Author: tianli

Synthetic Route of 346-06-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 346-06-5, name is (2-(Trifluoromethyl)phenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows.

Example 99; 5-(2-Trifluoromethylbenzyloxy)-quinazoline-2,4-diamine; [00297] Step 1; 2- (Trifluoromethyl)benzyl alcohol(1.15 g; 6.3 mmol) was added to a cooled (0 °C) slurry of sodium hydride (243.7 mg; 6 mmol) in dimethylformamide under nitrogen atmosphere. The reaction mixture was slowly warmed to room temperature, stirred for 45 min.. The reaction mixture was then added to a cooled (0 °C) solution of 2,6-difluorobenzonitrile in dimethylformamide , stirred for 3 hours at room temperature. The reaction mixture was poured on crushed ice-water, stirred, filtered, washed with water and dried to afford 1.39 grams of 2-fluoro-6-(2-trifluoro- methylphenyl-methoxy) benzonitrile as a white solid.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 346-06-5, (2-(Trifluoromethyl)phenyl)methanol.

Reference:
Patent; DECODE CHEMISTRY, INC.; SINGH, Jasbir; GURNEY, Mark E.; WO2005/123724; (2005); A1;,
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Related Products of 764-48-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 764-48-7, name is Ethylene Glycol Vinyl Ether. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: A dry and argon-flushed 10 mL Schlenk tube, equipped with a stirring bar and septum, wascharged with 2-(vinyloxy)ethanol (5, 132 mg, 1.50 mmol, 1.50 equiv) in Et2O (1.5 mL). Then,iPrMgBr (1.55 mmol, 1.55 equiv) was added dropwise at 25 C. After 5 min of stirring,Sc(OTf)3 (49.2 mg, 0.10 mmol, 0.10 equiv) and aldehyde 6 (1.00 mmol, 1.00 equiv) weresuccessively added and the reaction mixture was stirred at 40 C for the given time. After afull conversion was detected by GC-analysis, sat. aq. NH4Cl (15 mL) was added and theaqueous layer was extracted with EtOAc (3 x 15 mL). The combined organic layers weredried over Na2SO4, filtered and solvent was removed under reduced pressure. Purification viacolumn chromatography (SiO2) afforded expected products 4.

According to the analysis of related databases, 764-48-7, the application of this compound in the production field has become more and more popular.

Reference:
Article; Quinio, Pauline; Kohout, Laura; Roman, Daniela Sustac; Gaar, Jakob; Karaghiosoff, Konstantin; Knochel, Paul; Synlett; vol. 27; 11; (2016); p. 1715 – 1719;,
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Application of 2566-44-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2566-44-1, name is 2-Cyclopropylethanol, molecular formula is C5H10O, molecular weight is 86.13, as common compound, the synthetic route is as follows.

Take a single-necked flask and add 2-cyclopropylethanol (2.4g, 28mmol), DMF (30mL) in sequence, cool to 0 C, add sodium hydrogen (1.3g, 33mmol, 60% by mass), and stir the reaction mixture at room temperature for 20min Add 3- (benzyloxy) 2-bromo-6-iodopyridine (10g, 25.6mmol), heat to 100 C and continue stirring for 12h.Post-treatment: add water (50 mL) to quench the reaction, extract with ethyl acetate (20 mL × 3), combine the organic phases, wash the organic phase with saturated brine (50 mL × 3), dry over anhydrous sodium sulfate, filter, and concentrate under reduced pressure The filtrate and the residue were separated by silica gel column chromatography (PE / EA (V / V) = 2/1) to obtain the title compound as a colorless oil (6.8 g, 17 mmol, 67%).

Statistics shows that 2566-44-1 is playing an increasingly important role. we look forward to future research findings about 2-Cyclopropylethanol.

Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Huang Jianzhou; Ren Qingyun; Xiong Jinfeng; Liu Yang; Yu Fangcai; Liu Weishun; Wang Yifeng; Zhang Yingjun; (104 pag.)CN110903284; (2020); A;,
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Application of 612-16-8 , The common heterocyclic compound, 612-16-8, name is (2-Methoxyphenyl)methanol, molecular formula is C8H10O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: Reactions were performed in a magnetically stirred round bottomed flask fitted with acondenser and placed in a temperature controlled oil bath. 1,2-Diamine (2 mmol)was added to alcohol (3 mmol) and the reaction mixture was allowed to stir at 135C in an open (air) atmosphere. After disappearance of the diamine (reaction was monitored by TLC)or after the appropriate time, the reaction mixture was cooled to roomtemperature. The crude residue was further purified by column chromatography using silica gel (100-200 mesh) to afford pure products. All the products wereidentified on the basis of NMR and mass spectral data

The synthetic route of 612-16-8 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Marri, Mahender Reddy; Peraka, Swamy; Macharla, Arun Kumar; Mameda, Naresh; Kodumuri, Srujana; Nama, Narender; Tetrahedron Letters; vol. 55; 48; (2014); p. 6520 – 6525;,
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Electric Literature of 4139-61-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 4139-61-1, name is 6-Bromo-4-hydroxycoumarin. A new synthetic method of this compound is introduced below.

Step one: the 6 – bromo -4 – hydroxy coumarin (1 mmol) with triethylamine (1.5 mmol) dissolved in 10 ml dichloromethane after, cold water bath cooling, trifluoromethyl sulfonic acid anhydride (1.5 mmol) is added slowly dropping in the reaction system, the reaction 3 hours later, and steaming and to remove the solvent, after concentrating column separation (petroleum ether and ethyl acetate to the volume proportion 4:1) to obtain 6 – bromo -4 – trifluoromethanesulfonic acid ester – coumarin.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,4139-61-1, its application will become more common.

Reference:
Patent; Henan University of Technology; Wang Hongyan; Wei Xuning; Liu Yu; Guo Tao; Lin Xiangbin; Kong Linghui; (33 pag.)CN107629050; (2018); A;,
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Synthetic Route of 60666-70-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 60666-70-8, name is (2-Bromo-5-chlorophenyl)methanol, molecular formula is C7H6BrClO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Step 1. ((2-Bromo-5-chlorobenzyl)oxy)(tert-butyl)dimethylsilane. Triethylamine (0.30 mL, 2.15 mmol), DMAP (97 mg, 0.79 mmol) and tert-butyldimethylsilyl chloride (TBSCl; 698 mg, 4.63 mmol) were added to a solution of (2-bromo-5-chlorophenyl)methanol (500 mg, 2.26 mmol) in CH2Cl2 (11.3 mL) at room temperature. After stirring overnight, the reaction mixture was partitioned between saturated aqueous sodium bicarbonate (50 mL) and CH2Cl2 (200 mL). The phases were separated and the aqueous phase was extracted with CH2Cl2 (2*100 mL). The combined organic phase was washed with brine, dried (MgSO4), filtered and concentrated in vacuo.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 60666-70-8, (2-Bromo-5-chlorophenyl)methanol.

Reference:
Patent; Allergan, Inc.; Ngo, Vinh X.; Old, David W.; Burk, Robert M.; (55 pag.)US9540357; (2017); B1;,
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Reference of 7589-27-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 7589-27-7, name is 2-(4-Fluorophenyl)ethanol. This compound has unique chemical properties. The synthetic route is as follows.

To a solution of 2-(4-fluorophenyl)ethyl alcohol (13.4 mL, 107 mmol) in dry toluene (150 mL) at 0C was added phosphorous tribromide (21.1 mL, 224 mmol). The resulting mixture was stirred at ambient temperature for 5 days and then recooled to 0C and crushed ice (200 g) added. The aqueous layer was extracted with ether (2 x 120 mL) and the combined organic extracts were then washed with saturated aqueous sodium bicarbonate solution (2 x 30 mL), dried (MgSO4) and concentrated in vacuum. Distillation afforded 2-(4-fluorophenyl)ethyl bromide as a colorless oil (14.08g, 31%); b.p. 103C (at) 12 mm Hg.

According to the analysis of related databases, 7589-27-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Aventis Pharmaceuticals, Inc.; Hoechst Marion Roussel Deutschland GmbH; EP1734037; (2006); A2;,
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Electric Literature of 454-91-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.454-91-1, name is 1-[3-(Trifluoromethyl)phenyl]ethanol, molecular formula is C9H9F3O, molecular weight is 190.16, as common compound, the synthetic route is as follows.

Example 90 1-[3-(Trifluoromethyl)phenyl]ethyl N-{4-[(6,7-dimethoxy-4-quinazolinyl)oxy]phenyl}carbamate 4-[(6,7-Dimethoxy-4-quinazolinyl)oxy]aniline (89 mg) was added to toluene/triethylamine = 10/1 (9 ml), and the mixture was heated under reflux to prepare a solution. A solution of triphosgene (120 mg) in methylene chloride was then added to the solution, and the mixture was heated under reflux for 15 min. Subsequently, 3-trifluoromethyl-alpha-methylbenzyl alcohol (70 mg) was added thereto, and the mixture was further stirred with heating under reflux for 2 hr. After the completion of the reaction, the reaction solution was allowed to cool to room temperature before distilled water was added thereto. The mixture was subjected to separatory extraction with chloroform, followed by washing with a 1 N aqueous hydrochloric acid solution and saturated brine. The washed solution was dried over sodium sulfate and was concentrated. The residue was purified on a column using chloroform/methanol to give the title compound (80 mg, yield 48%). 1H-NMR (CDCl3, 400 MHz): 8.75 (1H, s), 8.07 (1H, s), 7.14 – 7.63 (8H, m), 6.95 (1H, s), 6.79 (1H, d, J = 8.8 Hz), 5.93 (1H, q, J = 6.6 Hz), 4.15 (3H, s), 4.09 (3H, s), 1.61 (3H, d, J = 6.6 Hz) Mass spectrometry value (ESI-MS, m/z): 514 (M++1)

Statistics shows that 454-91-1 is playing an increasingly important role. we look forward to future research findings about 1-[3-(Trifluoromethyl)phenyl]ethanol.

Reference:
Patent; KIRIN BEER KABUSHIKI KAISHA; EP1243582; (2002); A1;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 722-92-9, name is 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol, molecular formula is C9H7F6NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Computed Properties of C9H7F6NO

A solution of 2-(4-aminophenyl)- 1,1, 1,3,3, 3-hexafluoropropan-2-ol (0.88 g, 3.4 mmol), 2-acetamido-4-methylthiazole-5-sulfonyl chloride (0.79 g, 3.1 mmol) in acetone (15 mL) and 2,6-lutidine (0.73 mL, 6.2 mmol) was warmed to 60°C for 18 h. The reaction was judged complete by analytical HPLC (starting materials consumed). The solvent was removed in vacuo, and the crude residue was diluted with EtOAc and aq 1M HC1. The layers were separated, and the organic layer was washed with 1M HC1, sat aq NaHC03, brine, dried (MgS04), and concentrated to give a solid.Trituration with warm Et20/hexanes afforded N-(5-(N-(4-(l,l,l,3,3,3-hexafluoro-2- hydroxypropan-2-yl)phenyl)sulfamoyl)-4-methylthiazol-2-yl)acetamide (1.2 g, 86percent yield) as a light tan solid, >95percent pure as judged by analytical HPLC. A small amount of this was further purified by reverse-phase preparative HPLC to >99percent purity to give a colorless solid. 1H NMR (DMSO-J6, 400MHz) delta 12.5 (s, 1H); 10.8 (s, 1H); 8.6 (s, 1H); 7.60 (d, 2H); 7.25 (d, 2H); 2.30 (s, 3H); 2.15 (s, 3H); 13C NMR (DMSO-J6, 100MHz) delta 170.0, 159.6, 153.0, 139.4, 128.4, 126.8, 124.8, 121.9, 121.7, 120.3, 22.8, 16.3; 19F NMR (DMSO-J6, 376MHz) delta -74.1; HRMS (ESI-orbitrap) Calcd for C15Hi4F6N304S2, 478.0330; Found, 478.0319.

With the rapid development of chemical substances, we look forward to future research findings about 722-92-9.

Reference:
Patent; GRIFFIN, Patrick R.; ROUSH, William R.; KUMAR, Naresh; NUHANT, Philippe; BURRIS, Thomas; SOLT, Laura; WO2011/115892; (2011); A1;,
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