Author: tianli

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2002-24-6, name is 2-Aminoethanol hydrochloride. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 2002-24-6

9-(2′-hydroxyethylamino)-4-methyl-1 -nitroacridine 4-Methyl-1-nitro-9-phenoxyacridine (0.33 g) is dissolved in phenol (10 g), ethanolamine hydrochloride (0.2 g) is added and the mixture is heated at 80 C. for 0.5 hour. The reaction mixture is cooled to room temperature, diluted with ether, slowly poured into dry ether (200 ml) and acidified with ethereal solution of hydrogen chloride. The resulting precipitate is filtered off, washed with ether and crystallized from absolute ethanol to give 9-(2′-hydroxyethylamino)-4-methyl-1-nitroacridine monohydrochloride as orange crystals (0.27 g, 84%), m.p. 238 C. (decomp.) 1H NMR (d6DMSO): delta2.45 (s, 3H, CH3), 3.48 (q, 2H, H-2′), 3.65 (t, 2H, H-1′), 4.3 (t, 1H, OH), 7.1 (t, 1H, H-7), 2), 7.35 (d, 1H, J=7.8 Hz, H-3), 7.5 (t, 1H, H-6), 7.65 (d, 1H, J=8 Hz, H-5), 7.75 (d,1H, J=8.0 Hz, H-8).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 2002-24-6, 2-Aminoethanol hydrochloride.

Reference:
Patent; Konopa, Jerzy Kazimierz; Wysocka-Skrzela, Barbara; Tiwari, Raj; US2002/99211; (2002); A1;,
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Synthetic Route of 33420-52-9, Adding some certain compound to certain chemical reactions, such as: 33420-52-9, name is 2,2-Difluoropropan-1-ol,molecular formula is C3H6F2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 33420-52-9.

Example 2305- [9-(2,2-Difluoropropoxy)-6-methanesulfonyl-5- [(S)-oxan-4-yl(phenyl)methylj -5H-pyrido [3 ,2-bj indol-3-ylj -4-(2H3)methyl- 1-methyl- 1H-1 ,2,3-triazole To a stirred solution of 5- {9-fluoro-6-methanesulfonyl-5 – [(S)-oxan-4-yl(phenyl)methyl] -5H-pyrido [3 ,2-b]indol-3 -yl} -4-(2H3)methyl- 1-methyl-i H- 1,2,3 -triazole (31.0 mg, 0.0600 mmol) and 2,2-difluoropropan-2-ol (27.8 mg, 0.290 mmol) inNMP (0.30 mL) was added t-BuOK (25.9 mg, 0.230 mmol). This mixture was heated at65 C for 1 h and cooled to room temperature. The mixture was diluted with MeOH andpurified via preparative LC/MS with the following conditions: Column: Waters XBridgePhenyl, 19 x 200 mm, 5-rim particles; Mobile Phase A: 5:95 acetonitrile: water with 10-mM ammonium acetate; Mobile Phase B: 95:5 acetonitrile: water with 10-mMammonium acetate; Gradient: 15-70% B over 20 mm, then a 5-mm hold at 100% B; Flow: 20 mL/min. Fractions containing the desired product were combined and dried via centrifugal evaporation to give 5- [9-(2,2-difluoropropoxy)-6-methanesulfonyl-5 – oxan-4-yl(phenyl)methyl]-5H-pyrido [3 ,2-b]indol-3 -yl]-4-(2H3)methyl- i-methyl-i H15 1,2,3-triazole (13.8 mg, 37%). ?H NMR (500MHz, DMSO-d6) oe 8.60 (s, 1H), 8.29 (d,J8.8 Hz, 1H), 7.74 (s, 1H), 7.56 (br d, J7.7 Hz, 2H), 7.36-7.29 (m, 2H), 7.28-7.22 (m,1H), 7.18 (d, J=8.9 Hz, 1H), 6.74 (s, 1H), 4.67 (br t, J=12.0 Hz, 2H), 3.86 (br d, J15.iHz, 1H), 3.73 (s, 3H), 3.60-3.55 (m, 1H), 3.49 (brt,J=ii.5 Hz, 1H), 3.33 (br d,J11.8Hz, 1H), 3.23-3.16 (m, 1H), 2.54 (s, 3H), 1.95 (brt,J=19.4 Hz, 3H), 1.69 (br d,J10.8Hz, 1H), i.62-i.50(m, 1H), i.22(brd,J=8.8 Hz, 1H), 0.43 (brd,J=12.OHz, 1H).LCMS: RT = 1.731 mm; (ES): mlz (M+H)+ = 613.15, LCMS: Column: Waters Acquity UPLC BEH C 18, 2.1 x 50 mm, 1 .7-tim particles; Mobile Phase A: 5:95 acetonitrile:water with 10mM ammonium acetate; Mobile Phase B: 95:5 acetonitrile:water with 10mM ammonium acetate; Temperature: 50 C; Gradient: 0-100% B over 3 mm, then a 0.75-mmhold at 100% B; Flow: 1.11 mL/min. HPLC Purity at 220 nm: 95 %.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 33420-52-9, 2,2-Difluoropropan-1-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; NORRIS, Derek J.; DELUCCA, George V.; GAVAI, Ashvinikumar V.; QUESNELLE, Claude A.; GILL, Patrice; O’MALLEY, Daniel; VACCARO, Wayne; LEE, Francis Y.; DEBENEDETTO, Mikkel V.; DEGNAN, Andrew P.; FANG, Haiquan; HILL, Matthew D.; HUANG, Hong; SCHMITZ, William D.; STARRETT, JR, John E.; HAN, Wen-Ching; TOKARSKI, John S.; MANDAL, Sunil Kumar; WO2015/100282; (2015); A1;,
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Application of 39590-81-3, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 39590-81-3 as follows.

[1-(Hydroxymethyl)cyclopropyl]methanol obtained from Step A (0.2 g, 1.96 mmol), 4-bromo-2,6-difluoro-phenol (0.314 g, 1.5 mmol) and triphenylphosphine (0.393 g, 1.5 mmol) were dissloved in 24 mL of THF. Diisopropyl azocarboxylate (0.3 mL, 1.5 mmol) was added thereto, and the reaction mixture was stirred for 16 hours at room temperature. The mixture was concentrated under reduced pressure and purified by column chromatography to obtain the title compound (0.307 g, 70 %). 1H NMR (CDCl) delta 7.08 (2H, m), 4.08 (2H, s), 3.68 (2H, d), 1.84 (1H, t, OH), 0.62 (4H, m)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,39590-81-3, its application will become more common.

Reference:
Patent; LG LIFE SCIENCES LTD.; KIM, Young Kwan; PARK, Sang Yun; JOO, Hyun Woo; CHOI, Eun Sil; WO2014/209034; (2014); A1;,
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Synthetic Route of 10602-04-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 10602-04-7, name is (4-Ethynylphenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows.

(4-{3-Bromo-5-[2-(4-chloro-phenyl)-ethoxy]-phenylsulfanyl}-2-methyl-phenoxy)- acetic acid ethyl ester (270 mg; 0.46 mmol), (4-ethynyl-phenyl)-methanol (296 mg; 2.2 mmol), bis(triphenylphosphine) palladium (II) chloride (31.4 mg; 0.045 mmol) and copper iodide (6.4 mg; 0.034 mmol) were dissolved in a mixture of triethylamine (2 mL) and DMF (2 mL) under an atmosphere of nitrogen. The reaction mixture was reacted in a microwave oven at 110 °C for 1.5 h. The reaction mixture was evaporated to dryness, and 5percent aqueous citric acid (30 mL) and ethyl acetate (30 mL) was added. The two phases were separated and the aqueous phase was extracted with ethyl acetate (30 mL). The combined organic phases were dried and evaporated to dryness and purified by preparative HPLC (method B). Yield: 270 mg (83percent). HPLC-MS: m/z: 587.1 (M+H)+; Rt: 2.96 min.

According to the analysis of related databases, 10602-04-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; NOVO NORDISK A/S; WO2007/3581; (2007); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 62285-58-9, name is (2,6-Dimethylphenyl)methanol, the common compound, a new synthetic route is introduced below. Computed Properties of C9H12O

[0484] To a solution of (2,6-dimethyl-phenyl)-methanol (13.6 g, 100.00 mmol) in DCM (400 mL) was added PBr3 (5.7 g, 150.0 mmol) and pyridine (0.5 mL). The mixture was stirred at 0 C for 2 hrs. TLC showed the reaction was completed. The reaction was quenched with slow addition of ice water (50 mL). The aqueous phase was extracted with DCM (300 mL x3). The organic layer was washed with brine (500 mL), dried over Na2S04 and concentrated to give 2-bromom ethyl- 1,3 -dimethyl -benzene (19.1 g, yield: 96 %) as a yellow solid.

The synthetic route of 62285-58-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE; SMITH, Layton H.; PINKERTON, Anthony B.; HERSHBERGER, Paul; MALONEY, Patrick; MCANALLY, Danielle; (167 pag.)WO2019/32720; (2019); A1;,
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Electric Literature of 4249-72-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 4249-72-3, name is 2-Phenoxy-1-phenylethanol. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: Lignin model molecule (2-phenoxy-1-phenylethanol) wassynthesized according to the method reported by Rothenberg[9]. Catalytic hydrotreating of 2-phenoxy-1-phenylethanolwas carried out in a 100ml autoclave with Tefon liner.The catalyst (50mg) was added to a solution of 2-phenoxy-1-phenylethanol (150mg) in ethanol (2ml) and H2O(8ml).The autoclave was sealed and purged with H2several times.The reaction was performed at 170C with 2MPa hydrogenpressure for 6h. Then, the reactors were cooled down toroom temperature using an ice bath, and the organic productswere extracted with ethyl acetate (5ml × 2). The organic products mixtures were analyzed by GC and chlorobenzenewas used as an external standard. Identification of mainproducts was based on GC-MS as well as by comparisonwith authentic samples. The product distribution was shownon the mole basis. In consecutive batch tests, the catalystwas recovered by magnets and washed with EtOH for threetimes. The catalyst was recycled into the autoclave with thefeedstream.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 4249-72-3, 2-Phenoxy-1-phenylethanol.

Reference:
Article; Chen, Bingfeng; Li, Fengbo; Yuan, Guoqing; Catalysis Letters; vol. 147; 11; (2017); p. 2877 – 2885;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5259-98-3, name is 5-Chloropentan-1-ol, the common compound, a new synthetic route is introduced below. Safety of 5-Chloropentan-1-ol

5-chloro-l-pentanol (12,26 g, 0,1 mol) was dissolved in dry dichloromethane (400 mL). 3,4-Dihydro-2H-pyrane (12,62 g, 0,15 mol) and pyridine toluene-4-sulphonate (1,26 g, 5 mmol) was then added and the reaction mixture was stirred magneti- cally in a nitrogen atmosphere at room temperature over night. Sodium-hydrogen-carbonate, saturated solution (150 mL) was added and the phases were separated. The aqueous phase was then extracted with dichloromethane (4 x 25 mL). The com- bined dichloromethane phases were washed with water (2 x 20 mL) and then dried (MGS04). Dichloromethane was then dis- tilled out on a rotary evaporator and yielded 19,6 g (95 percent) of a pale yellow oil. NMR indicated a pure product.

The synthetic route of 5259-98-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; AXIMED AS; WO2005/25314; (2005); A1;,
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Related Products of 37585-16-3 , The common heterocyclic compound, 37585-16-3, name is (2-Amino-4-chlorophenyl)methanol, molecular formula is C7H8ClNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

B. N-(Benzylcarbonyl)-5-chloro-2-hydroxymethylaniline To a suspension of 5-chloro-2-hydroxymethyl aniline (8.00 g) in dichloromethane (400 ml) under nitrogen at room temperature, was added triethylamine (15.6 ml). The reaction mixture was cooled to 0 C. then phenyl acetyl chloride (14.80 ml) was added dropwise over 10 mins, and the reaction mixture was allowed to warm to room temperature and stir for 2 h. The mixture was washed with 1N HCl (2*250 ml) and brine (1*250 ml). The aqueous layers were re-extracted using CH2 Cl2 (1*250 ml) and the combined organic layers were dried (MgSO4), filtered and the solvent was removed under vacuum to leave an orange solid. The solid was suspended in MeOH (400 ml), sodium hydroxide (2.20 g) was added in water (100 ml) and the reaction mixture was allowed to stir under gentle heating (50 C.) for 45 mins. The methanol was removed in vacuo, then the aqueous residue was extracted with dichloromethane (1*200 ml) and the organic layer was washed with brine (1*150 ml) and saturated sodium hydrogen carbonate solution (1*150 ml). The organic layer was dried (MgSO4), filtered and the solvent was removed under vacuum to leave a solid. Trituration with diethyl ether gave the required compound (10.00 g).

