problems benzene (1)/methanol (2), n-hexane (1)/benzene (2) and benzene (1)/thiophene (2). The miscibility of organic solutes and DES was evaluated using the Flory-Huggins interaction parameter, and the result showed alcs. were good solvents for the DES. Moreover, the Hildebrand solubility parameters (I₂) of the DES were calculated, and the result revealed that the value showed a downward trend with the increase of temperature

Journal of Chemical Thermodynamics published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C5H12O2, HPLC of Formula: 111-29-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ning, Ling-li published the artcileAnalysis of curative effect of Hemabate combined with B-Lynch suture in treatment of postpartum hemorrhage caused by uterine asthenia, COA of Formula: C25H47NO8, the publication is Zhongguo Fuyou Baojian (2017), 32(18), 4595-4596, database is CAplus.

Purpose: The article explored the clin. effect of Hemabate combined with B-Lynch suture in the treatment of postpartum hemorrhage due to uterine asthenia. Methods: In the paper, 100 cases of postpartum hemorrhage due to uterine contraction and fatigue admitted to the Fuyang District Maternity and Child Health Hospital from March 2014 to March 2016 were selected as the research objects, and were divided into observation group and control group by random number method, with 50 cases in each group. The observation group was treated with Simabate combined with B-Lynch suture, and the control group was treated with traditional hemostasis. The clin. efficacy, operation time, intraoperative blood loss, 24 h postoperative blood loss, postoperative Hb level, hospital stay and postoperative complications were observed in the two groups. Results: The total effective rate of the observation group was 96.00%, and the control group was 80.00%. The difference between the two groups was statistically significant (P < 0.05); the operation time of the observation group was (49.98 ± 7.24) min, and the intraoperative blood loss was ( 514.43 ± 29.53) ml, 24 h postoperative blood loss was (125.97 ± 15.26) ml, hospitalization time was (7.92 ± 2.36) days, the control group was (71.41 ± 6.08) min, (720.16 ± 31.27) ml, (230.14 ± 21.91) ml, (10.04 ± 3.71)d, the difference between the two groups was statistically significant (P < 0.05). The Hb level of the observation group was higher than that of the control group, but the difference was not statistically significant (P > 0.05). The incidence of complications in the observation group was significantly lower than that in the control group, but the difference was not statistically significant (P > 0.05). Conclusion: The clin. effect of Simabate combined with B-Lynch suture in the treatment of postpartum hemorrhage due to uterine attenuation was definite and could shorten the operation time, to reduce intraoperative and postpartum hemorrhage, it was a fast, safe and easy way to stop bleeding, with fewer complications.

Zhongguo Fuyou Baojian published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, COA of Formula: C25H47NO8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lu, Xiaolei published the artcileStudy on the hydration product of ettringite in cement paste with ethanol-diisopropanolamine, SDS of cas: 122-20-3, the publication is Journal of Thermal Analysis and Calorimetry (2020), 139(2), 1007-1016, database is CAplus.

A review. Ettringite (AFt) is a very important hydration product of hardened cement pastes in the early stage. The effect of ethanol-diisopropanolamine (EDIPA) on the formation and transform process of AFt in cement pastes was systematically investigated in this paper. The results indicate that the AFt content in hardened cement pastes notably decreases due to the inhibition effect of EDIPA on the dissolution of gypsum. In addition, EDIPA promotes the transformation of AFt into calcium monosulfoaluminate hydrate and considerably alters the morphol. of AFt crystals from the acicular crystals to stubby rods crystals. The mechanism of the formation of EDIPA-Ca²⁺ complex by the interaction between Ca²⁺ in ettringite and the oxygen atoms in EDIPA mol. was proposed. EDIPA-Ca²⁺ complex can slow down or prevent the crystal growth process of AFt and lead to altering the morphol. of AFt crystals.

Journal of Thermal Analysis and Calorimetry published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C9H21NO3, SDS of cas: 122-20-3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Li, Chunxiang published the artcilePhotoluminescence properties of a novel cyclometalated iridium(III) complex with coumarin-boronate and its recognition of hydrogen peroxide, Related Products of alcohols-buliding-blocks, the publication is Dalton Transactions (2014), 43(14), 5595-5602, database is CAplus and MEDLINE.

A novel neutral iridium(III) complex-based phosphorescent probe (Ir-2) for hydrogen peroxide (H₂O₂) has been designed and synthesized by incorporating a benzeneboronic acid pinacol ester (bpe) moiety into 3-(benzothiazol-2-yl)-7-hydroxy-coumarin (Bthc) as a cyclometalated ligand (Bthc-bpe). The photophys. behavior of Ir-2 was investigated by UV-Vis absorption spectroscopy, photoluminescence spectroscopy, and quantum mech. calculations The absorption spectra of the complex Ir-2 are dominated by the cyclometalated ligand; thus it shows an intense absorption band in the visible region at 460 nm with a molar extinction coefficient (ε) of about 3 × 10⁴ M^-1 cm^-1, which is rarely found for typical polypyridine iridium(III) complexes. The complex Ir-2 displays efficient phosphorescent emission at 560 nm at room temperature originating from a mixed triplet metal-to-ligand charge-transfer (³MLCT, dπ(Ir) π* (Bthc-bpe)) and triplet intraligand (³ILCT, π-π* (Bthc-bpe)) excited states as suggested by the DFT computational studies. Upon reaction with H₂O₂, the complex displays an emission decrease induced by an intense intermol. aggregation due to the cleavage of the bulky benzeneboronic acid pinacol ester substituent, indicating that Ir-2 could act as an ON-OFF-type phosphorescent probe for H₂O₂. Addnl., selectivity studies reveal that the complex Ir-2 possesses high selectivity toward H₂O₂ over other reactive oxygen species (ROS).

Dalton Transactions published new progress about 25240-59-9. 25240-59-9 belongs to alcohols-buliding-blocks, auxiliary class Boronic acid and ester,Boronic Acids,Boronate Esters, name is 4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-ol, and the molecular formula is C6H13BO3, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Huang, Hong published the artcileSulfate adjustment for cement with triisopropanolamine: Mechanism of early strength enhancement, Application of Triisopropanolamine, the publication is Construction and Building Materials (2018), 516-522, database is CAplus.

This paper investigated the impacts of sulfate adjustment on strength, hydration and the microstructure of cement with triisopropanolamine (TIPA) to propose the mechanism of early strength enhancement from the microscopic point of view. The results showed that a single addition of TIPA was only good for cement strength promotion on 28 days. While an appropriate sulfate adjustment (∼0.6% in SO₃) was effective in enhancing the 1 day and 3 days strengths of cement with TIPA. When more sulfate was introduced, a clear delay in the AFt to AFm conversion and a steady increase of heat release could be observed during the early hydration of cement. QXRD analyses revealed that TIPA was able to promote the hydration of intermediate phases, particularly C₄AF, resulting in the fast formation of aluminate hydrates. The increased sulfate in cement with TIPA not only stabilized AFt formation but also promoted the silicate reaction in the early stages. SEM confirmed that the single addition of TIPA promoted the formation of coarse AFm clusters filling the pores of hardened cement paste. The increased sulfate restored the formation of fine AFt particles, which further refined the microstructure of the paste. Since the addition of TIPA and the adjustment of sulfate altered the hydration kinetics of intermediate phases, different aluminate hydrates intermixing with C-S-H could also be observed

Construction and Building Materials published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C9H21NO3, Application of Triisopropanolamine.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Raja, Krishnaswami S. published the artcileIcosahedral virus particles as polyvalent carbohydrate display platforms, Product Details of C13H15NO6S, the publication is ChemBioChem (2003), 4(12), 1348-1351, database is CAplus and MEDLINE.

Readily prepared from the icosahedral cowpea mosaic virus (one-twelfth of the structure of this scaffold is shown here, with attachment points in yellow) and electrophilic sugar derivatives, the resulting particles bind strongly to the lectin concanavalin-A, forming cross-linked networks. Measurements of binding strength demonstrate effective polyvalencies comparable to the most potent dendrimer- and polymer-based systems reported to date, with the added advantage of near at.-resolution control over structure.

ChemBioChem published new progress about 96345-79-8. 96345-79-8 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Gal and Man, name is (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C13H15NO6S, Product Details of C13H15NO6S.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Xiang, Jiajun published the artcileEfficacy of pulmonary surfactant combined with high-dose ambroxol hydrochloride in the treatment of neonatal respiratory distress syndrome, Name: trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, the publication is Experimental and Therapeutic Medicine (2019), 18(1), 654-658, database is CAplus and MEDLINE.

Clin. efficacy of pulmonary surfactant combined with high-dose ambroxol hydrochloride in the treatment of neonatal respiratory distress syndrome (NRDS) was investigated. One hundred child patients with NRDS in Linyi Central Hospital were collected according to the diagnostic criteria for RDS in the Pediatrics, and randomly divided into the treatment group (n=50) and the control group (n=50) based on different therapeutic methods. Patients in the control group were treated with basic treatment and high-dose ambroxol hydrochloride injection, while those in the treatment group were addnl. administered with pulmonary surfactant Curosurf based on conventional therapy in the control group. The chest X-rays were collected before the treatment and at 12 h after the drug administration, the degree of respiratory distress in child patients was observed and evaluated via Silverman grading, and changes in blood gas indexes were recorded before treatment and at 2, 6 and 12 h after the drug administration. The chest X-ray grade, Silverman grade and blood gas anal. results had no differences between the two groups before the treatment (P>0.05). In the treatment group, partial pressure of oxygen (PaO₂) and PH were increased and partial pressure of carbon dioxide (PaCO₂) was decreased compared with those in the control group at 2, 6 and 12 h after the drug administration (P<0.05). At 12 h after the drug administration, chest X-ray grade and Silverman grade in both groups were improved, which were significantly superior in the treatment group to those in the control group (P<0.01). Moreover, the efficacy in the treatment group was remarkably better than that in the control group at 12 h after drug administration (P<0.01). Pulmonary surfactant combined with high-dose ambroxol hydrochloride has definite efficacy in the treatment of NRDS, which can significantly improve the pulmonary infection, respiratory distress and blood gas indexes of child patients.

Experimental and Therapeutic Medicine published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C26H26N4O7, Name: trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Liu, Jiang published the artcileLate-stage construction of stapled peptides through Fujiwara-Moritani reaction between tryptophan and olefins, Safety of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, the publication is Chemical Communications (Cambridge, United Kingdom) (2021), 57(88), 11661-11664, database is CAplus and MEDLINE.

Herein, the first example of a palladium-catalyzed Fujiwara-Moritani reaction for olefination of tryptophan (Trp) residues, free from directing groups, was presented. The developed reaction proceeds efficiently for peptide modification, ligation and peptide stapling.

Chemical Communications (Cambridge, United Kingdom) published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C12H20O6, Safety of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zeng, Weizhu published the artcileProduction of 2-keto-L-gulonic acid by metabolically engineered Escherichia coli, Product Details of C6H10O7, the publication is Bioresource Technology (2020), 124069, database is CAplus and MEDLINE.

The 2-keto-L-gulonic acid (2-KLG) is the direct precursor for industrial vitamin C production The main biosynthetic method for 2-KLG production is the classical two-step fermentation route. However, disadvantages of this method are emerging, including high consumption of energy, difficulties in strain screening, complex operation, and poor stability. In this study, five recombinant Escherichia coli strains overexpressing different sorbose/sorbosone dehydrogenases were constructed and used for 2-KLG production By optimizing catalytic conditions and further expressing pyrroloquinoline quinone in the recombinant strain, the titer of 2-KLG reached 72.4 g/L, with a conversion ratio from L-sorbose of 71.2% in a 5-L bioreactor. To achieve direct biosynthesis of 2-KLG from D-sorbitol, a co-culture system consisting of Gluconobacter oxydans and recombinant E. coli was designed. With this co-culture system, 16.8 g/L of 2-KLG was harvested, with a conversion ratio from D-sorbitol of 33.6%. The approaches developed here provide alternative routes for the efficient biosynthesis of 2-KLG.

Bioresource Technology published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C3H5BN2O2, Product Details of C6H10O7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts