Author: tianli

Green, Scott B.; Lanier, Robert J. Jr.; Carey, Shane M.; Morgan, David R.; Gracz, Hanna; Sherman, Julian; Rodriguez, Ana; D′Antonio, Edward L. published the artcile< Synthesis, biochemical, and biological evaluation of C2 linkage derivatives of amino sugars, inhibitors of glucokinase from Trypanosoma cruzi>, Category: alcohols-buliding-blocks, the main research area is glucosamine mannosamine galactosamine inhibitor glucokinase inhibitor parasite protozoan; amino sugar inhibitor glucokinase Trypanosoma cruzi glucosamine protozoan parasite; Amino sugars; Chagas’ disease; Glucokinase; Inhibitors; Neglected tropical diseases.

Eighteen amino sugar analogs were screened against Trypanosoma cruzi glucokinase (TcGlcK), a potential drug-target of the protozoan parasite in order to assess for viable enzyme inhibition. The analogs were divided into three amino sugar scaffolds that included D-glucosamine (D-GlcN), D-mannosamine (D-ManN), and D-galactosamine (D-GalN); moreover, all but one of these compounds were novel. TcGlcK is an important metabolic enzyme that has a role in producing G6P for glycolysis and the pentose phosphate pathway (PPP). The inhibition of these pathways via glucose kinases (i.e., glucokinase and hexokinase) appears to be a strategic approach for drug discovery. Glucose kinases phosphorylate D-glucose with co-substrate ATP to yield G6P and the formed G6P enters both pathways for catabolism. The compound screen revealed five on-target confirmed inhibitors that were all from the D-GlcN series, such as compounds 1, 2, 4, 5, and 6. Four of these compounds were strong TcGlcK inhibitors (1, 2, 4, and 6) since they were found to have micromolar inhibitory constant (Ki) values around 20 μM. Three of the on-target confirmed inhibitors amino sugars, e.g. I-III, revealed notable in vitro anti-T. cruzi activity with IC50 values being less than 50 μM. Compound 1 was benzoyl glucosamine (BENZ-GlcN), a known TcGlcK inhibitor that was the starting point for the design of the compounds in this study; in addition, TcGlcK – I inhibition properties were previously determined [D′Antonio, E. L. et al. (2015) Mol. Biochem. Parasitol. 204, 64-76]. As such, compounds II-III were further evaluated biochem., where formal Ki values were determined as well as their mode of TcGlcK inhibition. The Ki values determined for compounds II-III were 107 ± 4 μM and 15.2 ± 3.3 μM, resp., and both of these compounds exhibited the competitive inhibition mode.

Bioorganic & Medicinal Chemistry Letters published new progress about Drug discovery. 5505-63-5 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H14ClNO5, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Yang; Bao, Jiamin; Zhang, Yu; Peng, Xue; Yu, Weijie; Wang, Tao; Yang, Dengtao; Liu, Qun; Zhang, Qian; Fu, Junkai published the artcile< Three-component aminofluorination of alkenes with electronically rich amino sources>, Category: alcohols-buliding-blocks, the main research area is alkene bromo dialkyl amine silver fluoride regioselective aminofluorination; fluoro alkyl amine preparation.

The first intermol. three-component aminofluorination of alkenes with electronically rich amino sources was developed via an umpolung strategy. In this reaction, electrophilic N-bromodialkylamines were employed as amine electrophiles, whereas multifunctional AgF served as both a nucleophilic fluoride source and a reductive catalyst, for the first time, to initiate a single-electron transfer with N-bromodialkylamines. The addition of hexafluoroisopropanol as a cosolvent was crucial to promote protonated alkylaminyl radical formation and maintain the nucleophilicity of fluoride ion. This protocol exhibited excellent functional-group tolerance toward various aryl and unactivated alkenes, furnishing the corresponding β-fluoroamines with high regioselectivity. Mechanistic investigation revealed an aziridinium intermediate via a radical pathway. The synthetic utility of this transformation was demonstrated by the aminofluorination of several bioactive mols., including an efficient route to a Rizatriptan analog. This finding holds promise for new discoveries in medicinal chem. and the amination reactions.