The synthetic route of 37585-16-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Merck, Sharp & Dohme Ltd.; US5614532; (1997); A;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.107859-98-3, name is Ethyl 3-(4-(hydroxymethyl)phenyl)propanoate, molecular formula is C12H16O3, molecular weight is 208.25, as common compound, the synthetic route is as follows.name: Ethyl 3-(4-(hydroxymethyl)phenyl)propanoate

Example 3 Ethyl 3-[4-(bromomethyl)phenyl]propanoate Carbon tetrabromide (1.27 g) and triphenylphosphine (805 mg) were added to a methylene chloride solution (5 mL) of the compound (533 mg) as produced in Example 2, followed by stirring at room temperature for 30 min. An aqueous saturated sodium hydrogencarbonate solution was added to the reaction mixture, and extraction was effected with ethyl acetate. The organic layer was washed with an aqueous saturated sodium chloride solution, dried over anhydrous sodium sulfate and concentrated. The resultant residue was purified on a silica gel column chromatography (n-hexane:ethyl acetate = 9:1) to give the subject title compound (667 mg) showing the following physico-chemical values: TLC: Rf 0.61 (n-hexane:ethyl acetate = 4:1); 1H-NMR (CDCl3): d 1.23, 2.61, 2.94, 4.13, 4.48, 7.18, 7.32.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,107859-98-3, Ethyl 3-(4-(hydroxymethyl)phenyl)propanoate, and friends who are interested can also refer to it.

Reference:
Patent; ONO PHARMACEUTICAL CO., LTD.; EP1785421; (2007); A1;,
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Related Products of 29055-08-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.29055-08-1, name is (2-(Methylamino)phenyl)methanol, molecular formula is C8H11NO, molecular weight is 137.179, as common compound, the synthetic route is as follows.

[00263] To a solution of 2-(N-methylamino)-benzylalcohol(b) (536 mg, 3.9 mmol) in dry dichloromethane (25 ml) and diisopropylethylamine (681 mul, 3.9 mmol) was added dropwise chloromethyl chloroformate (360 mul, 4.0 mmol) and the reaction mixture was stirred at 0° C. with occasional check of the reaction progress by t.l.c (n-hexane:ethyl acetate=2:1). After 2 h, the starting material disappeared on t.l.c and the solution was used directly for the following reaction. [00264] Step 2 [00265] To the reaction mixture were added diisopropylethylamine (900 mul, 5.0 mmol) and acetic anhydride (400 mg) and stirred for 3 h at ambient temperature. The reaction mixture was partitioned with dichloromethane (50 ml) and water (30 ml). The water layer was separated and extracted again with dichloromethane (50 ml). The combined organic layer was washed with brine (30 ml.x.2), dried over anhydrous sodium sulfate and concentrated under reduced pressure. The resulting yellowish oil was purified on a column of silica gel (wakogel C-200 10 g, eluent dichloromethane_methanol=200:1) to give the title compound(c) as colorless syrup (740 mg, 70percent). EI-MS: m/z 271(M+); 1H-NMR (270 MHz, CDCl3): delta 2.10 (3H, s), 3.30 (3H, s), 5.07-5.78 (2H, br.d), 5.60 (0.8H, d, J=5.9), 5.73 (0.8H, d, J=5.9), 5.85 (0.4H, br.s), 7.16-7.23 (1H, m), 7.37-7.49 (3H, m).

Statistics shows that 29055-08-1 is playing an increasingly important role. we look forward to future research findings about (2-(Methylamino)phenyl)methanol.

Reference:
Patent; Basilea Pharmaceutica AG; US6812238; (2004); B1;,
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