Author: tianli

Application of 6006-82-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6006-82-2, name is 2-(Benzo[d][1,3]dioxol-5-yl)ethanol, molecular formula is C9H10O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

B. 1-acetoxy-2-[(3,4-methylenedioxy)phenyl]ethane To a stirred solution of 2-(3,4-methylenedioxy)phenyl-1-ethanol (1.68 g, 10 mmol) in dry pyridine was added acetic anhydride and the resultant reaction mixture was stirred at 80 C. for 1 h. The reaction mixture was poured into ice-water and was extracted with ether (2*75 ml). The combined ether extract was washed with water (2*50 ml), 5% HCl (2*50 ml) and then with 5% NaHCO3 (2*50 ml). The organic layer was dried over magnesium sulfate and the solvent was removed under reduced pressure to give 1-acetoxy-2-[(3,4-methylenedioxy)phenyl]ethane as a solid (1.7 g, 81% yield).

According to the analysis of related databases, 6006-82-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Texas Biotechnology Corporation; US6432994; (2002); B1;,
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Synthetic Route of 112-70-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 112-70-9, name is 1-Tridecanol. This compound has unique chemical properties. The synthetic route is as follows.

EXAMPLE 1 [00073] The following Example describes the condensation esterification of DDDA using Fascat 2003 catalyst, a tin-based esterification catalyst from Elf Atochem, and the preparation of DDDA diesters with varying mole percent Telomer alcohol and Exxal 13. [00074] Reaction mixtures were prepared in 20 mL vials with the compositions indicated in table 4 below. One drop of Fascat 2003 (a product of Atochem) was added to each vial, and the reactions were heated at 200-250 C. for about 12 hours under a nitrogen sweep to remove evolved water. GC analysis of the reaction mixtures showed the expected three component ester mixture: RfO(O)C-(CH2)x-C(O)ORf; RhO(O)C-(CH2)x-C(O)ORh; and RhO(O)C-(CH2)x-C(O)ORf. The actual amount of each ester component present varied as expected with the relative amounts of Telomer alcohol and Exxal 13 present in the synthesis mixture. The appearance of the mixture formed from the respective additive and 150N oil as well as the solubility of the additive in 150N oil are also summarized in the Table 4. It is noteworthy that the fully fluorinated diester, vial 8, was more soluble when heated, but that the solution cooled to a gel-like state as the diester reprecipitated with cooling. Such behavior is very undesirable in a lubricant. This illustrates an important deficiency of the fully fluorinated diesters, since lubricants are often subjected to temperature cycling, and low-temperature performance is often critical.[TABLE-US-00005] TABLE 4 DDDA diesters with Telomer alcohol and Exxal 13 mol % Telomer Solubility in TelomerExxalalcohol 150 N DDDAalcohol13vs total oil atNo.(mmol)(mmol)(mmol)alcoholAppearance25 C. 15.150.2910.743liquid20%24.940.5810.515liquid35.151.349.8812honey->1% like45.052.48.8121very thick oil55.054.46.6240grease0.5% like65.135.625.4751grease?0.25% like75.158.262.7875beeswax like85.3411.060100paraffin0.1% like [00075] Wear test results for some of the above materials are shown in FIG. 2. It is clear from this figure that most of the wear benefit is achieved with only about 20 mole % Telomer alcohol in the diester. The wear response, quite surprisingly, is extremely non-linear. This is contrary to the linear response that might be expected if the wear-reducing effects were simply the net average from the concentration present of completely fluorinated diester (100% Telomer alcohol) and non-fluorinated ester (0% Telomer alcohol). This implies that the non-symmetric, partially fluorinated diesters of the present invention have better wear reducing properties than either the non-fluorinated or completely fluorinated diesters.

According to the analysis of related databases, 112-70-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; E. I. du Pont de Nemours and Company; US6734320; (2004); B2;,
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Reference of 2568-33-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2568-33-4, name is 3-Methylbutane-1,3-diol, molecular formula is C5H12O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of 3-methylbutan-l,3-diol (10.0 g, 96.1 mmol) in DCM (100 mL) was added 4- methylbenzene- l-sulfonyl chloride (20.1 g, 106 mmol) and TEA (24.3 g, 240 mmol). The reaction mixture was stirred at room temperature for 12 h. Then the mixture was extracted with DCM (150 mLx3). The combined organic layers were washed with water and brine, dried over MgSC”4, and filtered. The filtrate was concentrated under reduced pressure. The resulting residue was purified by chromatography over silica gel (eluting with PE_EA=5: 1) to give the title compound.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 2568-33-4, 3-Methylbutane-1,3-diol.

Reference:
Patent; MERCK SHARP & DOHME CORP.; BIFTU, Tesfaye; COLLETTI, Steven L.; HAGMANN, William K.; KAR, Nam Fung; JOSIEN, Hubert; NAIR, Anilkumar; NARGUND, Ravi; BIJU, Purakkattle; ZHU, Cheng; HU, Bin; WO2015/51496; (2015); A1;,
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Reference of 13401-56-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 13401-56-4, name is 3-Chloro-2,2-dimethylpropan-1-ol. This compound has unique chemical properties. The synthetic route is as follows.

7-Hydroxyindole (5.00 g, 37.55 mmol), 3-chloro-2,2-dimethyl-propan-1-ol (6.91 g, 56.33 mmol), triphenyl (1.57 g, 6.00 mmol) were dissolved in THF (150 mL), and after replacing with nitrogen, DIAD (15.19 g, 75.10 mmol) was added dropwise to the mixture. The mixture was stirred at 70 C for 12 hours. TLC showed the reaction was complete, the reaction solution was concentrated to dryness. The crude product was purified by column chromatography (PE: EA = 50: 1, 20: 1) to deliver the title compound (white solid, 3.5 g, yield 39.21%). 1H NMR (400MHz, CDCl3): delta 7.29 (s, 1H), 7.21 (t, J=4.0 Hz, 1H), 7.03 (t, J=8.0 Hz, 1H), 6.68 (d, J=8.0 Hz, 1H), 6.58 – 6.53 (m, 1H), 3.96 (s, 2H), 3.65 (s, 2H), 1.20 (s, 6H). LCMS (ESI) (5-95AB): m/z: 238.1 [M+1].

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 13401-56-4, 3-Chloro-2,2-dimethylpropan-1-ol.

Reference:
Patent; GUANGDONG ZHONGSHENG PHARMACEUTICAL CO., LTD; DING, Charles Z.; CHEN, Shuhui; ZHAO, Baoping; LIU, Xile; XIAO, Linxia; DING, Chao; WANG, Fei; LI, Jian; (153 pag.)EP3290419; (2018); A1;,
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Electric Literature of 50595-15-8, Adding some certain compound to certain chemical reactions, such as: 50595-15-8, name is tert-Butyl 2-hydroxyacetate,molecular formula is C6H12O3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 50595-15-8.

To a 20 mL reaction vial with magnetic stir bar was massed 4- chlorosulfonylbenzoyl chloride (See procedure above; SI-3, limiting reagent, 0.501 g, 2.10 mmol), and the vial was capped with a septum and positive pressure nitrogen line. Through the septum was added tetrahydrofuran (20 mL/g, 10 mL), and the vial was cooled in a dry ice/acetone bath. Upon equilibrating to temperature, triethylamine (2.0 eq, 0.58 mL, 4.2 mmol) was added in one portion, followed by 3-azidopropan-1-ol (1.0 eq, 0.219 grams, 0.20 mL, 2.09 mmol). The vial was allowed to react in the cooling bath. After one hour, complete conversion was observed (reaction progress monitored by HPLC), and tert-butyl glycolate (1.5 eq, 0.415 g, 3.14 mmol), and the cooling bath was removed and the vial was allowed to warm to room temperature. After one hour, conversion was observed to be 24percent, and the reaction was allowed to stir overnight at room temperature to reach completion. The crude reaction was diluted in ethyl acetate (40 mL/g, 20 mL), washed twice with water (20 mL/g each, 10 mL each), and finally brine (10 mL/g, 5 mL). The rich organic layer was dried over magnesium sulfate, filtered, and concentrated in vacuo. The oil thus obtained was purified by column chromatography (silica, heptane/ethyl acetate). SI-5 was obtained after concentration as a solid with a yield of 63percent (526 mg). The structure was confirmed with HSQC and HMBC spectroscopy; correlation was observed between the azidopropyl methylene and the carboxylate carbon, confirming connectivity. SI-5: 1H NMR (500 MHz, CDCl3) delta 8.22 (d, J = 7.9 Hz, 2H), 8.04 (d, J = 8.2 Hz, 2H), 4.55 (s, 2H), 4.48 (t, J = 6.1 Hz, 2H), 3.50 (t, J = 6.4 Hz, 2H), 2.08 (quintet, J = 6.3 Hz, 2H), 1.43 (s, 9H) ppm; 13C NMR (126 MHz, CDCl3) delta 164.7, 164.6, 140.0, 134.9, 130.3, 128.1, 83.6, 65.5, 62.8, 48.2, 28.1, 27.9 ppm; HRMS (ESI-TOF): calc?d for

According to the analysis of related databases, 50595-15-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; CREECH, Gardner, S.; KHEIRABADI, Mahboubeh; EASTGATE, Martin, D.; NIRSCHL, David, S.; CARTER, Percy, H.; (82 pag.)WO2018/227053; (2018); A1;,
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Synthetic Route of 112-70-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 112-70-9, name is 1-Tridecanol, molecular formula is C13H28O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Compound 1 (590mg, 1.0mmol), which was prepared from protoporphyrin IX (PPIX) under acid esterification conditions,17 was dissolved in HBr/acetic acid (25%, 30mL) under nitrogen atmosphere and the mixture was stirred for 2h. All volatile solvents were evaporated under vacuum to yield dimethyl 3,3?-(7,12-bis(1-bromoethyl)-3,8,13,17-tetramethylporphyrin-2,18-diyl)dipropionate (2) as a green colored liquid. The resulting liquid was directly dissolved in dichloromethane (50mL), and 1-tridecanol (2.2mmol, 441mg) and Cs2CO3 (2.2mmol, 304mg) were added to the dichloromethane solution. The reaction mixture was again stirred under nitrogen atmosphere for 2h and filtered. The resulting filtrate was concentrated under the reduced pressure and the residue was purified by preparative TLC on silica gel with CH2Cl2/MeOH (20:1) to give compound 3a (218mg, 23% yield) as a dark violet crystal. Rf=0.8 (CH2Cl2/MeOH 20:1); 1H NMR (400MHz, CDCl3, TMS) delta 10.63 (s, 1H), 10.61 (s, 1H), 10.11 (s, 1H), 10.08 (s, 1H), 6.09 (m, 2H), 4.41-4.45 (m, 4H), 3.73 (s, 3H), 3.71 (s, 3H), 3.70 (s, 3H), 3.69 (s, 3H), 3.68 (s, 3H) 3.67 (s, 3H), 3.65 (m, 4H), 3.28-3.32 (m, 4H), 2.25-2.27 (d, J=7.0Hz, 6H), 1.09-1.80 (m, 42H), 0.84 (t, J=12.9Hz, 6H); 13C NMR (75MHz, CDCl3, TMS) delta 173.7 (2C; C=O), 140.6, 140.4, 138.4, 138.2, 137.2, 136.8, 136.5 (16C; C pyrrole), 98.8, 98.6, 96.8, 96.1, 73.3 (2C, OCH) 69.6 (2C, OCH2), 51.74 (2C; CO2CH3), 37.0 (2C, CH3CH), 31.9 (2C; CH2COOMe), 30.3, 29.5, 29.3, 26.4, 25.5, (24C; -CH2-), 22.6 (2C; CH2CH2COO), 21.9, 14.1 (2C, CH3C pyrrole), 11.7ppm (2C; CH3C pyrrole); IR (NaCl disc) 3311, 2924, 2853, 1739, 1435, 1100cm-1; MS (ESI, positive): m/z (%): 991; HRMS (ESI, positive) m/z Calcd for C62H94N4O6 [M+H]+; 991.7252, found: 991.7252.

According to the analysis of related databases, 112-70-9, the application of this compound in the production field has become more and more popular.

Reference:
Article; Tachikawa, Shoji; El-Zaria, Mohamed E.; Inomata, Ryu; Sato, Shinichi; Nakamura, Hiroyuki; Bioorganic and Medicinal Chemistry; vol. 22; 17; (2014); p. 4745 – 4751;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 18776-12-0, name is 3-Chloro-1-phenylpropan-1-ol, the common compound, a new synthetic route is introduced below. Application In Synthesis of 3-Chloro-1-phenylpropan-1-ol

A. (1 -Bromo-3-chloropropyl)benzene; 3-Chloro-1 -phenyl-1 -propanol (1.71 g, 10 mmol) was dissolved in dry Et20 (27 ml_) and purged with N2. A solution of PBr3 (0.63 ml_, 6.6 mmol) in dry Et20 (27 mL) was added dropwise very slowly. The reaction was stirred for 2 h at room temperature, followed by washing with 5% aqueous sodium acetate (x2) and brine (x1 ). The organic fraction was dried (MgS04), filtered, and the solvent evaporated to dryness. The resulting crude mixture was purified by column chromatography (S1O2, hexane/EtOAc) to obtain the desired compound as a yellow oil in 45% yield (1 .06 g, 4.54 mmol).

The synthetic route of 18776-12-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PROUS INSTITUTE FOR BIOMEDICAL RESEARCH, S.A.; MUNOZ, Rosa; GARCIA-DELGADO, Noemi; FLORES, Ramon; SERRADELL, Neus; PROUS, Josep, R.; WO2012/13691; (2012); A1;,
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Reference of 41175-50-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 41175-50-2, name is 1,2,3,5,6,7-Hexahydropyrido[3,2,1-ij]quinolin-8-ol. A new synthetic method of this compound is introduced below.

Under Argon, fresh distilled DMF (2.8 mL) was added dropwise toPOCl3 (2.8 mL) at room temperature and stirred for 30 min to yield ared solution. Then a portion of 2,3,6,7-tetrahydro-1H,5H-pyrido[3,2,1-ij]quinolin-8-ol (3.15 g, 16.64 mmol, dissolved in 10 mL DMF) wasadded dropwise to the above solution and a scarlet suspension wasyielded. The mixture was stirred at room temperature for 30 min and80 C for 30 min until the reaction was completed, then the reactionmixture was poured into 150 mL of ice water. NaOH solution (20%)was added to adjust the pH to 6 and continue stirred for 2 h, and alarge amount of precipitate was obtained. The crude product was purifiedby flash column chromatography (PE:EA = 20:1, v/v) to give theproduct as a brown solid (2.50 g, yield: 69.1%). 1H NMR (500 MHz,CDCl3) delta 11.80 (s, 1H), 9.36 (s, 1H), 6.82 (s, 1H), 3.27 (m, 4H), 2.66 (t,J = 6.4, 6.4 Hz, 4H), 1.92 (q, J = 6.0, 6.0, 5.9 Hz, 4H). 13C NMR(126 MHz, CDCl3) delta 191.66, 159.41, 149.58, 131.25, 113.68, 110.75,105.35, 50.40, 50.04, 27.32, 21.77, 20.68, 19.75.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,41175-50-2, its application will become more common.

Reference:
Article; Gan, Yabing; Li, Haitao; Liu, Meiling; Yao, Shouzhuo; Yin, Guoxing; Yin, Peng; Yu, Ting; Zhang, Youyu; Zhou, Li; Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy; vol. 241; (2020);,
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Electric Literature of 112-70-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 112-70-9, name is 1-Tridecanol. This compound has unique chemical properties. The synthetic route is as follows.

To a solution of tridecanol (1.08 g, 5.31 mmol) in dichloromethane (20 mL), triphenyl phosphine (1.53 g, 5.84 mmol) and imidazole (0.39 g, 5.84 mmol) were added and cooled to0 C. I2 (1.48 g, 5.84 mmol) was added and the reaction mixture was stirred at room temperature for 3 h. After completion of starting materials, the reaction mixture was evaporated and diluted with hexane and passed through a Celite pad. The combined organic extracts were evaporated under reduced pressure to obtain the crude product which was purified by column chromatography (100- 200 mesh silica gel, eluent hexane) to furnish iodotridecane (1.43 g, 84%) as a low melting solid.

According to the analysis of related databases, 112-70-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; PHENOMENOME DISCOVERIES INC.; KHAN, M., Amin; WOOD, Paul, L.; GOODENOWE, Dayan; WO2013/71418; (2013); A1;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2568-33-4, name is 3-Methylbutane-1,3-diol, molecular formula is C5H12O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. COA of Formula: C5H12O2

5t (1.0 mmol), carbodiimide (CDI, 1.1 mmol), and DMAP(0.1 mmol) were sequentially added under air to a reaction tubeequipped with a stir bar and a septum. Et3N (1.5 mmol) and CH2Cl2(2 mL) was added by syringe and the resulting mixture vigorouslystirred for 3 h at ambient temperature. After this time, 8i(2.0 mmol) was sequentially added to this solution and the result-ing mixture again stirred for 14 h at ambient temperature. After thistime, the resulting solution was quenched with sat. NH4Claq andextracted with EtOAc. The solution obtained was ltered throughthe plug of silica gel and anhydrous MgSO4, and then concentratedby rotary evaporation. The pure product 9i was obtained byrecrystallization (65%, X mg, X mmol). IR(neat): 3484, 3341, 2970,1684, 1594, 1515, 1272, 1102 cm1.1H NMR (500 MHz, CDCl3) d: 8.59(brs, 1H), 8.02 (d, J 8.7 Hz, 2H), 7.63 (d, J 8.7 Hz, 2H), 4.49 (t,J 6.8 Hz, 2H), 2.05 (s, 6H), 1.98 (t, J 6.8 Hz, 2H), 1.32 (s, 6H);13CNMR (125 MHz, CDCl3) d: 170.30, 166.13, 141.66, 130.81, 126.32,119.23, 70.05, 62.49, 62.07, 41.80, 32.42, 29.81. HRESIMS calcd. forC16H23O4NBr (MH): 372.0810; found 372.0811.

With the rapid development of chemical substances, we look forward to future research findings about 2568-33-4.

Reference:
Article; Murata, Yumi; Takeuchi, Kentaro; Nishikata, Takashi; Tetrahedron; vol. 75; 18; (2019); p. 2726 – 2736;,
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