Author: tianli

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 111-46-6, name is 2,2′-Oxybis(ethan-1-ol), the common compound, a new synthetic route is introduced below. Recommanded Product: 111-46-6

1.122 g of tBuOK (potassium tert-butoxide) was dissolved in 6.5 ml of dry THF (tetrahydrofuran)2.12g of diethylene glycol was added under the protection of ice-water outer bath under argon, the reaction was stirred for 30 minutes, then 1.18g of bromopropyne was added dropwise,The reaction was complete after dropping 1 hour ice water bath, the reaction was carried out at room temperature for 12 hours, the reaction was stopped after diatomaceous earth filter layer, the filtrate evaporated to give a yellow oil, 300-400 mesh silica gel medium pressure separation,The mobile phase of petroleum ether: ethyl acetate = 4: 1, the product fractions were collected and evaporated to give the product 0.976g pale yellow oily product, yield 72.8%.

The synthetic route of 111-46-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Beijing Nerve Surgical Department Institute; Liu Qian; Zhang Yazhuo; Yang Xiaoxiao; CN106366075; (2017); A;,
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Synthetic Route of 929-06-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 929-06-6, name is 2-(2-Aminoethoxy)ethanol. This compound has unique chemical properties. The synthetic route is as follows.

To an ice-cold solution of 2-(2-aminoethoxyethanol) (10 g, 95.23 mmol) indichloromethane (500 mL) was added triethylamine (19.23 g, 190.47 mmol), followed by Boc-anhydride (22.62 g, 104.76 mmol) dropwise over fifteen minutes at 0 C. The reaction mixture was allowed to warm to rt and stirred for 18 h while monitoring by TLC.The solvent was removed under reduced pressure and the residue was taken up in ethyl acetate (400 mL) and washed with saturated ammonium chloride solution (2 x 250 mL).The organic layer was dried over anhydrous sodium sulphate and concentrated to give tert-butyl (2-(2-hydroxy)ethoxy)ethylcarbamate (10.9 g, 55.8%) as a colorless liquid. 1HNMR (400 MHz, DMSO-i/6) delta ppm 6.76 (1H, s), 4.56 (1H, t, J=5.2 Hz), 3.50-3.46 (2H, m), 3.41-3.36 (4H, m), 3.10-3.05 (2H, m), 1.38 (9H, s).

According to the analysis of related databases, 929-06-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; BOY, Kenneth M.; GUERNON, Jason M.; MACOR, John E.; THOMPSON III, Lorin A.; WU, Yong-Jin; ZHANG, Yunhui; WO2012/9309; (2012); A1;,
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Synthetic Route of 2807-30-9, Adding some certain compound to certain chemical reactions, such as: 2807-30-9, name is 2-Propoxyethanol,molecular formula is C5H12O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2807-30-9.

Compound 172: 2-((R)-1-[1,4]Dioxan-2-ylmethoxy)-9-(2-propoxy-ethoxy)-6,7-dihydro-pyrimido[6,1-a]isoquinolin-4-one Intermediate 7 (0.25 g, 0.76 mmol, 1 eq.), 2-Propoxy-ethanol (105 muL, 0.91 mmol, 1.2 eq.) and PPh3 (238 mg, 0.91 mmol, 1.2 eq.) were suspended in 1,4-dioxane (10 mL) and the mixture was degassed with N2. DIAD (0.180 mL, 0.91 mmol, 1.2 eq.) was added and the reaction was stirred at RT overnight. 0.3 eq. of DIAD and PPh3 were added, and the reaction mixture was stirred at room temperature for an extra 24 h. Reaction mixture was diluted with brine, extracted with EtOAc, dried over MgSO4 and concentrated. Crude product was purified on silicagel column to give compound 172.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 2807-30-9, 2-Propoxyethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; GALAPAGOS NV; LABEGUERE, Frederic Gilbert; NEWSOME, Gregory John Robert; ALVEY, Luke Jonathan; SANIERE, Laurent Raymond Maurice; FLETCHER, Stephen Robert; US2013/165437; (2013); A1;,
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Application of 180205-28-1 ,Some common heterocyclic compound, 180205-28-1, molecular formula is C5H11NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Part C To a solution of 1-(aminomethyl)cyclobutanol (62.5 mmol) in dichloromethane (312 mL) was added triethylamine (8.71 mL, 62.5 mmol) and 4-chloro-3-nitroquinoline (13.04 g, 62.5 mmol). More triethylamine (3 mL) was added almost immediately. The reaction was stirred under N2 for 10 days at room temperature, then was diluted with dichloromethane and washed with 1 M aqueous NaOH. A solid formed and was isolated by filtration. The organic layer was washed with water and brine, dried over Na2SO4, filtered, and concentrated under reduced pressure to yield a solid that was crystallized from 2-propanol. The resulting crystals were combined with the solid that was isolated from the extraction and the mixture was triturated with hot 2-propanol. The solid was isolated by filtration, washed with diethyl ether, and air dried to yield 12.83 g of 1-{[(3-nitroquinolin-4-yl)amino]methyl}cyclobutanol as yellow crystals.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,180205-28-1, its application will become more common.

Reference:
Patent; Radmer, Matthew R.; Moser, William H.; Moseman, Joan T.; Dellaria, Joseph F.; US2007/155767; (2007); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 153599-45-2, name is Methyl 3-(2-hydroxyethyl)benzoate, the common compound, a new synthetic route is introduced below. Application In Synthesis of Methyl 3-(2-hydroxyethyl)benzoate

3- (2-HYDROXYETHYL)- benzoic acid methyl ester (50 mg, 0.28 mmol) was dissolved in methanol (1 ml). 1N NaOH aqueous solution (1 ml) was added therein. The reaction mixture was stirred at room temperature for 1 hour to give 43 mg (yield: 95%, white solid) of the target compound. 1H NMR (400MHZ, CDC13) ; 52. 32 (br, 1H), 2.89 (t, J=6. 4Hz, 2H), 3.85 (t, J=6. 4Hz, 2H), 7.36 (t, J=7. 6Hz, 1H), 7.42 (D, J=5. 6Hz, 1H), 7.88 (d, J=8. 8Hz, 1H), 7.89 (s, 1H)

The synthetic route of 153599-45-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; JE IL PHARMACEUTICAL CO., LTD.; WO2004/113281; (2004); A1;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 78573-45-2, name is 3-(3-(Trifluoromethyl)phenyl)propan-1-ol, molecular formula is C10H11F3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 78573-45-2

(12-2) Synthesis of 1-(3-bromopropyl)-3-trifluoromethylbenzene (compound 12-2) Compound 12-1 (9.00 g) was dissolved in methylene chloride (80 ml), triphenylphosphine (12.8 g) and N-bromosuccinimide (8.63 g) were added under ice-cooling, and the mixture was stirred under ice-cooling for 1 hr, and further at room temperature for 3 hr. The reaction mixture was washed with water and saturated brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure. Diethyl ether (200 ml) was added, and the precipitated triphenylphosphine oxide was filtered off. The concentrate of the filtrate was purified by silica gel column chromatography (hexane alone) to give the object product (8.59 g) as a colorless oil. 1H-NMR(CDCl3) delta (ppm): 2.17-2.23(2H, m), 2.85(2H, t, J=7.5Hz), 3.40(2H, t, J=6.4Hz), 7.38-7.49(4H, m).

With the rapid development of chemical substances, we look forward to future research findings about 78573-45-2.

Reference:
Patent; Mitsubishi Tanabe Pharma Corporation; EP2168944; (2010); A1;,
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Related Products of 6351-10-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6351-10-6, name is 2,3-Dihydro-1H-inden-1-ol, molecular formula is C9H10O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: To a stirring mixture of the substrate (1 mmol) and RiHA (0.08 g) in CH3CN (3 mL),HMDS (0.75 mmol, 0.120 g) was added at room temperature. The progress of the reaction was monitored by TLC. After completion of the reaction, the mixture was filtered and the residue was washed with acetonitrile (5 mL). Evaporation of the solvent gave almost pure product(s). Further purification was carried out by bulb-to-bulb distillation under reduced pressure or recrystallization to afford pure silyl ether(s).

According to the analysis of related databases, 6351-10-6, the application of this compound in the production field has become more and more popular.

Reference:
Article; Shirini; Akbari-Dadamahaleh, Somayeh; Mohammad-Khah, Ali; Phosphorus, Sulfur and Silicon and the Related Elements; vol. 189; 5; (2014); p. 577 – 586;,
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Related Products of 355-80-6 ,Some common heterocyclic compound, 355-80-6, molecular formula is C5H4F8O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Glucose (9 g, 0.05 mol), 1-octafluoropentanol (116 g, 0.5 mol) and a catalyst (3.6 g) were placed in a glass reactor. The mixture was stirred for 5 h at 100 C under 200 Torr pressure. The unreacted glucose and the catalyst were separated by filtration, and the reaction products were obtained as a solution in fluoroalcohol. The alcohol was distilled off under reduced pressure on a rotary evaporator.Then 100 mL of water was added to the concentrated products and the remaining fluoroalcohol was removed as an azeotrope. In this way, the water solution of glucoside (containing 20% of non-volatile residue) was prepared. Next, the products were dried to give a pale-green viscous oil and analyzed by the GC/MS method. Analysis was performed using a HP 6890 series GC system (Hewlett-Packard, Palo Alto, CA, USA) equipped with a MSD detector (HP 5973 Network). A 30 m capillary column with 0.2 mm diameter, modified with HP-5M methylphenylsilicone, was used for separation of the reaction products.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 355-80-6, 2,2,3,3,4,4,5,5-Octafluoro-1-pentanol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Nowicki, Janusz; Mokrzycki, ?ukasz; Sulikowski, Bogdan; Molecules; vol. 20; 4; (2015); p. 6140 – 6152;,
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Electric Literature of 1346674-69-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1346674-69-8, name is (2,6-Dibromo-4-fluorophenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows.

Example 104m 2,6-Dibromo-4-fluorobenzyl Acetate 104m To a solution of (2,6-dibromo-4-fluorophenyl)methanol (1041) (20 g, 71 mmol) in CH2Cl2 (500 mL) at 0 C. was added pyridine (8.4 g, 107 mmol) and acetyl chloride (8.3 g, 107 mmol). The mixture was stirred at room temperature for 5 h. TLC showed the start material disappeared. The reaction was evaporated in vacuum and the residue was purified by silica-gel column chromatography eluting with petroleum ether/ethyl acetate (from 50:1 to 20:1) to give 104m as a white solid (20 g, 87%). MS: [M-Oac]+ 267. 1H NMR (500 MHz, CDCl3) delta 7.36 (d, J=7.5, 2H), 5.38 (s, 2H), 2.10 (s, 3H)

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1346674-69-8, (2,6-Dibromo-4-fluorophenyl)methanol.

Reference:
Patent; GENENTECH, INC.; Crawford, James John; Young, Wendy B.; US2013/116245; (2013); A1;,
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Electric Literature of 7073-69-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.7073-69-0, name is 2-(2-Bromophenyl)propan-2-ol, molecular formula is C9H11BrO, molecular weight is 215.087, as common compound, the synthetic route is as follows.

General procedure: Using diaryl acetylenesA 5-mL two-necked flask equipped with a stir bar was charged with [RhCl(cod)]2 (0.0125 mmol,6.16 mg), BINAP (0.0125 mmol, 7.78 mg), 1a-c (0.25 mmol), KI (0.25 mmol, 41.5 mg), and Na2CO3(1.0 mmol, 106.0 mg). The central neck of the flask was equipped with a reflux condenser havinga N2 gas-bag (2 L), which was connected by a three-way stopcock at its top, and a rubber septumwas inserted i n to the side neck. The flask was evacuated and backfilled with N2 (three times).Xylene (1.0 mL), 2a (0.75 mmol, 161.3 mg), and furfural (1.75 mmol, 168.2 mg), were then added.After degassing the reaction mixture three times by the freeze-pump-thaw method, the flask wasfilled with N2. The mixture was placed in an oil bath that had been preheated to 140 C for 20 h.After cooling to room temperature, the resulting solution was filtered through a pad of celite, andthe filtrate was concentrated in vacuo. The resulting crude product was purified by flash columnchromatography on silica-gel to afford 3aa-3ac.

Statistics shows that 7073-69-0 is playing an increasingly important role. we look forward to future research findings about 2-(2-Bromophenyl)propan-2-ol.

Reference:
Article; Furusawa, Takuma; Tanimoto, Hiroki; Nishiyama, Yasuhiro; Morimoto, Tsumoru; Kakiuchi, Kiyomi; Chemistry Letters; vol. 46; 7; (2017); p. 926 – 929;,
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