Author: tianli

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.78573-45-2, name is 3-(3-(Trifluoromethyl)phenyl)propan-1-ol, molecular formula is C10H11F3O, molecular weight is 204.19, as common compound, the synthetic route is as follows.Safety of 3-(3-(Trifluoromethyl)phenyl)propan-1-ol

Example 2 Synthesis of 3-[3-(trifluoromethyl)phenyl]-propionaldehyde (II) A solution of compound (V) (1.0 g, 4.90 mmol) in dichloromethane (20 ml) is cooled in water/ice bath, treated in succession with DMSO (770 mg, 9.80 mmol) and P2O5 (1.39 g, 9.80 mmol) and left under stirring for 30 minutes, while temperature raises to 20 C. The reaction mixture is then cooled in water/ice bath and triethylamine (2.4 ml, 17.15 mmol). The resulting solution is kept under stirring while temperature raises to 20 C. After one hour the mixture is treated with 5% HCl, the phases are separated and the organic one is further washed with 5% HCl. The organic phase is then washed with brine, dried over Na2SO4, filtered and concentrated under reduced pressure, to afford 0.99 g of the aldehyde of formula (II) in quantitative yield. 1H NMR (300 MHz, CDCl3), ppm: 9.83 (t, 1H, J 0.9 Hz), 7.48-7.38 (m, 4H), 3.02 (t, 2H, J 7.2 Hz), 2.82 (m, 2H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,78573-45-2, 3-(3-(Trifluoromethyl)phenyl)propan-1-ol, and friends who are interested can also refer to it.

Reference:
Alcohol – Wikipedia,
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Related Products of 1113-21-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1113-21-9, name is 3,7,11,15-Tetramethylhexadeca-1,6,10,14-tetraen-3-ol, molecular formula is C20H34O, molecular weight is 290.48, as common compound, the synthetic route is as follows.

The 5E, 9E, 13E-geranyl geranyl acetone (1) can be prepared by reacting 6E-10E-geranyl linalool (23) with diketene (24) catalyzed by DMAP in ethyl ether to give the ester 25. The ester 25 in the Carroll rearrangement using Al(OiPr)3 at elevated temperature can afford the desired 5E, 9E, 13E-geranyl geranyl acetone (1). In another approach, the GGA (1) can be prepared by treating geranyl linalool (23) with the Meldrum’s acid 26 in the Carroll rearrangement using Al(OiPr)3 at 160 C. Similarly, the use of tert-butyl acetoacetate (27) with geranyl linalool (23) in the Carroll rearrangement can also give the desired 5E,9E,13E-geranyl geranyl acetone (1).

Statistics shows that 1113-21-9 is playing an increasingly important role. we look forward to future research findings about 3,7,11,15-Tetramethylhexadeca-1,6,10,14-tetraen-3-ol.

Reference:
Patent; COYOTE PHARMACEUTICALS, INC.; Look, Gary C.; US2015/133431; (2015); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 105-13-5 ,Some common heterocyclic compound, 105-13-5, molecular formula is C8H10O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure for selective mono PMB protection of diols: (Z)-4-((4-Methoxybenzyl)oxy)but-2-en-1-ol (Table 5, entry 1): A mixture of cis-2-butene-1,4-diol (200 mg, 2.3 mmol), p-anisyl alcohol (345 mg, 2.5 mmol), and catalytic amount (10% w/w, 20 mg) of Amberlyst-15 resin in anhydrous CH2Cl2 (10 mL) was refluxed. After 3 h, the crude reaction mixture was filtered through a Whatman filter paper and the residue washed with CH2Cl2, dried (over anhydrous Na2SO4), filtered and concentrated in vacuo and purified using flash chromatography (pet ether/ethyl acetate 70:30) to provide 401 mg (85%) of pure product as a colorless dense liquid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 105-13-5, (4-Methoxyphenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Chavan, Subhash P.; Harale, Kishor R.; Tetrahedron Letters; vol. 53; 35; (2012); p. 4683 – 4686;,
Alcohol – Wikipedia,
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Related Products of 623-04-1 , The common heterocyclic compound, 623-04-1, name is (4-Aminophenyl)methanol, molecular formula is C7H9NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of 4-aminobenzyl alcohol (2.0g, 16.24mmol) in dry DMF (20mL) were added tert-butyldimethylsilyl chloride (3.67g, 24.35mmol) and imidazole (2.21g, 32.46mmol), the resulting mixture was further stirred for 5hat room temperature. The reaction mixture was then diluted with saturated brine solution and extracted with CH2Cl2. The organic layer was separated and washed with brine solution for several times, then dried over anhydrous Na2SO4, evaporated under vacuum, the obtained brown residue was purified by silica gel chromatography (petroleum ether-ethyl acetate), a brown oil was obtained (3.15g, 82%). 1H NMR (CDCl3, 400MHz) delta7.12 (d, 2H, J=8.4Hz), 6.67 (d, 2H, J=8.0Hz), 4.62 (s, 2H), 3.80 (brs, 2H), 0.91 (s, 9H), 0.08 (s, 6H).

The synthetic route of 623-04-1 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Fei, Qiang; Zhou, Li; Wang, Feiyi; Shi, Ben; Li, Chunbao; Wang, Rui; Zhao, Chunchang; Dyes and Pigments; vol. 136; (2017); p. 846 – 851;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 106-28-5, (2E,6E)-3,7,11-Trimethyldodeca-2,6,10-trien-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: (2E,6E)-3,7,11-Trimethyldodeca-2,6,10-trien-1-ol, blongs to alcohols-buliding-blocks compound. name: (2E,6E)-3,7,11-Trimethyldodeca-2,6,10-trien-1-ol

Example 11. Synthesis of Acetic acid 3,7,11-trimethyl-dodeca-2,6,10-trienyl ester, or Farnesyl acetate To a solution of farnesol (100g, 0.45 mol), potassium carbonate (90 g, 0.65 mol) and 4-dimethylamino pyridine (0.5 g) in EtOAc (300 ml) at 0C, acetic anhydride (66.5 g, 0.65 mol) was added dropwise. The reaction was finished in 2 hrs. All the contents of the reaction flask were transferred to a conical flask containing EtOAc (600 ml) and treated with the dropwise addition of a saturated NaHCO3 solution. After neutralization, the organic layer was separated and washed with water (2 x 80 ml), brine (80 ml), and dried over MgSO4 and then removed under vacuum to yield the farnesyl acetate (108 g, 92%). 1H NMR(400 MHz, CDCl3): 5.34 (t, 1H, J = 6.04 Hz), 5.07 (m, 2H), 4.57 (d, 2H, J = 6.84 Hz), 2.10-2.05 (m, 11H), 1.97-1.95 (m, 2H), 1.68-1.66 (m, 6H), 1.58 (s, 6H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,106-28-5, (2E,6E)-3,7,11-Trimethyldodeca-2,6,10-trien-1-ol, and friends who are interested can also refer to it.

Reference:
Patent; Mehta, Dilip; Eburon Organic International; Mohan, Priya; Shastri, Mayank; Reid, Ted; EP2868658; (2015); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 33420-52-9, Adding some certain compound to certain chemical reactions, such as: 33420-52-9, name is 2,2-Difluoropropan-1-ol,molecular formula is C3H6F2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 33420-52-9.

To a cooled (0 C) solution of 2,2-difluoropropan-l-ol (3.17 g, 33.0 mmol) and pyridine (2.97 mL, 36.7 mmol) in CH3CN (100 mL) was added dropwise Tf20 (5.70 mL, 33.8 mmol). The reaction was stirred for 30 min at 0 C. To the cooled slurry was added a cold solution of methyl 4-methyl-5-(l-(piperidin-4-yl)propyl)thiophene-3 -carboxylate hydrochloride (2.6 g, 7.34 mmol) and K2C03 (9.13 g, 66.0 mmol) in CH3CN (20 mL). The reaction was allowed to warm to RT, then heated at 50 C overnight. The reaction was evaporated to dryness under vacuum, taken up in DCM, washed with water, brine, dried (Na2S04), filtered, and concentrated under vacuum. The residue was purified by silica gel chromatography (Isco RediSep Rf Gold 120 g, 5% EtOAc:hexanes) to give methyl 5-(1- (1-(2,2-difluoropropyl)piperidin-4-yl)propyl)-4-methylthiophene-3-carboxylate (2.05 g, 5.42 mmol, 73.8 % yield) as a yellow oil. 1H NMR (400 MHz, CDCl3) delta 8.00 (s, 1H), 3.85 (s, 3H), 2.99 (d, J=11.12 Hz, 1H), 2.86 (d, J=11.12 Hz, 1H), 2.53-2.75 (m, 3H), 2.37 (s, 3H), 2.04-2.27 (m, 2H), 1.84-2.01 (m, 2H), 1.62 (t, J=18.69 Hz, 4H), 1.30-1.47 (m, 5H), 0.76 (t, J=7.33 Hz, 3H). MS(ES) [M+H]+ 360.2.

