Author: tianli

Fu, Yuan; Yuan, Qin; Lin, Shang; Liu, Wen; Du, Gang; Zhao, Li; Zhang, Qing; Lin, De-Rong; Liu, Yun-Tao; Qin, Wen; Li, De-Qiang; Wu, Ding-Tao published the artcile< Physicochemical characteristics and biological activities of polysaccharides from the leaves of different loquat (Eriobotrya japonica) cultivars>, Formula: C6H12O6, the main research area is Eriobotrya leaf physicochem polysaccharide; Binding properties; Enzyme inhibition; Eriobotrya japonica; Loquat; Polysaccharides; Weight-average molecular weights.

In order to explore polysaccharides from loquat leaves (LLPs) as functional food ingredients for prevention and treatment of obesity and type 2 diabetes, the physicochem. characteristics, in vitro binding properties, and inhibitory effects on α-amylase and α-glucosidase of polysaccharides from the leaves of different loquat cultivars, including ‘Baiyu’, ‘Chuannong8’, ‘Yuanbao’, and ‘Dawuxing’, were investigated and compared. Results showed that the contents of total uronic acids and degree of esterification in LLPs ranged from (27.04 ± 1.76)% to (41.46 ± 1.91)%, and from (20.54 ± 0.11)% to (26.90 ± 0.10)%, resp. The weight-average mol. weights of LLPs ranged from 4.307 × 106 Da to 5.101 × 106 Da, and the major constituent monosaccharides of LLPs were rhamnose, galacturonic acid, arabinose, and galactose. Furthermore, LLPs exerted strong in vitro fat binding, cholesterol binding, and bile acid binding capacities, as well as remarkable inhibitory effects on α-amylase and α-glucosidase, which might be attributed to their mol. weights, mol. weight distributions, and degree of esterification. Results are helpful for better understanding of chem. structures and bioactivities of polysaccharides from loquat leaves, and LLPs had good potential to be explored as functional food ingredients for prevention and treatment of obesity and type 2 diabetes.

International Journal of Biological Macromolecules published new progress about Bile acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Formula: C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Singh, Vivek Kumar; Donthireddy, S. N. R.; Pandey, Vipin K.; Rit, Arnab published the artcile< RuII-Complexes of heteroditopic chelating NHC ligands: effective catalysts for the β-alkylation of secondary alcohols and the synthesis of 2-alkylaminoquinoline derivatives following the dehydrogenative protocol>, Application In Synthesis of 5344-90-1, the main research area is ruthenium NHC imidazolylidene triazolylidene cymene complex preparation coupling catalyst; coupling primary secondary alc preparation aralkyl alc ruthenium catalyst; quinoline amine preparation cyclization amino alc nitrile ruthenium catalyst.

RuII-Complexes of chelating heteroditopic N-heterocyclic carbene ligands I·BF4 (1a-c; R = 2,4,6-Me3, 4-OMe, 4-CF3) featuring imidazol-2-ylidene (ImNHC) and 1,2,3-triazol-5-ylidene (tzNHC) donors connected via a CH2 spacer, were found to be very effective catalysts for the cross-coupling of secondary alcs. ArCH(OH)Me and primary alcs. RCH2OH with the elimination of H2O, yielding aralkyl alcs. ArCH(OH)CH2CH2R (Ar = substituted Ph, 2-naphthyl, 2-thienyl; R = aryl, hetaryl, C5H11). Diverse β-alkylated secondary alcs. were thus obtained by following this method in excellent yields of up to 95% by employing a very low catalyst 1a loading of 0.01-0.001 mol% along with the inexpensive base KOH. Mechanistically, the present protocol follows the borrowing hydrogen strategy which was established by various control experiments including deuterium labeling experiments and importantly, 1H NMR and ESI-MS analyses validated the participation of a Ru-H species in the catalytic cycle. Remarkably, the present system displayed the highest Ru-based TON of 396 000 for the β-benzylation of 1-phenylethanol with a catalyst loading of 1 ppm (0.0001 mol%). Addnl., diverse 2-alkylaminoquinoline derivatives were synthesized in a one-pot manner from 2-aminobenzyl alc., 2-arylacetonitrile, and various primary alcs.

Organic & Biomolecular Chemistry published new progress about Alkylation. 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Application In Synthesis of 5344-90-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Azizi, Kobra; Akrami, Sedigheh; Madsen, Robert published the artcile< Manganese(III) Porphyrin-Catalyzed Dehydrogenation of Alcohols to form Imines, Tertiary Amines and Quinolines>, Application of C7H9NO, the main research area is manganese porphyrin chloride catalyst dehydrogenative coupling alcs amine; imine synthesis; tertiary amine synthesis; quinoline synthesis; alcohols; dehydrogenation; homogeneous catalysis; manganese; synthetic methods.

Manganese(III) porphyrin chloride complexes have been developed for the first time as catalysts for the acceptorless dehydrogenative coupling of alcs. and amines. The reaction has been applied to the direct synthesis of imines, tertiary amines and quinolines where only hydrogen gas and/or water are formed as the byproduct(s). The mechanism is believed to involve the formation of a manganese(III) alkoxide complex which degrades into the aldehyde and a manganese(III) hydride species. The latter reacts with the alc. to form hydrogen gas and thereby regenerates the alkoxide complex.

Chemistry – A European Journal published new progress about Aliphatic alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Application of C7H9NO.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhao, Hui; Gao, Kai; Ma, Haichen; Yip, Tsz Chun; Dai, Wei-Min published the artcile< Synthesis of the C19-C30 bis-THF fragment of iriomoteolide-13a via stepwise SN2 cyclization and intramolecular syn-oxypalladation>, Application In Synthesis of 627-27-0, the main research area is iriomoteolide fragment preparation; alkyne cyclization asym dihydroxylation.

The C19-C30 bis-THF fragment I [stereo = R or S] of the proposed structure of iriomoteolide-13a were synthesized. The ω-mesyloxy-substituted stereotetrad possessing three continuous hydroxy groups was generated by an anti-aldol reaction and asym. dihydroxylation was the key steps. Upon heating in pyridine, the stereotetrad underwent an SN2 cyclization to form the C19-C22 THF ring chemoselectively. The propargylic alc., after cleavage of the C28-OPMB ether, was reduced to the corresponding allylic alc. with spontaneous removal of the C23-OTBS protecting group. Finally, the ene triol was subjected to the Pd(II)-catalyzed intramol. syn-oxypalladation to give the C23-C26 THF ring. It was found that the C21-OH group, which might form a chelated Pd(II) complex along with the C23-OH group, was tolerated during the syn-oxypalladation process.

Organic Chemistry Frontiers published new progress about Cyclization, stereoselective. 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Application In Synthesis of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Hai-ou; Liu, Si-hong; Zhou, Xue-jie; Yang, Xiao-yue; Gao, Qi; Tanokura, Masaru; Xue, You-lin published the artcile< Treatment with hydrogen peroxide improves the physicochemical properties of dietary fibres from Chinese yam peel>, Computed Properties of 492-62-6, the main research area is hydrogen peroxide Chinese yam peel dietary fiber physicochem property.

Summary : Yam is a common ‘medicine food homol.’ vegetable in Asia, and its peel is often considered a food residue during processing or cooking. In this work, the effects of hydrogen peroxide modification on the dietary fibers (DFs) from Chinese yam peel (CYP) were investigated. The structural characteristics of soluble dietary fiber (SDF), insoluble dietary fiber (IDF), modified soluble dietary fiber (MSDF) and modified insoluble dietary fiber (MIDF) were analyzed using Fourier-transform IR spectroscopy, X-ray diffraction, differential scanning calorimetry, granularity anal., SEM and GC-MS (monosaccharide composition). As results, after modification with hydrogen peroxide, the sizes of the DFs were reduced and MIDF exposed more cellulose. Experiments on the physicochem. and functional properties of DFs showed that MSDF and MIDF obtained a better water holding capacity, oil absorption capacity, swelling capacity and absorption abilities with altered structures, which is of great importance in food processing and development.

International Journal of Food Science and Technology published new progress about Crystallinity. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Computed Properties of 492-62-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hu, Guodong; Zhong, Miao; Zhao, Jintao; Gao, Hao; Gan, Lu; Zhang, Hong; Zhang, Shengxiang; Fang, Jianguo published the artcile< Fluorescent Probes for Imaging Protein Disulfides in Live Organisms>, Product Details of C19H16O, the main research area is fluorescent probe imaging protein disulfide in vivo; environment-sensitive probes; fluorescent probes; in vivo imaging; mouse stroke model; protein disulfides; two-photon.

Cellular redox homeostasis is predominantly controlled by the ratio of thiols and disulfides, and reversible thiol-disulfide exchange reactions are fundamental of the biol. redox regulation. However, due to the dynamic exchanges of thiols and disulfides, the detection, especially the in situ detection, of protein disulfides (PDS) is challenging. We employ the strategy, i.e., the increase of emission upon an environment-sensitive dye binding to proteins, to design PDS probes and discover a two-photon probe PDSTP590 (S6) (I) that selectively recognizes PDS in live organisms. With the aid of the probe, we further disclose the elevation of PDS in brains of the mouse stroke model.

ACS Sensors published new progress about Bovine serum albumin Role: ANT (Analyte), BSU (Biological Study, Unclassified), ANST (Analytical Study), BIOL (Biological Study). 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Product Details of C19H16O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Choong, Ingrid C.; Serafimova, Iana; Fan, Junfa; Stockett, David; Chan, Erica; Cheeti, Sravanthi; Lu, Yafan; Fahr, Bruce; Pham, Phuongly; Arkin, Michelle R.; Walker, Duncan H.; Hoch, Ute published the artcile< A diaminocyclohexyl analog of SNS-032 with improved permeability and bioavailability properties>, Synthetic Route of 6850-39-1, the main research area is diaminocyclohexyl analog SNS 032 preparation permeability bioavailability CDK inhibition.

The identification of a selective CDK2, 7, and 9 inhibitor (compound 4) with improved permeability is described. Compound 4 exhibits comparable CDK selectivity profile to SNS-032, but shows improved permeability and higher bioavailability in mice.

Bioorganic & Medicinal Chemistry Letters published new progress about Antitumor agents. 6850-39-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H13NO, Synthetic Route of 6850-39-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Jia, Mengyun; Chen, Jiajun; Liu, Xiaozhen; Xie, Mingyong; Nie, Shaoping; Chen, Yi; Xie, Jianhua; Yu, Qiang published the artcile< Structural characteristics and functional properties of soluble dietary fiber from defatted rice bran obtained through Trichoderma viride fermentation>, Product Details of C6H12O6, the main research area is Trichoderma fermentation soluble dietary fiber defatted rice bran.

Trichoderma viride was utilized to ferment the defatted rice bran (DRB), and soluble dietary fiber was prepared before and after fermentation, named as B-SDF and F-SDF, resp. Optimum fermentation conditions for yield of F-SDF were determined using response surface methodol. (RSM). The yield of F-SDF was significantly increased from 10.5 (weight/weight, %) to 33.4 (weight/weight, %) under the optimal conditions (inoculum size = 10%, pH = 5.8 and time = 41 h). Fourier transform IR spectroscopy (FTIR) demonstrated that both B-SDF and F-SDF had typical characteristics of the IR spectrum of polysaccharides, and X-ray diffraction (XRD) revealed they were mainly substances of amorphous structure. In addition, F-SDF showed looser structure by SEM (SEM) anal., increased mol. weight by high-performance gel permeation chromatog. (HPGPC) anal., and more complex monosaccharide composition by high-performance anion exchange chromatog. (HPAEC) anal. Furthermore, functional properties anal. showed that F-SDF exhibited higher water-holding capacity (WHC), oil-holding capacity (OHC), water solubility (WS) and cholesterol absorption capacity (CAC) than B-SDF. In summary, the present study suggested that SDF from defatted rice bran obtained through Trichoderma viride fermentation has a higher potential to be used as a functional ingredient in foods.

Food Hydrocolloids published new progress about Dietary fiber. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Product Details of C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hirbawi, Nadia; Lin, Patricia C.; Jarvo, Elizabeth R. published the artcile< Halogenation Reactions of Alkyl Alcohols Employing Methyl Grignard Reagents>, Electric Literature of 627-27-0, the main research area is alkyl halide preparation; alc alkyl Grignard reagent halogenation.

Herein, an example of Grignard reagents acting as halide nucleophiles to form alkyl iodides RI [R = 1-(4-methoxyphenyl)-5-phenylpentan-3-yl, 4-phenylbutan-2-yl, 4-(2H-1,3-benzodioxol-5-yl)butan-2-yl, etc.] and alkyl bromides R1Br [R1 = 3-[4-(3-methoxyphenyl)phenyl]propyl, 2-(6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethyl, 3-(4-bromophenyl)propyl, etc.] was reported. This work establishes that Grignard reagents can convert alkyl mesylates ROMs/R1OMs into alkyl halides RI/R1Br, as well as be employed in a one-pot halogenation reaction starting from alcs. ROH/R1OH, which proceed through mesylate intermediates. The halogenation reaction is confirmed to occur by an SN2 pathway with the inversion of configuration and is demonstrated to be efficient on a gram scale.

Journal of Organic Chemistry published new progress about Alcohols Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Electric Literature of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Caputo, Lucia; Piccialli, Ilaria; Ciccone, Roselia; de Caprariis, Paolo; Massa, Antonio; De Feo, Vincenzo; Pannaccione, Anna published the artcile< Lavender and coriander essential oils and their main component linalool exert a protective effect against amyloid-β neurotoxicity>, Quality Control of 78-70-6, the main research area is Lavender Coriander essential oil linalool neuroprotective agent neurotoxicity; Alzheimer’s disease; amyloid-β oligomers; coriander essential oil; lavender essential oil; linalool; neuroprotection.

Alzheimer’s disease (AD) is a neurodegenerative disorder leading to cognitive deficits and cognitive decline. Since no cure or preventing therapy is currently available to counteract AD, natural-derived compounds are investigated to find new potential neuroprotective agents for its treatment. In the present study, we tested the neuroprotective effect of lavender and coriander essential oils (EOs) and their main active constituent linalool, against the neurotoxicity elicited by Aβ1-42 oligomers, a key mol. factor in the neurodegeneration of AD. Importantly, our findings on neuronally differentiated PC12 cells exposed to Aβ1-42 oligomers are in accordance with previous in vivo studies reporting the neuroprotective potential of lavender and coriander EOs and linalool. We found that lavender and coriander EOs at the concentration of 10μg/mL as well as linalool at the same concentration were able to improve viability and to reduce nuclear morphol. abnormalities in cells treated with Aβ1-42 oligomers for 24 h. Lavender and coriander EOs and linalool also showed to counteract the increase of intracellular reactive oxygen species production and the activation of the pro-apoptotic enzyme caspase-3 induced by Aβ1-42 oligomers. Our findings provide further evidence that these EOs and their main constituent linalool could be natural agents of therapeutic interest against Aβ1-42-induced neurotoxicity.

Phytotherapy Research published new progress about Alzheimer disease. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Quality Control of 78-70-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts