Author: tianli

Electric Literature of 504-63-2 ,Some common heterocyclic compound, 504-63-2, molecular formula is C3H8O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Add hexadecane bromide (1.52 g, 5 mmol) to the reaction flask.And 1,3-propanediol (1.14 g, 15 mmol),Add 5 ml of dimethyl sulfoxide and 5 ml of tetrahydrofuran to dissolve.Add sodium hydroxide (800mg, 20mmol)The reaction was carried out for 24 hours at room temperature.Dilute with 10 ml of water,Adjust the pH to neutral with 2M dilute hydrochloric acid,Extracted with ethyl acetate 3 times,Combine the organic phase,Washed with saturated brine and concentrated.Purified by silica gel column chromatography to give compound 1.0g, Yield: 66.7%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 504-63-2, 1,3-Propanediol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Shenzhen Tajirui Bio-pharmaceutical Co., Ltd.; Wang Yihan; Zhao Jiuyang; (46 pag.)CN109485676; (2019); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2568-33-4, name is 3-Methylbutane-1,3-diol, the common compound, a new synthetic route is introduced below. category: alcohols-buliding-blocks

To a 50 mL three-necked flask equipped with a side tower packed column charged with 20 g of molecular sieve (4 A), a condenser, a thermometer and a drying tube, 0.26 g of the iron salen complex obtained in Production Example 1, 1.04 g of isoprene glycol (10 mmol),40 g (400 mmol) of methyl methacrylate and 0.08 g of phenothiazine were charged, the flask was immersed in an oil bath set at 120 C. under atmospheric stirring conditions so that the internal temperature of the flask was 100 to 105 C., The distillate fraction was fully refluxed through molecular sieves and transesterification reaction was carried out for 11 hours while returning to the reaction system. Composition analysis of the obtained reaction solution according to Test Example 1 revealed that isoprene glycol was not detected, isoprene glycol monomethacrylate was 0.1%, and isoprene glycol dimethacrylate was 99.9%. To this reaction solution, unreacted methyl methacrylate was distilled off using a rotary evaporator, 5 g of hexane was added, and the precipitated solid was suction filtered using filter paper (removal of solid matter). 5 g of 10 w / v% nitric acid aqueous solution was added to the obtained filtrate, and washing was carried out by mixing and the aqueous layer was removed by separation (washing with an acidic solution). Saturated sodium bicarbonate water was added to the obtained hexane solution to neutralize until the pH became 7. Hexane was distilled off from the hexane solution obtained by liquid separation to obtain 2.05 g of the objective isoprene glycol dimethacrylate.Composition analysis of the obtained target product according to Test Example 1 revealed that isoprene glycol was not detected, isoprene glycol monomethacrylate was 0.1%, and isoprene glycol dimethacrylate was 99.9%. The results evaluated according to Test Examples 1 to 3 are shown in Table 1.

The synthetic route of 2568-33-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; KURARAY COMPANY LIMITED; TAKAHATA, YUSUKE; KAJIYASHIKI, TSUYOSHI; HOSOKI, TOMOYA; (21 pag.)JP2018/104360; (2018); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 4704-94-3 ,Some common heterocyclic compound, 4704-94-3, molecular formula is C4H10O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of 2-hydroxymethyl-1,3-propanediol (20 g,189 mmol) in dry acetone (600 ml) freshly annealed molecularsieves (4A) and p-toluenesulfonic acid monohydrate (2 g,10.5 mmol) were added. Reaction mixture was stirred overnightat room temperature. Mixture was filtered over kieselguhr. Tothe filtrate DOWEX (D1 OH-, 7 g) was added and the mixture washeated to 40 C and stirred for 30 min. Suspension was filtered overfrit (S3) and Et3N (0.5 ml) was added to the filtrate for stabilization.Solvent was evaporated in vacuo and obtained crude material wasdried under vacuum. Crude product 24 was obtained as colourlessoil and used in the next reaction step without purification. Reactionwas monitored by TLC.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 4704-94-3, 2-(Hydroxymethyl)propane-1,3-diol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; ?pa?ek, Petr; Keough, Dianne T.; Chavchich, Marina; Dra?insky, Martin; Janeba, Zlatko; Naesens, Lieve; Edstein, Michael D.; Guddat, Luke W.; Hockova, Dana; Bioorganic and Medicinal Chemistry; vol. 25; 15; (2017); p. 4008 – 4030;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 702-98-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 702-98-7, name is 2-Methyladamantan-2-ol. A new synthetic method of this compound is introduced below.

Comparative Example 1 Preparation of 2-methyl-2-adamantyl methacrylate from 2-methyl-2-adamantanol in the presence of triethyl amine 150 g (0.9 mole) of 2-methyl-2-adamantanol, 900 ml of tetrahydrofuran (THF) and 132 ml of methacrylic chloride were charged in a three neck flask, and stirred. The contents of the flask were cooled on an ice bath, and maintained at a temperature of not more than 10 C. 226 g of triethyl amine was slowly dropwise added to the resulting reaction mixture. After the mixture was reacted overnight at an ordinary temperature, iced water was portionwise added to the mixture. The reaction was further continued at -20 C. for 2 hours, and then at room temperature for one hour. An organic layer was separated from the mixture, washed with a saturated aqueous solution of sodium hydrogencarbonate and then with a saturated brine, and dried on anhydrous magnesium sulfate. The resulting product was concentrated to obtain 180 g of a raw product. Following concentration, the raw product was purified on a column of silica gel to obtain 161.4 g of a pure product (yield: 76.5%). An analysis of the thus obtained product indicated that the product was the target compound, i.e., 2-methyl-2-adamantyl methacrylate.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,702-98-7, 2-Methyladamantan-2-ol, and friends who are interested can also refer to it.

Reference:
Patent; Fujitsu Limited; US6248920; (2001); B1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 26021-57-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 26021-57-8, name is 3,4-Dihydro-2H-benzo[b][1,4]oxazin-6-ol. This compound has unique chemical properties. The synthetic route is as follows.

c1) (S)-(3-((3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)oxy)pyrrolidin-1-yl)(tetrahydro-2H-pyran-4-yl)methanone A stirred solution of 3,4-dihydro-2H-benzoxazin-6-ol (CAS registry 26021-57-8) (0.140 g, 0.926 mmol) in DMF (3 ml) was treated with sodium hydride (60% in mineral oil, 0.445 g, 1.111 mmol) at rt. After 10 min at rt, (R)-1-(tetrahydro-2H-pyran-4-carbonyl)pyrrolidin-3-yl methanesulfonate (0.283 g, 1.019 mmol) was added. The vial was capped and heated to 50 C. for 3 h. After this time, the reaction mixture was concentrated under reduced pressure. The residue was dissolved in EtOAc (50 ml), and water (50 ml) was added. The organic layer was washed with a saturated NaCl solution (20 ml), dried with MgSO4, filtered and concentrated under reduced pressure. The crude product was purified by flash chromatography on silica gel (DCM/methanol gradient) to provide the title compound as a grey amorphous solid. HPLC RtM10=2.07 min; ESIMS: 333 [(M+H)+]. 1H NMR (400 MHz, DMSO-d6): delta 6.55-6.50 (m, 1H), 6.15-6.11 (m, 1H), 6.07-6.00 (m, 1H), 5.77 (br s, 1H), 4.88-4.74 (m, 1H), 4.06-4.01 (m, 2H), 3.90-3.22 (m, 10H), 2.75-2.58 (m, 1H), 2.15-1.95 (m, 2H), 1.65-1.45 (m, 4H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 26021-57-8, 3,4-Dihydro-2H-benzo[b][1,4]oxazin-6-ol.

Reference:
Patent; NOVARTIS AG; CARAVATTI, Giorgio; CHAMOIN, Sylvie; FURET, Pascal; HOGENAUER, Klemens; HURTH, Konstanze; KALIS, Christoph; KAMMERTOENS, Karen; LEWIS, Ian; MOEBITZ, Henrik; SMITH, Alexander Baxter; SOLDERMANN, Nicolas; WOLF, Romain; ZECRI, Frederic; US2013/165436; (2013); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 1875-88-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1875-88-3, name is 2-(4-Chlorophenyl)ethanol, molecular formula is C8H9ClO, molecular weight is 156.61, as common compound, the synthetic route is as follows.

General procedure: To a stirred solution of the Dess-Martin reagent (DMP) (1.5mmol) in CH2Cl2 (10mL) under nitrogen, the alcohol (1.0mmol) was added dropwise. The reaction mixture was stirred for 2h and subsequently quenched with saturated aqueous sodium thiosulfate (20mL). After 15min of stirring the layers were separated, the organic layer was washed with water (50mL) and brine (2×50mL) and the aqueous layer was washed with EtOAc (2×25mL). The combined organic layers were dried over Na2SO4, filtered and the solvent was removed under reduced pressure. The thus obtained semisolid was triturated with 10% EtOAc in hexanes. The solid was removed by filtration. The filtrate was concentrated under reduced pressure to yield the final product.

The chemical industry reduces the impact on the environment during synthesis 1875-88-3, I believe this compound will play a more active role in future production and life.

Reference:
Article; Eleftheriadis, Nikolaos; Poelman, Hessel; Leus, Niek G.J.; Honrath, Birgit; Neochoritis, Constantinos G.; Dolga, Amalia; Doemling, Alexander; Dekker, Frank J.; European Journal of Medicinal Chemistry; vol. 122; (2016); p. 786 – 801;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 31952-16-6, Adding some certain compound to certain chemical reactions, such as: 31952-16-6, name is 2,2-Dibenzylpropane-1,3-diol,molecular formula is C17H20O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 31952-16-6.

To a solution of (PhCH2)2C(CH2OH)2 (14.4 g, 0.06 mol) in 40 mL of anhydrous pyridine at 0 C was added with stirring under an inert atmosphere 16 mL (26 g, 0.21 mol) of SOCl2 in ca. 2 h. The resulting mixture was refluxed for 2 h and then stirred at room temperature for 15 h. After cooling to 0 C, equal volumes of CH2Cl2 and water (200 mL each) were added to the reaction mixture. The separated organic layer was washed with an aqueous solution of HCl (pH 4) and then with distilled water. After the CH2Cl2 solution was treated with sodium sulfate, the solvent was removed under reduced pressure. To the resulting oily residue was added ethyl ether (30 mL) until an off-white solid precipitated, which was recrystallized from ethanol to give 10 g of crystalline (PhCH2)2C(CH2Cl)2 (61% yield). 1H NMR (CDCl3, 20 C, 200.13 MHz): d 7.5-7.2 (m, 10 H, Ph), 3.23 (s, 4 H,CH2Cl), 2.91 (s, 4 H, CH2Ph).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 31952-16-6, 2,2-Dibenzylpropane-1,3-diol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; CONSIGLIO NAZIONALE DELLE RICERCHE; EP941230; (2004); B1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 15258-73-8, name is (2,6-Dichlorophenyl)methanol. A new synthetic method of this compound is introduced below., Recommanded Product: 15258-73-8

To a solution of H-2 (5.11 g, 20.0 mmol), PPh3 (5.30 g, 20.0 mmol), and 2,6-dichlorobenzylalcohol (3.54 g, 20.0 mmol) in dry THF (100 mL) at 0 C. under Ar is added DEAD (3.15 mL, 20.0 mmol). The reaction mixture is kept at 0 C. for 1.5 h and at rt for 1.5 h. It is concentrated to a residue, that is purified by silica flash chromatography (17:3 hexanes/EtOAc) to give 7.61 g of the title compound: TLC (1 7:3 hexanes/EtOAc) Rf 0.57; 1H NMR (CD3SOCD3, 300 MHz) delta 7.85 (1H), 7.62 (1H), 7.58-7.45 (3H), 5.34 (2H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 15258-73-8, (2,6-Dichlorophenyl)methanol.

Reference:
Patent; Pharmacia & Upjohn Company; Tanabe Seiyaku Co., Ltd.; US6685617; (2004); B1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 109-83-1 ,Some common heterocyclic compound, 109-83-1, molecular formula is C3H9NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

10 g (calculated on the basis of the dry substance) of a Cu/Ni-based Raney catalyst (Degussa AG, BOO 111) was placed first as a suspension in water in a 600 ml autoclave with stirrer, pressure control valve and jacket heating and 75 g N-methyl-ethanolamine as well as 204 g of a 20% by weight sodium hydroxide solution were added. The autoclave was closed and the contents were heated to a temperature of 160 C. with the aid of the jacket heating. An increasing pressure of hydrogen was generated in this process which was kept at 10 bar (absolute) by the controlled opening of the pressure control valve. The release of gas was completely finished after 4 hours and the reactor was cooled to 90 C. After the stirrer was switched off, the catalyst sedimented within one hour and a portion of the supernatant clear solution of Na sarcosinate was moved from the autoclave through a plunge pipe. The catalyst remained in the reactor and could be used again in further batches.For each further cycle the suspension of catalyst remaining in the reactor was admixed with the said amounts of N-methylethanolamine and sodium hydroxide solution and the reaction was started by heating.With the exception of the initial batch, 270 g of a colourless solution of Na sarcosinate containing 40.0% by weight (corresponds to a yield of 97.2% of theory) was obtained per cycle.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,109-83-1, its application will become more common.

Reference:
Patent; Thalhammer, Franz; Gastner, Thomas; US2009/163739; (2009); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2050-25-1, name is 2-(2-(Benzyloxy)ethoxy)ethanol, the common compound, a new synthetic route is introduced below. Recommanded Product: 2-(2-(Benzyloxy)ethoxy)ethanol

Sodium hydride (4.08 g, 102 mmol) was added portionwise to an ice bath-cooled solution of 2-(2-(benzy- loxy)ethoxy)ethanol (9.14 mE, 51.0 mmol) in THF (200 mE) over 15 minutes. The reaction was stirred for 1 h after which time tert-butyl 2-bromoacetate (8.97 mE, 61.1 mmol) in THF (50 mE) was added dropwise over 1 h. The reaction was stirred at ice bath temperature for 3 hand quenched with ammonium chloride (50 mE). TBME (250 mE) was added and the organic layer washed with brine (2×200 mE). The organic layer was concentrated onto silica and the crude product was purified by chromatography on silica gel (220g column, 0-50% EtOAc/isohexane) to afford the sub-titlecompound (1.95 g) as a colourless oil. ?H NMR (400 MHz, DMSO-d6) oe 7.43-7.20 (m,5H), 4.50 (s, 2H), 3.99 (s, 2H), 3.66-3.47 (m, 8H), 1.42 (s,9H)

The synthetic route of 2050-25-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Respivert Limited; Topivert Pharma Limited; FYFE, Matthew Colin Thor; THOM, Stephen Malcolm; (88 pag.)US2017/291917; (2017); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts