Author: tianli

Reference of 349-75-7 , The common heterocyclic compound, 349-75-7, name is (3-(Trifluoromethyl)phenyl)methanol, molecular formula is C8H7F3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: To a mixture of the alcohol (3.839 mmol), K2CO3 (2.0 equiv, 7.678 mmol) and cyanuric acid (0.1 equiv, 0.384 mmol) in 20 mL of ethyl acetate were added TEMPO or AZADO (3 mol%, 0.115 mmol) and 12% NaOCl (1.2 equiv, 4.607 mmol, Wako Pure Chemical Industries, Ltd.) at 0-10C. The mixture was then stirred to complete. The reaction mixture was extracted with ethyl acetate. The organic layer was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography to afford the corresponding product.

The synthetic route of 349-75-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Fukuda, Naohiro; Izumi, Minoru; Ikemoto, Tomomi; Tetrahedron Letters; vol. 56; 25; (2015); p. 3905 – 3908;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1883-32-5, name is 2,2-Diphenylethanol, molecular formula is C14H14O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Application In Synthesis of 2,2-Diphenylethanol

General procedure: Substrates, 1 and 2, were synthesized by the same method of 2-adamantyl chloroformate. The triphosgene treated in toluene at 0-4 C (ice bath) for 20 min. The mixture of 2-phenylethanol or 2,2-diphenylethanol with pyridine was prepared in toluene at room temperature. Then the latter mixture was added to the former solution slowly. After the stirring for 1 h, the organic mixture was washed with water and dried by magnesium sulfate. The solvent was removed by the evaporation, the colorless oil (1) or white solid (2) was obtained as a crude product. The substrate 1 was purified from vacuum distillation (120 C and 18 torr) and the substrate 2 was recrystallized by using ligroin. Solvents were purified as described previously.

With the rapid development of chemical substances, we look forward to future research findings about 1883-32-5.

Reference:
Article; Park, Kyoung-Ho; Yang, Gi-Hoon; Kyong, Jin Burm; Bulletin of the Korean Chemical Society; vol. 35; 8; (2014); p. 2263 – 2270;,
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Synthetic Route of 534-03-2 ,Some common heterocyclic compound, 534-03-2, molecular formula is C3H9NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

(1) N-(4-Phenoxybenzenesulfonyl)serinol After triethylamine (10.12 g, 100 mmol) was added dropwise to a solution of serinol (3.64 g, 40 mmol) in a mixture of dioxane (100 ml) and water (200 ml), the mixture was stirred at room temperature for 30 minutes. To the reaction mixture, a solution of 4-phenoxybenzenesulfonyl chloride (10.75 g, 40 mmol) in dioxane (100 ml) was added dropwise and this was stirred for 3 hours. Most of the solvent was evaporated under reduced pressure and the residue was extracted with ethyl acetate. The organic layer was washed with water, dried over anhydrous magnesium sulfate and concentrated under reduced pressure to afford the desired compound (10.62 g, yield 82%) as a white powder. 1H-Nuclear magnetic resonance spectrum (400 MHz, CDCl3-DMSO-d6) delta ppm: 7.84 (2H, d, J=8Hz), 7.41 (2H, t, J=8Hz), 7.22 (2H, t, J=7Hz), 7.09-7.01 (4H, m), 6.69 (1H, d, J=7Hz), 4.10-4.06 (1H, m), 3.63-3.45 (4H, m).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 534-03-2, 2-Aminopropane-1,3-diol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Sankyo Company Limited; EP1069110; (2001); A1;,
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Application of 149965-40-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 149965-40-2, name is (5-Bromo-2-chlorophenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows.

(2-Chloro-5-(4,4,5,5-tetramethyl-1 ,3,2-dioxaborolan-2-yl)phenyl)methanol A suspension of (5-bromo-2-chlorophenyl)methanol (2.08 g, 9.39 mmol), potassium acetate (3.50 g, 35.7 mmol) and 4,4,4′,4′,5,5,5′,5′-octamethyl-2,2′-bi(1 ,3,2-dioxaborolane) (2.77 g, 10.89 mmol) degassed with a stream of nitrogen for ~10 mins after which time bis(triphenylphosphine)palladium(ll) chloride (0.396 g, 0.563 mmol) was added and the mixture was heated to 120 C for 30 minutes in a microwave at high power. After this time, the suspension was cooled and filtered through celite using ethyl acetate to wash the celite. The dark colored solution was washed with water (4x gently), brine (1x), dried over magnesium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by flash chromatography to give the title compound (2.76g, 68.9%), LC-MS m/z 267.7 (M+H)+, 1 .0 minutes (ret time), 63 % purity.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 149965-40-2, (5-Bromo-2-chlorophenyl)methanol.

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; ASTEX THERAPEUTICS LIMITED; KERNS, Jeffrey K.; LI, Tindy; YAN, Hongxing; HEIGHTMAN, Thomas Daniel; WOOLFORD, Alison Jo-Anne; GRIFFITHS-JONES, Charlotte Mary; WILLEMS, Hendrika Maria Gerarda; (109 pag.)WO2016/203400; (2016); A1;,
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Related Products of 534-03-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.534-03-2, name is 2-Aminopropane-1,3-diol, molecular formula is C3H9NO2, molecular weight is 91.1091, as common compound, the synthetic route is as follows.

Fmoc-beta-alanine (84.5 g, 271 mmol) and N-hydroxysuccinimide (31.2 g, 271 mmol) are dissolved in dichloromethane (850 mL) and DMF (43 mL) with magnetic stirring. N,N-dicyclohexylcarbodiimide (56.0 g, 271 mmol) dissolved in dichloromethane (100 mL) is added in one portion. After stirring 1.5 hours at room temperature, the reaction mixture was filtered, and transferred to a mixture of serinol (24.7 g, 271 mmol) in pyridine (380 mL) and allowed to react 16 hours overnight. The mixture is evaporated to a semi-solid residue, and co-evaporated 3*400 mL toluene to remove the remaining pyridine. The solid residue is refluxed in dichloromethane (3.0 L) and stored at -20 C. for 2 hours. The product was collect by filtration in a sintered glass funnel, and washed 2*1000 mL dichloromethane, and 1*1000 mL diethyl ether. Drying overnight under high vacuum yielded 92.8 g (89%) of 1.

The chemical industry reduces the impact on the environment during synthesis 534-03-2, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Nelson Biotechnologies, Inc.; Glen Research Corporation; US2011/77389; (2011); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 15258-73-8, name is (2,6-Dichlorophenyl)methanol, the common compound, a new synthetic route is introduced below. name: (2,6-Dichlorophenyl)methanol

To an ice cooled solution of (2, 6-dichloro-phenyl)-methanol (5 G, 28. 2 MMOL) in anhydrous tetrahydrofuran (200 mL) was added sodium hydride (1. 13 G, 28. 2 mmol, 60% disp.) slowly under nitrogen atmosphere. After stirring for 30 minutes, 3, 5-dibromo-pyrazin-2-ylamine (7. 08 g, 28. 2 MMOL) in anhydrous tetrahydrofuran (50 mL) was added via an addition funnel. Once the addition was complete the ice bath was removed and the reaction was REFLUXED under nitrogen and monitored by reversed phase HPLC. After 18 hr HPLC showed that the majority of the starting 3, 5-dibromo-pyrazin-2- ylamine had been consumed and the reaction was allowed to cool to room temperature. The reaction mixture was concentrated in vacuum until 50 mL remained. The mixture was diluted with ethyl acetate (200 mL) and extracted with 50% brine (2 X 200 ML). The organic layer was dried over anhydrous magnesium sulfate and concentrated in vacuum. The crude product was purified using a silica gel column ELUTING with 1 : 1 ETHYL ACETATE/DICHLOROMETHANE TO YIELD 5-BROMO-3- (2, 6-DICHLORO-BENZYLOXY)- PYRAZIN-2-YLAMINE as a white solid (8. 17 G, 83% yield).

The synthetic route of 15258-73-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SUGEN, INC.; WO2004/76412; (2004); A2;,
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Adding a certain compound to certain chemical reactions, such as: 5182-44-5, 2-(3-Chlorophenyl)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 5182-44-5, blongs to alcohols-buliding-blocks compound. name: 2-(3-Chlorophenyl)ethanol

General procedure: 2.5mmol thiazole-4-carboxyli acid and 2.0mmol alcohol were dissolved in 25mL dichloromethane (DCM) in a dry flask with continuous stirring, followed by the addition of 2.5mmol 3-(3-dimethylaminopropyl) -1-ethylcarbodiimide hydrochloride. When the temperature of the reaction system cooled to 0C, 0.2mmol 4-dimethylaminopyridine was added dropwise and reacted for 1hat 0C. Then the temperature was elevated to room temperature for another 4h reaction. The reaction was stopped by adding 25mL saturated NaHCO3 solution and extracted twice with 20mL dichloromethane (2×20mL). The extracted organic layers were first dried by anhydrous Na2SO4, and then filtered and concentrated under vacuum distillation, obtaining the crude products. Finally, the crude products were further purified using column chromatography (ethy lacetate:petroleum ether, 1:5).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,5182-44-5, its application will become more common.

Reference:
Article; Li, Shengrong; Chen, Siyu; Fan, Jilin; Cao, Zhen; Ouyang, Weihao; Tong, Ning; Hu, Xin; Hu, Jie; Li, Peishan; Feng, Zifeng; Huang, Xi; Li, Yuying; Xie, Mingshan; He, Ruikun; Jian, Jingyi; Wu, Biyuan; Xu, Chen; Wu, Weijian; Guo, Jialiang; Lin, Jing; Sun, Pinghua; European Journal of Medicinal Chemistry; vol. 145; (2018); p. 64 – 73;,
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Related Products of 62058-03-1 , The common heterocyclic compound, 62058-03-1, name is trans-4-Aminoadamantan-1-ol, molecular formula is C10H17NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: To a solution of ethyl 1-phenyl-5-(2-methyl-4-oxobutan-2-yl)-1H-pyrazole-4-carboxylate 14b (45 mg, 0.15 mmol) in CHCl3 (9 mL) was added trans-5-hydroxy-2-adamantylamine (25 mg, 0.15 mmol), acetic acid (0.025 mL, 0.45 mmol) and sodium triacetoxyborohydride (85 mg, 0.45 mmol) at room temperature. After stirring at ambient temperature for 16 hours, the reaction mixture was quenched with aq. NaHCO3, extracted with CHCl3, and washed with aq. NaCl. The combined organic layer was dried over Na2SO4 and concentrated in vacuo. The residue was dissolved in methanol (0.30 mL), and added 1.0 N NaOH (0.22 mL, 0.22 mmol) at room temperature. After stirring at ambient temperature for 16 hours, the solvent was removed under vacuum. The mixture of the residue in CHCl3 (1.5 mL) and DIPEA (0.078 mL, 0.45 mmol) and HBTU (35 mg, 0.15 mmol) was stirred at room temperature. After 16 hours, the reaction mixture was quenched with aq. NaHCO3, extracted with CHCl3, and washed with aq. NaCl., then purified with column chromatography (silica gel, eluting with CHCl3/methanol) to give the title compound as a white solid (0.025 g, 42 percent yield).

The synthetic route of 62058-03-1 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Udagawa, Shuji; Sakami, Satoshi; Takemura, Takahiro; Sato, Mikiya; Arai, Takahiro; Nitta, Aiko; Aoki, Takumi; Kawai, Koji; Iwamura, Tomokatsu; Okazaki, Seiji; Takahashi, Takehiro; Kaino, Mie; Bioorganic and Medicinal Chemistry Letters; vol. 23; 6; (2013); p. 1617 – 1621;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2568-33-4, name is 3-Methylbutane-1,3-diol. This compound has unique chemical properties. The synthetic route is as follows. category: alcohols-buliding-blocks

(210a) 3-Hydroxy-3-methylbutanal Pyridinium chlorochromate (2.6 g, 12 mmol) and Celite (5 g) were sufficiently ground in a mortar and were suspended in methylene chloride (50 mL). To this mixture, a methylene chloride solution (10 mL) of 3-methyl-1,3-butanediol (1.1 g, 10 mmol) was added. The resulting mixture was stirred at room temperature for 3 hr and then filtered. The filtrate was concentrated under reduced pressure. The resulting crude product was purified by silica gel column chromatography (Biotage, eluding solvent; hexane: ethyl acetate = 2: 3) to obtain 0.47 g (yield: 45%) of the title compound as a colorless oily material. 1H-NMR (400 MHz, CDCl3) delta ppm: 9.85 (1H, t, J = 2.0 Hz), 2.63 (2H, d, J = 2.0 Hz), 1.34 (6H, s).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 2568-33-4, 3-Methylbutane-1,3-diol.

Reference:
Patent; Sankyo Company, Limited; EP1798229; (2007); A1;,
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Application of 2568-33-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2568-33-4, name is 3-Methylbutane-1,3-diol, molecular formula is C5H12O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a cooled solution of 53 (2.0 g, 19.20 mmol, 1.0eq) in dichioromethane (40 mE) was added pyridine (3.03 g,38.4 mmol, 2.0 eq) followed by mesyl chloride (2.29 g,20.16 mmol, 1.05 eq) dropwise at 0 C. The reaction mixturewas stirred at room temperature for 1 h. After completion ofreaction, reaction mixture was transferred into ice cold waterand product was extracted with dichloro methane. Organic layer was combined, dried over sodium sulphate and concentrated under reduced pressure to obtain 53.1. (1.5 g, 42.86%), MS(ES): mlz 183.06 [M+H].

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 2568-33-4, 3-Methylbutane-1,3-diol.

Reference:
Patent; Nimbus Lakshmi, Inc.; Masse, Craig E.; Greenwood, Jeremy Robert; Mondal, Sayan; Cowen, Scott D.; McLean, Thomas H.; (624 pag.)US2019/31664; (2019); A1;,
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