Author: tianli

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Chemistry – A European Journal called Bright Luminescent Platinum(II)-Biaryl Emitters Synthesized Without Air-Sensitive Reagents, Author is Wakasugi, Chuei; Yoshida, Masaki; Sameera, W. M. C.; Shigeta, Yasuhiro; Kobayashi, Atsushi; Kato, Masako, which mentions a compound: 12080-32-9, SMILESS is C1=CCC/C=CCC/1.[Pt+2].[Cl-].[Cl-], Molecular C8H12Cl2Pt, HPLC of Formula: 12080-32-9.

Transition-metal complexes bearing biaryl-2,2′-diyl ligands tend to show intense luminescence. However, difficulties in synthesis have prevented their further functionalization and practical applications. Herein, a series of platinum(II) complexes bearing biaryl-2,2′-diyl ligands, which have never been prepared in air, were synthesized through transmetalation and successive cyclometalation of biarylboronic acids. This approach does not require any air- or moisture-sensitive reagents and features a simple synthesis even in air. The resulting (Et4N)2[Pt(m,n-F2bph)(CN)2] (m,n-F2bph=m,n-difluorobiphenyl-2,2′-diyl) complexes exhibit intense green emissions with high quantum efficiencies of up to 0.80 at 298 K. The emission spectral fitting and variable-temperature emission lifetime measurements indicate that the high quantum efficiency was achieved because of the tight packing structure and strong σ-donating ability of bph.

As far as I know, this compound(12080-32-9)HPLC of Formula: 12080-32-9 can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Dichloro(1,5-cyclooctadiene)platinum(II)( cas:12080-32-9 ) is researched.Category: alcohols-buliding-blocks.Gholivand, Khodayar; Maghsoud, Yazdan; Kahnouji, Mohammad; Hosseini, Mahdieh; Satari, Mohammad; Abdolmaleki, Parviz; Roe, Stephen Mark published the article 《Platinum(II) complexes containing hydrazide-based aminophosphine ligands: Synthesis, molecular structures, computational investigation and evaluation as antitumour agents》 about this compound( cas:12080-32-9 ) in Applied Organometallic Chemistry. Keywords: DFT FMO platinum chloride diphenylphosphinoamino complex; antitumor activity platinum chloride diphenylphosphinoamino complex; crystal structure platinum chloride diphenylphosphinoamino complex preparation. Let’s learn more about this compound (cas:12080-32-9).

Four new N,N-bis(diphenylphosphino)amine ligands (amine = 1-amino-4-methylpiperazine (L1), N-aminophthalimide (L2), 4-aminomorpholine (L3) and hydrazine dihydrochloride (L4)) and their Pt(II) complexes C1, C2, C3 and C4 were synthesized and characterized using IR and NMR spectroscopies. The crystal structures of C1, C2 and C3 were determined using single-crystal x-ray diffraction techniques. The antitumor activities of the synthesized complexes determined using MTT assay on MDA-MB-231 cell line revealed that the studied complexes, especially C2, significantly suppressed the proliferation of these cancer cells in a dose- and time-dependent manner (e.g. at a complex concentration of 100 μg ml-1, in 24 h, the reduction of the cell viability was 88.00, 38.89, 83.35 and 64.28% for C1-C4, resp.). Theor. approaches were also used to investigate the energy and the nature of metal-ligand and metal-chlorine interactions in the complexes, which could explain their biol. activities. The interaction between ligand and Pt is stronger in C2, while the Pt-Cl interaction is weaker in this complex in comparison with the other complexes.

As far as I know, this compound(12080-32-9)Category: alcohols-buliding-blocks can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Protti, Stefano; Dichiarante, Valentina; Dondi, Daniele; Fagnoni, Maurizio; Albini, Angelo published an article about the compound: 3-Bromo-4-chloronitrobenzene( cas:16588-26-4,SMILESS:BrC1=C(C=CC(=C1)[N+](=O)[O-])Cl ).Recommanded Product: 3-Bromo-4-chloronitrobenzene. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:16588-26-4) through the article.

The photodehalogenation of fluoro- or chlorobenzene derivatives smoothly generates triplet and singlet Ph cations (3,1Ar+) and potentially benzyne. These intermediates lead to different products, which warrants exploring the direct effect of substituents. SiMe3 and SnMe3 groups have been found to be convenient probes since they affect neither the photophysics nor the primary dehalogenation of 4-chloroanisole and 4-chloro- (or 4-fluoro-) N,N-dimethylaniline (except for the case of 4-fluoro-3-(trimethylstannyl)aniline, which was preferentially demetallated). The stabilization by these groups (with SnMe3 ca. 10 kcal mol-1 for the triplets and 20 kcal mol-1 for the singlets, as computed by using (U)B3LYP DFT method with LANL2DZ basis set) made 1Ar+ the lowest state with stannylated and silylated anisoles and solvolysis the main process. On the other hand, donating substituents and an acidic solvent favored the triplet cation chem., a quite general process leading to reduction or (in the presence of π bond nucleophiles) to arylation. Noteworthily, the stannylated 4-N,N-dimethylaminophenyl cation eliminated the Me3Sn+ group, opening an unprecedented path to the corresponding benzyne. Apart from the control of the chem. output, the photostabilizing effect found with a silyl group may be useful for designing less phototoxic fluorinated drugs.

As far as I know, this compound(16588-26-4)Recommanded Product: 3-Bromo-4-chloronitrobenzene can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Product Details of 7661-33-8. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 1-(4-Chlorophenyl)pyrrolidin-2-one, is researched, Molecular C10H10ClNO, CAS is 7661-33-8, about Carbon-13, nitrogen-15m, and oxygen-17 NMR chemical shifts of substituted 1-phenyl-2-pyrrolidinones. Author is Ruostesuo, P.; Hakkinen, A. M.; Karjalainen, J..

The C-13 and N-15 NMR chem. shifts and the direct C-proton coupling constants of 1-phenyl-2-pyrrolidinone and its 2′-Me,3′-Me,4′-Me,2′-chloro,3′-chloro,4′-chloro,3′-methoxy,4′-methoxy and 4′-nitro derivatives were measured in di-Me sulfoxidde. The O-17 NMR chem. shifts of some of the compounds were determined in acetone. The effect of substituents on the chem. shifts of carbonyl carbons correlates well with the Hammett substituent parameters and the N chem. shifts seem to follow a similar trend. The variation of the O chem. shift due to the substituents is small. The chem. shifts of aromatic carbons can mainly be derived using the substituent parameters of benzene, some deviation probably due to steric effects is observable, however.

As far as I know, this compound(7661-33-8)Product Details of 7661-33-8 can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 12080-32-9. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: Dichloro(1,5-cyclooctadiene)platinum(II), is researched, Molecular C8H12Cl2Pt, CAS is 12080-32-9, about Understanding Doping Effects on Electronic Structures of Gold Superatoms: A Case Study of Diphosphine-Protected M@Au12 (M = Au, Pt, Ir). Author is Hirai, Haru; Takano, Shinjiro; Nakamura, Toshikazu; Tsukuda, Tatsuya.

Dopants into ligand-protected Au superatoms have been hitherto limited to group X-XII elements (Pt, Pd, Ag, Cu, Hg, and Cd). To expand the scope of the dopants to the group IX elements, the authors synthesized unprecedented [IrAu12(dppe)5Cl2]+ [IrAu12; dppe = 1,2-bis(diphenylphosphino)ethane] and [PtAu12(dppe)5Cl2]2+ (PtAu12) and compared their electronic structures with that of [Au13(dppe)5Cl2]3+ (Au13). Single-crystal x-ray diffractometry, 31P{1H} NMR, and Ir L3-edge extended X-ray absorption fine structure anal. of IrAu12 revealed that the single Ir atom is located at the center of the icosahedral IrAu12 core. Electrochem. anal. demonstrated that the energy levels of the highest occupied MOs are upshifted in the order of Au13 < PtAu12 < IrAu12. This trend was qual. explained in such a manner that the jellium core potential at the central position becomes shallower by replacing Au+ with Pt0 and further with Ir-. IrAu12 underwent reversible redox reactions between the charge states of 1+ and 2+. The gradual increase of the energy gap between the HOMO and LUMO in the order of Au13 < PtAu12 < IrAu12 was observed by electrochem. measurement and optical spectroscopy. This study provides a simple guiding principle to tune the electronic structures of heterometal-doped superatoms. The orbital energies of [IrAu12(dppe)5Cl2]+ (IrAu12) and [PtAu12(dppe)5Cl2]2+ (PtAu12) were compared with those of [Au13(dppe)5Cl2]3+ (Au13) by electrochem. anal. The superat. orbitals were shifted up in the order of IrAu12 > PtAu12 > Au13. The result was explained by the upshift of the bottom of the effective potential due to different formal charge states of the dopants. Whereas Au was incorporated as Au+, Ir and Pt were incorporated as Ir- and Pt0, resp.

This literature about this compound(12080-32-9)Application of 12080-32-9has given us a lot of inspiration, and I hope that the research on this compound(Dichloro(1,5-cyclooctadiene)platinum(II)) can be further advanced. Maybe we can get more compounds in a similar way.

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Wang, Lei; Li, Sun; Bluemel, Marcus; Puttreddy, Rakesh; Peuronen, Anssi; Rissanen, Kari; Enders, Dieter researched the compound: (5aS,10bR)-2-(2,6-Diethylphenyl)-4,5a,6,10b-tetrahydro-2H-indeno[2,1-b][1,2,4]triazolo[4,3-d][1,4]oxazin-11-ium tetrafluoroborate( cas:1787246-78-9 ).Recommanded Product: 1787246-78-9.They published the article 《Switchable Access to Different Spirocyclopentane Oxindoles by N-Heterocyclic Carbene Catalyzed Reactions of Isatin-Derived Enals and N-Sulfonyl Ketimines》 about this compound( cas:1787246-78-9 ) in Angewandte Chemie, International Edition. Keywords: spirocyclopentane oxindole preparation heterocycle carbene catalyst enal sulfonyl ketimine; N-heterocyclic carbenes; asymmetric synthesis; heterocylces; organocatalysis; spiro-compounds. We’ll tell you more about this compound (cas:1787246-78-9).

A novel NHC-catalyzed annulation protocol for the asym. synthesis of biol. important β-lactam fused spirocyclopentane oxindoles with four contiguous stereocenters, including two quaternary carbon centers, was developed. Alternatively, spirocyclopentane oxindoles containing an enaminone moiety can be achieved using the same starting materials, isatin-derived enals, and N-sulfonyl ketimines, in the presence of a slightly different NHC catalytic system. This switchable annulation strategy enables the selective assembly of both heterocyclic scaffolds with good yields and excellent enantioselectivities for a broad range of substrates.

This literature about this compound(1787246-78-9)Recommanded Product: 1787246-78-9has given us a lot of inspiration, and I hope that the research on this compound((5aS,10bR)-2-(2,6-Diethylphenyl)-4,5a,6,10b-tetrahydro-2H-indeno[2,1-b][1,2,4]triazolo[4,3-d][1,4]oxazin-11-ium tetrafluoroborate) can be further advanced. Maybe we can get more compounds in a similar way.

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Safety of 1-(4-Chlorophenyl)pyrrolidin-2-one. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 1-(4-Chlorophenyl)pyrrolidin-2-one, is researched, Molecular C10H10ClNO, CAS is 7661-33-8, about Hydrogen bonding of pyrrole, indole and carbazole with substituted 1-phenyl-2-pyrrolidinones. Author is Karjalainen, J.; Virtanen, P. O. I..

The equilibrium constants (K) for the 1:1 H-bonded complexes between I (R = Me, Ph, substituted Ph) with pyrrole, indole, and carbazole were determined in CCl4 by IR. Hammett LFER were observed for each K and Δ υNH (the difference between pores and associated NH stretch). I (R = Me) is a stronger H acceptor than I (R = Ph, substituted Ph). The proton donor ability increases in the order; pyrrole < indole < carbazole. The ΔG°, ΔH°, ΔS° for the complexation are determined This literature about this compound(7661-33-8)Safety of 1-(4-Chlorophenyl)pyrrolidin-2-onehas given us a lot of inspiration, and I hope that the research on this compound(1-(4-Chlorophenyl)pyrrolidin-2-one) can be further advanced. Maybe we can get more compounds in a similar way.

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Robarge, Kirk D.; Brunton, Shirley A.; Castanedo, Georgette M.; Cui, Yong; Dina, Michael S.; Goldsmith, Richard; Gould, Stephen E.; Guichert, Oivin; Gunzner, Janet L.; Halladay, Jason; Jia, Wei; Khojasteh, Cyrus; Koehler, Michael F. T.; Kotkow, Karen; La, Hank; La Londe, Rebecca L.; Lau, Kevin; Lee, Leslie; Marshall, Derek; Marsters, James C.; Murray, Lesley J.; Qian, Changgeng; Rubin, Lee L.; Salphati, Laurent; Stanley, Mark S.; Stibbard, John H. A.; Sutherlin, Daniel P.; Ubhayaker, Savita; Wang, Shumei; Wong, Susan; Xie, Minli published an article about the compound: 3-Bromo-4-chloronitrobenzene( cas:16588-26-4,SMILESS:BrC1=C(C=CC(=C1)[N+](=O)[O-])Cl ).COA of Formula: C6H3BrClNO2. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:16588-26-4) through the article.

SAR for a wide variety of heterocyclic replacements for a benzimidazole led to the discovery of functionalized 2-pyridyl amides as novel inhibitors of the hedgehog pathway. The 2-pyridyl amides were optimized for potency, PK, and drug-like properties by modifications to the amide portion of the mol. resulting in I (GDC-0449). Amide I produced complete tumor regression at doses as low as 12.5 mg/kg BID in a medulloblastoma allograft mouse model that is wholly dependent on the Hh pathway for growth and is currently in human clin. trials, where it is initially being evaluated for the treatment of BCC.

This literature about this compound(16588-26-4)COA of Formula: C6H3BrClNO2has given us a lot of inspiration, and I hope that the research on this compound(3-Bromo-4-chloronitrobenzene) can be further advanced. Maybe we can get more compounds in a similar way.

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Roles played by carbene substituents during ligand transfer reactions between tungsten fischer carbene complexes and [Pt(COD)Cl2], published in 2021-12-01, which mentions a compound: 12080-32-9, mainly applied to tungsten Fischer carbene ligand transfer reaction platinum chloride; platinum biscarbene triscarbene carbene complex preparation crystal structure; mol structure platinum biscarbene triscarbene carbene complex, Formula: C8H12Cl2Pt.

Fischer carbene ligand transfer reactions from [W{C(X)(C6H4-4-R)}(CO)5] (X = OEt: a series; X = NMe2: b series), containing remote tertiary amino substituents R = R’2N at the Ph ring, to Pt(II) of [Pt(COD)Cl2] precursors, were studied. The number of carbene ligands transferred per Pt ion in these cases are determined by the electronic and steric properties of the heteroatoms of the carbene ligand. Thus, neutral bis(carbene) complexes, [Pt{C(X)(C6H4-4-R)}2Cl2], (R = H (1a); R = NR’2 and R’ = Me (2a), Ph (3a), or 4-BrC6H4 (4a)), are formed from the ethoxycarbene precursors (X = OEt), while cationic tris(carbene) complexes [Pt{C(X)(C6H4-4-R)}3Cl]+ Z-, (R = H (1b) and R = NR’2 and R’ = Me (2b), Ph (3b), or 4-BrC6H4 (4b)) were obtained from the aminocarbene precursors (X = NMe2), the latter with different counterions Z- = Cl-, [W(CO)5Cl]- or PF-6. Electro- and spectroelectrochem. studies indicate consecutive oxidations of the individual carbene ligands, but also a lack of electronic interactions across the (X)C:Pt:C(X) linkages.

This literature about this compound(12080-32-9)Formula: C8H12Cl2Pthas given us a lot of inspiration, and I hope that the research on this compound(Dichloro(1,5-cyclooctadiene)platinum(II)) can be further advanced. Maybe we can get more compounds in a similar way.

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Lapierre, Etienne A.; Piers, Warren E.; Lin, Jian-Bin; Gendy, Chris researched the compound: Dichloro(1,5-cyclooctadiene)platinum(II)( cas:12080-32-9 ).Computed Properties of C8H12Cl2Pt.They published the article 《Synthesis and Structures of Stable PtII and PtIV Alkylidenes: Evidence for π-Bonding and Relativistic Stabilization》 about this compound( cas:12080-32-9 ) in Chemistry – A European Journal. Keywords: electrochem pi bonding platinum palladium alkylidene complex stabilization; crystal structure mol platinum palladium alkylidene complex preparation optimized; carbenes; palladium; pincer ligands; platinum; relativistic effects. We’ll tell you more about this compound (cas:12080-32-9).

Isolable cationic PtII and PtIV alkylidenes, proposed intermediates in catalytic organic transformations, are reported. The bonding in these species was probed by exptl., structural, spectroscopic, electrochem. and computational methods, providing direct evidence for π-bonding, the often-theorized relativistic stabilization of these species, and the influence of oxidation state.

This literature about this compound(12080-32-9)Computed Properties of C8H12Cl2Pthas given us a lot of inspiration, and I hope that the research on this compound(Dichloro(1,5-cyclooctadiene)platinum(II)) can be further advanced. Maybe we can get more compounds in a similar way.

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts