Author: tianli

Related Products of 2240-88-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 2240-88-2, name is 3,3,3-Trifluoropropan-1-ol. This compound has unique chemical properties. The synthetic route is as follows.

Example 19 3-[(4-Methoxyphenyl)amino]-4-phenyl-1-(3, 3, 3-TRIFLUOROPROPYL)-LH-PYRROLE-2, 5-dione To a solution of 3-[(4-methoxyphenyl)amino]-4-phenyl-1H-pyrrole-2, 5-dione (0.17 mmol, 50 mg), 3,3, 3-TRIFLUOROPROPAN-1-OL (0.19 mmol, 21 mg), diethyl azodicarboxylate (0.19 mmol, 33 mg) in dry THF (1 ML) was added triphenylphosphine (0.19 mmol, 49 mg) in dry THF (1 mL). The mixture was heated in a microwave reactor at 130°C for six min.. After cooling, the reaction mixture was purified by HPLC (95percent 0. 1M ammonium acetate buffer: 5percent CH3CN X 100percent CH3CN) to give 51 mg (77percent) of the title COMPOUND. 1H NMR (400 MHz, CDCl3) 8 7.27 (bs, 1H), 7.17-7. 06 (m, 3H), 7.00-6. 95 (m, 2H), 6.64-6. 55 (M, 4H), 3. 89 (t, J=7.3 Hz, 2H), 3.70 (s, 3H), 2.61-2. 48 (M, 2H).

According to the analysis of related databases, 2240-88-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ASTRAZENECA AB; WO2005/5417; (2005); A1;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 67853-03-6, name is Methyl 3-(hydroxymethyl)benzoate, molecular formula is C9H10O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: Methyl 3-(hydroxymethyl)benzoate

General procedure: A solution of the appropriate ethyl or methyl esters 21a-d (1.0 mmol) in methanol (5 mL) was prepared in a 10 mL CEM microwave vessel. Hydrazine hydrate 50% (5.0 mmol) was added, the vessel was capped and placed in a microwave reactor and the reaction carried out with the following method in dynamic mode: 140 C, 60 min, 100 W, with high stirring. After completion the reaction mixture was transferred to a round bottom flask and the solvent evaporated under reduced pressure. The crude product was transferred to an Erlenmeyer flask and suspended in dichloromethane, heated at 50 C for 5 min, rapidly vacuum filtered and washed with the same solvent, to obtain the pure product (yield 80-90%). When the product was found to be still not pure, the purification procedure was repeated.

With the rapid development of chemical substances, we look forward to future research findings about 67853-03-6.

Reference:
Article; Rupiani, Sebastiano; Buonfiglio, Rosa; Manerba, Marcella; Di Ianni, Lorenza; Vettraino, Marina; Giacomini, Elisa; Masetti, Matteo; Falchi, Federico; Di Stefano, Giuseppina; Roberti, Marinella; Recanatini, Maurizio; European Journal of Medicinal Chemistry; vol. 101; (2015); p. 63 – 70;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6338-55-2, name is 2-(2-(2-Aminoethoxy)ethoxy)ethanol, molecular formula is C6H15NO3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Formula: C6H15NO3

To a stirring mixture of 2-[2-(2-aminoethoxy)ethoxy]ethanol (S108A, 25.0 g, 167 mmol) and N-methyl morpholine (21.0 mL, 191 mmol) in dioxane (100 mL) was added dropwise a solution of Fmoc-OSu (62.2 g, 184 mmol) in dioxane (50 mL). After stirring overnight, the reaction was concentrated in vacuo to afford a light yellow oil. The crude was re-dissolved in EtOAc and washed with sat. NaHCO3 (aq.) and brine. The organic layer was removed in vacuo to afford an oil, which was purified by SiO2 chromatography to provide the FmocNH-PEG2-OH (S108, 55 g, 88% yield). ESI+ m/z calcd 371.4, found 372.2 [M+H]+.

With the rapid development of chemical substances, we look forward to future research findings about 6338-55-2.

Reference:
Patent; TOLLNINE, INC.; PONS, Jaume; WAN, Hong I.; BRADSHAW, Curt W.; SIM, Bang Janet; KUO, Tracy Chia-Chien; (239 pag.)WO2020/81744; (2020); A1;,
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Electric Literature of 18068-06-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 18068-06-9, name is 4-Methoxycyclohexanol. A new synthetic method of this compound is introduced below.

