Author: tianli

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 6240-11-5, name is 1-Adamantaneethanol. A new synthetic method of this compound is introduced below., Formula: C12H20O

EXAMPLE 1 Methyl-1-(2-(1-adamantyl)ethyl)-5-diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylate. A solution of 11.8 mL trifluoromethanesulfonic anhydride in 70 mL dichloromethane is chilled to -70 C. and treated dropwise with a solution composed of 12.6 g 1-adamantyl-2-hydroxyethane, 12.2 mL diisopropylethylamine and 70 mL dichloromethane. The solution is allowed to warm to -55 C. over 45 min then a solution of 25 g N,1-bis-BOC-histidine methyl ester (J. Chem. Soc., Perkin Trans. I 1982; 1553-61.) in 70 mL dichloromethane is added dropwise. The reaction is then stirred at 25 C. for 24 hr and poured into pH=7, 0.25M potassium phosphate buffer (500 mL), stirring vigorously. The organic layer is separated, washed with the same buffer, dried and concentrated. 3-(2-(1-Adamantyl)ethyl)-N-BOC-histidine methyl ester is isolated by chromatography on silica gel (chloroform-methanol, 99:1) as a gum. NMR (CDCl3) 3.85 (m,2H,NCH2).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 6240-11-5, 1-Adamantaneethanol.

Reference:
Patent; Warner-Lambert Company; US4812462; (1989); A;,
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Synthetic Route of 109-83-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 109-83-1, name is 2-(Methylamino)ethanol. This compound has unique chemical properties. The synthetic route is as follows.

A solution of 4-methoxy-2,3,6-trimethylbenzenesulfonyl chloride (2.29 g, 9.19 mmol) in THF (30 ml) was added dropwise to a solution of 2-methyl- aminoethanol (0.89 g, 0.95 ml, 11.8 mmol) and Et3N (5 ml) in THF (15 ml) at O 0C. The mixture was subsequently stirred at RT for 5 h and then concentrated in vacuo, the residue was taken up in NaHCO3 solution, and the mixture was extracted with EtOAc (3 x 30 ml). The combined organic phases were dried with Na2SO4 and concentrated in vacuo. Yield: 2.38 g (90 %)

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 109-83-1, 2-(Methylamino)ethanol.

Reference:
Patent; GRUeNENTHAL GMBH; WO2009/109364; (2009); A1;,
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Adding a certain compound to certain chemical reactions, such as: 60666-70-8, (2-Bromo-5-chlorophenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: alcohols-buliding-blocks, blongs to alcohols-buliding-blocks compound. category: alcohols-buliding-blocks

Example 74 Synthesis of 2-bromo-5-chloro-3-t-butyldimethylsilyloxy-methylbenzene To the solution of 2-bromo-5-chlorobenzylalcohol (10 g) from Example 73 and imidazole (3.23 g) in dry DMF (50ml) was added dropwise t-butyl chloro dimethylsilane in dry DMF (10 ml) for 20 minutes at -0° C. After addition, the mixture was stirred for 30 minutes at room temperature. The mixture was diluted with ether, and washed with saturated sodium chloride solution, dried over anhydrous sodium sulfate. After removal of the solvent under reduced pressure, the residue was purified by chromatography on a silica gel column (hexane:methylene chloride=4:1) to give the title compound (13.3 g; 88percent).

The synthetic route of 60666-70-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Mochida Pharmaceutical Co., Ltd.; US5587392; (1996); A;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 552331-15-4, name is 1-(5-Bromo-2-fluorophenyl)ethanol. This compound has unique chemical properties. The synthetic route is as follows. name: 1-(5-Bromo-2-fluorophenyl)ethanol

To a solution of compound 2A-2 (46.0 g, 210.0 mmol) and triethylsilane (48.8 g, 420.0 mmol, 66.9 mL) in DCM (500.0 mL) was added BF3.Et20 (59.6 g, 420.0 mmol, 51.8 mL) at 0C. The mixture was stirred at 25C for 2 h, concentrated, quenched by addition of Sat.NaHC03 (200 mL) at 0C, and extracted with ethyl acetate (200 mL chi 3). The combined organic layers were washed with brine (200 mL chi 3), dried over Na2S04, filtered and concentrated. The residue was purified by column chromatography (Si02) to afford compound 2A-3 (24.0 g, crude). 1H NMR (CHLOROFORM-d, 400MHz) delta 1 1 (dd, J= 2.2, 6.6 Hz, 1H), 7.27 – 7.21 (m, 1H), 6.87 (t, J= 9.2 Hz, 1H), 2.62 (q, J= 7.5 Hz, 2H), 1.20 (t, J= 7.6 Hz, 3H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 552331-15-4, 1-(5-Bromo-2-fluorophenyl)ethanol.

Reference:
Patent; QUENTIS THERAPEUTICS, INC.; VACCA, Joseph P.; LI, Dansu; BETTIGOLE, Sarah; (184 pag.)WO2018/222918; (2018); A1;,
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Adding a certain compound to certain chemical reactions, such as: 617-94-7, 2-Phenyl-2-propanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C9H12O, blongs to alcohols-buliding-blocks compound. HPLC of Formula: C9H12O

General procedure: In a round-bottom flask, benzylic alcohol 1a (10 mmol, 2.0 equiv.), benzenesulfonyl chloride 2a (13 mmol, 1.3 equiv.) and NMP (2.5 equiv.). Then, DCE (3 mL) were added. The mixture was stirred at 80 C for 1.5 h. After completion of the reaction (monitoredby TLC), water (10 mL) was added and the mixture was extracted with ethyl acetate (3*10 mL). The combined organic phase was dried over anhydrous Na2SO4, filtered, and evaporated under reduced pressure. The crude product was purified by flash chromatography on silica gel to give the desired alkyl chlorides 3.

The synthetic route of 617-94-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Zheng, Dagui; Mao, Liu-Liang; Zhu, Xian-Hong; Zhou, An-Xi; Synthetic Communications; vol. 48; 21; (2018); p. 2793 – 2800;,
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Electric Literature of 14320-38-8, Adding some certain compound to certain chemical reactions, such as: 14320-38-8, name is Cyclopent-3-enol,molecular formula is C5H8O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 14320-38-8.

Step 1: Toluene-4-sulfonic acid cyclopent-3-enyl ester Cyclopent-3-ene-1-ol (200 mg, 2.38 mmol) was dissolved in pyridine (2.5 ml) and p-toluenesulfonyl chloride (558 mg, 2.92 mmol) was added portionwise at 0 C. After the addition was completed the reaction mixture was stirred at 0 C. for 3 h and then kept in the fridge overnight. Then it was poured into to a mixture of ice and diluted HCl (pH ~5). The solid was filtered off, washed with diluted HCl and dried to obtain the title compound as off-white solid (447 mg, 79%). MS (EI): 256.2 (M+NH4)+.

According to the analysis of related databases, 14320-38-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Banner, David; Ceccarelli, Simona M.; Grether, Uwe; Haap, Wolfgang; Hilpert, Hans; Kuehne, Holger; Mauser, Harald; Plancher, Jean-Marc; Sanchez, Ruben Alvarez; US2010/317647; (2010); A1;,
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Synthetic Route of 111-46-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.111-46-6, name is 2,2′-Oxybis(ethan-1-ol), molecular formula is C4H10O3, molecular weight is 106.1204, as common compound, the synthetic route is as follows.

A mixture of 2- (2-methoxyethoxy) ethanol(2A) (21.2 g, 0.2 mol) andCesium carbonate (8.55 g, 0.05 mol) was dissolved in N, N-dimethylformamide (50 mL), Benzyl bromide (27.7 g, 0.085 mol) was added and stirred at room temperature for 3 daysThe The reaction solution was added with water (300 mL) and extracted with ethyl acetate (100 mL x 2)The combined organic phases were washed with saturated brine, dried over anhydrous sodium sulfate,The filtrate was concentrated under reduced pressure and the residue was purified by silica gel column chromatography(Petroleum ether / ethyl acetate (v / v) = 1: 0 to 5: 1) to give the title product2- (2-benzyloxyethoxy) ethanol (2B) as a pale yellow oil(4.0 g, yield 40%).

The chemical industry reduces the impact on the environment during synthesis 111-46-6, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Sichuan Haisco Pharmaceutical Co.,Ltd.; Wei, Yonggang; Qiu, Guanpeng; Lu, Yonghua; Zhu, Guozhi; (40 pag.)TW2017/8238; (2017); A;,
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Related Products of 37585-25-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 37585-25-4, name is (2-Amino-5-chlorophenyl)methanol, molecular formula is C7H8ClNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a stirred solution of 2-amino-5-chlorophenylmethanol (11.1g, 70.4mmol) in tetrahydrofuran (50mL) was added imidazole (5.27g, 77.5mmol), followed by careful addition of terf-butyldimethylchlorosilane (10.62g, 70.4mmol). The reaction mixture was stirred for 24 hours. Imidazole (528mg, 7.75mmol) and tert-butyldimethylchlorosilane (1.06g, 7.03mmol) were then added. After 1 hour the solid was filtered off and washed with diethyl ether (2 x 20ml_) and the filtrate was washed with water (10mL), brine (10ml_), dried over magnesium sulfate and concentrated in vacuo to give the product as a brown oil, 18.83g (98%).1H NMR (400 MHz, CDCI3): 5 0.07 (6H, s), 0.90 (9H, s), 4.63 (2H, s), 6.60 (1H, d), 7.01 (1H, d), 7.05 (1H, m); LRMS: m/z APCI+272[MH+].

According to the analysis of related databases, 37585-25-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; PFIZER LIMITED; PFIZER INC.; WO2006/21882; (2006); A1;,
Alcohol – Wikipedia,
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Adding a certain compound to certain chemical reactions, such as: 702-82-9, 3-Aminoadamantan-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 3-Aminoadamantan-1-ol, blongs to alcohols-buliding-blocks compound. Recommanded Product: 3-Aminoadamantan-1-ol

General procedure: N-Ethyl-N’-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDCI) (0.15 g, 0.78 m Mol, 1.2 equiv) and 3-amino-5,7-dimethyladamantan-1-ol (9b) (0.15 g, 0.76 m Mol, 1.06 equiv) were successively added to a solution of 2-(3-oxobenzo[d]isothiazol-2(3H)-yl)acetic acid (8) (0.15 g, 0.72 m Mol, 1.0 equiv) in anhydrous DMF (5 mL) at ambient temperature. The resulting reaction mixture was stirred at ambient temperature for 70 h. The solvent was evaporated under reduced pressure and the residue was partitioned between water (20 mL) and ethyl acetate (10 mL). The aqueous phase was additionally extracted with ethyl acetate (3 * 7 mL). The combined organic layer was successively washed with 5% aqueous solution of citric acid (7 mL), 5% aqueous solution of NaHCO3 (8 mL), brine (10 mL), dried over anhydrous Na2SO4, filtered and evaporated under reduced pressure. Crystallization of the crude product from a mixture consisting from ethyl acetate and hexanes provided 1c (47 mg, 17%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,702-82-9, 3-Aminoadamantan-1-ol, and friends who are interested can also refer to it.

Reference:
Article; Zhulenkovs, Dmitrijs; Rudevica, Zhanna; Jaudzems, Kristaps; Turks, Maris; Leonchiks, Ainars; Bioorganic and Medicinal Chemistry; vol. 22; 21; (2014); p. 5988 – 6003;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 3319-15-1, name is 1-(4-Methoxyphenyl)ethanol. A new synthetic method of this compound is introduced below., COA of Formula: C9H12O2

General procedure: In a typical reaction, alcohol (0.4 mmol) was mixed with AlCl3 (0.02 mmol, 5 mol%) and triphenylphosphine (PPh3, 0.02 mmol, 5 mol%) in nitromethane (1.0 mL). Thereafter the mixture was stirred at 80 C for 2 h. After the reaction, the mixture was cooled to room temperature, and the product was isolated using preparative thin layer chromatography (TLC, eluting solution: petroleum ether/ethyl acetate, 5/1 (v/v)). Tests for substrate scope were all performed with an analogous procedure.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 3319-15-1, 1-(4-Methoxyphenyl)ethanol.

Reference:
Article; Liu, Changhui; Pan, Bin; Gu, Yanlong; Cuihua Xuebao/Chinese Journal of Catalysis; vol. 37; 6; (2016); p. 979 – 986;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts