Author: tianli

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Synthesis, characterization, and photophysical properties of cyclometalated N-Heterocyclic carbene Platinum(II) complexes, published in 2019-02-01, which mentions a compound: 12080-32-9, Name is Dichloro(1,5-cyclooctadiene)platinum(II), Molecular C8H12Cl2Pt, SDS of cas: 12080-32-9.

Cyclometalated platinum complexes I (R = Me, 3-thienylmethyl; X1, X2 = H, benzo) were prepared by a two-step, one-pot procedure and characterized; the complexes showed photoluminescence at 450-550 nm. Thiophene and benzothiophene ligands containing N-heterocyclic carbene (NHC) moieties were used to synthesize five and six-membered Pt(II) metallacycles. Ligand scaffolding was synthesized using two methods. The ligands were synthesized using a coupling reaction, utilizing Cu2O as the catalyst or were synthesized using a nucleophilic substitution reaction. The ligands were then metalated by chelate-assisted C-H activation. The synthesis, characterization, reactivity, and photophys. properties of these NHC-functionalized, cyclometalated products are reported.

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Application In Synthesis of tert-Butyl 5-bromo-1H-indazole-1-carboxylate. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: tert-Butyl 5-bromo-1H-indazole-1-carboxylate, is researched, Molecular C12H13BrN2O2, CAS is 651780-02-8, about Scaffold oriented synthesis. Part 4: Design, synthesis and biological evaluation of novel 5-substituted indazoles as potent and selective kinase inhibitors employing heterocycle forming and multicomponent reactions. Author is Akritopoulou-Zanze, Irini; Wakefield, Brian D.; Gasiecki, Alan; Kalvin, Douglas; Johnson, Eric F.; Kovar, Peter; Djuric, Stevan W..

The synthesis and biol. evaluation of 5-substituted indazoles as kinase inhibitors is reported. The compounds were synthesized in a parallel synthesis fashion from readily available starting materials employing heterocycle forming and multicomponent reactions and were evaluated against a panel of kinase assays. Potent inhibitors were identified for Gsk3β, Rock2, and Egfr.

There is still a lot of research devoted to this compound(SMILES：CC(C)(C)OC(=O)N1N=CC2=CC(Br)=CC=C12)Application In Synthesis of tert-Butyl 5-bromo-1H-indazole-1-carboxylate, and with the development of science, more effects of this compound(651780-02-8) can be discovered.

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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Nuclear-substituted derivatives of 4,4′-diaminodiphenyl sulfone》. Authors are Berg, S. S..The article about the compound:3-Bromo-4-chloronitrobenzenecas:16588-26-4,SMILESS:BrC1=C(C=CC(=C1)[N+](=O)[O-])Cl).Quality Control of 3-Bromo-4-chloronitrobenzene. Through the article, more information about this compound (cas:16588-26-4) is conveyed.

The therapeutic effect of (4-H3NC6H4)3SO3 prompted the investigation of the halogen derivatives; these were tested orally in vivo against Staphylococcus aureus and Streptococcus pyogenes in mice; a decrease in toxicity in the order Cl < Br < iodine, together with corresponding decrease in activity, was observed 2,4-Br(O2N)C6H3NH2 (18.5 g.), through the diazo reaction, gives 12.5 g. 1-chloro-2-bromo-4-nitrobenzene, b0.1 100°, m. 61°. p-O2NC6H4SH (1.55 g.) and 0.4 g. NaOH in 20 cc. EtOH, added to 1.9 g. 3,4-Cl2C6H3NO2 in 10 cc. EtOH and refluxed 2 h., give 1.3 g. 2-chloro-4,4'-dinitrodiphenyl sulfide (I), yellow, m. 144°; the 2-Br analog, yellow, m. 159°, and the 2-I analog, yellow, m. 168°. 3,4-Cl2C6H3NO2 (15 g.) in 60 cc. EtOH, treated (5 min.) with 10 g. Na2S.9H2O in 40 cc. 25% aqueous EtOH and refluxed 6 h., gives 7.2 g. [2,4-Cl(O2N)C6H3]2S, yellow, m. 163°; the portion (3 g.) insoluble in 95% AcOH is the compound C24H12O5N4Cl4S2, probably RN(→O):NR, where R = 3,4-Cl[2,4-Cl(O2N)C6H3S]C6H3S-, red, m. 195°. 2,2'-Diiodo-4,4'-dinitrodiphenyl sulfide (II), pale red, m. 186°. 2,4-Br(O2N)C6H3OH yields an acetate (III), pale yellow, m. 86°; 13 g. III, 7.8 g. p-O2NC6H4SH, 3 g. K2CO3, and 100 cc. Me2CO, refluxed 2 h., yield 6 g. 4,4'-dinitro-2-acetoxydiphenyl sulfide (IV), yellow, m. 100°. Dropwise addition of 7.5 g. KMnO4 in 50 cc. hot H2O to 10 g. I in 150 cc. boiling AcOH gives 8 g. 2-chloro-4,4'-dinitrodiphenyl sulfone (V), m. 182-3°; 2-Br analog, m. 162°, 2-I analog, pale yellow, m. 165°; the sulfone from II, yellow, m. 260°. IV yields 4,4'-dinitro-2-hydroxydiphenyl disulfone, yellow, m. 216°. Reduced Fe (10 g.), added slowly to 5 g. V in 200 cc. boiling AcOH and the mixture heated 10 min. at 90°, gives 3 g. 2-chloro-4,4'-diaminodiphenyl sulfone, pale yellow, m. 114°; 2-Br analog, yellow, m. 157°; 2-I analog, buff, m. 207°. 2,2'-Dichloro-4,4'-diaminodiphenyl sulfone, orange, m. 263°; 2,2'-di-I analog, m. 280°. 4,4'-Diamino-2-hydroxydiphenyl sulfone, m. 134-5° [sulfate, m. 208° (decomposition)] (cf. Burton and Hoggarth, C.A. 39, 4854.7). There is still a lot of research devoted to this compound(SMILES：BrC1=C(C=CC(=C1)[N+](=O)[O-])Cl)Quality Control of 3-Bromo-4-chloronitrobenzene, and with the development of science, more effects of this compound(16588-26-4) can be discovered.

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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Ji, Radhe Shyam; Raghuvanshi, Abhinav; Jha, Badrinath; Mathur, Pradeep researched the compound: Dichloro(1,5-cyclooctadiene)platinum(II)( cas:12080-32-9 ).Synthetic Route of C8H12Cl2Pt.They published the article 《Reactions of [Ru6(μ6–C)(C6H5CH3)(CO)14]: Synthesis of some new Ru-Pt carbonyl clusters and diphosphine substitution》 about this compound( cas:12080-32-9 ) in Journal of Organometallic Chemistry. Keywords: carbido ruthenium carbonyl cluster reaction platinum diphosphine; crystal mol structure carbido ruthenium carbonyl platinum diphosphine complex. We’ll tell you more about this compound (cas:12080-32-9).

Three new RuPt clusters [Ru6Pt(μ6-C)(C6H5CH3)(CO)13(COD)] (2), [Ru6Pt(μ6-C)(C6H5CH3)(CO)14(PPh3)] (3) and [Ru6Pt2(μ6-C)(C6H5CH3)(CO)13(PPh3)3] (4) were obtained from the reaction of [Ru6(μ6-C)(C6H5CH3)(CO)14] (1) with two different Pt precursors. Both 2 and 3 consists of a Ru6Pt cluster with face capped octahedron metal core, whereas, 4 has a unique Ru6Pt2 cluster core structure with doubly capped octahedron. Further, CO substitution behavior of 1 was studied with diphosphine ligands, which results in the formation of mono and bi substituted products, which also show the removal of the toluene cap by the dppe ligand. All the compounds were characterized structurally by x-ray diffraction anal.

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called In Situ Synthesized Silica-Supported Co@N-Doped Carbon as Highly Efficient and Reusable Catalysts for Selective Reduction of Halogenated Nitroaromatics, published in 2020-09-15, which mentions a compound: 16588-26-4, Name is 3-Bromo-4-chloronitrobenzene, Molecular C6H3BrClNO2, Recommanded Product: 3-Bromo-4-chloronitrobenzene.

Silica-supported Co@N-doped carbon (Co@CN/SiO2) catalysts were first prepared by a one-step impregnation with a mixed solution of cobalt nitrate, glucose and urea, followed by in situ carbonization and reduction The Co@CN/SiO2 catalysts were investigated for the selective reduction of nitro aromatics RNO2 (R = Ph, 4,5-dichloro-2-nitroaniline, 2-chloro-3-nitropyridine, etc.) to the corresponding anilines RNH2 using hydrazine hydrate. The Co@CN/SiO2-500 carbonized at 500°C exhibited the highest catalytic activity and excellent stability without any decay of activity after 6 cycles for the reduction of nitrobenzene. Both metallic Co atoms and Co-N species formed in the Co@CN/SiO2 catalysts were active, but the Co-N species were dominant active sites. The high activities of the Co@CN/SiO2 catalysts were attributed to the synergistic effect between the Co and N atoms, promoting heterolytic cleavage of hydrazine to form H+/H- pairs. Representative examples demonstrated that the Co@CN/SiO2-500 could completely transform various halogen-substituted nitro aromatics to the corresponding halogenated anilines with high TOFs and selectivity of >99.5%.

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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 3-Bromo-4-chloronitrobenzene(SMILESS: BrC1=C(C=CC(=C1)[N+](=O)[O-])Cl,cas:16588-26-4) is researched.Application In Synthesis of 2-Bromomethyl-1,3-dioxolane. The article 《Structurally Simple Inhibitors of Lanosterol 14α-Demethylase Are Efficacious In a Rodent Model of Acute Chagas Disease》 in relation to this compound, is published in Journal of Medicinal Chemistry. Let’s take a look at the latest research on this compound (cas:16588-26-4).

We report structure-activity studies of a large number of dialkyl imidazoles as inhibitors of Trypanosoma cruzi lanosterol-14α-demethylase (L14DM). The compounds have a simple structure compared to posaconazole, another L14DM inhibitor that is an anti-Chagas drug candidate. Several compounds display potency for killing T. cruzi amastigotes in vitro with values of EC50 in the 0.4-10 nM range. Two compounds were selected for efficacy studies in a mouse model of acute Chagas disease. At oral doses of 20-50 mg/kg given after establishment of parasite infection, the compounds reduced parasitemia in the blood to undetectable levels, and anal. of remaining parasites by PCR revealed a lack of parasites in the majority of animals. These dialkyl imidazoles are substantially less expensive to produce than posaconazole and are appropriate for further development toward an anti-Chagas disease clin. candidate.

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Tosolini, Massimo; Avo, Joao; Parola, Antonio Jorge; Balducci, Gabriele; Tecilla, Paolo published an article about the compound: Dichloro(1,5-cyclooctadiene)platinum(II)( cas:12080-32-9,SMILESS:C1=CCC/C=CCC/1.[Pt+2].[Cl-].[Cl-] ).Safety of Dichloro(1,5-cyclooctadiene)platinum(II). Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:12080-32-9) through the article.

A new sterically encumbered sym. substituted 4,5-bis(diphenylphosphino)acenaphthene ligand (L) has been prepared The ligand readily forms distorted square-planar complexes with group 10 metal ions [Ni(II), Pd(II), Pt(II)] and a dimeric tetrahedral complex with Cu(I). The x-ray structures of the ligand and of the complexes show a notably short distance between the two phosphorus atoms, well below than twice the van der Waals radius of P, due to the steric requirements of the rigid acenaphthene backbone. Moreover, in the complexes a stabilizing π-π interaction between two Ph rings belonging to the two P atoms is present. The [LCuCl]2 complex is weakly fluorescent both in solution and in the solid state with higher quantum yield as a solid where it exhibits thermally-activated delayed fluorescence and phosphorescence. [LPdCl2] and [LCuCl]2 behave as chloride transporters across a liposomal phospholipid membrane with the Pd(II) complex displaying a very high activity.

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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 1-(4-Chlorophenyl)pyrrolidin-2-one( cas:7661-33-8 ) is researched.Formula: C10H10ClNO.Lebedev, A. T.; Mazur, D. M.; Kudelin, A. I.; Fedotov, A. N.; Gloriozov, I. P.; Ustynyuk, Yu. A.; Artaev, V. B. published the article 《Cyclization of N-arylcyclopropanecarboxamides into N-arylpyrrolidinones-2 under electron ionization and in the condensed phase》 about this compound( cas:7661-33-8 ) in Rapid Communications in Mass Spectrometry. Keywords: cyclization arylcyclopropanecarboxamide arylpyrrolidinone electron ionization condensed phase. Let’s learn more about this compound (cas:7661-33-8).

Mass spectrometry is known as an excellent method to predict the behavior of organic compounds in solution The behavior of organic compounds in the gas-phase inside an ion source of a mass spectrometer allows their intrinsic properties to be defined, avoiding the influence of intermol. interactions, counter ions and solvent effects. Arylpyrrolidinones-2 were obtained by condensed phase synthesis from the corresponding N-arylcyclopropanecarboxamides. Electron ionization (EI) with accurate mass measurements by high-resolution time-of-flight mass-spectrometry and quantum chem. calculations were used to understand the behavior of the mol. radical cations of N-arylcyclopropanecarboxamides and N-arylpyrrolidinones-2 in the ion source of a mass spectrometer. The geometries of the mols., transition states, and intermediates were fully optimized using DFT-PBE calculations Fragmentation schemes, ion structures, and possible mechanisms of primary isomerization were proposed for isomeric N-arylcyclopropanecarboxamides and N-arylpyrrolidinones-2. Based on the fragmentation pattern of the N-arylcyclopropanecarboxamides, isomerization of the original M+· ions into the M+· ions of the N-arylpyrrolidinones-2 was shown to be only a minor process. On the contrary, this cyclization proceeds easily in the condensed phase in the presence of the Bronsted acids. Based on the exptl. data and quantum chem. calculations the principal mechanism of decomposition of the mol. ions of N-arylcyclopropanecarboxamides involves their direct fragmentation without any rearrangements. An alternative mechanism is responsible for the isomerization of a small portion of the higher energy mol. ions into the corresponding N-arylpyrrolidinones-2 ions.

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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: Dichloro(1,5-cyclooctadiene)platinum(II)(SMILESS: C1=CCC/C=CCC/1.[Pt+2].[Cl-].[Cl-],cas:12080-32-9) is researched.Synthetic Route of C3H7ClO2. The article 《Phosphane-functionalized heavier tetrylenes: synthesis of silylene- and germylene-decorated phosphanes and their reactions with Group 10 metal complexes》 in relation to this compound, is published in Dalton Transactions. Let’s take a look at the latest research on this compound (cas:12080-32-9).

The stable phosphine-functionalized heavier tetrylenes E(tBu2bzam)pyrmPtBu2 (E = Si (1Si), Ge (1Ge); tBu2bzam = N,N’-di-tertbutylbenzamidinate; HpyrmPtBu2 = di-tert-butyl(2-pyrrolylmethyl)phosphine) were prepared by reacting the amidinatotetrylenes E(tBu2bzam)Cl (E = Si, Ge) with LipyrmPtBu2. The reactions of 1Si and 1Ge with selected M0 and MII (M = Ni, Pd, Pt) metal precursors gave square-planar [MCl2{κ2E,P-E(tBu2bzam)pyrmPtBu2}] (M = Ni, Pd, Pt; E = Si, Ge), tetrahedral [Ni{κ2E,P-E(tBu2bzam)pyrmPtBu2}(cod)] (E = Si, Ge; cod = 1,5-cyclooctadiene) and triangular [M{κ2E,P-E(tBu2bzam)pyrmPtBu2}(PPh3)] (M = Pd, Pt; E = Si, Ge) complexes, showing that 1Si and 1Ge are excellent Si,P- and Ge,P-chelating ligands that, due to their large steric bulk, are able to stabilize three-coordinate Pd0 and Pt0 complexes.

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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: Dichloro(1,5-cyclooctadiene)platinum(II)(SMILESS: C1=CCC/C=CCC/1.[Pt+2].[Cl-].[Cl-],cas:12080-32-9) is researched.Name: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide. The article 《Synthesis, Coordination and Electrochemistry of a Ferrocenyl-Tagged Aminobisphosphane Ligand》 in relation to this compound, is published in European Journal of Inorganic Chemistry. Let’s take a look at the latest research on this compound (cas:12080-32-9).

Group 10 element diphosphine square planar complexes [FcN(CH2PPh2)2MY2] (Fc = ferrocenyl; M = Ni, Pd, Pt; Y = Cl, Br), Group 11 tetraphosphine tetrahedral complexes [[FcN(CH2PPh2)2]2M]X (M = Cu, Ag, Au; X = BF4, SbF6) and gold binuclear complexes [FcN(CH2PPh2AuCl)2], [FcN(CH2PPh2)2Au]2[SbF6]2 were prepared and examined for their redox activity. Introducing a ferrocene moiety into a mol. results in the incorporation of a metal center and a redox active moiety. The ligand FcN(CH2PPh2)2 (1) was prepared by alkylation of ferrocenamine FcNH2 with hydroxymethylphosphine HOCH2PPh2 and converted to diselenide FcN(CH2P(Se)Ph2)2 (1-Se) for crystallog. identification. Furthermore, a pair of open and cyclic digold(I) complexes containing bis-phosphane 1 as a P,P-bridging ligand, were isolated. Ligand 1, the corresponding phosphane selenide 1-Se and all complexes (except for the poorly soluble [(μ(P,P’)-1)2Au2][SbF6] and unstable [Ag(1-κ2P,P’)2][SbF6]) were further analyzed by cyclic voltammetry.

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