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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 1-(4-Chlorophenyl)pyrrolidin-2-one, is researched, Molecular C10H10ClNO, CAS is 7661-33-8, about Rhodium(III)-Catalyzed C-H Vinylation of Arenes: Access to Functionalized Styrenes.Name: 1-(4-Chlorophenyl)pyrrolidin-2-one.

An effective method were developed for Rh(III)-catalyzed direct vinylation of arenes to give functionalized styrenes, using vinyltriethoxysilane as a convenient and inexpensive vinyl source. A wide variety of substrates, including 1-aryl-2-pyrrolidinones, anilines, benzamides and ketones were compatible with this reaction. Moreover, this method can be applied to the two-step synthesis of functionalized indoles. Mechanistic investigation reveals that the reaction probably proceeds through an oxidative Heck/desilylation pathway.

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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Lu, Hongtao; Geng, Zhiyue; Li, Jingya; Zou, Dapeng; Wu, Yusheng; Wu, Yangjie researched the compound: 3-Bromo-4-chloronitrobenzene( cas:16588-26-4 ).Computed Properties of C6H3BrClNO2.They published the article 《Metal-Free Reduction of Aromatic Nitro Compounds to Aromatic Amines with B2pin2 in Isopropanol》 about this compound( cas:16588-26-4 ) in Organic Letters. Keywords: metal free aromatic nitro reduction bispinacolato diboron isopropanol; aromatic amine preparation green chem. We’ll tell you more about this compound (cas:16588-26-4).

A metal-free reduction of aromatic nitro compounds to the corresponding amines has been achieved by a combination of B2pin2 and KOtBu in isopropanol. A series of nitro compounds containing various reducible functional groups were chemoselectively reduced in good to excellent yields.

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Quality Control of Dichloro(1,5-cyclooctadiene)platinum(II). The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Dichloro(1,5-cyclooctadiene)platinum(II), is researched, Molecular C8H12Cl2Pt, CAS is 12080-32-9, about Understanding Doping Effects on Electronic Structures of Gold Superatoms: A Case Study of Diphosphine-Protected M@Au12 (M = Au, Pt, Ir). Author is Hirai, Haru; Takano, Shinjiro; Nakamura, Toshikazu; Tsukuda, Tatsuya.

Dopants into ligand-protected Au superatoms have been hitherto limited to group X-XII elements (Pt, Pd, Ag, Cu, Hg, and Cd). To expand the scope of the dopants to the group IX elements, the authors synthesized unprecedented [IrAu12(dppe)5Cl2]+ [IrAu12; dppe = 1,2-bis(diphenylphosphino)ethane] and [PtAu12(dppe)5Cl2]2+ (PtAu12) and compared their electronic structures with that of [Au13(dppe)5Cl2]3+ (Au13). Single-crystal x-ray diffractometry, 31P{1H} NMR, and Ir L3-edge extended X-ray absorption fine structure anal. of IrAu12 revealed that the single Ir atom is located at the center of the icosahedral IrAu12 core. Electrochem. anal. demonstrated that the energy levels of the highest occupied MOs are upshifted in the order of Au13 < PtAu12 < IrAu12. This trend was qual. explained in such a manner that the jellium core potential at the central position becomes shallower by replacing Au+ with Pt0 and further with Ir-. IrAu12 underwent reversible redox reactions between the charge states of 1+ and 2+. The gradual increase of the energy gap between the HOMO and LUMO in the order of Au13 < PtAu12 < IrAu12 was observed by electrochem. measurement and optical spectroscopy. This study provides a simple guiding principle to tune the electronic structures of heterometal-doped superatoms. The orbital energies of [IrAu12(dppe)5Cl2]+ (IrAu12) and [PtAu12(dppe)5Cl2]2+ (PtAu12) were compared with those of [Au13(dppe)5Cl2]3+ (Au13) by electrochem. anal. The superat. orbitals were shifted up in the order of IrAu12 > PtAu12 > Au13. The result was explained by the upshift of the bottom of the effective potential due to different formal charge states of the dopants. Whereas Au was incorporated as Au+, Ir and Pt were incorporated as Ir- and Pt0, resp.

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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 3-Bromo-4-chloronitrobenzene, is researched, Molecular C6H3BrClNO2, CAS is 16588-26-4, about Metal-Free Reduction of Aromatic Nitro Compounds to Aromatic Amines with B2pin2 in Isopropanol.Product Details of 16588-26-4.

A metal-free reduction of aromatic nitro compounds to the corresponding amines has been achieved by a combination of B2pin2 and KOtBu in isopropanol. A series of nitro compounds containing various reducible functional groups were chemoselectively reduced in good to excellent yields.

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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Tosolini, Massimo; Avo, Joao; Parola, Antonio Jorge; Balducci, Gabriele; Tecilla, Paolo researched the compound: Dichloro(1,5-cyclooctadiene)platinum(II)( cas:12080-32-9 ).Name: Dichloro(1,5-cyclooctadiene)platinum(II).They published the article 《Sterically Encumbered 4,5-Bis(diphenylphosphino)acenaphthene Ligand and Its Ni(II), Pd(II), Pt(II), and Cu(I) Complexes》 about this compound( cas:12080-32-9 ) in European Journal of Inorganic Chemistry. Keywords: sterically encumbered diphenylphosphinoacenaphthene ligand preparation crystal mol structure complexation; nickel palladium platinum copper diphenylphosphinoacenaphthene preparation crystal mol structure. We’ll tell you more about this compound (cas:12080-32-9).

A new sterically encumbered sym. substituted 4,5-bis(diphenylphosphino)acenaphthene ligand (L) has been prepared The ligand readily forms distorted square-planar complexes with group 10 metal ions [Ni(II), Pd(II), Pt(II)] and a dimeric tetrahedral complex with Cu(I). The x-ray structures of the ligand and of the complexes show a notably short distance between the two phosphorus atoms, well below than twice the van der Waals radius of P, due to the steric requirements of the rigid acenaphthene backbone. Moreover, in the complexes a stabilizing π-π interaction between two Ph rings belonging to the two P atoms is present. The [LCuCl]2 complex is weakly fluorescent both in solution and in the solid state with higher quantum yield as a solid where it exhibits thermally-activated delayed fluorescence and phosphorescence. [LPdCl2] and [LCuCl]2 behave as chloride transporters across a liposomal phospholipid membrane with the Pd(II) complex displaying a very high activity.

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Nucleophilic substitution of aromatic chlorine in diazonium ions by bromide ions, published in 1962, which mentions a compound: 16588-26-4, Name is 3-Bromo-4-chloronitrobenzene, Molecular C6H3BrClNO2, Quality Control of 3-Bromo-4-chloronitrobenzene.

To determine why a Cl atom in a suitably substituted diazonium ion should not be replaced by a Br- ion, the reaction of 2-chloro-5-nitrobenzenediazonium ion in an HBr-AcOH-H2O medium at 25° was studied. It was found that some of the aromatic Cl is “”frozen in”” and no quant. conversion of aromatic Cl to Br can occur; the reverse reactions are considerably more rapid than the forward ones, so that a small amount of Cl- ions generated in the exchange reaction produces an equilibrium containing comparable amounts of each, despite the large excess of HBr; and the equilibrium is continually being disturbed by the side-reactions, which cannot be suppressed by increasing the Br- ion concentration

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Multifunctional Pt(II)-Based Metallo-Supramolecular Polymer with Carboxylic Acid Groups: Electrochemical, Mechanochemical, Humidity, and pH Response, published in 2020-09-11, which mentions a compound: 12080-32-9, Name is Dichloro(1,5-cyclooctadiene)platinum(II), Molecular C8H12Cl2Pt, Category: alcohols-buliding-blocks.

We report multifunctional Pt(II)-based metallo-supramol. polymer with carboxylic acid groups (polyPtC). The polymer showed multi-stimuli-responsive emission to electrochem. redox, mech. force, humidity, and pH. It also exhibited humidity-responsive ionic conductivity Furthermore, it displayed electrofluorochromism. The emission switching between the two transition states (3MLCT/3LLCT and 3MMLCT) was based on the reversible changes of the interchain Pt-Pt interaction in polyPtC, which was caused by the secondary interaction or the crystalline-amorphous transition. The ionic conductivity of polyPtC was responsible for the humidity and the real-time humidity sensor with the polymer film was demonstrated on interdigitated Pt-electrodes. A solid-state electrochromic device with the polymer film was successfully fabricated to show reversible yellow-to-black electrochromism. In addition, it was revealed by the electrofluorochromic study that the pristine 3MLCT/3LLCT emission was quenched in the electrochem. reduced state (the black state), because the radical anion species of the ligand (tpy·-) generated at the neg. potential caused the repulsion among the polymer chains, expanded the Pt-Pt distance, and prevented the emission.

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HPLC of Formula: 7661-33-8. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 1-(4-Chlorophenyl)pyrrolidin-2-one, is researched, Molecular C10H10ClNO, CAS is 7661-33-8, about Synthesis and pharmacological evaluation of benzamide derivatives as potent and selective sigma-1 protein ligands. Author is Donnier-Marechal, Marion; Carato, Pascal; Larchanche, Paul-Emmanuel; Ravez, Severine; Boulahjar, Rajaa; Barczyk, Amelie; Oxombre, Benedicte; Vermersch, Patrick; Melnyk, Patricia.

A series of novel N-(aminoalkyl)benzamide derivatives such as I [m = 2, 3; R1 = Me; R2 = Bn, (CH2)2C6H4; R1R2 = (CH2)4, (CH2)2O(CH2)2, (CH2)2NMe(CH2)2, etc.; R3 = H, 4-n-Bu, 4-Cl, etc.] and N-benzyl-N-methyl-propan-1-amine derivatives II [X = CH2NH, SO2NH, NHC(O)] was designed, synthesized and pharmacol. evaluated. In vitro competition binding assays against sigma proteins (sigma-1 S1R and sigma-2 S2R) revealed that most of them conferred S2R/S1R selectivity toward without cytotoxic effects on SY5Y cells, especially with compounds I [m = 2, 3; R1 = Me; R2 = Bn]. Some selected compounds were also evaluated for their agonist and antagonist activities on a panel of 40 receptors and results showed the importance of the nature and the position with halogeno atom on the benzamide scaffold, the length chain and also the contribution of the hydrophobic part on the amine group. Among them, compounds I [m = 2, 3; R1 = Me; R2 = Bn; R3 = 4-Cl, 4-CN, 4-NO2] showed excellent affinity for S1R (Ki = 1.2-3.6 nM), selectivity for S2R (Ki up to 1400 nM) and high selectivity index (IC50(SY5Y)/Ki(S1R) ratio from 28/000 to 83/000). Furthermore, these compounds I and II presented an excellent safety profile over 40 other receptors.

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COA of Formula: C8H12Cl2Pt. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Dichloro(1,5-cyclooctadiene)platinum(II), is researched, Molecular C8H12Cl2Pt, CAS is 12080-32-9, about Mustards-Derived Terpyridine-Platinum Complexes as Anticancer Agents: DNA Alkylation vs. Coordination. Author is Adams, Muneebah; Sullivan, Matthew P.; Tong, Kelvin K. H.; Goldstone, David C.; Hanif, Muhammad; Jamieson, Stephen M. F.; Hartinger, Christian G..

The development of bifunctional platinum complexes with the ability to interact with DNA via different binding modes is of interest in anticancer metallodrug research. Therefore, we report platinum(II) terpyridine complexes to target DNA by coordination and/or through a tethered alkylating moiety. The platinum complexes were evaluated for their in vitro antiproliferative properties against the human cancer cell lines HCT116 (colorectal), SW480 (colon), NCI-H460 (non-small cell lung), and SiHa (cervix) and generally exhibited potent antiproliferative activity although lower than their resp. terpyridine ligands. 1H NMR spectroscopy and/or ESI-MS studies on the aqueous stability and reactivity with various small biomols., acting as protein and DNA model compounds, were used to establish potential modes of action for these complexes. These investigations indicated rapid binding of complex PtL3 to the biomols. through coordination to the Pt center, while PtL4 in addition alkylated 9-ethylguanine. PtL3 was investigated for its reactivity to the model protein hen egg white lysozyme (HEWL) by protein crystallog. which allowed identification of the Nδ1 atom of His15 as the binding site.

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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: Dichloro(1,5-cyclooctadiene)platinum(II), is researched, Molecular C8H12Cl2Pt, CAS is 12080-32-9, about Photochemistry of 1,5-Cyclooctadiene Platinum Complexes for Photoassisted Chemical Vapor Deposition.Recommanded Product: 12080-32-9.

Quantum yields for disappearance of (COD)PtMe2 (1a) and (COD)PtMeCl (1b) were determined at 334 nm in C6D6 solvent. Chain reactions initiated by formation of a Me radical were proposed to be the cause of quantum yields higher than unity (Φ = 5.52 ± 0.40 for 1a) when the reaction mixtures included C4F9I. The chain reactions were suppressed in the presence of the radical trap 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO), which resulted in measured disappearance quantum yields of Φ = 0.037 ± 0.003 for (COD)PtMe2 and Φ = 0.44 ± 0.02 for (COD)PtMeCl at 334 nm. Weak luminescence was observed for 1a and 1b, and it was determined that emissive decay is not competitive with Pt-CH3 bond homolysis. DFT studies enabled assignment of both SBLCT and MLCT transitions in the UV/vis spectra of 1a, while 1b only exhibits MLCT transitions. These effects can be attributed to the symmetry of the mol. and its electronic structure.

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