XXXXXVIII.2 4-Fluoro-2-(cis-4-methoxy-cyclohexyloxy)-phenylamine and 4-Fluoro-2-(trans-4-methoxy-cyclohexyloxy)-phenylamine A mixture of 18.9 g 2-nitro-5-fluorophenol and 19 g 4-methoxycyclohexanol in 250 ml THF were placed in a water bath with cold water. 41 g DTAD and 47 g triphenylphosphine were added simultaneously. The reaction mixture was stirred for 2 hours at room temperature. 1.9 g Pd/C (10%) were added and the reaction mixture hydrogenated (50 psi hydrogen) at room temperature for 20 hours. The mixture was filtered and concentrated. Methylene chloride was added to the residue and the mixture was extracted two times with HCl (2M). The water phase were adjusted to basic pH by addition of aq. sodium hydroxide solution (4M) and extracted two times with methylene chloride. The combined organic phases were dried over sodium sulfate, filtered and concentrated. Purification was achieved by column chromatographie on silica (eluent: methylene chloride/EtOAc=9:1).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,18068-06-9, its application will become more common.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; US2011/217311; (2011); A1;,
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Electric Literature of 75476-86-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 75476-86-7, name is 6-Bromo-2,3-dihydro-1H-inden-1-ol. A new synthetic method of this compound is introduced below.

To a solution of 6-bromo-2,3-dihydro-1 H-inden-1 -ol (1 .50 g, 7.04 mmol) in DOM (3.5 mL) wasadded thionyl chloride (1.028 mL, 14.08 mmol). The resulting reaction mixture was stirred atambient temperature for 1 h. The reaction mixture was evaporated under vacuum to afford product 6-bromo-1-chloro-2,3-dihydro-1 H-indene (1.6225 g, 7.01 mmol, 100% yield). 1H NMR (400 MHz, CHLOROFORM-d) ppm 2.33- 2.44 (m, 1 H) 2.63 (dq, J=14.24, 7.22 Hz, 1 H) 2.86 (ddd, J=1 6.00, 7.97, 4.14 Hz, 1 H) 3.13 (dt, J=1 5.81, 7.65 Hz, 1 H) 5.37 (dd, J=6.53, 3.51 Hz, 1H) 7.14 (d, J=8.03 Hz, 1 H) 7.39 (d, J=8.03 Hz, 1 H) 7.57 (s, 1 H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,75476-86-7, its application will become more common.

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; ASTEX THERAPEUTICS LIMITED; KERNS, Jeffrey K.; YAN, Hongxing; CALLAHAN, James Francis; HEIGHTMAN, Thomas Daniel; BOEHM, Jeffrey Charles; WOOLFORD, Alison Jo-Anne; (250 pag.)WO2016/203401; (2016); A1;,
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Synthetic Route of 33036-62-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 33036-62-3, name is 4-Bromo-1-butanol, molecular formula is C4H9BrO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

2-(4-Bromobutoxy)-tetrahydro-2H-pyran (52). 3,4-Dihydro-2H-pyran (8.5 mL, 90.96 mmol) was added dropwise to the dichloromethane (20 mL) solution of 51 (10.7 g, 69.93 mmol) and p-toluenesulfonic acid monohydrate (26.5 mg, 0.1372 mmol). The mixture was stirred at room temperature over night. After removing the solvent, the residue was purified by flash chromatography on silica gel with 5:1 hexanes/ethyl acetate as the eluent to yield product 52 as a colorless oil (15.3 g, 92%). 1H NMR (400 MHz, CDCl3): delta 1.48-1.62 (m, 4H), 1.68-1.85 (m, 4H), 1.94-2.02 (m, 2H), 3.40-3.53 (m, 4H), 3.74-3.88 (m, 2H), 4.57-4.59 (m, 1H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 33036-62-3, 4-Bromo-1-butanol.

Reference:
Patent; TARGANTA THERAPEUTICS, INC.; US2010/113333; (2010); A1;,
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Adding a certain compound to certain chemical reactions, such as: 616-29-5, 1,3-Diaminopropan-2-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 616-29-5, blongs to alcohols-buliding-blocks compound. Product Details of 616-29-5

Step 1 : Di-tert-butyl (2-hydroxypropane-l,3-diyl)dicarbamate [00217] A solution of l,3-diaminopropan-2-ol (3.0 g, 33.3 mmol) in water (7 mL) was added to a solution of di-tert-butyldicarbonate (16.0 g, 73.7 mmol) in dioxane (400 mL). The reaction mixture was stirred for 22 h at room temperature then concentrated in vacuo. The resulting solid was dissolved in CH2C12 (300 mL), washed with water (300 mL), and dried (MgS04). Concentration in vacuo gave di-tert-butyl (2-hydroxypropane-l,3- diyl)dicarbamate (9.0 g) as a faint-yellow oil, which was used without further purification. 1H NMR (300 MHz, CDC13) delta 5.09 (br, 2H), 3.78-3.73 (m, 1H), 3.55 (br, 1H), 3.34-3.12 (m, 4H), 1.46 (s, 18H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,616-29-5, its application will become more common.

Reference:
Patent; PRESAGE BIOSCIENCES, INC.; DECKWERTH, Thomas; KLEINMAN, Edward; RUAN, Fuqiang; BAKER, William; KLINGHOFFER, Richard; (126 pag.)WO2016/196393; (2016); A2;,
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Application of 2807-30-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 2807-30-9, name is 2-Propoxyethanol. This compound has unique chemical properties. The synthetic route is as follows.

Step 1: Synthesis of intermediate 3 a shown by formula (3 a); [Show Image] A four-necked reactor equipped with a condenser, a thermometer, and a dropping funnel was charged with 15 g (0.09 mol) of 5-formylsalicylic acid, 28.1 g (0.27 mol) of ethylene glycol monopropyl ether, 1.7 g (0.009 mol) of p-toluenesulfonic acid monohydrate, and 1000 ml of toluene under a nitrogen stream to prepare a homogenous solution. The solution was stirred for eight hours under reflux. Water produced during the reaction was removed together with toluene by azeotropic dehydration while adding toluene. After completion of the reaction, the reaction mixture was washed with water. After drying the toluene layer over anhydrous magnesium sulfate, magnesium sulfate was filtered off. Toluene was evaporated from the filtrate under reduced pressure to obtain a yellow oil. The yellow oil was purified by silica gel column chromatography (n-hexane:THF=3:1) to obtain 12.6 g of a light yellow solid intermediate 3a (yield: 55.5%). The structure of the intermediate 3a was identified by 1H-NMR. 1H-NMR (400 MHz, CDCl3, TMS, delta ppm): 11.34 (s, 1H), 9.89 (s, 1H), 8.42 (d, 1H, J=2.0 Hz), 8.01 (dd, 1H, J=2.0 Hz, J=8.6 Hz), 7.11 (d, 1H, J=8.6 Hz), 4.56 (t, 2H, J=4.6), 3.80 (t, 2H, J=4.6 Hz), 3.49 (t, 2H, J=6.6 Hz), 1.68-1.59 (m, 2H), 0.94 (t, 3H, J=7.6 Hz)

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 2807-30-9, 2-Propoxyethanol.

Reference:
Patent; Zeon Corporation; EP2143710; (2010); A1;,
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Related Products of 769-30-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 769-30-2, name is Benzo[d][1,3]dioxol-4-ylmethanol. A new synthetic method of this compound is introduced below.

To a solution of 4-hydroxymethyl-benzo[1 ,3]dioxole (1.00 g, 6.6 mmol) and carbon tetrabromide (3.50 g, 10.5 mmol) in anhydrous tetrahydrofuran (30 ml.) was added at 00C triphenylphosphine (2.80 g, 10.5 mmol) in solution in tetrahydrofuran (10 mL). The resulting reaction mixture was stirred at room temperature for 2 hours. Water (30 mL) was added followed by ethyl acetate (30 mL). The organic layer was washed first with a concentrated aqueous sodium hydrogenocarbonate solution (30 mL) and then brine (30 mL), dried over anhydrous potassium carbonate and concentrated in vacuum. The resulting crude product was purified by flash chromatography on silica gel, eluting with cyclohexane – dichloromethane (7:3) to afford the title compound (1.23 g, 87%) as colorless oil.[00694] 1H NMR (CDCI3): delta 6.86 – 6.75 (m, 3H), 6.02 (s, 2H), 4.47 (s, 2H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,769-30-2, Benzo[d][1,3]dioxol-4-ylmethanol, and friends who are interested can also refer to it.

Reference:
Patent; NPS PHARMACEUTICALS, INC.; WO2007/44796; (2007); A2;,
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Related Products of 15852-73-0, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 15852-73-0 as follows.

General procedure: OMS-2-SH-B (20 mg, 10 mol%), benzyl alcohol (0.3 mmol) and benzamidine (0.5 mmol) were added into a Schlenk tube. Then, air was removed and toluene (1 mL) was added by a syringe under O2 atmosphere. If substituted benzyl alcohol was liquid, it was added with toluene under O2 balloon protection. If methyl benzene was used as substrate instead of benzyl alcohol, it was added as solvent (1 mL) into the reaction tube by syringe under O2 atmosphere. The mixture was stirred for required time at certain temperature for 20 h. The resulting mixture was cooled down, filtered and washed with EtOAc, and concentrated under reduced pressure to give the crude product. Finally, the product was purified by silica gel chromatography to yield the pure product.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,15852-73-0, its application will become more common.

Reference:
Article; Shen, Jian; Meng, Xu; Catalysis Communications; vol. 127; (2019); p. 58 – 63;,
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