Author: tianli

Ling, Zhang published the artcileEffect of carboprost tromethamine in prevention of postpartum hemorrhage in cesarean section., Recommanded Product: 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, the publication is Pakistan journal of pharmaceutical sciences (2018), 31(5(Special)), 2257-2262, database is MEDLINE.

Carboprost tromethamine is a synthetic prostaglandin derivative, which can effectively promote law contraction of the uterus and significantly reduce the amount of bleeding during and after delivery. In this study, we explored the effect of carboprost tromethamine on the prevention of postpartum hemorrhage after cesarean section and the effect on coagulation function and hemodynamics. At the same time, the effects of oxytocin and carboprost tromethamine were studied in different groups. The results showed that the amount of 2h bleeding (256.7±65.21) mL and the amount of 24h hemorrhage (308.3±78.3) after the operation were significantly decreased, and the difference was statistically significant (P<0.05). After the operation, the levels of APTT, TT and Fib in the two groups were significantly lower than those before the operation. The levels of SBP (119.4±8.24) mmHg and DBP (79.6±6.21) mmHg in the experimental group were significantly higher than those of the control group. In summary, carboprost tromethamine has a significant effect on the prevention of postpartum hemorrhage in cesarean section, and has a significant effect on improving the state of hypercoagulable blood and maintaining the stable hemodynamic state, which has clinical a value.

Pakistan journal of pharmaceutical sciences published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, Recommanded Product: 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

He, Jing published the artcileEffect of ambroxol hydrochloride lavage with electronic bronchoscope on PCT and CRP levels in elderly patients with pneumonia and respiratory failure, Formula: C13H19Br2ClN2O, the publication is Guizhou Yiyao (2021), 45(3), 380-381, database is CAplus.

The effects of ambroxol hydrochloride lavage with electronic bronchoscope on inflammatory factors procalcitonin (PCT) and C-reactive protein (CRP) in elderly patients with pneumonia complicated with respiratory failure were analyzed. There was no significant difference in the levels of PCT and CRP between the observation group and the control group before treatment. One week after treatment, PCT and CRP in the two groups decreased, and the observer was lower than that in the control group. Studies have shown that ambroxol hydrochloride lavage through electronic bronchoscope can effectively reduce the level of inflammatory factors in elderly patients with pneumonia complicated with respiratory failure, improve pulmonary function and blood gas indexes, and does not increase the rate of adverse reactions or complications. It is a treatment scheme suitable for elderly patients with pneumonia complicated with respiratory failure.

Guizhou Yiyao published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Formula: C13H19Br2ClN2O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Strunskaya, E. I. published the artcileElectrochemical Reduction and Oxidation of 3,4-Disubstituted 1,2,5-Thiadiazoles, Category: alcohols-buliding-blocks, the publication is Russian Journal of General Chemistry (Translation of Zhurnal Obshchei Khimii) (2003), 73(5), 806-815, database is CAplus.

The electron-acceptor N and S atoms in 3,4-disubstituted 1,2,5-thiadiazoles are responsible for much decreased reduction potentials and much increased oxidation potentials of these compounds compared with the corresponding carbocyclic derivatives The thiadiazole ring is resistant to oxidation, and the reversible electron transfer gives rise to fairly stable radical cations. Reductive stability of the heterocycle depends on the nature of its substituents and on the medium: when nucleophile substituents are present, 2-electron transfer in aprotic media results in heterocycle ring opening with iminonitrile formation, whereas in the presence of 2 readily leaving groups, the electron transfer induces cleavage of the complete heterocycle ring into inorganic anions.

Russian Journal of General Chemistry (Translation of Zhurnal Obshchei Khimii) published new progress about 30165-97-0. 30165-97-0 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Thiadiazole,Alcohol, name is 4-Morpholino-1,2,5-thiadiazol-3-ol, and the molecular formula is C6H8O6, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Jana, Sripati published the artcilePhotoinduced Proton-Transfer Reactions for Mild O-H Functionalization of Unreactive Alcohols, Product Details of C3H5F3O, the publication is Angewandte Chemie, International Edition (2020), 59(14), 5562-5566, database is CAplus and MEDLINE.

Hexafluoroisopropanol is typically considered as an unreactive solvent and not as a reagent in organic synthesis. Herein, we report on a mild and efficient photochem. reaction of aryl diazoacetates with hexafluoroisopropanol that enables, under stoichiometric reaction conditions, the synthesis of fluorinated ethers in excellent yield. Mechanistic studies indicate there is a preorganization of hexafluoroisopropanol and the diazoalkane acts as an unreactive hydrogen-bonding complex. Only after photoexcitation does this complex undergo a protonation-substitution reaction to the reaction product. Investigations on the applicability of this photochem. transformation show that a broad variety of acidic alcs. can be subjected to this transformation and thus demonstrate the feasibility of this concept for O-H functionalization reactions (54 examples, up to 98% yield).

Angewandte Chemie, International Edition published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, Product Details of C3H5F3O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Fan, Tian-Yun published the artcileStructure-activity relationship and biological evaluation of berberine derivatives as PCSK9 down-regulating agents, Recommanded Product: 2-Methoxy-4-(2-nitroethyl)phenol, the publication is Bioorganic Chemistry (2021), 104994, database is CAplus and MEDLINE.

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a secreted protein and its deficiency markedly enhances the survival rate of patients with cardiovascular diseases (CVDs). Forty berberine (BBR) derivatives I (R¹ = H, MeO, R² = MeO, OH, PhCH₂O, EtO, R³ = MeO, OH, EtO, R²R³ = OCH₂O, R⁴ = H, MeO, R⁵ = H, Cl, MeO, PhCH₂O, cyclobutylmethoxy, etc., R⁶ = MeO, OH, R⁷ = MeO, EtO, H) were synthesized and evaluated for their activity on down-regulating the transcription of PCSK9 in HepG2 cells, taking BBR as the lead. Structure-activity relationship (SAR) anal. revealed that the 2,3-dimethoxy moiety might be beneficial for activity. Among them, I (R¹ = R⁴ = R⁷ = H, R² = R³ = R⁶ = MeO, R⁵ = p-F₃CSC₆H₄CH₂O) (II) displayed the most potent activity with an IC₅₀ value of 9.5 ± 0.5μM, better than that of BBR. Also, it significantly decreased the PCSK9 protein level at the cellular level, as well as in the liver and serum of mice in vivo. Furthermore, II markedly increased LDLR expression and LDL-C clearance via down-regulating PCSK9 protein. The mechanism of action of II is targeting HNF1α and/or Sp1 cluster modulation upstream of PCSK9, a different one from BBR. Therefore, II might have the potential to be a novel PCSK9 transcriptional inhibitor for the treatment of atherosclerosis, worthy for further investigation.

Bioorganic Chemistry published new progress about 528594-30-1. 528594-30-1 belongs to alcohols-buliding-blocks, auxiliary class Nitro Compound,Benzene,Phenol,Ether, name is 2-Methoxy-4-(2-nitroethyl)phenol, and the molecular formula is C9H11NO4, Recommanded Product: 2-Methoxy-4-(2-nitroethyl)phenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chen, Jiayu published the artcileCharacterization of the key differential volatile components in different grades of Dianhong Congou tea infusions by the combination of sensory evaluation, comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry, and odor activity value, Synthetic Route of 106-25-2, the publication is LWT–Food Science and Technology (2022), 113755, database is CAplus.

Aroma is an important factor in evaluating tea infusion quality. In this study, the aroma quality of 44 Dianhong Congou tea infusions was classified into high-quality group and non-high-quality group according to the sensory evaluation. The volatile components were investigated by using headspace solid phase microextraction combined with comprehensive two-dimensional gas chromatog.-time-of-flight mass spectrometry. A total of 258 volatile components were identified, of which the three component types with the highest relative percentages were alcs. (17.05%), aldehydes (15.12%), and heterocycles (15.12%). Clear discrimination was achieved by orthogonal partial least squares discrimination anal. (R2Y = 0.94, Q2 = 0.82). In addition, 69 important differential compounds were identified based on variable importance in the projection value (VIP > 1.0) and one-way ANOVA (p < 0.05). Moreover, seven common key odorants with odor activity values (OAVs) >1 were screened out, including (E, E)-2,4-heptadienal, linalool, 1-octene-3-one, geraniol, β-myrcene, (Z)-4-heptenal, and nonanal. Aroma character impact value indicated that linalool performed a pos. supportive role in the aroma quality of Dianhong Congou tea infusions, while (E, E)-2,4-heptadienal neg. affected the aroma quality. These results contribute to providing a theor. support for directional processing of high-quality black tea.

LWT–Food Science and Technology published new progress about 106-25-2. 106-25-2 belongs to alcohols-buliding-blocks, auxiliary class Natural product, name is cis-3,7-Dimethyl-2,6-Octadien-1-Ol, and the molecular formula is C10H18O, Synthetic Route of 106-25-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Hou published the artcileEnantioseparation of amino acid and mandelic acid enantiomers using Garphos derivatives as chiral extractants, Application of 2-Hydroxy-2-phenylacetic acid, the publication is Chirality (2022), 34(9), 1239-1246, database is CAplus and MEDLINE.

In this paper, Garphos with different substituents were employed as chiral extractants to enantiosep. racemic amino acid and mandelic acid. The influences of metal precursors, pH of aqueous solution, Garphos-metal concentration, extraction temperature, and substituent effect on extraction were investigated. The results indicated that the substituent groups significantly affected the π-π interaction between extractant and substrate. And the separation factors (α) for Garphos could be remarkably improved by regulating substituent groups. Garphos-II-Pd, Garphos-VI-Pd, Garphos-III-Pd, Garphos-I-Cu, Garphos-VI-Cu, and Garphos-V-Pd were the most efficient extractants for phenylalanine (Phe), homophenylalanine (Hphe), 4-nitrophenylalanine (Nphe), 3-chlorophenylglycine (Cpheg), mandelic acid (MA), and 2-chlormandelic acid (CMA) with α values of 2.40, 2.37, 5.37, 1.59, 5.98, and 3.69, resp. This work provided an important reference for the design of efficient chiral extractants in future work.

Chirality published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C21H20BrNO4S, Application of 2-Hydroxy-2-phenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Xuewei published the artcileYnamide-Mediated Intermolecular Esterification, Recommanded Product: 4-(1H-Pyrrol-1-yl)phenol, the publication is Journal of Organic Chemistry (2020), 85(9), 6188-6194, database is CAplus and MEDLINE.

An ynamide-mediated one-pot, two-step intermol. esterification via the condensation of carboxylic acids with nucleophilic hydroxyl species is reported. A broad substrate scope with respect to carboxylic acids, alcs., and phenols is observed The α-acyloxyenamide intermediates formed by the addition of carboxylic acids to ynamides proved to be effective acylating reagents for the esterification of alc. and phenol derivatives with the assistance of base catalysis. Notably, the racemization of the α-chiral center of carboxylic acids can be avoided.

Journal of Organic Chemistry published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C18H35NO, Recommanded Product: 4-(1H-Pyrrol-1-yl)phenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Li, Jun published the artcileSynthesis, properties and drug potential of the photosensitive alkyl- and alkylsiloxy-ligated silicon phthalocyanine Pc 227, SDS of cas: 597-52-4, the publication is Photochemical & Photobiological Sciences (2014), 13(12), 1690-1698, database is CAplus and MEDLINE.

The photosensitive, alkyl- and alkylsiloxy-ligated Si phthalocyanine, SiPc[(CH₂)₃SH][OSiMe₂(CH₂)₃NMe₂], Pc 227, was prepared and characterized. This phthalocyanine yields the exptl. photodynamic therapy (PDT) drug Pc 4, SiPc[OH][OSiMe₂(CH₂)₃NMe₂], when irradiated with red light. To provide an understanding of the process by which Pc 227 and other alkyl-alkylsiloxysilicon phthalocyanines such as Pc 227 are photolyzed, bond dissociation energy, natural bond orbital (NBO) charge distribution, spin d. distribution, nucleus-independent chem. shift (NICS), and electron localization function (ELF) calculations were carried out on two models related to it. These show that the lowest energy pathway for the photolysis of Pc 227 is a homolysis involving a phthalocyanine π radical having a low Si_Pc-C bond dissociation energy. The promise of the results of this study for synthetic chem. and drug development is discussed.

Photochemical & Photobiological Sciences published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C6H16OSi, SDS of cas: 597-52-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Jaumaux, Pauline published the artcileLocalized Water-In-Salt Electrolyte for Aqueous Lithium-Ion Batteries, Name: Pentane-1,5-diol, the publication is Angewandte Chemie, International Edition (2021), 60(36), 19965-19973, database is CAplus and MEDLINE.

Water-in-salt (WIS) electrolytes using super-concentrated organic lithium (Li) salts are of interest for aqueous Li-ion batteries. However, the high salt cost, high viscosity, poor wettability, and environmental hazards remain a great challenge. Herein, we present a localized water-in-salt (LWIS) electrolyte based on low-cost lithium nitrate (LiNO₃) salt and 1,5-pentanediol (PD) as inert diluent. The addition of PD maintains the solvation structure of the WIS electrolyte, improves the electrolyte stability via hydrogen-bonding interactions with water and NO₃^– mols., and reduces the total salt concentration By in situ gelling the LWIS electrolyte with tetraethylene glycol diacrylate (TEGDA) monomer, the electrolyte stability window can be further expanded to 3.0 V. The as-developed Mo₆S₈|LWIS gel electrolyte|LiMn₂O₄ (LMO) batteries delivered outstanding cycling performance with an average Coulombic efficiency of 98.53% after 250 cycles at 1 C.

Angewandte Chemie, International Edition published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C5H12O2, Name: Pentane-1,5-diol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts