Author: tianli

Kamatsuka, Takuto; Shinokubo, Hiroshi; Miyake, Yoshihiro published the artcile< Design and synthesis of tunable ligands with 4,4'-bipyridyl as an electron-accepting unit and their rhenium complexes>, Electric Literature of 660867-80-1, the main research area is rhenium bipyridine pendant amine phosphine complex preparation reduction catalyst; carbon dioxide reduction photocatalyst rhenium bipyridine carbonyl complex; crystal structure rhenium bipyridine pendant amine complex; mol structure rhenium bipyridine pendant amine complex.

We have designed and prepared a series of rhenium complexes with 4,4′-bipyridyl, [(2-R1-6-R2-2′-CH2Q-4,4′-bpy)ReCl(CO)3] (2a-i, Q = NEt2, PtBu2, POtBu2; R1, R2 = H, Me, Cl, Br) as an electron-accepting unit. Electrochem. studies revealed that oxidation and reduction of these complexes occurred on the rhenium center and the 4,4′-bipyridyl skeleton, resp. The redox potentials of the rhenium complexes are controllable by tuning the substituents on the 4,4′-bipyridyl skeleton and the coordinating groups to the rhenium center. We have also examined the reactivity of the rhenium complexes in electrochem. and photochem. CO2 reduction

Organometallics published new progress about Crystal structure. 660867-80-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H18BNO2, Electric Literature of 660867-80-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Morris, Louis J.; Hill, Michael S.; Mahon, Mary F.; Manners, Ian; McMenamy, Fred S.; Whittell, George R. published the artcile< Heavier Alkaline-Earth Catalyzed Dehydrocoupling of Silanes and Alcohols for the Synthesis of Metallo-Polysilylethers>, Name: Triphenylmethanol, the main research area is alk earth alkoxide preparation catalyst dehydrocoupling silane alc; crystal structure dinuclear barium calcium strontium bridging phenylmethoxide ferrocenylsiloxane; mol structure dinuclear barium calcium strontium bridging phenylmethoxide ferrocenylsiloxane; dehydrocoupling kinetics silane alc alk earth triphenylmethoxide catalyst; metallopolysilylether preparation; alkaline earth metals; barium; calcium; dehydrocoupling; metallopolymers; strontium.

The dehydrocoupling of silanes and alcs. mediated by heavier alk.-earth catalysts, [Ae{N(SiMe3)2}2·(THF)2] (I-III) and [Ae{CH(SiMe3)2}2·(THF)2], (IV-VI) (Ae = Ca, Sr, Ba) is described. Primary, secondary, and tertiary alcs. were coupled to phenylsilane or diphenylsilane, whereas tertiary silanes are less tolerant towards bulky substrates. Some control over reaction selectivity towards mono-, di-, or tri-substituted silylether products was achieved through alteration of reaction stoichiometry, conditions, and catalyst. The ferrocenyl silylether, FeCp(C5H4SiPh(OBn)2) (2), was prepared and fully characterized from the ferrocenylsilane, FeCp(C5H4SiPhH2) (1), and benzyl alc. using Ba catalysis. Stoichiometric experiments suggested a reaction manifold involving the formation of Ae-alkoxide and hydride species, and dimeric Ae-alkoxides [(Ph3CO)Ae(μ2-OCPh3)Ae(THF)] (3a-c, Ae = Ca, Sr, Ba) were isolated and fully characterized. Mechanistic experiments suggested a complex reaction mechanism involving dimeric or polynuclear active species, whose kinetics are highly dependent on variables such as the identity and concentration of the precatalyst, silane, and alc. Turnover frequencies increase on descending Group 2 of the periodic table, with the Ba precatalyst III displaying an apparent 1st-order dependence in both silane and alc., and an optimum catalyst loading of 3 mol% Ba, above which activity decreases. With precatalyst III in THF, ferrocene-containing poly- and oligosilylethers with ferrocene pendent to (P1-P4) or as a constituent (P5, P6) of the main polymer chain were prepared from 1 or Fe(C5H4SiPhH2)2 (4) with diols 1,4-(HOCH2)2-(C6H4) and 1,4-(CHMeOH)2(C6H4), resp. The resultant materials were characterized by NMR spectroscopy, gel permeation chromatog. (GPC) and DOSY NMR spectroscopy, with estimated mol. weights >20,000 Da for P1 and P4. The Fe centers display reversible redox behavior and thermal anal. showed P1 and P5 to be promising precursors to magnetic ceramic materials.

Chemistry – A European Journal published new progress about Alcohols Role: PEP (Physical, Engineering or Chemical Process), PRP (Properties), RCT (Reactant), PROC (Process), RACT (Reactant or Reagent). 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Name: Triphenylmethanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Abubakar, Samaila; Bala, Muhammad D. published the artcile< Transfer Hydrogenation of Ketones Catalyzed by Symmetric Imino-N-heterocyclic Carbene Co(III) Complexes>, Electric Literature of 403-41-8, the main research area is ketone imino NHC cobalt transfer hydrogenation catalyst; alc preparation.

The synthesis of new moisture-sensitive imine-functionalized N-heterocyclic carbene (NHC) precursor salts [1-(2-[(hydroxyl-benzylidene)-amino]-ethyl)-3-R-3H-imidazole-1-ium bromide; R = Me, Et, and benzyl] is reported. Subsequent deprotonation of precursor and coordination of the in situ generated NHC ligands to CoBr2 led to the isolation of air-stable six-coordinate Co(III) complexes, resp. All the salts and complexes were fully characterized. Single-crystal X-ray anal. of Co(III) complexes showed octahedral Co centers hexacoordinated to two NHC carbons, two imine nitrogen atoms, and two phenolate oxygens in the form [C~NÕ(Co3+)CÑÕ]. The complexes were used in the catalytic transfer hydrogenation (CTH) of a range of ketones in 2-propanol as the solvent and hydrogen donor. Based on a low catalyst concentration of 0.4 mol %, significant conversions in the range of 70-99% were recorded at high turnover frequencies up to 1635 h-1. A mechanism to account for the steps involved in the CTH of cyclohexanone by complex is proposed and supported by data from cyclic voltammetry, low-resolution mass spectrometry, UV, and IR spectroscopic techniques.

ACS Omega published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Electric Literature of 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Xu, Chunfa; Loh, Charles C. J. published the artcile< A Multistage Halogen Bond Catalyzed Strain-Release Glycosylation Unravels New Hedgehog Signaling Inhibitors>, Safety of ((3aR,5R,5aS,8aS,8bR)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-5-yl)methanol, the main research area is glycosylation catalyst glycoside triazole preparation; click alkyne azide triazole cycloaddition catalyst preparation glycoside antitumor.

Halogen bonding (XB) has recently emerged as a promising noncovalent activation mode that can be employed in catalysis. However, methodologies utilizing XB remain rare, and the hydrogen-bonding (HB) catalysis congeners are more widespread in comparison. Herein, we demonstrate a remarkable case whereby employment of XB catalysis in strain-release glycosylation generates O,N-glycosides in excellent anomeric selectivity exceeding HB activation. Deeper investigation unraveled XB catalyst dependencies on multiple stages of the mechanism and a hitherto unknown XB-glycosyl acceptor activation. We present a proof of concept to interrogate sp3-rich glycosidic chem. space for novel biol. activity, by integrating XB-catalyzed construction of a glycosidic compound collection, and evaluating these analogs via cell-based phenotypic screens. We show that XB-catalyzed strain-release glycosylation defines a new class of glycosides that inhibit the hedgehog signaling pathway through a nonsmoothened mode of action, opening new opportunities to combat acquired cancer resistance.

Journal of the American Chemical Society published new progress about 1,3-Dipolar cycloaddition reaction. 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, Safety of ((3aR,5R,5aS,8aS,8bR)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-5-yl)methanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Chong; Hu, Bowen; Chen, Dafa; Xia, Haiping published the artcile< Manganese(I)-Catalyzed Transfer Hydrogenation and Acceptorless Dehydrogenative Condensation: Promotional Influence of the Uncoordinated N-Heterocycle>, Category: alcohols-buliding-blocks, the main research area is manganese pyridylquinoline pyridylnaphthyridine preparation catalyst transfer hydrogenation dehydrogenative condensation; transfer hydrogenation ketone aldehyde catalyzed manganese carbonyl pyridylquinoline pyridylnaphthyridine; dehydrogenative condensation alc ketone catalyzed manganese carbonyl pyridylnaphthyridine; crystal structure manganese carbonyl bipyridinol complex.

The four bidentate Mn(I) complexes [(C5H4N-C5H3N-OH)Mn(CO)3Br] (1), [(C9H6N-C5H3N-OH)Mn(CO)3Br] (2), [(C8H5N2-C5H3N-OH)Mn(CO)3Br] (3), and [(C8H5N2-C5H3N-OCH3)Mn(CO)3Br] (4) were synthesized. These complexes were tested as catalysts for the transfer hydrogenation of ketones, and 3 showed the highest activity. The reactions proceeded well with 0.5 mol % of catalyst loading and 20 mol % of t-BuOK at 85° for 24 h. Also, 3 was also used as a catalyst for the synthesis of primary alcs. via transfer hydrogenation of aldehydes and the synthesis of 1,2-disubstituted benzimidazoles and quinolines via acceptorless dehydrogenative condensations.

Organometallics published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ye, Danfeng; Liu, Zhiyuan; Sessler, Jonathan L.; Lei, Chuanhu published the artcile< Base-free oxidation of alcohols enabled by nickel(II)-catalyzed transfer dehydrogenation>, Related Products of 403-41-8, the main research area is ketone preparation; alc nickel catalyst transfer dehydrogenation oxidation.

An efficient nickel(II)-catalyzed transfer dehydrogenation oxidation of alcs. was reported that relies on cyclohexanone as the formal oxidant and does not require the use of an external base. The synthetic utility of this protocol was demonstrated via the facile oxidation of structurally complicated natural products.

Chemical Communications (Cambridge, United Kingdom) published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Related Products of 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Moons, Sam J.; Rossing, Emiel; Heming, Jurriaan J. A.; Janssen, Mathilde A. C. H.; van Scherpenzeel, Monique; Lefeber, Dirk J.; de Jonge, Marien I.; Langereis, Jeroen D.; Boltje, Thomas J. published the artcile< Structure-Activity Relationship of Fluorinated Sialic Acid Inhibitors for Bacterial Sialylation>, Synthetic Route of 5505-63-5, the main research area is mannosamine fluorosialic acid synthesis antibacterial SAR Haemophilus influenzae sialylation.

Bacterial pathogens such as Nontypeable Haemophilus influenzae (NTHi) can evade the immune system by taking up and presenting host-derived sialic acids. Herein, we report a detailed structure-activity relationship of sialic acid-based inhibitors that prevent the transfer of host sialic acids to NTHi. We report the synthesis and biol. evaluation of C-5, C-8, and C-9 derivatives of the parent compound 3-fluorosialic acid (SiaNFAc). Small modifications are tolerated at the C-5 and C-9 positions, while the C-8 position does not allow for modification. These structure-activity relationships define the chem. space available to develop selective bacterial sialylation inhibitors.

Bioconjugate Chemistry published new progress about Antibacterial agents. 5505-63-5 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H14ClNO5, Synthetic Route of 5505-63-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Rai, Randhir; Chand, Dillip Kumar published the artcile< Copper nanoparticles (CuNPs) catalyzed chemoselective reduction of nitroarenes in aqueous medium>, Quality Control of 5344-90-1, the main research area is gluconate stabilized copper nanoparticle preparation; aryl amine chemoselective preparation; nitroarene reduction copper nanocatalyst.

A procedure for practical synthesis of CuNPs from CuSO4·5H2O was established, under appropriate reaction conditions, using rice (Oryza sativa) as an economic source of reducing as well as a stabilizing agent. Optical and microscopic techniques were employed for the characterization of the synthesized CuNPs and the sizes of the particles were found to be in the range of 8 ± 2 nm. The nanoparticles were used as a catalyst for chemoselective reduction of aromatic nitro compounds to corresponding amines ArNH2 [Ar = 4-HOC6H4, 4-BrC6H4, 4-HOOCC6H4, etc.] under ambient conditions and water as a reaction medium.

Journal of Chemical Sciences (Berlin, Germany) published new progress about Aromatic amines Role: SPN (Synthetic Preparation), PREP (Preparation). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Quality Control of 5344-90-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Becker, Vivien; Hui, Xin; Nalbach, Lisa; Ampofo, Emmanuel; Lipp, Peter; Menger, Michael D.; Laschke, Matthias W.; Gu, Yuan published the artcile< Linalool inhibits the angiogenic activity of endothelial cells by downregulating intracellular ATP levels and activating TRPM8>, Application of C10H18O, the main research area is linalool TRPM8 antiangiogenic agent angiogenesis; ATP; Angiogenesis; Endothelial cells; Linalool; TRPM8; Vascularization.

Angiogenesis crucially contributes to various diseases, such as cancer and diabetic retinopathy. Hence, anti-angiogenic therapy is considered as a powerful strategy against these diseases. Previous studies reported that the acyclic monoterpene linalool exhibits anticancer, anti-inflammatory and anti-oxidative activity. However, the effects of linalool on angiogenesis still remain elusive. Therefore, we investigated the action of (3R)-(-)-linalool, a main enantiomer of linalool, on the angiogenic activity of human dermal microvascular endothelial cells (HDMECs) by a panel of angiogenesis assays. Non-cytotoxic doses of linalool significantly inhibited HDMEC proliferation, migration, tube formation and spheroid sprouting. Linalool also suppressed the vascular sprouting from rat aortic rings. In addition, Matrigel plugs containing linalool exhibited a significantly reduced microvessel d. 7 days after implantation into BALB/c mice. Mechanistic analyses revealed that linalool promotes the phosphorylation of extracellular signal-regulated kinase (ERK), downregulates the intracellular level of ATP (ATP) and activates the transient receptor potential cation channel subfamily M (melastatin) member (TRPM)8 in HDMECs. Inhibition of ERK signaling, supplementation of ATP and blockade of TRPM8 significantly counteracted linalool-suppressed HDMEC spheroid sprouting. Moreover, ATP supplementation completely reversed linalool-induced ERK phosphorylation. In addition, linalool-induced ERK phosphorylation inhibited the expression of bone morphogenetic protein (BMP)-2 and linalool-induced TRPM8 activation caused the inhibition of β1 integrin/focal adhesion kinase (FAK) signaling. These findings indicate an anti-angiogenic effect of linalool, which is mediated by downregulating intracellular ATP levels and activating TRPM8.

Angiogenesis published new progress about Angiogenesis. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Application of C10H18O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lei, Jin-Cai; Ruan, Yu-Xiong; Luo, Sheng; Yang, Jin-Song published the artcile< Stereodirecting Effect of C3-Ester Groups on the Glycosylation Stereochemistry of L-Rhamnopyranose Thioglycoside Donors: Stereoselective Synthesis of α- and β-L-Rhamnopyranosides>, Application In Synthesis of 4064-06-6, the main research area is rhamnopyranoside stereoselective synthesis ester group stereodirecting glycosylation effect.

The tuning effect of C3-ester groups on the glycosylation stereochem. of L-rhamnopyranose (L-Rha) Et thioglycoside donors is described. On one hand, the L-Rha thioglycoside donors carrying 3-O-arylcarbonyl or levulinoyl group undergo highly α-selective glycosylation to afford a wide variety of α-L-rhamnoside products in high chem. yields. On the other hand, the glycosylation of the 3-O-4-nitropicoloyl and 2-pyrazinecarbonyl group substituted L-Rha thioglycosides displays β-stereoselectivity. Only or predominant β anomeric products are obtained when these L-Rha donors couple with the primary or reactive secondary acceptors, while the β-selectivity may decrease significantly when these donors react with less reactive secondary alcs. The synthetic utility of the newly developed α- and β-directing L-Rha donors I and II has been demonstrated by the efficient synthesis of a structurally unique trisaccharide III, which is derived from the cell wall polysaccharide of Sphaerotilus natans.

European Journal of Organic Chemistry published new progress about Alkoxycarbonyl groups. 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, Application In Synthesis of 4064-06-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts