Author: tianli

Related Products of 627-27-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 627-27-0, name is But-3-en-1-ol, molecular formula is C4H8O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

But-3-en-1-yl methanesulfonate 8 was prepared from 3-buten-1-ol using the protocol described byD. Pei et al.:2 methanesulfonyl chloride (1.10 equiv, 110 mmol, 8.51 mL) was added dropwise to asolution of 3-buten-1-ol (1.00 equiv, 100 mmol, 7.21 g) and triethylamine (1.10 equiv, 110 mmol,15.3 mL) in CH2Cl2 (0.20 L) at 0 C. The mixture became cloudy. After 5 min of stirring, the coldbath was removed and stirring was continued for 1 h. The reaction mixture was then washed withsaturated NaHCO3 aqueous solution (0.10 L) and H2O (0.10 L). The organic layer was dried overMgSO4, filtered and concentrated to afford mesylate 8 (14.3 g, 95.2 mmol, 95%) as a colourless oilthat was used as such, without purification.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 627-27-0, But-3-en-1-ol.

Reference:
Article; Wolan, Andrzej; Kowalska-Six, Justyna A.; Rajerison, Holisoa; Cesario, Michele; Cordier, Marie; Six, Yvan; Tetrahedron; vol. 74; 38; (2018); p. 5248 – 5257;,
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Related Products of 52273-77-5, Adding some certain compound to certain chemical reactions, such as: 52273-77-5, name is 2-(3-Aminophenyl)ethanol,molecular formula is C8H11NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 52273-77-5.

(28B) Methyl trans-4-{[3-(2-hydroxyethyl)phenyl]amino}cyclohexanecarboxylate [0325] 2-(3-Aminophenyl)ethanol (4.45 g, 32.4 mmol) produced in (28A), ethyl 4-cyclohexanonecarboxylate (5.52 g, 32.4 mmol), and acetic acid (18.5 mL, 324 mmol) were dissolved in tetrahydrofuran (100 mL), and sodium triacetoxy borohydride (13.8 g, 64.9 mmol) was added thereto, and then, the resulting mixture was stirred at room temperature for 4 hours. To the reaction solution, water was added, and the organic matter was extracted with ethyl acetate. The organic layer was washed with a saturated aqueous solution of sodium chloride and then dried over anhydrous magnesium sulfate and filtered. Then, the solvent was distilled off under reduced pressure, whereby a crude product was obtained. The obtained crude product was purified by silica gel column chromatography (hexane:ethyl acetate = 70:30 to 45:55 (v/v)), whereby the target compound was obtained as a colorless oil (1.93 g, yield: 19%). 1H NMR(CDCl3, 400MHz): delta1.09-1.21(2H, m), 1.26(3H, t, J=7.2Hz), 1.51-1.65(2H, m), 2.01-2.10(2H, m), 2.16-2.24(2H, m), 2.29(1H, tt, J=3.6, 12.1Hz), 2.78(2H, t, J=6.5Hz), 3.25(1H, tt, J=3.6, 11.2Hz), 3.40-3.59(1H, brs), 3.84(2H, q, J=6.0Hz), 4.14(2H, q, J=7.2Hz), 6.41-6.49(2H, m), 6.55(1H, d, J=7.4Hz), 7.11(1H, t, J=7.6Hz).

According to the analysis of related databases, 52273-77-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Daiichi Sankyo Company, Limited; TODA, Narihiro; TAKANO, Rieko; SHIDA, Takeshi; KATAGIRI, Takahiro; IWAMOTO, Mitsuhiro; ASHIDA, Shinji; YAMAZAKI, Mami; EP2623492; (2013); A1;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 616-29-5, name is 1,3-Diaminopropan-2-ol. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of 1,3-Diaminopropan-2-ol

To a solution of 3-1 (3.00 g, 33.3 mmol) in dichloromethane (300 mL) was added triethylamine (5.10 mL, 36.6 mmol), 4-dimethylaminopyridine (DMAP, 40.7 mg, 0.333 mmol), and tert-butyldiphenylsilyl chloride (TBDPSCI, 9.13 mL, 35.0 mmol), and the mixture was stirred at room temperature for 5 hours. The solvent was removed by concentration in vacuo and chromatographed by flash chromatography on silica gel (chloroform/methanol = 5: 1) to give 3-2 (8.28 g, 76%). 1H MR (400 MHz, CDC13): delta 1.08 (s, 9H), 2.70-2.79 (m, 4H), 3.60-3.63 (m, 1H), 7.36-7.45 (m, 6H), 7.67-7.70 (m, 4H). MS (CI+) m/z: 329 (MH+).

With the rapid development of chemical substances, we look forward to future research findings about 616-29-5.

Reference:
Patent; MERCK SHARP & DOHME CORP.; INTERVET INTERNATIONAL B.V.; KYORIN PHARMACEUTICAL CO. LTD.; SINGH, Sheo B.; WARRASS, Ralf; ULLRICH, Joachim; KAWASHIMA, Mikako; FUKUDA, Yasumichi; TAKANO, Hisashi; (92 pag.)WO2016/123146; (2016); A1;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 112-47-0, name is 1,10-Decanediol, molecular formula is C10H22O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 112-47-0

EXAMPLE 3 10-Bromo-1-decanol A solution of 1,10-dihydroxydecane (80 g) in 47% hydrobromic acid (650 ml) was stirred at 80C whilst being continuously extracted with petroleum ether (boiling range 80-100), for 24 hours. The organic extracts were neutralised with solid potassium carbonate, filtered, and the filtrates evaporated to dryness. The resultant dark oil was fractionally distilled (Vigreaux apparatus) to give a colourless oil, boiling point 102-104 (0.01 mm Hg). Part of this oil (52 g) was purified by preparative HPLC (silica; eluents:diethyl ether/hexane 1:1) to remove a significant 1,10-dibromodecane impurity, finally yielding the title compound as a colourless oil.

With the rapid development of chemical substances, we look forward to future research findings about 112-47-0.

Reference:
Patent; Lilly Industries Limited; EP190042; (1991); B1;,
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Reference of 10488-69-4 ,Some common heterocyclic compound, 10488-69-4, molecular formula is C6H11ClO3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example 14: Preparation of Ethyl (R)-4-CYANO-3-HYDROXYYRATE FROM ETHYL (S)-4-CHLORO-3- hydroxybutyrate To a 250 mL vessel connected to an automatic titrater by a pH electrode and a feeding tube for addition of base (7.5 M NaOH) was charged water (83.5 mL) and 0.7 g of halohydrin dehalogenase SEQ ID NO: 24. The mixture was stirred for 30 minutes. The titrater was activated and set to maintain pH 7. Then, 25percent aqueous HCN (9.26 ml, 8.6 g) was charged over 20 minute to make A 2.3percent HCN solution. The mixture was heated at 40 °C for 10 minutes, then ethyl (S) -4-chloro-3-hydroxybutyrate (5 g) was charged over 1 hour. The automatic titrater maintained the pH at 7 by the addition of 2M NaOH. After 20 hrs, GC analysis of a butyl acetate extract of a reaction sample showed the conversion of the ethyl (S)-4-CHLORO-3-HYDROXYBUTYRATE to ethyl (R)-4-CYANO-3-HYDROXYBUTYRATE was 95percent.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,10488-69-4, its application will become more common.

Reference:
Patent; CODEXIS, INC.; WO2005/18579; (2005); A2;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2867-59-6, name is 3-Aminobutan-1-ol, molecular formula is C4H11NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Quality Control of 3-Aminobutan-1-ol

75 g of D-malic acid (0.56 mol) in 250 ml of anhydrous ethanol, stirred at room temperature, the system was dissolved, then added dropwiseA 50 g mixture of 3-amino-1-butanol (0.56 mol) in racemic mixture was added dropwise and warmed to 30-40C. The system was dissolved and 0.5 g of (S)-3-amino-1-butanol was added. D Malate salt as a seed crystal, and stirring during heat preservation, the solid precipitated after half an hour, continue to stir for 2 to 3 hours, slowly to room temperature, and continue to cool to 5 to 10 C for half an hour, suction filtration, to obtain an optical purity of 90.8 %ee.The D-malate salt of (S)-3-amino-1-butanol.The resulting (S)-3-amino-1-butanol D-malate with an optical purity of 90.8% ee was suspended in 200 ml of anhydrous ethanol, warmed to reflux, and the system was dissolved, slowly cooled, and the cooling process was solid. Gradually precipitated, cooled to room temperature, stirred for 1~2 hours, continued cooling to 5~10C, and kept stirring for 0.5 hour. Filtered to obtain an optical purity of 98.7%e.The D-malate salt of (S)-3-amino-1-butanol.The above-mentioned recrystallized D-malate salt of (S)-3-amino-1-butanol having an optical purity of 98.7% ee was suspended in 150 ml of anhydrous ethanol, and the temperature was raised to reflux. After the system was dissolved, the temperature was slowly lowered. The solids gradually precipitated, dropped to room temperature, incubated for 1 to 1.5 hours while stirring, and continued to cool down to 5 to 10C for half an hour, filtered by suction, and vacuum dried at 50C to a constant weight to give an optical purity of 99.4% ee.(S). D-malate salt of 3-amino-1-butanol.The above-mentioned recrystallized D-malate salt of (S)-3-amino-1-butanol having an optical purity of 99.4%ee was suspended in 120 ml of absolute ethanol, and the temperature was raised to reflux. After the system was dissolved, the temperature was gradually lowered. Solids gradually precipitated, dropped to room temperature, incubated for 1 to 1.5 hours while stirring, and continued to cool to 5 to 10C for half an hour, filtered, and vacuum dried at 50C to constant weight.50.4 g of D-malate salt with an optical purity of 99.9% ee.(S)-3-amino-1-butanol are obtained,Yield 40.3%.

With the rapid development of chemical substances, we look forward to future research findings about 2867-59-6.

Reference:
Patent; Shanghai Disainuo Pharmaceutical Co., Ltd.; Shanghai Disainuo Chemical Pharmaceutical Co., Ltd.; Yancheng Disainuo Pharmaceutical Co., Ltd.; Shanghai Chuangnuo Pharmaceutical Group Co., Ltd.; Li Jinliang; Zhao Nan; Wu Jun; (10 pag.)CN107793320; (2018); A;,
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Electric Literature of 2568-33-4, Adding some certain compound to certain chemical reactions, such as: 2568-33-4, name is 3-Methylbutane-1,3-diol,molecular formula is C5H12O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2568-33-4.

The 3 – methyl – 1, 3 butanediol (14 A) (5.0 g, 48 mmol) dissolved in dichloromethane (100 ml) in, add triethylamine (9.7 g, 96 mmol), 0 C slow […] carboxylic acid isopropyl ester (8.8 g, 72 mmol), transfusion reaction at room temperature for 3 hours. The reaction solution by adding water (100 ml) washing, for liquid phase after the saturated salt water (100 ml × 1) washing, drying with anhydrous sodium sulfate, filtered, the filtrate is concentrated under reduced pressure, the residue with silica gel column chromatography (ethyl acetate/petroleum ether (v/v)=1/10 – 1/1) separating and purifying, to obtain the title compound (3 – hydroxy -3 – methyl – butyl) isopropyl carbonate (14 B), colorless oily matter (4.5 g, yield 49%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 2568-33-4, 3-Methylbutane-1,3-diol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Sichuan Hai Sike Pharmaceutical Co., Ltd.; Qiu Guanpeng; Wei Yonggang; Lu Yonghua; Huang Qingping; Liao Pengfei; (41 pag.)CN107382870; (2017); A;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 3597-91-9, name is [1,1′-Biphenyl]-4-ylmethanol. A new synthetic method of this compound is introduced below., COA of Formula: C13H12O

General procedure: p-Nitrobenzyl alcohol (0.25 g, 1.63 mmol) was dissolved in anhydrous CH2Cl2 under N2. Triethylamine (0.227 mL, 1.63 mmol) was added and the resulting solution was cooled to 0 C. S2Cl2 (65.3 muL, 0.82 mmol) was added dropwise over 20 min. The solution was stirred at 0 C for 2 h before being allowed to equilibrate to room temperature for 3 h. The reaction was quenched with dH20, washed with 2 × 20 mL aliquots of brine. The aqueous phase was extracted with CH2Cl2 (2 × 10 mL), and the combined organic was dried over MgSO4, filtered, and concentrated under reduced pressure. Column chromatography with a 2.5:1 ratio of hexanes:ethyl acetate afforded:

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 3597-91-9, [1,1′-Biphenyl]-4-ylmethanol.

Reference:
Article; Stoutenburg, Eric G.; Palermo, Anne E.; Priefer, Ronny; Thermochimica Acta; vol. 551; (2013); p. 99 – 103;,
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Reference of 6153-05-5 , The common heterocyclic compound, 6153-05-5, name is (Z)-3-Methylpent-2-en-4-yn-1-ol, molecular formula is C6H8O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

(Z)-3-Mehylpent-2-en-4-yn-1-ol(side chain) (68 mg, 0.70 mmol) in dry THF (3.5 mL) was cooled to ?80 °C unde ran atmosphere of Ar. n-Butyllithium(0.90 mL, 1.58 M) was then added slowly. After being stirred for 30 min at ?80°C, a solution of the 6 (64 mg, 0.35mmol) in dry THF (0.5 mL) was added to the stirred mixture. The reaction mixture was stirred for a further 15 min at ?80 °C and then the ice bath was removed. The reaction mixture was stirred at room temperature for 90 min. After quenching with sat. NH4Cl solution (100 mL), it was extracted withEtOAc (15 mL × 3). The organic layer was washed with brine, dried over Na2SO4,and concentrated in vacuo. The residual oil was purified by silica gel chromatography with 55percent EtOAc in hexane to obtain 7 (58 mg, 59percent) as a yellow oil. 1H NMR (270 MHz, CDCl3): deltaH 1.12 (3H, s,H3-8? or 9?), 1.17 (3H, s, H3-8? or 9?), 1.88 (3H, d, J=1.0, H3-6), 1.94 (2H, s, H2-5?),2.08 (1H, s, -OH), 3.96 (4H, br s, -OCH2CH2O-), 4.29(2H, d, J=5.3 Hz, H2-1),5.60 (1H, d, J=9.9 Hz, H-2? or 3?),5.87 (1H, td, J=5.3 and 1.0 Hz, H-2),5.89 (1H, d, J=9.9 Hz, H-2? or 3?); 13CNMR (68 MHz, CDCl3): deltaC 22.6, 23.0, 25.6, 39.2, 43.7,61.6, 64.3, 64.5, 72.0, 77.2, 84.1, 104.7, 120.5, 127.0, 134.0, 136.1. HRMS (m/z): [M+Na]+ calcd. for C16H22O4Na,301.1416; found, 301.1415.

The synthetic route of 6153-05-5 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Takeuchi, Jun; Ohnishi, Toshiyuki; Okamoto, Masanori; Todoroki, Yasushi; Bioorganic and Medicinal Chemistry Letters; vol. 25; 17; (2015); p. 3507 – 3510;,
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Related Products of 349-95-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.349-95-1, name is (4-(Trifluoromethyl)phenyl)methanol, molecular formula is C8H7F3O, molecular weight is 176.14, as common compound, the synthetic route is as follows.

4-methyl-benzenesulfonamide (171mg, 1mmol), catalyst A (8.3mg, 0.01mmol, 1.0mol%), cesium carbonate (33mg, 0.1mmol, 0.1equiv.), 4- trifluoromethylbenzyl alcohol ( 211mg, 1.2mmol) and water (1ml) were successively added to the reaction flask 25mlSchlenk.After the reaction mixture was reacted at 120 15 hours, cooled to room temperature.Heavy precipitate precipitated, water was removed by filtration, the filter cake was washed with water three times to give the title compound, yield: 84%

Statistics shows that 349-95-1 is playing an increasingly important role. we look forward to future research findings about (4-(Trifluoromethyl)phenyl)methanol.

Reference:
Patent; Nanjing University of Science & Technology; Li, Feng; Qu, panpan; Sun, chunlou; Ma, Juan; (17 pag.)CN104418678; (2016); B;,
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