Chem published new progress about Alkenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ozkan, Ilknur; Taylan, Secil; Eroglu, Nermin; Kolac, Nurcan published the artcile< The Relationship between Malnutrition and Subjective Taste Change Experienced by Patients with Cancer Receiving Outpatient Chemotherapy Treatment>, Related Products of 1492-18-8, the main research area is human malnutrition taste change cancer chemotherapy.

Taste changes and malnutrition are two important problems in patients with different types of cancer. This study was conducted to evaluate the relationship between malnutrition and subjective taste changes experienced by cancer patients receiving outpatient chemotherapy. The study used a cross-sectional design and was carried out with 1382 patients with cancer receiving outpatient chemotherapy. Of the patients, 63.1% experienced taste changes. It was determined that 8.8% of patients had malnutrition according to the Mini Nutritional Assessment. The mean scores of patients experiencing malnutrition and being at risk for malnutrition from all sub-dimensions of The Chemotherapy-induced Taste Alteration Scale (CiTAS) were found to be higher than the patient group evaluated to have normal nutrition. It was determined that a unit increase in the scores of the parageusia and phantogeusia subscales of the CiTAS increased the risk of malnutrition by 3.36 times (%95CI = 2.68-4.02). In line with these results, we recommend that patients with cancer receiving chemotherapy should be routinely evaluated in terms of taste changes in clin. practice and that they should be followed up in terms of malnutrition in the presence of taste changes.

Nutrition and Cancer published new progress about Bladder neoplasm. 1492-18-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C20H21CaN7O7, Related Products of 1492-18-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ota, Eisuke; Wang, Huaiju; Frye, Nils Lennart; Knowles, Robert R. published the artcile< A Redox Strategy for Light-Driven, Out-of-Equilibrium Isomerizations and Application to Catalytic C-C Bond Cleavage Reactions>, Synthetic Route of 167938-56-9, the main research area is light driven redox neutral isomerization cyclic aliphatic alc; linear carbonyl compound preparation out of equilibrium isomerization.

We report a general protocol for the light-driven isomerization of cyclic aliphatic alcs. to linear carbonyl compounds These reactions proceed via proton-coupled electron-transfer activation of alc. O-H bonds followed by subsequent C-C β-scission of the resulting alkoxy radical intermediates. In many cases, these redox-neutral isomerizations proceed in opposition to a significant energetic gradient, yielding products that are less thermodynamically stable than the starting materials. A mechanism is presented to rationalize this out-of-equilibrium behavior that may serve as a model for the design of other contrathermodynamic transformations driven by excited-state redox events.

Journal of the American Chemical Society published new progress about C-C bond cleavage (photo-). 167938-56-9 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H17NO3, Synthetic Route of 167938-56-9.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Oner, Z.; Altinoz, E.; Elbe, H.; Ekinci, N. published the artcile< The protective and therapeutic effects of linalool against doxorubicin-induced cardiotoxicity in Wistar albino rats>, Related Products of 78-70-6, the main research area is linalool doxorubicin cardiotoxicity therapeutics; Doxorubicin; MDA; cardiotoxicity; caspase-3; linalool; oxidative stress.

The aim of the present study was to determine the protective and therapeutic effects of linalool (LIN) against doxorubicin (DOX)-induced cardiotoxicity in rats histol. and biochem. In experiments, 64 male Wistar albino rats were randomly divided into eight groups (n = 8). These groups were control (C) (0.9% saline solution), DOX (20 mg/kg DOX), LIN50 (50 mg/kg LIN), LIN100 (100 mg/kg LIN), DOX + LIN50 (20 mg/kg DOX and 50 mg/kg LIN), DOX + LIN100 (20 mg/kg DOX and 100 mg/kg LIN), LIN50 + DOX (50 mg/kg LIN and 20 mg/kg DOX), and LIN100 + DOX (100 mg/kg LIN and 20 mg/kg DOX). It was determined that histopathol. changes significantly decreased in groups treated with LIN after DOX administration. While the caspase-3 immunostaining was highly evident in DOX group apoptotic cells (p < 0.001, for all), the intensity of caspase-3 immunostaining in the treatment groups decreased (p < 0.05). While DOX administration resulted in a significant increase in malondialdehyde (MDA) levels and plasma Creatine kinase (CK) and lactate dehydrogenase (LDH) levels in cardiac tissue when compared to the C groups, it was observed that DOX + LIN administration led to a significant decrease in MDA, plasma CK and LDH levels and a significant increase in glutathione (GSH), superoxide dismutase, and catalase enzyme levels. Finally, it was concluded that DOX led to heavy cardiotoxicity and DOX + LIN administration could remove cardiomyopathy symptoms. Human & Experimental Toxicology published new progress about Apoptosis. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Related Products of 78-70-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bains, Amreen K.; Singh, Vikramjeet; Adhikari, Debashis published the artcile< Homogeneous Nickel-Catalyzed Sustainable Synthesis of Quinoline and Quinoxaline under Aerobic Conditions>, Application In Synthesis of 5344-90-1, the main research area is amine alc nickel catalyst dehydrogenative coupling green; quinoline preparation; quinoxaline preparation.

Dehydrogenative coupling-based reactions have emerged as an efficient route toward the synthesis of a plethora of heterocyclic rings. Herein, we report an efficacious, nickel-catalyzed synthesis of two important heterocycles such as quinoline and quinoxaline. The catalyst is molecularly defined, is phosphine-free, and can operate at a mild reaction temperature of 80°C. Both the heterocycles can be easily assembled via double dehydrogenative coupling, starting from 2-aminobenzyl alc./1-phenylethanol and diamine/diol, resp., in a shorter span of reaction time. This environmentally benign synthetic protocol employing an inexpensive catalyst can rival many other transition-metal systems that have been developed for the fabrication of two putative heterocycles. Mechanistically, the dehydrogenation of secondary alc. follows clean pseudo-first-order kinetics and exhibits a sizable kinetic isotope effect. Intriguingly, this catalyst provides an example of storing the trapped hydrogen in the ligand backbone, avoiding metal-hydride formation. Easy regeneration of the oxidized form of the catalyst under aerobic/O2 oxidation makes this protocol eco-friendly and easy to handle.

Journal of Organic Chemistry published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Application In Synthesis of 5344-90-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Guo, Kun; Zhao, Zhigang; Luo, Liang; Wang, Shihui; Zhang, Rui; Xu, Wei; Qiao, Guo published the artcile< Untargeted GC-MS metabolomics reveals the metabolic responses in the gills of Chinese mitten crab (Eriocheir sinensis) subjected to air-exposure stress>, Recommanded Product: D-Glucosaccharic acid, the main research area is metabolome air exposure stress gas chromatog mass spectrometry Eriocheir; Air-exposure stress; Eriocheir sinensis; Gill; Metabolic pathway; Metabolomics.

Desiccation is a common stress experienced by crabs during aquaculture and transportation. In China, the crustacean, Chinese mitten crab (Eriocheir sinensis), is economically important. However, little is known about the mol. pathways underlying physiol. stress. Here, by using untargeted gas chromatog.-mass spectrometry metabolomics, we investigated the metabolic responses of the gills of E. sinensis subjected to air-exposure stress by six biol. replicates of the control group (CG) and the air-exposure stress group (AG). Metabolomic anal. identified 43 differential metabolites in the AG vs. the CG that could be potential biomarkers of desiccation stress. In addition, integrated anal. of key metabolic pathways revealed the involvement of histidine metabolism; glycine, serine and threonine metabolism; the pentose phosphate pathway; the citrate cycle (TCA cycle); and nicotinate and nicotinamide metabolism These findings indicated the special physiol. responses to air-exposure stresses in this species.

Ecotoxicology and Environmental Safety published new progress about Desiccation. 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Recommanded Product: D-Glucosaccharic acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Das, Jagadish; Vellakkaran, Mari; Banerjee, Debasis published the artcile< Nickel-Catalyzed Alkylation of Ketone Enolates: Synthesis of Monoselective Linear Ketones>, Electric Literature of 5344-90-1, the main research area is ketone alc nickel monoselective alkylation catalyst; linear ketone preparation green chem.

Herein we have developed a Ni-catalyzed protocol for the synthesis of linear ketones. Aryl, alkyl, and heteroaryl ketones as well as alcs. yielded the monoselective ketones in up to 90% yield. The catalytic protocol was successfully applied in to a gram-scale synthesis. For a practical utility, applications of a steroid derivative, oleyl alc., and naproxen alc. were employed. Preliminary catalytic investigations involving the isolation of a Ni intermediate and defined Ni-H species as well as a series of deuterium-labeling experiments were performed.

Journal of Organic Chemistry published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Electric Literature of 5344-90-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Mashhoori, Mahboobeh-Sadat; Sandaroos, Reza; Zeraatkar Moghaddam, Ali published the artcile< Design of a New Poly Imidazolium-Tagged Cobalt (II) Schiff Base Complex for Selective Oxidation of Alcohols and Sulfides in a Water Solvent>, Quality Control of 699-12-7, the main research area is polyimidazolium tagged cobalt Schiff base complex catalyst; alc sulfide selective oxidation.

In this study, a new catalyst including polymeric imidazolium ionic liquid functionalized Cobalt (II) Schiff base complex [PIL-SB-Co (II)] was prepared and characterized using various analyses like FT-IR, H-NMR, FE-SEM, Energy-dispersive X-ray, thermogravimetric anal., and ICP-OES. Then, its catalytic activity was studied in oxidation reaction of sulfides and alcs. This polymeric heterogeneous catalyst can catalyze the oxidation reactions in water as a green solvent, and mild conditions (room temperature) with good to excellent yields of sulfoxides, aldehydes, and ketones as worthwhile and critical products. First preparation and characterization of poly ionic liquid functionalized Co (II) Schiff base catalyst. First oxidation reaction of sulfides and alcs. catalyzed by polymeric ionic liquid Schiff base complex. Oxidation reaction of sulfides and alcs. to sulfoxides and aldehydes and ketones in water as a green solvent and room temperature Reusable catalyst at least for five runs.

Polycyclic Aromatic Compounds published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, Quality Control of 699-12-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhuang, Jinda; Xiao, Qing; Feng, Tao; Huang, Qingrong; Ho, Chi-Tang; Song, Shiqing published the artcile< Comparative flavor profile analysis of four different varieties of Boletus mushrooms by instrumental and sensory techniques>, Safety of 2-Ethylhexan-1-ol, the main research area is Boletus flavor sensory evaluation; Aroma-active compounds; Boletus; Gas chromatography–olfactometry; Odor activity value; Partial least squares regression; Solvent assisted flavor evaporation.

Mushrooms from different varieties and manufacturing methods show different flavor profiles. In order to understand the sensory attributes and aroma compounds of boletus, the discrepancy of aroma profile in four varieties of boletus was determined using gas chromatog.-olfactometry combined with sensory anal. and partial least squares regression anal. (PLSR). Sensory anal. revealed that Boletus Edulis had potent roasted and buttery attributes, Boletus Aereu exhibited woody note and Boletus Auripes Pk presented powerful floral and smoky aromas, while Boletus Rubellus Krombh showed weakness in five sensory attributes. The quant. anal. revealed that the dominant volatiles in boletus samples were esters, aldehydes, acids, alcs., pyrazines, ketones and phenols. A total of 42 potent aroma compounds (OAVs > 1) were determined by aroma extract dilution anal. and quant. anal. 1-Octen-3-ol and 2,5-dimethylpyrazine were the potent aroma compounds among four boletus samples. In addition, the key aroma compounds were 3-(methylthio)propionaldehyde and 2,6-dimethylpyrazine in Boletus edulis. Isovaleric acid, 2,6-dimethylpyrazine, benzeneacetaldehyde and (E)-2-octenal were the key aroma compounds in Boletus aereu. In Boletus auripes Pk, isovaleric acid, 3-ethylphenol and 2,6-dimethylpyrazine were the key aroma compounds, while 3-methylvaleric acid, isovaleric acid and 2,3-dimethylpyrazine significantly contributed to the aroma of boletus rubellus Krombh.

Food Research International published new progress about Acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 104-76-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H18O, Safety of 2-Ethylhexan-1-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts