Author: tianli

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 52059-53-7, name is 2-(3-Fluorophenyl)ethanol, molecular formula is C8H9FO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 2-(3-Fluorophenyl)ethanol

(ii) To a stirred suspension of pyridinium chlorochromate (75.5 g, 0.35 mol) in dry dichloromethane (300 ml) under a nitrogen atmosphere was added 2-(3-fluorophenyl)ethanol (43 g, 0.31 mol) dropwise. After the addition the mixture was stirred for 1 hour, allowed to stand overnight then poured down a florisil column. The column was washed with ether and the combined filtrate and washings were evaporated to leave the crude 3-fluorophenyl acetaldehyde as an unstable liquid which was not purified further (34 g), NMR delta 9.75 (1H, t), 7.3 (1H, m), 7.05-6.9 (3H, m), 3.7 (2H, d).

With the rapid development of chemical substances, we look forward to future research findings about 52059-53-7.

Reference:
Patent; Larkin; John P.; Weston; John B.; Smith; Ian H.; Palmer; Christopher J.; Casida; John E.; US5204333; (1993); A;,
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Adding a certain compound to certain chemical reactions, such as: 456-47-3, 3-Fluorobenzyl alcohol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 456-47-3, blongs to alcohols-buliding-blocks compound. category: alcohols-buliding-blocks

General procedure: To the stirred mixture of 4-tert-butyl benzyl alcohol (1 mmol, 0.164 g) and ethyl formate (2 mL), tribromo melamine (0.1 mmol) was added without additional solvents. The resulting mixture was stirred at room temperature for 30 min. The reaction was monitored by TLC. On completion of reaction, the product was extracted with CH2Cl2 (5 mL × 4). The organic layer was separated, dried over anhydrous Na2SO4 (1.5 g), and concentrated under reduced pressure. Finally, the organic solvents were evaporated, and 4-tert-butylbenzyl formate was obtained in 92% yield. The identity of the product was confirmedby comparing the physical and spectral data with those of the known compound.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,456-47-3, its application will become more common.

Reference:
Article; Hajjami, Maryam; Ghorbani-Choghamarani, Arash; Karamshahi, Zahra; Norouzi, Masoomeh; Cuihua Xuebao/Chinese Journal of Catalysis; vol. 35; 2; (2014); p. 260 – 263;,
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Reference of 722-92-9 , The common heterocyclic compound, 722-92-9, name is 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol, molecular formula is C9H7F6NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Step 10: tert-Butyl 1-{[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]carbamoyl}-5-(methylsulfamoyl)-1,3-dihydro-2H-isoindole-2-carboxylate (0505) (0506) 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol (2.84 g, 10.94 mmol) was added to a mixture of 2-(tert-butoxycarbonyl)-5-(N-methylsulfamoyl)isoindoline-1-carboxylic acid (3 g, 8.42 mmol), HATU (4.16 g, 10.94 mmol) and DIPEA (2.94 mL, 16.84 mmol) in DCM (50 mL) under nitrogen. The resulting mixture was stirred at room temperature for 2 hours. The reaction mixture was quenched with saturated NH4Cl (75 mL), extracted with DCM (3×75 mL), the organic layer was dried over Na2SO4, filtered and evaporated to afford orange solid. The crude product was purified by flash silica chromatography, elution gradient 30 to 50percent EtOAc in petroleum ether. Pure fractions were evaporated to dryness to afford tert-butyl 1-((4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)carbamoyl)-5-(N-methylsulfamoyl)isoindoline-2-carboxylate (3.00 g, 59.6percent) as a yellow solid. (0507) LC/MS: m/z=598 [M+H]+. 1H NMR (300 MHz, DMSO-d6, mixture of rotamers, 1.8*:1) delta 1.36*, 1.48 (s, 9H), 2.43 (d, 3H), 4.63-4.87 (m, 2H), 5.60-5.77 (m, 1H), 7.49-7.85 (m, 8H), 8.66*, 8.67 (s, 1H), 10.75 (s, 1H).

The synthetic route of 722-92-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; AstraZeneca AB; NARJES, Frank; OLSSON, Roine Ingemar; VON BERG, Stefan; LEVER, Sarah; (112 pag.)US2017/166527; (2017); A1;,
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Synthetic Route of 68327-04-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 68327-04-8, name is (1S,2S)-2-Aminocyclopentanol hydrochloride, molecular formula is C5H12ClNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Examples of Synthesis of Carboxamides from Diketoacid Precursor; Representative Example 1; (l S,2S)-4-(5-(2,4-difluorobenzyl)-l -(2-fluorobenzyl)-2-oxo-l,2-dihydropyridin-3-yl)-2- hydroxy-N-(2-hydroxycyclopentyl)-4-oxobut-2-enamide (9).; To a chilled solution of the 4-(l-(2-fluorobenzyl)-5-(4-fluorobenzyl)-2-oxo-l ,2- dihydropyridin-3-yl)-2-hydroxy-4-oxobut-2-enoic acid 8 (150 mg, 0.338 mmol) indimethyl formamide (DMF) (2.0 mL), was added hydroxybenzotriazole (HOBT) (50 mg, 0.372 mmol), followed by l-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride EDCI-HCl (71 mg, 0.372 mmol). The resulting mixture was stirred for 30 min. A solution of ( l S,2S)-(+)-trans-2-aminocyclopentanol hydrochloride and NaHC03 (31 mg, 0.372 mmol) was added. The resulting mixture was stirred for 2h at 0- 5 C. Thin layer chromatography 05918344(TLC) analysis indicated completion, hence cold water was added to the reaction mixture and then extracted with ethyl acetate (2 x 20 m L). The combined organic phase was separated and washed with water twice, then once with IN HC1 solution, then saturated aqueous NaHCO.? solution. Concentration in vacuo afforded the crude product which was passed through a short plug of silica gel eluting with chloroform, the eluent was concentrated and the residual triturated with hexanes affording the product as a yellow solid in 117 mg (66.0%). The residual solvent was removed in vacuo affording pure product as a yellow solid, mp 60.0- 62.9 C, [a]20D +24.0 (c 0.01, MeOH}. UV (MeOH) 396 nm (epsilon 14,455), 318 nm (epsilon 6327). NMR (CDCI3, 500 MHz): delta 15.33 (bs, IH), 8.16 (d, IH, J= 2.0Hz), 8.08 (s, 111), 7.61-6.85 (m, 9Eta), 5.22 (s, 2Eta), 4.11 (m, IH), 3.94 (m, IH), 3.78 (s, IH), 2.23 (m. III).2.10 (m, IH), 1.88 (m, IH), 1.78 (m, 211).1.59 (m, IH).13C NMR (CDCI3, 125 MHz): delta 181.3, 180.6, 163.4, 163.3, 162.4, 162.1, 162.0, 161.4, 161.3, 160.4, 160.1, 160.0, 159.2, 145.5, 143.9, 142.3, 141.6, 132.4.1 2.4.132.3, 131.5.131.4, 131.3, 131.3, 131.2, 130.7, 130.6, 125.0, 124.9, 124.8, 122.8, 122.7, 122.5, 122.2.122.2, 122.1, 122.1.117.1, 115.9, 115.7, 115.6, 111.9, 111.9, 111.8, 111.7, 104.7, 104.5, 104.3,98.3,79.5,79.3,61.0,60.6,51.5,47.7,47.3, 32.9, 32.8, 32.7, 30.8, 30.7, 30.5, 21.7, 21.5. HRMS (M+H)+ calculated mass 527.1794 for C28H26F3N2O5, found 527.1799.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 68327-04-8, (1S,2S)-2-Aminocyclopentanol hydrochloride.

Reference:
Patent; UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.; NAIR, Vasu; OKELLO, Maurice, O.; NISHONOV, Abdumalik, A.; MISHRA, Sanjaykumar; WO2011/71849; (2011); A2;,
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Adding a certain compound to certain chemical reactions, such as: 67853-03-6, Methyl 3-(hydroxymethyl)benzoate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of Methyl 3-(hydroxymethyl)benzoate, blongs to alcohols-buliding-blocks compound. Quality Control of Methyl 3-(hydroxymethyl)benzoate

Entry 27 Boron trifluoride etherate (25 muL, 0.20 mmol, 0.2 eq.) was added dropwise at -20C under argon to a stirred solution of 2,3,4,6-tetra-O-acetyl-alpha-d-galactopyranosyl trichloroacetimidate (1c) (500 mg, 1.01 mmol, 1 eq.) and methyl 3-hydroxymethylbenzoate (2d) (503 mg, 3.03 mmol, 3 eq.) in freshly distilled CH2Cl2 (8 mL). After 1 hour, Et3N (0.2 mL) was injected into the reaction mixture. Then, the solvent was evaporated, the residue was purified by silica gel column chromatography (PE:EtOAc, 5:1 to 3:1) to afford (1-methoxycarbonylphen-3-yl)methyl 2,3,4,6-tetra-O-acetyl-beta-d-galactoside (3e) as a white foam (397 mg, 79%). Rf = 0.27 (PE:EtOAc = 2:1); [alpha]D20 = -31.8 (c = 0.4, CH2Cl2); 1H NMR (400 MHz, CDCl3), delta (ppm): 7.94 (m, 2H, 2 HAr), 7.46 (d, J = 7.6 Hz, 1H, HAr), 7.40 (t, J = 8.0 Hz, 1H, HAr), 5.36 (d, J = 2.9 Hz, 1H, H4), 5.26 (dd, J = 10.4, 8.0 Hz, 1H, H2), 4.97 (dd, J = 10.5, 3.4 Hz, 1H, H3), 4.91 (d, J = 12.6 Hz, 1H, OCH2a), 4.65 (d, J = 12.6 Hz, 1H, OCH2b), 4.51 (d, J = 8.0 Hz, 1H, H1), 4.21-4.06 (m, 2H, H6), 3.91-3.85 (m, 4H, OMe, H5), 2.13 (s, 3H, COCH3), 2.03 (s, 3H, COCH3), 2.03 (s, 3H, COCH3), 1.95 (s, 3H, COCH3); 13C NMR (100 MHz, CDCl3), delta (ppm): 170.5 (C=O), 170.3 (C=O), 170.2 (C=O), 169.6 (C=O), 166.8 (COOMe), 137.3 (CAr), 132.2 (CAr-H), 130.4 (CAr), 129.2 (CAr-H), 128.70 (CAr-H), 128.65 (CAr-H), 100.0 (C1), 70.9 (C3), 70.8 (C5), 70.1 (OCH2), 68.8 (C2), 67.1 (C4), 61.3 (C6), 52.2 (OMe), 20.7 (3 × COCH3), 20.6 (COCH3); HRMS m/z: calcd. for C23H28NaO12, [M+Na]+ 519.1473, found 519.1466.

The synthetic route of 67853-03-6 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Wang, Shuai; Lafont, Dominique; Rahkila, Jani; Picod, Benjamin; Leino, Reko; Vidal, Sebastien; Carbohydrate Research; vol. 372; (2013); p. 35 – 46;,
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Reference of 2002-24-6, Adding some certain compound to certain chemical reactions, such as: 2002-24-6, name is 2-Aminoethanol hydrochloride,molecular formula is C2H8ClNO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2002-24-6.

1-Nitro-9-Hydroxyethylaminoacridine This compound is synthesised generally using the methods described in EP 38579. Specifically, 2 g of 2-amino-ethanol hydrochloride is added to 6.4 g of 1-nitro-9-phenoxyacridine dissolved in 20 g of freshly distilled phenol. The mixture is heated for 40 minutes at a temperature of 80 C. and then cooled, diluted with ether. It is then poured into dry ether that was acidified with an ethereal solution of hydrogen chloride. The orange colored precipitate of 1-nitro-9-(2-hydroxyethylamino)-acridine hydrochloride, obtained in this way is filtered and crystallized from dry ethanol. The melting point of the compounds obtained was 170 C., with decomposition. Yield 91%. Elementary analysis for the formula: C15H14N3O3Cl:calculated:56.47%; C, 4.42%; H, 13.17%; N. determined: 56.44%; C, 4.40%; H, 13.03%; N.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 2002-24-6, 2-Aminoethanol hydrochloride, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Tiwari, Raj; Miller, Daniel G.; Konopa, Jerzy Kazimierz; Wysocka-Skrzela, Barbara; US2002/37831; (2002); A1;,
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Reference of 3973-18-0, Adding some certain compound to certain chemical reactions, such as: 3973-18-0, name is Propynol ethoxylate,molecular formula is C5H8O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3973-18-0.

General procedure: Alkynes 16 or 11a-11d (6mmol) were added to a solution of salinomycin azido derivative 15 (10mmol), Na ascorbate (1mmol), and copper sulphate (3mmol) in tert-butanol (5mL) at 4C, followed by adding water (5mmol), and stirring continuously for 24hat 55C. Then, the reaction was extracted with ethyl acetate. The combined organic layers were washed with brine, dried over anhydrous Na2SO4, filtered, and concentrated in vacuum. The product was purified by flash chromatography to give 1,2,3-triazole derivatives 3a-3g and 4a-4d.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 3973-18-0, Propynol ethoxylate, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Huang, Minjian; Deng, Zixin; Tian, Jian; Liu, Tiangang; European Journal of Medicinal Chemistry; vol. 127; (2017); p. 900 – 908;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 186602-93-7, name is (2-Amino-4-(trifluoromethyl)phenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 186602-93-7

5.1.105 6,7-Didehydro-17-methyl-7′-trifluoromethylquinolino[2′,3′:6,7]morphinan-3,14beta-diol hydrochloride (SYK-72) SYK-72 was prepared from compound 28c according to the procedure used to prepare SYK-27. Yield, 73%; a white amorphous solid. Mp 233-234 C (dec). Anal. Calcd for C25H23F3N2O2·1.0HCl·0.8H2O: C, 61.11; H, 5.25; N, 5.70. Found: C, 61.11; H, 5.36; N, 5.83.

With the rapid development of chemical substances, we look forward to future research findings about 186602-93-7.

Reference:
Article; Ida, Yoshihiro; Matsubara, Ayaka; Nemoto, Toru; Saito, Manabu; Hirayama, Shigeto; Fujii, Hideaki; Nagase, Hiroshi; Bioorganic and Medicinal Chemistry; vol. 20; 19; (2012); p. 5810 – 5831;,
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Adding a certain compound to certain chemical reactions, such as: 455-01-6, 2-(3-(Trifluoromethyl)phenyl)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C9H9F3O, blongs to alcohols-buliding-blocks compound. HPLC of Formula: C9H9F3O

General procedure: To a stirred solution of betulonic acid (3, 0.883 g, 1.94 mmol) in anhydrous CH2Cl2 (10 mL) was added oxylchoride (1.70 mL,19.45 mmol) at rt and kept for 2 h. The solvent was removed under vaccum, and another 3 mL CH2Cl2 was added to the residue and then removed again. To the residue was added anhydrous CH2Cl2 (8 mL), 2-cyclopropylethanol (0.5025 g, 5.83 mmol) and triethyl amine (2.71mL, 19.44 mmol), and the mixture was stirred for 24 h at rt. After removal of solvent under vaccumn, the residue was purified by silica gel column chromatography (hexane/EtOAcas eluent) to provide desired compound 10 (760 mg). White solid, yield 75%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,455-01-6, 2-(3-(Trifluoromethyl)phenyl)ethanol, and friends who are interested can also refer to it.

Reference:
Article; Li, Jizhen; Goto, Masuo; Yang, Xiaoming; Morris-Natschke, Susan L.; Huang, Li; Chen, Chin-Ho; Lee, Kuo-Hsiung; Bioorganic and Medicinal Chemistry Letters; vol. 26; 1; (2016); p. 68 – 71;,
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Related Products of 83647-43-2, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 83647-43-2 as follows.

Step B. The intermediate from Step A above (18.1 g) was dissolved in anhydrous CH2Cl2 (150 mL) under nitrogen and the reaction vessel was cooled to 00C in an ice bath. To this cooled solution was added PBr3 (5.52 mL) over a 10 min period. Once the addition was complete, the reaction mixture was warmed to room temperature and stirred for an additional 12 h. The mixture was cooled in an ice bath and quenched by the dropwise addition of MeOH (20 mL). The organic phase was washed with saturated NaHCO3 (2 x 150 mL), dried over anhydrous MgSO4, filtered, and then concentrated to afford the intermediate (23.8 g; 97 %) as viscous oil. 1H-NMR (CDCl3) delta = 2.50 (s, 3 H), 4.50 (s, 2 H), 7.00 (t, H), 7.25 (d, 1 H), 7.50 (d, 1 H). Step B. Under a nitrogen atmosphere PBr3 (5.52 mL) was added over a lO min period to an ice cooled solution of the title compound from Step A above (18.1 g) in anhydrous CH2Cl2 (15O mL). The cooling bath was removed and mixture stirred at room temperature for 12 h. The mixture was cooled (0-5C), quenched by dropwise addition of MeOH (20 mL), washed with saturated aqueous NaHCO3 (2 x 15O mL), dried (MgSO4), filtered and concentrated to afford the title compound as a viscous oil (23.8 g, 97%). 1H-NMR (CDCl3) delta = 7.50 (d, 1 H), 7.25 (d, 1 H), 7.00 (t, 1 H), 4.50 (s, 2 H), 2.50 (s, 3 H)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,83647-43-2, its application will become more common.

Reference:
Patent; ALANTOS PHARMACEUTICALS HOLDING, INC.; WO2008/63671; (2008); A2;,
Alcohol – Wikipedia,
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