Author: tianli

Adding a certain compound to certain chemical reactions, such as: 623-50-7, Ethyl 2-hydroxyacetate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 623-50-7, blongs to alcohols-buliding-blocks compound. Product Details of 623-50-7

General procedure: To a stirred solution of esters 2a-2j (70 mmol) in MeOH (30 mL) cooled in an ice-water bath was added dropwise 80% aqueous hydrazine hydrate (6.26 g, 100 mmol). The resulting solution was stirred at room temperature (2a-2b or 2d-2j), or reflux (2c), until the completion of reaction as indicated by TLC analysis (typically within 5 h). The reaction mixture was evaporated on a rotary evaporator to give a residue, which was purified by column chromatography through a short silica gel column to yield 3a-3k after trituration with n-hexane if possible.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,623-50-7, Ethyl 2-hydroxyacetate, and friends who are interested can also refer to it.

Reference:
Article; Tian, He; Liu, Wei; Zhou, Zhixing; Shang, Qian; Liu, Yuqiang; Xie, Yafei; Liu, Changying; Xu, Weiren; Tang, Lida; Wang, Jianwu; Zhao, Guilong; Molecules; vol. 21; 11; (2016);,
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Adding a certain compound to certain chemical reactions, such as: 748805-85-8, (2-Amino-5-fluorophenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 748805-85-8, blongs to alcohols-buliding-blocks compound. Recommanded Product: 748805-85-8

To a Schlenk tube were added (2-aminophenyl)methanols 1 (0.2 mmol), aldehydes 2 (0.3 mmol), CAN (0.3 mmol), CuCl (0.02 mmol), 2,2′-bipyridine (0.02 mmol), TEMPO (0.02 mmol), CsOH(0.5 mmol), and CH3CN (2 mL). Next the tube was charged with O2 (1 atm), and was stirred constantly at 30 C for 24 h, then at 60 C for 24 h. After the completion of the reaction, the reaction mixture was cooled to room temperature, diluted with ethyl acetate, and washed with brine. After the aqueous layer was extracted with ethyl acetate, the combined organic layers were dried over anhydrous MgSO4 and evaporated under reduced pressure. The residue was purified by flash column chromatography (hexane/ethyl acetate) to afford the desired products 3.

The synthetic route of 748805-85-8 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Ye, Leping; Yu, Lin; Zhu, Lijun; Xia, Xiaodong; Molecules; vol. 18; 11; (2013); p. 13860 – 13869;,
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Related Products of 627-30-5, Adding some certain compound to certain chemical reactions, such as: 627-30-5, name is 3-Chloropropan-1-ol,molecular formula is C3H7ClO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 627-30-5.

General procedure: A 250 mL round-bottom flask equipped with aTeflon-coated magnetic stirring bar, reflux condenser and drying tube wascharged with 3.46 g (20.0 mmol, 1.0 eq) 4-bromophenol (13). It was dissolved in 100 mLDMF and 5.54 g (40.0 mmol, 2.0 eq) K2CO3, 332 mg(2.00 mmol, 10 mol%) KI and 30.0 mmol (1.5 eq) of thedesired chloroalcohol were added, respectively. Afterwards the colorlesssuspension was heated in an oil bath to 120 C and vigorously stirred atthis temperature until reaction control viaTLC showed full conversion of the starting material (20 h to 40 h).The resulting brownish suspension was cooled to room temperature and thesolvent was carefully removed in the vacuum of an oil pump. Afterwards200 mL EtOAc were added to the brownish residue, the organic phase was washedwith H2O (2 x 100 mL), brine (1 x 100 mL), dried over MgSO4,filtered and concentrated on a rotary evaporator. Finally, the brownish, oilyresidue was purified via flash column chromatography (250 g SiO2,21.0 x 6.0 cm) and the colorless liquid dried under high vacuum

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 627-30-5, 3-Chloropropan-1-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Leypold, Mario; Wallace, Paal W.; Kljajic, Marko; Schittmayer, Matthias; Pletz, Jakob; Illaszewicz-Trattner, Carina; Guebitz, Georg M.; Birner-Gruenberger, Ruth; Breinbauer, Rolf; Tetrahedron Letters; vol. 56; 41; (2015); p. 5619 – 5622;,
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Adding a certain compound to certain chemical reactions, such as: 79418-41-0, 3-Amino-7-hydroxy-2H-chromen-2-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 79418-41-0, blongs to alcohols-buliding-blocks compound. COA of Formula: C9H7NO3

General procedure: 3-Amino-7-hydroxy-2H-chromen-2-one (0.56 g, 31 mmol) and the appropriate benzaldehyde (31 mmol) were dissolved in absolute EtOH (10 mL) and refluxed for 2 h. The precipitate formed was collected and washed with hot EtOH. In this way, the following (E)-7-hydroxy-3-(benzylidenimino)- 2H-chromen-2-ones 1-6 were prepared.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,79418-41-0, its application will become more common.

Reference:
Article; Nunez, Carolina; Morales, Nicole; Garcia-Beltran, Olimpo; Mascayano, Carolina; Fierro, Angelica; Medicinal Chemistry Research; vol. 26; 11; (2017); p. 2707 – 2717;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.4704-94-3, name is 2-(Hydroxymethyl)propane-1,3-diol, molecular formula is C4H10O3, molecular weight is 106.12, as common compound, the synthetic route is as follows.Formula: C4H10O3

To a 100 mL round bottomed flask equipped with a magnetic stir bar containing THF (75 mL) was placed a (4 g, 38 mmol, 1 equiv). To this solution was added b (4.5 g, 43 mmol, 1.15 equiv), PTSA (0.2 g, 1.1 mmol, 0.03 equiv) and the reaction was allowed to stir at room temperature for 2 h. After the reaction was complete, solvent was removed in vacuo. The residue was purified over silica gel. Product eluted out in 60percent EtOAc:Hexanes mixture in a gradient elution on a Combiflash purification system. Isolated 86 (5 g, 91percent) as a colorless oil. MS: [M+H]+: 147.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,4704-94-3, 2-(Hydroxymethyl)propane-1,3-diol, and friends who are interested can also refer to it.

Reference:
Patent; SIEMENS MEDICAL SOLUTIONS USA, INC.; WO2008/124703; (2008); A2;,
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Electric Literature of 46190-45-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.46190-45-8, name is Methyl 4-(2-hydroxyethyl)benzoate, molecular formula is C10H12O3, molecular weight is 180.2005, as common compound, the synthetic route is as follows.

A solution of 13 (1.16 g, 6.44 mmol) in CH2Cl2 (20 mL) was added DAST (1.56 g, 9.66 mmol) at 0 C. The mixture was warmed to ambient temperature and stirred overnight, then ethyl acetate(100 mL) was added, washed with water (50 mL), saturated Na2CO3 (50 mL), saturated NaCl (50 mL), and dried over Na2SO4.After evaporation of the solvent in vacuo, the crude product was purified by chromatography with hexane-ether (10:1) to afford 1.06 g (91%) of 15 as a colorless oil. TLC Rf 0.25 (hexane-ether10:1); 1H NMR (300 MHz, CDCl3) delta 8.01 (d, J = 8.4 Hz, 2H), 7.33(d, J = 8.1 Hz, 2H), 4.67 (dt, J = 47.1 Hz, J = 6.3 Hz, 2H), 3.93 (s,3H), 3.08 (dt, J = 24.6 Hz, J = 6.3 Hz, 2H).

The chemical industry reduces the impact on the environment during synthesis 46190-45-8, I believe this compound will play a more active role in future production and life.

Reference:
Article; Li, Aixiao; Mishra, Yogesh; Malik, Maninder; Wang, Qi; Li, Shihong; Taylor, Michelle; Reichert, David E.; Luedtke, Robert R.; MacH, Robert H.; Bioorganic and Medicinal Chemistry; vol. 21; 11; (2013); p. 2988 – 2998;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 7314-44-5, name is (2,4-Dimethoxyphenyl)methanol, the common compound, a new synthetic route is introduced below. Formula: C9H12O3

EXAMPLE 2 5-Chloro-3-cyclohexyl-1,3-dihydro-1-(2,4-dimethoxybenzyl)-2H-benzimidazol-2-one A solution of 0.537 g of 1-hydroxymethyl-2,4-dimethoxybenzene in 5 ml of ether is cooled to -10 C., under a nitrogen atmosphere, and a solution of 0.1 ml of phosphorus tribromide in 2 ml of ether is added dropwise. The 1-bromomethyl-2,4-dimethoxybenzene thus obtained is stored in solution at -30 C.

The synthetic route of 7314-44-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SANOFI; US5661169; (1997); A;,
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Related Products of 2854-16-2 , The common heterocyclic compound, 2854-16-2, name is 1-Amino-2-methylpropan-2-ol, molecular formula is C4H11NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of the compound (53 mg, 0.1 mmol) obtained in Reference Example 28 in dichloromethane (2 mL) were added 1-amino-2-methylpropan-2-ol (18 mg, 0.2 mmol) and PyBOP [registered trade mark, benzotriazol-1-yl-oxy-tris(pyrrolidino)phosphonium hexafluorophosphate (benzotriazal-1-yl-oxy-tris(pyrrolidino)phosphonium hexafluorophosphate)] (52 mg, 0.1 mmol), and the mixture was stirred at room temperature.After 16 hr, 10percent aqueous citric acid solution was added to the reaction mixture, and the mixture was extracted with ethyl acetate.The organic layer was extracted, washed with water and saturated brine, and dried over sodium sulfate.After concentration under reduced pressure, the residue was purified by silica gel column (chloroform:methanol=100:0 – 98:2) to give the object product (51 mg, 89percent).The product was dissolved in ethyl acetate (1 mL), 4 mol/L hydrogen chloride-ethyl acetate solution (1 ml, 4 mmol) was added thereto, and the mixture was stirred at room temperature.After 14 hr, the mixture was concentrated under reduced pressure.To the obtained residue was added 2 mol/L aqueous sodium hydroxide solution, and the mixture was extracted with chloroform.The organic layer was extracted, washed with saturated brine, and dried over sodium sulfate.After concentration under reduced pressure, the residue was purified by silica gel column (chloroform :methanol=100:0 – 95:5) to give the object product (32 mg, 76percent).1H-NMR (CDCl3) delta 1.10(t, J = 7.0Hz, 3H), 1.29(s, 6H), 1.36(d, J = 6.8Hz, 3H), 3.21(dd, J= 5.3, 3.6Hz, 1H), 3.29-3.51(m, 4H), 3.61-3.73(m, 2H), 3.97(d, J = 14.3Hz, 1H), 4.11(d, J = 14.3Hz, 1H), 4.21(dt, J = 15.3, 4.2Hz, 1H), 4.33(m, 1H), 6.90-7.07(m, 6H), 7.68(dd, J = 8.3, 0.9Hz, 1H), 7.83(brt, J = 6.0Hz, 1H).

The synthetic route of 2854-16-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Dainippon Sumitomo Pharma Co., Ltd.; EP2380881; (2011); A1;,
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Related Products of 101-32-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 101-32-6, name is 2,2-(Benzylimino)diethanol. A new synthetic method of this compound is introduced below.

Synthesis was performed according to the published procedure[17] with some alterations as mentioned below. 2,2′-(Benzylazanediyl)bis(ethan-1-ol) (759 mg, 3.89 mmol) in anhydrous THF (40 mL) was transferred into the two-necked flask under argon atmosphere. A solution of 1 M potassium tert-butoxide in THF(8.03 g, 71.56 mmol) was slowly injected into the reaction mixture. Pentaethylene glycol di(p-toluenesulfonate) (2.12 g, 3.89 mmol) was dissolved in anhydrous THF (20 mL) and added to the reaction mixture dropwise. The mixture was stirred for 2.5 h at 40 C. TLCanalysis (ethyl acetate/MeOH 5:1, Rf of 4 = 0.29) indicated that thereaction was completed immediately. THF was evaporated under reduced pressure. The product was dissolved in ethyl acetate (50 mL) and extracted with 5% hydrochloric acid (v/v) (3 x 50 mL).T he water layer was collected, and neutralized by 1 M NaOH and the product was extracted three times with ethyl acetate(3 x 80 mL). The organic layer was collected and evaporated todryness. The crude product was purified by column chromatographyon silica with ethyl acetate/MeOH/TEA 15:1:0.1 as an eluent. After some impurities were washed out, the mobile phase was changed to ethyl acetate/MeOH/TEA 15:3:1 as the eluent. Yield: 792 mg (51%) of colorless oil. 1H NMR (500 MHz, CDCl3, 25 C):d 2.74-2.93 (m, 4H, CH2), 3.59-3.72 (m, 26 H, CH2) and 7.22e7.41 ppm (m, 5 H, Bn-H); MS (APCI): m/z 398.7 [MH]. The other analytical data corresponded well with data published in the literature

At the same time, in my other blogs, there are other synthetic methods of this type of compound,101-32-6, 2,2-(Benzylimino)diethanol, and friends who are interested can also refer to it.

Reference:
Article; Lochman, Lukas; Svec, Jan; Roh, Jaroslav; Novakova, Veronika; Dyes and Pigments; vol. 121; (2015); p. 178 – 187;,
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Synthetic Route of 39590-81-3, Adding some certain compound to certain chemical reactions, such as: 39590-81-3, name is 1,1-Bis(Hydroxymethyl)cyclopropane,molecular formula is C5H10O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 39590-81-3.

Step 1; Synthesis of 1,1-bis(methanesulfonyloxymethyl)cyclopropane 1,1-Bishydroxymethylcyclopropane(3.0 g, 29.4 mmol) in 40 ml of dichloromethane was mixed with triethylamine (11.9 g, 118 mmol), and methanesulfonyl chloride (10.1 g, 88.2 mmol) was added dropwise with cooling with ice. The reaction solution was stirred for 2 hours while it was gradually warmed to room temperature. After the reaction, chloroform and water were added, and the organic layer was separated, washed with water, then dried with saturated aqueous sodium chloride and over anhydrous sodium sulfate and concentrated under reduced pressure. The resulting residue was purified by silica gel chromatography (n-hexane/ethyl acetate = 9/1 to 1/1) to obtain 2.85 g of the desired product as a white solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 39590-81-3, 1,1-Bis(Hydroxymethyl)cyclopropane, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Nissan Chemical Industries, Ltd.; EP2336104; (2011); A1;,
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