Author: tianli

Synthetic Route of 75476-86-7, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 75476-86-7 as follows.

(a) A solution of 6-bromo-indan-1 -ol (1 mmol) and NEt3 (4 mmol) in dry THF (5 ml_) was stirred at -15 5C under argon. A solution of methanesulfonyl chloride (2 mmol) in dry THF (1 ml_) was cooled to -78 5C and then slowly added to the alcohol solution maintaining the temperature below 0 5C. The reaction mixture was stirred for 2h at -15 5C and then purged with dimethylamine gas (12 mmol). The reaction mixture was allowed to warm to room temperature and stirred overnight. Then, it was filtered to remove salts and solvent was evaporated. Crude was dissolved in CH2CI2 and extracted with HCI 1 M (3x). The aqueous phase was basified withNaOH 6M to pH 8-9 and extracted with CH2CI2. The combined organic extracts were dried over MgS04 and concentrated to dryness. The crude was used in next step without further purification.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,75476-86-7, its application will become more common.

Reference:
Patent; LABORATORIOS DEL DR. ESTEVE, S.A.; GARCIA-LOPEZ, Monica; TORRENS-JOVER, Antoni; ALONSO-XALMA, Monica; WO2011/42343; (2011); A1;,
Alcohol – Wikipedia,
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Adding a certain compound to certain chemical reactions, such as: 702-82-9, 3-Aminoadamantan-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 702-82-9, blongs to alcohols-buliding-blocks compound. category: alcohols-buliding-blocks

In the 2L reaction flask, 138.6 g of 3-amino-1-adamantanol was added.105.7g of potassium carbonate,5.3g potassium iodideAnd 900ml acetone,Stir and heat to 50-55C,Intermediate 2 in 110g was added dropwise in 1hMixed with 600 ml acetone,Stirred and incubated for 2 h, TLC detected the reaction was complete.Filter and rinse the filter cake with 300 ml hot acetone.The combined filtrate and washings were concentrated under reduced pressure at 35-45[deg.] C. to a remaining amount of about 770 ml, cooled to 0-10[deg.] C., and incubated for 2 hours while stirring.The filter cake was washed with 100ml of acetone, 40 ~ 50 cake was dried in vacuo 4h, to give a crude vildagliptin 173.5g, a yield of 89.8%. The 3L reaction flask was filled with 170g of crude product and 1870ml of acetone.Stir and heat to 50-55C,Stir until the solids are completely dissolved,Add 8.5g of activated carbon, heat and stir for 0.5h.Heat filtered and washed with 80 ml acetone.The filtrate was stirred and lowered to a temperature of 10-20C.Stir and stir for 2h.After filtration, the filter cake was washed with 80 ml of acetone, and the filter cake was vacuum dried at 40-50 C. for 4 hours to obtain 139.8 g of Vildagliptin with a yield of 82.2%. The content of 3-amino-1-adamantanol was 0.03%. 0.02%, no isomers detected, purity 99.8%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,702-82-9, its application will become more common.

Reference:
Patent; Hebei Medical University; Zhang Kai; Xue Na; Shi Xiaowei; Chen Xinghe; Wang Yabo; Lv Tao; (14 pag.)CN106966947; (2017); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 62285-58-9, (2,6-Dimethylphenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: (2,6-Dimethylphenyl)methanol, blongs to alcohols-buliding-blocks compound. Recommanded Product: (2,6-Dimethylphenyl)methanol

General procedure 1 (GPl) Step l:To the commercially available alcohols (0.288 mmol), placed in vials (20 mL) equipped with screw caps, were added a solution of 2-(4-carboxymethyl-phenylsulfanylmethyl)-benzoic acid 2,2,2-trichloro-ethyl ester (125mg, 0.288mmol), EDCxHCl (83mg, 0.435mmol), DMAP (3.5mg, 0.029mmol) and DCM (4 mL). The reaction mixtures were stirred at rt overnight. The mixtures were quenched with 0.25M HCl (4 mL) and the two phases were separated through phase separators. The organic phases were concentrated and used without further purification into the next step.; Example 33 2-[4-(2,6-Dimethyl-benzyloxycarbonylmethyl)-phenylsulfanylmethyl]-benzoic acidThe titled compound was prepared according to GPl. Step 1: Using (2,6-dimethyl-phenyl)- methanol as the alcohol. Step 2: The reaction time was 2 days. Yield: 37mg (31 %). 1H NMR (600 MHz, (CD3)2SO, (CH3)2SO): delta 2.24 (s, 6H), 3.61 (s, 2H), 4.54 (s, 2H), 5.10 (s, 2H), 7.00 (d, 2H), 7.08-7.14 (m, 3H), 7.22 (d, 2H), 7.27-7.34 (m, 2H), 7.36-7.40 (m, IH), 7.82 (d, IH); Mass spectrum: M-H+ 419.

The synthetic route of 62285-58-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ALBIREO AB; WO2008/108735; (2008); A1;,
Alcohol – Wikipedia,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.13674-16-3, name is Methyl 2-hydroxy-3-phenylpropanoate, molecular formula is C10H12O3, molecular weight is 180.2, as common compound, the synthetic route is as follows.Recommanded Product: Methyl 2-hydroxy-3-phenylpropanoate

EXAMPLE 14 2-[4′-(2-Benzoyl-benzofuran-3-yl)-biphenyl-4-yloxy]-3-phenyl-propionic acid The title compound was prepared from 4′-(2-benzoyl-benzofuran-3-yl)-biphenyl-4-ol, and 3-phenyllactic acid methyl ester, in substantially the same manner, as described in Example 1, steps g-h, and was obtained as a yellow solid, mp 159-161 C.; MS m/e 538 (M+); Analysis for: C36H26O5 Calc’d: C, 80.28; H, 4.86 Found: C, 80.15; H, 4.91.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,13674-16-3, Methyl 2-hydroxy-3-phenylpropanoate, and friends who are interested can also refer to it.

Reference:
Patent; American Home Products Corporation; US6232322; (2001); B1;,
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Adding a certain compound to certain chemical reactions, such as: 2919-23-5, Cyclobutanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C4H8O, blongs to alcohols-buliding-blocks compound. COA of Formula: C4H8O

Sodium hydride (60% dispersion in mineral oil, 0.066 g, 1.65 mmol) was added portionwise to a stirring solution of cyclobutanol (0.12 g, 1.66 mmol) in THF (10 mL) at room temperature over 10 min. The mixture was stirred for 1 h, and was treated with compound 254 (0.50 g, 1.1 1 mmol). The mixture was heated at 60 C under nitrogen overnight, cooled to room temperature, and quenched with aq. sat. KH2PO4 (50 mL). The solvent was evaporated in vacuo and the residue was extracted with EtOAc (50 mL). The organic extract was washed with brine (100 mL), dried over MgS04, filtered, and concentrated. The residue was purified by flash chromatography (silica gel, eluting with 50% EtOAc in hexanes) to give compound 260a (0.54 g, quantitative yield) as an off-white foamy solid. m/z = 486 (M+l).

The synthetic route of 2919-23-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; REATA PHARMACEUTICALS, INC.; JIANG, Xin; BENDER, Christopher, F.; VISNICK, Melean; HOTEMA, Martha, R.; SHELDON, Zachary, S.; LEE, Chitase; CAPRATHE, Bradley, William; BOLTON, Gary; KORNBERG, Brian; (497 pag.)WO2018/111315; (2018); A1;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 329218-12-4, name is 3-Bromo-4-chlorobenzyl Alcohol, molecular formula is C7H6BrClO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. name: 3-Bromo-4-chlorobenzyl Alcohol

B. Methanesulfonic acid 3-bromo-4-chloro-benzyl esterO I I?^ l l OO I To a mixture of 3-bromo-4-chloro-phenyl)-methanol (6.0 g, 27.1 mmol) in THF (50 mL ) under nitrogen at Oo C is added triethyl amine (3.6 g, 35.3 mmol) followed by methanesulfonyl chloride (4.0 g, 35.3 mmol). After stirring at ambient temperature for 1 h the reaction is poured into a mixture of NaHCO3/H2O/ice and extracted with EtOAc. The organic layer is washed with saturated aqueous NaCI, dried over MgSO4, filtered and concentrated in vacuo to provide the desired product (8.0 g, 99%) as a white solid.1 H NMR (300 MHz, CDCI3) delta 7.49 (m, 1 H), 7.49 (m, 1 H), 7.28 (m, 1 H), 5.17 (s, 2H), 3.00 (s, 3H).

With the rapid development of chemical substances, we look forward to future research findings about 329218-12-4.

Reference:
Patent; SANOFI; CHOI-SLEDESKI, Yong Mi; LIANG, Guyan; NIEDUZAK, Thaddeus R.; POLI, Gregory B.; SHUM, Patrick Wai-Kwok; STOKLOSA, Gregory T.; ZHAO, Zhicheng; WO2011/79102; (2011); A1;,
Alcohol – Wikipedia,
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Electric Literature of 4442-79-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 4442-79-9, name is 2-Cyclohexylethanol. A new synthetic method of this compound is introduced below.

A flame-dried 50 mL flask was charged with 2-cyclohexylethanol (696 mg, 5.00mmol) in dry THF (10 mL). The mixture was cooled at 0 C and sodium hydride (60wt% on mineral oil, 300 mg, 7.50 mmol) was added in one portion. After stirring for10 min, allyl bromide (0.65 mL, 7.50 mmol) was added dropwise at the sametemperature. The cooling bath was removed and the suspension was stirred at roomtemperature for 30 min. The reaction mixture was then heated to reflux for 16 h. Afterfull conversion, the suspension was cooled to room temperature and quenched by theaddition of a saturated aqueous solution of NH4Cl (10 mL). The biphasic mixture wasthen extracted with Et2O (3 x 10 mL). The combined organic layers were dried overNaSO4 and concentrated in vacuo. The crude material was purified by columnchromatography on silica gel (Pet. Ether/EtOAc 100:1); Colorless oil; 87% yield;

At the same time, in my other blogs, there are other synthetic methods of this type of compound,4442-79-9, 2-Cyclohexylethanol, and friends who are interested can also refer to it.

Reference:
Article; Voutyritsa, Errika; Triandafillidi, Ierasia; Tzouras, Nikolaos V.; Nikitas, Nikolaos F.; Pefkianakis, Eleftherios K.; Vougioukalakis, Georgios C.; Kokotos, Christoforos G.; Molecules; vol. 24; 9; (2019);,
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Application of 1875-88-3, Adding some certain compound to certain chemical reactions, such as: 1875-88-3, name is 2-(4-Chlorophenyl)ethanol,molecular formula is C8H9ClO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1875-88-3.

PREPARATION B-XI 2-(4-chloro)phenyl-1-mesyloxyethane To a stirring solution of 3.00 mL (22.16 mMol) 2-(4-chloro)phenyl-1-ethanol in 75 mL tetrahydrofuran at 0 C. were added 4.63 mL (33.24 mMol) triethylamine followed by 1.89 mL (24.38 mMol) methanesulfonyl chloride. The reaction mixture was allowed to stir at room temperature for 18 hours. The reaction mixture was then poured into water and extracted well with ethyl acetate. The organic phases were combined, washed with water, dried over sodium sulfate and concentrated under reduced pressure to give 5.18 gm (99.6%) of the title compound.

According to the analysis of related databases, 1875-88-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Eli Lilly and Company; US5962473; (1999); A;,
Alcohol – Wikipedia,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 60666-70-8, name is (2-Bromo-5-chlorophenyl)methanol. A new synthetic method of this compound is introduced below., HPLC of Formula: C7H6BrClO

Compound 17-3 (0421) To a solution of compound 17-2 (8.0 g, 36.1 mmol) in THF (60 mL) was added NaH (60percent, 1.88 g, 46.9 mmol) at 0° C. After addition, the reaction mixture was stirred at room temperature for 30 min. Iodomethane (10.25 g, 72.2 mmol) was added and stirred for another 30 min. The reaction was then quenched with sat. ammonium chloride (50 mL) and extracted with ethyl acetate (50 mL×3). The combined organic layers were washed with brine (60 mL), dried over Na2SO4, filtered, concentrated to afford 17-3 as a white solid (7.23 g, yield 85percent).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 60666-70-8, (2-Bromo-5-chlorophenyl)methanol.

Reference:
Patent; Nivalis Therapeutics, Inc.; Wasley, Jan; Rosenthal, Gary J.; Sun, Xicheng; Strong, Sarah; Qiu, Jian; US9138427; (2015); B2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 1805-32-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1805-32-9, name is 3,4-Dichlorobenzyl alcohol. A new synthetic method of this compound is introduced below.

General procedure: All the reactions were carefully carried out at 40C in a 25ml flask. In a typical procedure an amount of catalyst along with H2O2 was used for the oxidation process under mild conditions. The oxidation process was monitored by thin layer chromatography technique.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1805-32-9, 3,4-Dichlorobenzyl alcohol, and friends who are interested can also refer to it.

Reference:
Article; Judy Azar, Amir Reza; Safaei, Elham; Mohebbi, Sajjad; Materials Research Bulletin; vol. 70; (2015); p. 753 – 761;,
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