Author: tianli

Related Products of 104-38-1, Adding some certain compound to certain chemical reactions, such as: 104-38-1, name is 1,4-Bis(2-hydroxyethoxy)benzene,molecular formula is C10H14O4, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 104-38-1.

A solution of 4-bis(2-hydroxyethoxy) benzene (6.0 g 30 mmol) and triphenylphosphine (18.9 g,72.1 mmol) in dry acetonitrile (200 mL) was cooled with an ice bath. Under vigorous stirring, carbon tetrabromide (24.0 g, 72.4 mmol) was slowly added. The mixture was stirred at room temperature for 12 hours. Then cold water (200 mL) was added to the reaction mixture to give white precipitation. The precipitate was collected, washed with methanol/water (3:2, 3 ¡Á 100 mL), recrystallized from methanol, and dried under vacuum to afford 1 as white crystals, 82.7% (14.5 g, 24.8mmol).

According to the analysis of related databases, 104-38-1, the application of this compound in the production field has become more and more popular.

Reference:
Article; Xiao, Xue-Dong; Bai, Ya-Li; Liu, Jia-Qi; Wang, Jun-Wen; Tetrahedron Letters; vol. 57; 30; (2016); p. 3385 – 3388;,
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Adding a certain compound to certain chemical reactions, such as: 3637-61-4, Cyclopentanemethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 3637-61-4, blongs to alcohols-buliding-blocks compound. SDS of cas: 3637-61-4

Preparation E Cyclopentylmethyl Iodide Methanesulfonyl chloride (25.5 mL) was added dropwise to a solution of cyclopentanemethanol (32.4 mL) and triethylamine (46 mL) in dichloromethane (500 ml) at 0 C. After stirring overnight at room temperature, the mixture was sequentially washed with water, 2% hydrochloric acid, 4% aqueous sodium bicarbonate and water again. Following drying over sodium sulfate, the solvent was removed under vacuum, affording crude cyclopentylmethyl methanesulfonate (ca. 50 g) as a colourless oil.

The synthetic route of 3637-61-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Pharmacia & Upjohn S.p.A.; US6482827; (2002); B1;,
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Adding a certain compound to certain chemical reactions, such as: 25574-11-2, 3-(4-Bromophenyl)propan-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C9H11BrO, blongs to alcohols-buliding-blocks compound. HPLC of Formula: C9H11BrO

Reference Example 1 4-(3-Benzyloxypropyl)bromobenzene A suspension of sodium hydride (60%, 0.97 g), 3-(4-bromophenyl)-1-propanol (1.0 g) and benzyl bromide (0.69 ML) in benzene (24 ML) was stirred under reflux for 7 hours.. After cooling to room temperature, a saturated aqueous ammonium chloride solution (50ML) was added to the reaction mixture, and the mixture was extracted with ethyl acetate (100 ML).. The organic layer was washed with water (40 ML) and brine (40 ML) and dried over anhydrous sodium sulfate.. The solvent was removed under reduced pressure, and the residue was purified by column chromatography on silica gel (eluent: hexane/ethyl acetate = 20/1) to give 4-(3-benzyloxypropyl)bromobenzene (1.4 g).1H-NMR (CDCl3) delta ppm: 1.85-2.00 (2H, m), 2.60-2.75 (2H, m), 3.47 (2H, t, J=6.2Hz), 4.50 (2H, s), 7.00-7.10 (2H, m), 7.20-7.45 (7H, m)

The synthetic route of 25574-11-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Kissei Pharmaceutical Co., Ltd.; EP1367060; (2003); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1467-84-1, name is (trans-4-Aminocyclohexyl)methanol, the common compound, a new synthetic route is introduced below. category: alcohols-buliding-blocks

To a solution of trans-4-aminocyclohexyl)methanol (CXXXIV) (1.0 g, 6.04 mmol) and HATU (2.78 g, 7.30 mmol) in DMF (15 mL) was added DIPEA (4.03 mL, 23.07 mmol) and the mixture was stirred for 10 min. Then, 5-bromo-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole-3-carboxylic acid (LII) (2.5 g, 7.69 mmol) was added and the mixture was stirred at room temperature for 18 h. The LC-MS of mixture showed near completion of the starting material. The solvents were concentrated in vacuo, the residue partitioned between EtOAc and saturated aqueous NaHCO3, organic layer was separated, washed with water and brine. The organic layer was dried over anhydrous Na2SO4, solvents removed in vacuo and the crude product was purified by column chromatography using (90-100% EtOAc/hexanes) to obtain 5-bromo-N-trans-4-(hydroxymethyl)cyclohexyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole-3-carboxamide (CXXXV) as a white solid (2.06 g, 4.72 mmol, 61.4% yield). ESIMS found for C20H26BrN3O3 m/z 438.1 (M+H).

The synthetic route of 1467-84-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Samumed, LLC; KC, Sunil Kumar; Mak, Chi Ching; Mittapalli, Gopi Kumar; Hofilena, Brian Joseph; Eastman, Brian Walter; Cao, Jianguo; Chiruta, Chandramouli; Bollu, Venkataiah; (145 pag.)US2019/263821; (2019); A1;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.147034-01-3, name is (2,5-Dibromophenyl)methanol, molecular formula is C7H6Br2O, molecular weight is 265.93, as common compound, the synthetic route is as follows.Computed Properties of C7H6Br2O

To a stirred solution of (2,5-dibromo-phenyl)-methanol (45 g, 170 mmol) in THF (1000 mL) is added 60% NaH in mineral oil (10 g, 250 mmol) at 0 C. The mixture is stirred for 30 min and allyl bromide (25 g, 203 mmol) is added. Then the mixture is warmed up to room temperature for 12 hrs. The reaction is quenched with ice and the mixture is extracted with EtOAc. The organic layers are combined, dried and concentrated to give the crude product. Purification by flash column chromatography affords 45 g of 2-allyloxymethyl-l,4-dibromo-benzene.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,147034-01-3, (2,5-Dibromophenyl)methanol, and friends who are interested can also refer to it.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; CHEN, Zhidong; COGAN, Derek; GUO, Xin; MARSHALL, Daniel Richard; MEYERS, Kenneth Michael; ZHANG, Yunlong; (130 pag.)WO2016/89800; (2016); A1;,
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Related Products of 92409-15-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 92409-15-9, name is 2-(2-Methoxyphenoxy)-1-(4-methoxyphenyl)propane-1,3-diol, molecular formula is C17H20O5, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

In 5 ml of quartz optical reaction tube, adding 0.05 mmol 2-(2-methoxyphenoxy)-1-(4-methoxyphenyl)-1,3-propanediol, 5 mg mpg-C3N4Catalyst, magneton, and add 1 ml solvent acetonitrile (substrate concentration is 0.05 mol/L). Air above the oxygen displacement reaction tube, and the opening is sealed, is arranged in the integrated light in the reaction device, the rotating speed of 500 r/min, the illumination wavelength is 405 nm (the power of 6 W), temperature constant at 40C, reaction 8 h. After the reaction, gas chromatography – mass spectrum detecting the product, and for high performance liquid chromatography quantitative, substrate conversion and product yield is shown in table 1.

According to the analysis of related databases, 92409-15-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Dalian Institute of Chemical Physics; Wang Feng; Liu Huifang; Wang Min; Li Hongji; Luo Nengchao; Su Kaiyi; (14 pag.)CN109456160; (2019); A;,
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Reference of 770-71-8, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 770-71-8 as follows.

Example 1 Synthesis of (chloromethyl) (1-adamantylmethyl) ether represented by a structural formula: A Kjeldahl flask having a volume of 50 ml equipped with a nozzle for introducing hydrogen chloride gas was charged with 1.66 g (10 mmol) of 1-adamantylmethanol, 0.60 g (20 mmol) of paraformaldehyde, 1.20 g (10 mmol) of magnesium sulfate and 30 ml of dried dichloromethane, and it was cooled to 0C on an ice bath and stirred. Hydrogen chloride gas generated by mixing 10 g of sodium chloride with 50 ml of conc. sulfuric acid was blown thereinto through the nozzle for one hour. After further stirring for 60 minutes, magnesium sulfate was filtered, and then the solution was analyzed by gas chromatography to confirm that 1-adamantylmethanol was completely converted and that the intended product was obtained at a selectivity of 94.5 %. Hydrogen chloride and dichloromethane were removed, and then refining was carried out by distillation to isolate 1.87 g (8.72 mmol, yield 87.2 %) of the intended product. The analytical results of the above compound are shown below. ¡¤Nuclear magnetic resonance spectrometry (NMR): CDCl31H-NMR (500 MHz): 1.53 (6H, f), 1.64 to 1.72 (6H, d), 1.97 (3H, e), 3.25 (2H, b), 5.50 (2H, a),13C-NMR (126 MHz): 28.18 (e), 37.11 (d or f), 39.45 (d or f), 33.49 (c), 81.34 (b), 84.25 (a) ¡¤Infrared spectrometry (IR): 2905 cm-1 (C-H; str.), 1157 cm-1 (C-O-C; str.), 650 cm-1 (C-Cl; str.) ¡¤ Boiling point (bp): 130 to 133C/0.7 kPa

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,770-71-8, its application will become more common.