According to the analysis of related databases, 33420-52-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED; KNIGHT, Steven David; NEWLANDER, Kenneth Allen; TIAN, Xinrong; (112 pag.)WO2016/66697; (2016); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 27489-62-9 ,Some common heterocyclic compound, 27489-62-9, molecular formula is C6H13NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

4.2.31 8-(trans-4-Hydroxycyclohexylamino)-1-(3-morpholinopropyl)oxazolo[4,5-g]quinazolin-2(1H)-one (6e) Trans-4-aminocyclohexanol (148 mg, 1.28 mmol) and TEA (150 mg, 2.14 mmol) was added to a solution of compound 13 (300 mg, 1.07 mmol) in isopropanol (12 ml) and stirred at 60 C for 24 h. The mixture was cooled to room temperature and concentrated in vacuo, the residue was treated with aqueous NaHCO3 (10 ml) and extracted with EtOAc/MeOH (20:1, 30 ml). The organic layer was washed with brine, dried over MgSO4, and concentrated. Chromatography of the residue on silica gel with DCM-MeOH (90/1,v/v) gave 361 mg (yield, 79%) of the title compound as pale yellow solid: Mp: 312-315 C; HRMS, ESI+, m/z: Calcd for C22H30N5O4 (M + H)+, 428.2292; found, 428.2295; 1H NMR (500 MHz, DMSO-d6) delta:8.70 (1H, s), 7.80 (1H, s), 7.74 (1H, s), 4.14 (1H, s), 4.00 (2H, t, J = 6.4 Hz), 3.52 (4H, t, J = 4.2 Hz), 2.33 (2H, t, J = 6.3 Hz), 2.26 (4H, m), 2.00 (2H, p, J = 6.4 Hz); 13C NMR (75 MHz, DMSO-d6) delta:165.61, 159.43, 153.45, 153.26, 152.57, 152.00, 148.36, 148.27, 147.64, 147.03, 134.26, 132.23, 120.73, 112.49, 106.61, 106.06, 106.38, 101.58, 100.19, 66.00, 65.86, 55.01, 54.77, 54.15, 53.16, 53.12, 40.59, 40.33, 22.19, 22.91.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 27489-62-9, trans-4-Aminocyclohexanol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Lin, Jinsheng; Shen, Wei; Xue, Jingwei; Sun, Juan; Zhang, Xue; Zhang, Can; European Journal of Medicinal Chemistry; vol. 55; (2012); p. 39 – 48,10;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 4728-12-5 ,Some common heterocyclic compound, 4728-12-5, molecular formula is C7H14O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To dichloromethane solution (100 ml) of 14 (6.38 g, 43.64 mmol), triethylamine (9.08 ml, 65.47 mmol) was added, and methane sulfonyl chloride (3.69 ml, 48.01 mmol) was dropped while cooling in ice with shaking, and stirred for 30 min at the same temperature. The reaction mixture was added cold water, and extracted with ethyl acetate. The extract was washed with water, dried, and evaporated to dryness under reduced pressure, and the residue was purified by silica gel column chromatography (solvent: ethyl acetate/n-hexane = 1/2), to obtain 15 (9.66 g, 99percent) of oily light yellow substance. APCI-MS m/z 225[M+H]+

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,4728-12-5, its application will become more common.

Reference:
Patent; Tohoku University; EP2103611; (2009); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 96-35-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 96-35-5, name is Methyl 2-hydroxyacetate. This compound has unique chemical properties. The synthetic route is as follows.

A mixture ofmethyl 2-hydroxyacetate (9 g, 0.1 mol,equiv) and hydrazine hydrate (9.6 ml, 1.5 equiv, 85%) in methanol (100 ml) was refluxed for 8 h before methanol and exceesive hydrazine hydrate were evaporated. Toluene was added and evaporated again to remove the residual water to give the title compound as a white solid which could be used in next step without further purification.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 96-35-5, Methyl 2-hydroxyacetate.

Reference:
Patent; Shen, Jianhua; Wang, Yiping; Wang, Kai; US2014/171431; (2014); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 2568-33-4, Adding some certain compound to certain chemical reactions, such as: 2568-33-4, name is 3-Methylbutane-1,3-diol,molecular formula is C5H12O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2568-33-4.

Step 1: 4-Chloro-2-methyl-butan-2-ol 10.0 g (96.0 mmol)_3-methyl-1 ,3-butandiol is dissolved in 30.0 ml toluene and 10.7 g (106 mmol) TEA is added. The funnel is rinsed with 10.0 ml toluene. The mixture is heated to 80C and a mixture of 1 1 .6 g (101 mmol) methanesulfonyl chloride and 3.00 ml toluene is added. After complete addition, the funnel is rinsed with 7.00 ml toluene and the reaction mixture is heated to reflux for approx. 3h. After full conversion (GC) the mixture is cooled to 20 C and 40.0 ml water is added. Stirring is continued for a short period and the aqueous phase is separated. Then, approx. 10 ml of the organic phase is distilled off in vacuum. The crude toluene solution of the product is used for the next step.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 2568-33-4, 3-Methylbutane-1,3-diol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; DAHMANN, Georg; WAGNER, Holger; ECKHARDT, Matthias; FRANK, Markus; SANTAGOSTINO, Marco; SCHNAUBELT, Juergen; STERTZ, Uwe; PACHUR, Thorsten; WO2015/44073; (2015); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts