Author: tianli

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 4719-04-4, Name is 2,2′,2”-(1,3,5-Triazinane-1,3,5-triyl)triethanol, SMILES is OCCN1CN(CCO)CN(CCO)C1, in an article , author is Feola, Alessandro, once mentioned of 4719-04-4, Name: 2,2′,2”-(1,3,5-Triazinane-1,3,5-triyl)triethanol.

Alprazolam-associated death: suicide or unintentional overdose?

Alprazolam is a psychoactive triazolo-benzodiazepine, commonly prescribed for the treatment of anxiety disorders and considered safe due to its high therapeutic index. It is frequently detected in polydrug-related deaths but there are very few cases of fatal intoxication by alprazolam not in combination with alcohol or other drugs. A fatal poisoning by alprazolam in a 60-years old male physician has been reported. At autopsy, no evidence of traumatic injuries or diseases was observed except for signs of bronchopneumonia and slight hypertrophy of the left ventricle. Alprazolam and its major metabolite (alpha-hydroxyalprazolam) were detected in biological samples through liquid chromatography-tandem mass spectrometry (LC-MS/MS). High concentrations of alprazolam and alpha-hydroxyalprazolam were found, respectively, in femoral blood 0.45 and 0.03 mg/L, urine 2.12 and 0.42 mg/L, bile 1.33 and 0.56 mg/L, liver 3.81 and 0.28 mg/L. Alprazolam alone was also detected in vitreous humour (0.19 mg/L) and in stomach content (0.34 mg/L). No conclusive information confirmed the hypothesis of a suicidal ingestion of alprazolam. However, an alprazolam drug-related death was assessed based on the pre-existing cardiovascular and respiratory defects. The high levels of alprazolam several times greater than the therapeutic range contributed to death due to its respiratory and central nervous system-depressant effects.

Interested yet? Read on for other articles about 4719-04-4, you can contact me at any time and look forward to more communication. Name: 2,2′,2”-(1,3,5-Triazinane-1,3,5-triyl)triethanol.

Reference:
Alcohol – Wikipedia,
,Alcohols – Chemistry LibreTexts

Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 4719-04-4, Name is 2,2′,2”-(1,3,5-Triazinane-1,3,5-triyl)triethanol, molecular formula is C9H21N3O3, belongs to alcohols-buliding-blocks compound, is a common compound. In a patnet, author is Wang, Zhouli, once mentioned the new application about 4719-04-4, Recommanded Product: 4719-04-4.

Changes in aroma components and potential Maillard reaction products during the stir-frying of pork slices

Stir-fried pork slices are kinds of traditional pork processing products in China, which are usually cooked at high temperature with different seasonings. Because of their special quality and flavor, these products gain consumers’ preference. However, there are few studies on their physicochemical properties, aroma composition and safety. In this study, the changes in basic components, aroma components and potentially hazardous substances during the stir-frying of pork slices were determined. The effects of the different ratios of fat meat to lean meat and vinegar on these indicators were evaluated, and the formation of potential Maillard reaction products was also analyzed. The results indicated that water content, chrominance values of L* and b* exhibited decreasing trends; a* value displayed a trend of decline first and then rising, while the fat content showed a rising trend during the processing. Appropriate stir-frying can promote the formation of aldehydes, while the content of acids, ketones, and terpenes decreased during processing. The change of alcohols has no obvious rule. Some sulfur compounds not found in raw meat were also detected. Different ratios of fat meat and lean meat changed the kinds of aroma components, while vinegar altered the types and their contents. Besides, the contents of acrylamide and 5-HMF changed significantly, and that of benzo(a)pyrene remained at a low level. The addition of vinegar can enhance the amount of acrylamide and 5-HMF but has no obvious effect on benzo(a)pyrene. Besides, 8 kinds of Maillard reaction products (acrylamide, 5-HMF, benzo(a)pyrene, 5-methylfurfural, pyrazine, 4-methylimidazole, pyrraline, and 5- hydroxymethyl – 2-furancarboxylic acid) were determined, and some of them were harmful to product quality and human health. The results showed that the processing time of pork slices should be controlled within 60 min.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 4719-04-4. The above is the message from the blog manager. Recommanded Product: 4719-04-4.

Reference:
Alcohol – Wikipedia,
,Alcohols – Chemistry LibreTexts

In an article, author is Canavez, Andrezza Di Pietro Micali, once mentioned the application of 100-86-7, SDS of cas: 100-86-7, Name is 2-Methyl-1-phenyl-2-propanol, molecular formula is C10H14O, molecular weight is 150.22, MDL number is MFCD00004465, category is alcohols-buliding-blocks. Now introduce a scientific discovery about this category.

Integrated approaches to testing and assessment as a tool for the hazard assessment and risk characterization of cosmetic preservatives

The safety assessment of cosmetic products is based on the safety of the ingredients, which requires information on chemical structures, toxicological profiles, and exposure data. Approximately 6% of the population is sensitized to cosmetic ingredients, especially preservatives and fragrances. In this context, the aim of this study was to perform a hazard assessment and risk characterization of benzalkonium chloride (BAC), benzyl alcohol (BA), caprylyl glycol (CG), ethylhexylglycerin (EG), chlorphenesin (CP), dehydroacetic acid (DHA), sodium dehydroacetate (SDH), iodopropynyl butylcarbamate (IPBC), methylchloroisothiazolinone and methylisothiazolinone (MCI/MIT), methylisothiazolinone (MIT), phenoxyethanol (PE), potassium sorbate (PS), and sodium benzoate (SB). Considering the integrated approaches to testing and assessment (IATA) and weight of evidence (WoE) as a decision tree, based on published safety reports. The hazard assessment was composed of a toxicological matrix correlating the toxicity level, defined as low (L), moderate (M), or high (H) and local or systemic exposure, considering the endpoints of skin sensitization, skin irritation, eye irritation, phototoxicity, acute oral toxicity, carcinogenicity, mutagenicity/genotoxicity, and endocrine activity. In a risk assessment approach, most preservatives had a margin of safety (MoS) above 100, except for DHA, SDH, and EG, considering the worst-case scenario (100% dermal absorption). However, isolated data do not set up a safety assessment. It is necessary to carry out a rational risk characterization considering hazard and exposure assessment to estimate the level of risk of an adverse health outcome, based on the concentration in a product, frequency of use, type of product, route of exposure, body surface location, and target population.

If you are interested in 100-86-7, you can contact me at any time and look forward to more communication. SDS of cas: 100-86-7.

Reference:
Alcohol – Wikipedia,
,Alcohols – Chemistry LibreTexts

Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 7541-49-3, Name is 3,7,11,15-Tetramethylhexadec-2-en-1-ol, SMILES is CC(C)CCCC(C)CCCC(C)CCC/C(C)=C/CO, in an article , author is Larach, Daniel B., once mentioned of 7541-49-3, Name: 3,7,11,15-Tetramethylhexadec-2-en-1-ol.

Patient Factors Associated With Opioid Consumption in the Month Following Major Surgery

Objective: The aim of this study was to determine preoperative patient characteristics associated with postoperative outpatient opioid use and assess the frequency of postoperative opioid overprescribing. Summary Background Data: Although characteristics associated with inpatient opioid use have been described, data regarding patient factors associated with opioid use after discharge are lacking. This hampers the development of individualized approaches to postoperative prescribing. Methods: We included opioid-naive patients undergoing hysterectomy, thoracic surgery, and total knee and hip arthroplasty in a single-center prospective observational cohort study. Preoperative phenotyping included self-report measures to assess pain severity, fibromyalgia survey criteria score, pain catastrophizing, depression, anxiety, functional status, fatigue, and sleep disturbance. Our primary outcome measure was self-reported total opioid use in oral morphine equivalents. We constructed multivariable linear-regression models predicting opioids consumed in the first month following surgery. Results: We enrolled 1181 patients; 1001 had complete primary outcome data and 913 had complete phenotype data. Younger age, non-white race, lack of a college degree, higher anxiety, greater sleep disturbance, heavy alcohol use, current tobacco use, and larger initial opioid prescription size were significantly associated with increased opioid consumption. Median total oral morphine equivalents prescribed was 600 mg (equivalent to one hundred twenty 5-mg hydrocodone pills), whereas median opioid consumption was 188 mg (38 pills). Conclusions: In this prospective cohort of opioid-naive patients undergoing major surgery, we found a number of characteristics associated with greater opioid use in the first month after surgery. Future studies should address the use of non-opioid medications and behavioral therapies in the perioperative period for these higher risk patients.

Interested yet? Read on for other articles about 7541-49-3, you can contact me at any time and look forward to more communication. Name: 3,7,11,15-Tetramethylhexadec-2-en-1-ol.

Reference:
Alcohol – Wikipedia,
,Alcohols – Chemistry LibreTexts

770-71-8, Name is Adamantan-1-ylmethanol, molecular formula is C11H18O, Application In Synthesis of Adamantan-1-ylmethanol, belongs to alcohols-buliding-blocks compound, is a common compound. In a patnet, author is Narayanan, Kannan Badri, once mentioned the new application about 770-71-8.

Biocompatible, antibacterial, polymeric hydrogels active against multidrug-resistant Staphylococcus aureus strains for food packaging applications

Microbial infections caused by multidrug-resistant (MDR) bacteria have become a public health threat and cause substantial morbidity and mortality in hospitals as well as in the community and livestock. Pseudomonas aeruginosa YUSA1 isolated from freshwater was found to contain an antagonistic compound against MRSA and other MDR S. aureus strains. The crude ethyl acetate extract (CEE) of cell-free supernatant exhibited in vitro antibacterial and antibiofilm properties against MRSA. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values of CEE (as determined by broth-dilution) against MRSA were 25 and 50 mu g/ml, respectively. The effect of CEE on MRSA biofilm formation was assessed by crystal violet staining and an MTT viability assay. Pretreatment of human skin fibroblasts (HSFs) with CEE dose-dependently inhibited MRSA adhesion and invasion, and in vitro cytotoxicity analysis showed CEE was compatible with HSFs at its MIC and MBC. In addition, an CEE containing poly(vinyl alcohol) (PVA/CEE) hydrogel fabricated by freeze-drying method exhibited significant anti-MRSA activity at concentrations >= 200 mu g/ml. Our results indicate CEE-incorporated PVA polymeric hydrogels have potential use as a food packaging material with antibacterial and antifouling effects on MRSA and other MDR S. aureus strains.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 770-71-8. The above is the message from the blog manager. Application In Synthesis of Adamantan-1-ylmethanol.

Reference:
Alcohol – Wikipedia,
,Alcohols – Chemistry LibreTexts

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Product Details of 2009-83-8, 2009-83-8, Name is 6-Chlorohexan-1-ol, molecular formula is C6H13ClO, belongs to alcohols-buliding-blocks compound. In a document, author is Huo, Rong, introduce the new discover.

A novel Bi-based crystalline molecular material: fluorescence response of the high efficient detection and recognition of the organic amines and white luminescence tuning

A novel Bi-based crystalline molecular materials Bi(C2O4)(3)(NMP)(2) (Bi-NMP) have successfully synthesized by the reaction of Bi(NO3)(3)center dot 5H(2)O, N-Methylpyrrolidone (NMP) in the solution of methyl alcohol. Structural analysis indicates that the Bi-NMP shows a novel 2D planar structure. The luminescent behavior for the Bi-NMP has been investigated at room temperature. The results have shown that Bi-NMP can be used as a chemical sensor for multifunctional testing such as aliphatic amines and aromatic amines detection, because of its strong fluorescence properties. When detecting cyclohexylamine (CHA), the K was 2.5 x 10(5) M–(1),( )and the detection limit was 0.99 mu M. When detecting m-phenylenediamine(MPD), the K-sv was 5.5 x 10(3) M-1, and the detection limit was 45.7 mu M. When detecting o-phenylenediamine (OPD), the K was 5.4 x 10(3) M-1, and the detection limit of Bi-NMP was calculated to be 49.9 mu M. In particular, for o-phenylenediamine (OPD), Bi-NMP has a unique switching effect. Therefore, Bi-NMP has not only a detection function but also a recognition function for o-phenylenediamine (OPD), m-phenylenediamine (MPD) and p-phenylenediamine (PPD). In addition, white-light emission is achieved through a reasonable tuning proportion by mixing Sm-3(+) in Bi-NMP. (C) 2020 Elsevier B.V. All rights reserved.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 2009-83-8. Product Details of 2009-83-8.

Reference:
Alcohol – Wikipedia,
,Alcohols – Chemistry LibreTexts

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 105-13-5, Name is (4-Methoxyphenyl)methanol, molecular formula is C8H10O2. In an article, author is Kalong, Munsuree,once mentioned of 105-13-5, HPLC of Formula: C8H10O2.

Hydrogen-free hydrogenation of furfural to furfuryl alcohol and 2-methyl-furan over Ni and Co-promoted Cu/gamma-Al2O3 catalysts

Catalytic transformation of furfural to furfuryl alcohol and 2-methylfuran without H-2 supply toward transfer hydrogenation process using 2-propanol as a H-2 source was systematically investigated over the bimetallic NiCuAl and CoCuAl catalysts in comparison with the monometallic CuAl, NiAl, and CoAl catalysts. The XRD analysis confirmed the generation of Ni-Cu and Co-Cu alloys after the reduction in presence of H-2. The interaction between Cu and Ni or Co resulted in a simplicity of the reduction behavior of Ni and Co species observed in H-2-TPR experiments. It was evident from pyridine adsorption FTIR analysis that the formation of bimetallic NiCu and Co-Cu alloys apparently improved the stronger Lewis acidic sites. The influences of reaction temperature and time were examined and optimized to maximize the yields of furfuryl alcohol and 2-methylfuran. The highest two major products yield and selectivity with lower by-products were obtained over the NiCuAl and CoCuAl catalysts compared with the CuAl and NiAl catalysts. The superior performance of the bimetallic catalysts was attributed to the stronger Lewis acidic centre on the catalyst surface. The CoCuAl catalyst was found to have lower catalyst deactivation and carbon deposition among the CuAl and NiCuAl catalysts under H-2-free atmosphere.

Interested yet? Keep reading other articles of 105-13-5, you can contact me at any time and look forward to more communication. HPLC of Formula: C8H10O2.

Reference:
Alcohol – Wikipedia,
,Alcohols – Chemistry LibreTexts

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 112-47-0, Name is 1,10-Decanediol, SMILES is OCCCCCCCCCCO, in an article , author is Mejldal, Anna, once mentioned of 112-47-0, HPLC of Formula: C10H22O2.

Stability of Posttreatment Reductions in World Health Organization (WHO) Drinking Risk Levels and Posttreatment Functioning in Older Adults with DSM-5 Alcohol Use Disorder: Secondary Data Analysis of the Elderly Study

Background Studies have found that reductions in World Health Organization (WHO) drinking risk levels may be a stable outcome of treatment for alcohol use disorder (AUD) and associated with functional improvements. The aim of this study was to investigate whether posttreatment reductions in WHO drinking risk levels are stable over time among older adults and associated with a decrease in consequences of drinking and AUD symptoms and improved quality of life. Methods Participants. Individuals 60+ years old, suffering from DSM-5 AUD (n = 693), and seeking outpatient treatment. Measurements. WHO drinking risk levels, prior to treatment and at all follow-up points up to 1 year after treatment start, were assessed with Form 90. Outcomes at follow-up included consequences of drinking (Drinker Inventory of Consequences), quality of life (WHOQOL-BREF), and DSM-5 AUD symptoms (Mini International Neuropsychiatric Interview). Logistic regression and linear mixed models were used to examine the probability of maintaining risk-level reductions at follow-up and the association between risk-level reductions and outcomes, respectively. Results Reductions in risk levels were maintained over time (at least 1 level: OR 5.39, 95% CI 3.43, 8.47; at least 2 levels: OR 9.30, 95% CI 6.14, 14.07). Reductions were associated with reduced consequences of drinking and number of AUD symptoms, and minor, but statistically significant, improvements in quality of life. Conclusions Maintaining reductions in WHO risk levels appears achievable for older adults seeking treatment for AUD. The small reduction of AUD symptoms and improvement of quality of life indicates that these reductions may not be adequate as the only treatment goal.

Interested yet? Read on for other articles about 112-47-0, you can contact me at any time and look forward to more communication. HPLC of Formula: C10H22O2.

Reference:
Alcohol – Wikipedia,
,Alcohols – Chemistry LibreTexts

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 104-38-1, Name is 1,4-Bis(2-hydroxyethoxy)benzene, formurla is C10H14O4. In a document, author is Jayasekara, Harindra, introducing its new discovery. Safety of 1,4-Bis(2-hydroxyethoxy)benzene.

Lifetime alcohol intake, drinking patterns over time and risk of stomach cancer: A pooled analysis of data from two prospective cohort studies

Alcohol consumption is causally linked to several cancers but the evidence for stomach cancer is inconclusive. In our study, the association between long-term alcohol intake and risk of stomach cancer and its subtypes was evaluated. We performed a pooled analysis of data collected at baseline from 491 714 participants in the European Prospective Investigation into Cancer and Nutrition and the Melbourne Collaborative Cohort Study. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated for incident stomach cancer in relation to lifetime alcohol intake and group-based life course intake trajectories, adjusted for potential confounders including Helicobacter pylori infection. In all, 1225 incident stomach cancers (78% noncardia) were diagnosed over 7 094 637 person-years; 984 in 382 957 study participants with lifetime alcohol intake data (5 455 507 person-years). Although lifetime alcohol intake was not associated with overall stomach cancer risk, we observed a weak positive association with noncardia cancer (HR = 1.03, 95% CI: 1.00-1.06 per 10 g/d increment), with a HR of 1.50 (95% CI: 1.08-2.09) for >= 60 g/d compared to 0.1 to 4.9 g/d. A weak inverse association with cardia cancer (HR = 0.93, 95% CI: 0.87-1.00) was also observed. HRs of 1.48 (95% CI: 1.10-1.99) for noncardia and 0.51 (95% CI: 0.26-1.03) for cardia cancer were observed for a life course trajectory characterized by heavy decreasing intake compared to light stable intake (P-homogeneity = .02). These associations did not differ appreciably by smoking or H pylori infection status. Limiting alcohol use during lifetime, particularly avoiding heavy use during early adulthood, might help prevent noncardia stomach cancer. Heterogeneous associations observed for cardia and noncardia cancers may indicate etiologic differences.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 104-38-1 help many people in the next few years. Safety of 1,4-Bis(2-hydroxyethoxy)benzene.

Reference:
Alcohol – Wikipedia,
,Alcohols – Chemistry LibreTexts

Let¡¯s face it, organic chemistry can seem difficult to learn, Safety of Oct-1-en-3-ol, Especially from a beginner¡¯s point of view. Like 3391-86-4, Name is Oct-1-en-3-ol, molecular formula is alcohols-buliding-blocks, belongs to alcohols-buliding-blocks compound. In a document, author is Manaj, Savio, introducing its new discovery.

Techniques for measuring carbon and oxygen isotope compositions of atmospheric CO2 via isotope ratio mass spectrometry

Measuring the stable isotope compositions of atmospheric CO2 is common in earth and atmospheric sciences, and various analytical methods have been developed utilizing continuous-flow (CF) or dual-inlet (DI) isotope ratio mass spectrometry (IRMS). Air is typically collected via passive, manual, or automated collection methods and the volume of the air sample ranges from 10 to 300 mL for CF-IRMS to >1 L for DI-IRMS to yield a measurable amount of atmospheric CO2 gas. It has been determined that the integrity of vials and flasks for air sample storage can be compromised after 3 days of air collection for delta C-13 values and within 10 hours for delta O-18 values. Air samples must be purified after collection to remove constituents of air, such as Ar, O-2, N-2, N2O, and water vapor, to avoid isobaric interferences during mass spectrometric measurement. Purification is generally undertaken by utilizing commercial or custom-made preconcentration devices, the blanking method for CF-IRMS, or an offline/online cryogenic separation using a vacuum line for DI-IRMS. Ambient N2O is a component of air that may affect analytical results and thus must either be corrected for or be removed using a gas chromatographic column. In some cases, water is removed during air collection by using a common chemical desiccant, magnesium perchlorate (Mg(ClO4)(2)), or by a dry ice/alcohol mixture (-78 degrees C). Lastly, a linearity issue for IRMS due to the low amount of purified CO2 from a typical ambient air sample must be considered. In general, analytical precisions of 0.02-0.21 parts per thousand and 0.04-0.34 parts per thousand for CF-IRMS and 0.01-0.02 parts per thousand and 0.01-0.02 parts per thousand for DI-IRMS are expected for delta C-13 and delta O-18 measurements, respectively.

If you are hungry for even more, make sure to check my other article about 3391-86-4, Safety of Oct-1-en-3-ol.

Reference:
Alcohol – Wikipedia,
,Alcohols – Chemistry LibreTexts