Reference:
Patent; IDEMITSU KOSAN COMPANY LIMITED; EP1577285; (2005); A1;,
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Related Products of 311-86-4 ,Some common heterocyclic compound, 311-86-4, molecular formula is C3H4BrF3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

733.2 mg of calcium hydroxide and 3343.3 mg of water were added to the reaction flask with the rectification apparatus.The mixture was heated to 90 C with stirring, and 1345 mg of 2-bromo-3,3,3-trifluoro-1-propanol was slowly added dropwise thereto for 1 h to obtain 1,1,1-trifluoro-2,3-epoxypropane. After chromatographic analysis, the yield was 74% and the selectivity was 100%, as shown in Figure 4.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 311-86-4, 2-Bromo-3,3,3-trifluoropropan-1-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Shanxi Prolong Petroleum Group Fugui Chemical Co., Ltd.; Dalian Institute of Chemical Physics; Liu Jianguo; Deng Weiqiao; Yang Fengbin; Yin Shuangliang; Sun Tongrui; Meng Qingyu; Zhang Ling; Wu Haitao; (15 pag.)CN109369602; (2019); A;,
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Adding a certain compound to certain chemical reactions, such as: 61487-25-0, (2-Amino-3-chlorophenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: (2-Amino-3-chlorophenyl)methanol, blongs to alcohols-buliding-blocks compound. name: (2-Amino-3-chlorophenyl)methanol

Example 82 Preparation of 2-chloro-6-methoxymethylaniline A solution of 4.00 g (25.4 mmol) of 2-amino-3-chlorobenzyl alcohol in 30 ml of dry THF was cooled to -78C, treated with 16.7 ml (26.7 mmol) of 1.60 M n-butyllithium in hexane, warmed to 0-5C, treated with 3.61 g (25.4 mmol) of methyl iodide and heated at reflux for 5.5 hours. The solvent was removed by evaporation at reduced pressure. The residue was partitioned between 175 ml of ether and water, and the organic phase was separated and dried (MgSO4). The solvent was removed by evaporation at reduced pressure, and the residue was purified by HPLC eluding with EtoAc-hexane (5:95, v/v) to afford 1.1 g of the desired product as a pale brown oil. IR and 1H NMR spectra were in agreement with the assigned structure.

The synthetic route of 61487-25-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; THE DOW CHEMICAL COMPANY; EP142152; (1991); B1;,
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Application of 110-73-6, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 110-73-6 as follows.

[0284] To the solution of compound of Example 1 (120 mg, 0.136 mmol) and catalytic amount of dimethylaminopyridine in CH2Cl2 (2 mL) at 0 C. was added pyridine (0.20 mL, 2.48 mmol) and diphosgen (0.08 mL, 0.66 mmol). The reaction was warmed to room temperature and stirred for 20 h. 2-(Ethylamino)ethanol (0.2 mL, 2.05 mmol) was added to the reaction and the mixture was stirred for another 16 h before being diluted with ethyl acetate (50 mL). The organic solution was washed with sat. aq. NH4Cl (5 mL¡Á2), sat. aq. NaHCO3 (5 mL) and brine, dried over MgSO4, and concentrated. The crude product was purified by chromatography (silica gel, 94:6:0.3 dichloromethane/methanol/conc. NH4OH). The purified product was dissolved in methanol (5 mL) and stirred at room temperature for 72 h. Concentration and purification by chromatography (silica gel, 92:8:0.3 dichloromethane/methanol/conc. NH4OH) yielded 17 mg (13%) of the title compound. MS 954 (M+H)+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,110-73-6, its application will become more common.

Reference:
Patent; Henninger, Todd C.; Macielag, Mark J.; Marinelli, Brett A.; Zhu, Bin; US2004/18994; (2004); A1;,
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